Explanipedia

Capacitação de cuidadores de idosos no contexto do envelhecimento e velhices Open

M Santos, Gabriel Alves Saraiva, Flávia Thayanne Barbosa de Sousa, Rosy Maria de Oliveira Barbosa, Paulo Nathan Andrade Santos Lima , et al. · 2025

Objetivo: Relatar as experiências vivenciadas por acadêmicos do curso de graduação em enfermagem durante um projeto de extensão acerca da capacitação dos cuidadores informais de idosos, desenvolvido em uma Universidade Pública, localizado …

Diagnóstico precoce e tratamento da sepse: uma revisão bibliográfica Open

Taiana Caira Barbosa Galves, Izadora Pesquero Perelli, Glória Maria Vicentim, M Santos · 2025

A sepse representa um grave problema de saúde pública caracterizado por resposta imunológica desregulada frente a uma infecção, culminando em altas taxas de morbimortalidade e custos hospitalares elevados. Justifica-se, portanto, investiga…

Assessment of the Effects of Cigarette Smoke on the Renal Morphology of WISTAR Rats Open

Cristiane Gomes Fernandes Freire, Lorena Araújo da Cunha, Mateus Andrade Stecca, Isabele Masson de Brito, Renata Cunha Silva , et al. · 2025

Smoking is a major public health concern worldwide. The toxic components of cigarettes, such as nicotine, can cause abuse, dependence, and tissue damage. This study aimed to evaluate the effects of exposure to cigarette smoke on the renal …

Estudo sobre a aptidão cardiorrespiratória de integrantes da Polícia Militar do Tocantins Open

D Gomes, M Santos, Welere Gomes Barbosa · 2025

O presente estudo analisou a aptidão cardiorrespiratória dos policiais militares tocantinenses a partir da implementação da avaliação periódica de saúde na Polícia Militar do Estado do Tocantins. Foi utilizada metodologia de pesquisa epide…

Uma abordagem geral da diabetes mellitus gestacional Open

Carlos Cardoso, M Santos, Nuno Sousa · 2025

Objetivo: Descrever as características da Diabetes Mellitus Gestacional (DMG). Revisão bibliográfica: A DMG é definida por uma intolerância a glicose diagnosticada na gestação. Dentre os principais fatores de risco estão a idade materna av…

Acidente Vascular Cerebral e suas complicações neuropsiquiátricas: Depressão e ansiedade após AVC Open

Giovanna Sant’Anna da Costa, Leonardo Miguel Fiori, João Moura, Prímula Viana Campos, M Santos , et al. · 2025

O Acidente Vascular Cerebral (AVC) é uma das principais causas de incapacidade e morte globalmente, com complicações neuropsiquiátricas como depressão e ansiedade impactando significativamente a qualidade de vida dos sobreviventes. Este es…

Amnésia Global Transitória: Causas, manifestações clínicas e abordagem diagnóstica Open

E. Cater, Joanne Lins, Renato Cunha, Maria Eduarda Ferreira Silva, Gustavo Souza , et al. · 2025

A Amnésia Global Transitória (AGT) é uma condição neurológica caracterizada pela perda súbita e temporária da memória episódica, sem alterações cognitivas significativas, e com recuperação completa geralmente em menos de 24 horas. Embora s…

Avanços e Desafios na Cirurgia de Emergência: Abordagens Contemporâneas no Manejo de Traumas Abdominais Open

F. A. Brasileiro Filho, Daniel Araújo Pinheiro, Daniel Gonçalves Menegazzo, Diego Silva Souza, Diego de Carvalho Maia , et al. · 2025

A cirurgia de emergência, particularmente no manejo de traumas abdominais, é um dos campos mais desafiadores da medicina, devido à necessidade de um diagnóstico rápido e de decisões cirúrgicas precisas. Nas últimas décadas, houve avanços s…

Impacto da prática de exercícios físicos na prevenção de quedas em pacientes idosos: revisão integrativa Open

Salma Esmael Bobo Chidassicua, Tânia Martins, Karla de Oliveira Silva, Ricardo Antônio Vieira, M Santos , et al. · 2025

Introdução: Estima-se que anualmente, cerca de 40% dos idosos sofram de quedas, resultando em consequências físicas, sociais e psíquicas. Objetivo: Analisar as evidências científicas produzidas acerca do impacto da prática de exercícios fí…

Os benefícios da analgesia peridural durante o trabalho de parto normal: uma revisão de literatura Open

Glória Maria Vicentim, M Santos, Cristiane Zanncani, Wilson Lenarduzzi, Angela Maffi Paiva , et al. · 2025

A dor relacionada ao trabalho de parto e parto é uma preocupação histórica para as mulheres, com o primeiro método moderno de analgesia obstétrica introduzido em 1847. Os mecanismos de dor incluem dilatação cervical, contrações miometriais…

Validation of the SCORE2 risk prediction algorithm in a Portuguese population: A new model to estimate 10-year cardiovascular disease incidence in Europe Open

M Temtem, M I Mendonça, M Santos, Débora Sá, Francisco Alves de Sousa , et al. · 2024

SCORE2 improved population stratification by identifying higher-risk patients, enabling early preventive measures. It showed good discriminative ability for all ASCVE.

Barriers and facilitators of adherence to tuberculosis treatment in children and adolescents Open

M Santos, Bruna Costa, Maria Clara Rodrigues, Claudete Aparecida Araújo Cardoso · 2024

Introduction: Tuberculosis (TB), an infectious and contagious disease, requires prolonged treatment and usually affects socially vulnerable patients, which increases the risk of abandonment during its course. Children and adolescents are s…

Genetic risk score and epicardial adipose tissue: the new tools with impact on cardiovascular risk assessment Open

M Temtem, M I Mendonça, J Sousa, M Serrão, M Santos , et al. · 2023

Background Cardiovascular disease (CVD) remains the leading cause of death worldwide. One of its main contributors is coronary artery disease (CAD), a complex multifactorial disease influenced by hereditary and environmental factors. A bet…

Prognostic change of adding coronary calcium score and genetic risk score to European SCORE2 in a moderate risk region Open

M Temtem, R Palma Dos Reis, M Serrão, M Santos, D Sa , et al. · 2023

Introduction Cardiovascular disease is a public health issue remaining the leading cause of death worldwide. One of its main contributors is coronary artery disease (CAD), a complex multifactorial disease with the influence of hereditary a…

ZNF259 rs964184 genetic variant is associated with metabolic syndrome in a Portuguese population Open

D Sa, M I Mendonça, M Santos, M Temtem, Francisco Alves de Sousa , et al. · 2023

Background Zinc finger protein (ZPR1) encoded by the ZNF259 gene has been associated with defects in transcription and cell cycle progression. Additionally, the promoter site of ZPR1 binds to peroxisome proliferator-activated receptor gamm…

Could a high epicardial adipose tissue volume increase the ability of the calcium score to discriminate cardiovascular events in an asymptomatic population? Open

M Temtem, M I Mendonça, J Sousa, M Serrão, M Santos , et al. · 2023

Background Evidence indicates that an elevated calcium score (CAC) is a risk marker for subclinical atherosclerosis and cardiovascular (CV) events in the asymptomatic population. Recent research has shown that high epicardial adipose tissu…

Coronary artery calcium score is a predictive tool for cardiovascular events in an asymptomatic population Open

Francisco Alves de Sousa, M I Mendonça, M Temtem, M Serrão, M Santos , et al. · 2023

Background Recent research highlights the role of the coronary artery calcium score (CAC Score) in evaluating the severity of subclinical atherosclerosis in asymptomatic individuals without apparent cardiovascular disease (CVD). However, t…

TCF21 gene and cardiovascular events in a coronary population Open

D Sa, M I Mendonça, M Santos, M Temtem, Francisco Alves de Sousa , et al. · 2023

Background Recent research showed that TCF21 expression in precursor cells that migrate into the disease lesions contributes to the fibrous cap, stabilizing the lesions and preventing heart attacks. Targeted deletion of the transcription f…

A better understanding of coronary artery disease molecular biology through an intermediate phenotype Open

D Sa, M I Mendonça, M Santos, M Temtem, Francisco Alves de Sousa , et al. · 2023

Coronary Artery Disease (CAD) remains a common cause of death worldwide; over half of these deaths are asymptomatic until the first fatal presentation. Previous studies have often compared coronary artery calcification (CAC) with coronary …

PSRC1 rs599839 G allele may promote protection from coronary artery disease in a Madeira Island population Open

Francisco Alves de Sousa, M I Mendonça, D Sa, M Temtem, M Santos , et al. · 2023

Previous research associates the PSRC1 gene on the chromosomal locus 1p13.3 with coronary artery disease (CAD). Specifically, the A wild allele of the PSRC1 rs599539 A>G was identified as a risk allele for CAD, and the mutated G minor a…

Transcription factor 21 gene and prognosis in a coronary population Open

M Santos, M I Mendonça, M Temtem, Débora Sá, Ana Célia Sousa , et al. · 2023

Synergy among Genes and Genes-Environment on Coronary Artery Disease Risk and Prognosis Open

M I Mendonça, M Santos, M Temtem, Débora Sá, Francisco Alves de Sousa , et al. · 2023

Introduction: Genetic and environmental factors contribute to predisposition to cardiovascular disease (CVD). Complex pathophysiological processes that may modulate this effect are unknown.

Diagnóstico Complicado: Uma Corda Aberrante da Valva Mitral Open

M Santos, Mariana Paiva, Joana Ferreira, S Guerreiro · 2023

Caso Apresenta-se o caso de um homem de 52 anos, com antecedentes de hepatite-C e abuso de drogas endovenosas, que estava internado no serviço de infectologia de outro hospital por espondilodiscite e abcesso no músculo psoas. Durante o int…

Impact of genetic information on coronary disease risk in Madeira: The GENEMACOR study Open

M I Mendonça, Andreia Pereira, J Monteiro, J Sousa, M Santos , et al. · 2022

Lipoprotein(a) and cardiovascular outcomes in patients with coronary artery disease and impaired glucose metabolism Open

D Sa, R Palma Dos Reis, M Santos, M Temtem, A C Sousa , et al. · 2022

Introduction Lipoprotein(a) [Lp(a)] is an LDL-like molecule composed of a part of apolipoprotein(a) bounding covalently to apolipoprotein B-100. High plasma Lp(a) levels were associated with MACE in stable CAD patients. Recent research sho…

Clinical Case 22—When the unusual appears Open

Ana Margarida de Abreu Temtem, Débora Sá, M Santos, Sofia Leça, R. Rodrigues , et al. · 2022

Clinical case A 57 years old female, smoker, presented to emergency department with a constrictive chest and epigastric pain lasting for 30 minutes. Admission electrocardiogram showed a sinus bradycardia and ST elevation in the inferior le…

Genetic information or coronary artery calcium score? What is more helpful in today's clinical practice? Open

D Sa, M I Mendonça, M Temtem, M Santos, M Serrão , et al. · 2022

Introduction Coronary artery calcium (CAC) score has emerged as the most predictive cardiovascular risk marker in asymptomatic individuals, capable of adding prognostic information beyond the traditional risk factors (TRF). Genetic risk sc…

Poster No. 104 Impact of pre-treatment with a P2Y12 receptor inhibitor on delay to CABG surgery in a real-world population with non-ST segment elevation acute coronary syndrome Open

D Gomes, B Rocha, Jorge Ferreira, Mariana Paiva, Rita Reis Santos , et al. · 2022

Background ESC guidelines for non-ST elevation acute coronary syndromes (NSTE-ACS) recommend against P2Y12 pre-treatment receptor inhibitors (P2Y12i) in patients undergoing early invasive management (< 24 h). The rationale is, in part, …

Clinical Case 10—An unusual case of thrombocytopenia following transfemoral aortic valve implantation Open

Ana Débora Câmara de Sá, André Antunes, M Santos, M Temtem, J Sousa , et al. · 2022

Clinical Case: An 85-year-old female patient with diabetes, hypertension, obesity, chronic kidney disease and severe aortic stenosis was submitted to transcatheter aortic valve implantation (TAVI). During procedure unfractionated heparin w…

Comparison between the European SCORE and the updated SCORE2 for cardiovascular outcomes Open

M Temtem, M I Mendonça, M Serrão, M Santos, D Sa , et al. · 2022

Introduction The European Systematic Coronary Risk Evaluation (SCORE) has predicted a 10-year risk of CVD since 1986. It included only fatal CVD outcomes, underestimating the total CVD burden, especially for younger people. To counteract t…

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