Marcin Siwek
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View article: The role of mindfulness training supported by virtual reality in the nonpharmacological treatment of schizophrenia-research design
The role of mindfulness training supported by virtual reality in the nonpharmacological treatment of schizophrenia-research design Open
This paper presents the outcome of a clinical trial planning process developed during multicenter, multidisciplinary seminars with prospective collaborators. The study protocol, designed according to the Oxford Quality Assessment System, o…
View article: The impact of neurological and cerebellar soft signs on psychosocial functioning in bipolar disorder
The impact of neurological and cerebellar soft signs on psychosocial functioning in bipolar disorder Open
Background Patients with bipolar disorder (BD) present motor dysfunctions in the form of neurological and cerebellar soft signs (NSS and CSS, respectively). Little is known about the clinical utility of these symptoms and their impact on p…
View article: The CARE project – study protocol and pilot results from the Polish population
The CARE project – study protocol and pilot results from the Polish population Open
Introduction Negative symptoms of schizophrenia (SZ) are a critical unmet need of SZ treatment. In the past years, clinical tools were developed and guidance papers for the evaluation and management of negative symptoms of SZ were publishe…
View article: Systematic Review of Studies on Group Mindfulness–Based Interventions for Individuals Suffering from Schizophrenia Spectrum Disorders
Systematic Review of Studies on Group Mindfulness–Based Interventions for Individuals Suffering from Schizophrenia Spectrum Disorders Open
Objectives The aim of this study was to determine whether group mindfulness-based interventions (MBIs) offer important support for pharmacological therapy for people suffering from schizophrenia spectrum disorders. Method Searches of elect…
View article: Psychopharmacological treatment in elderly patients
Psychopharmacological treatment in elderly patients Open
Mental disorders in the elderly occur much more often than in young adults, and their prevalence increases significantly with age and in the case of people receiving institutional care. Psychopharmacotherapy in an elderly patient is much m…
View article: Chronotype in individuals with exercise addiction – preliminary analysis
Chronotype in individuals with exercise addiction – preliminary analysis Open
Introduction Exercise addiction (EA) is conceptualized as the uncontrolled practice of physical activity, with repetition of that behavior despite the negative effects on the individual [Khazaal et al. Rev Med Suisse. 2024; 20(882):1354-13…
View article: Trazodone effectiveness in depression: impacts of trazodone extended release vs SSRIs on the health status and quality of life of patients with major depressive disorder
Trazodone effectiveness in depression: impacts of trazodone extended release vs SSRIs on the health status and quality of life of patients with major depressive disorder Open
Introduction Early research on the pharmacotherapy for major depressive disorder (MDD) has largely focused on symptomatic improvements, whereas this focus has shifted to functioning and quality of life in recent years. Studies have confirm…
View article: Managing depression in the elderly: real-world clinical considerations and perspectives
Managing depression in the elderly: real-world clinical considerations and perspectives Open
This study aims to elucidate current trends in clinical practice for managing depression in elderly patients, focusing on the utilization of pharmacotherapeutics and integrated care models to improve patient outcomes. A comprehensive surve…
View article: The effects of clinical and pharmacological factors on the ratio of clozapine to norclozapine in psychiatric patients
The effects of clinical and pharmacological factors on the ratio of clozapine to norclozapine in psychiatric patients Open
Background Due to its exceptional effectiveness, clozapine (CLO), whose metabolite is norclozapine (NCLO), is a drug of choice in the management of treatment-resistant schizophrenia. The purpose of this study was to assess the factors modi…
View article: Green rush and red warnings: Retrospective chart review of adverse events of interactions between cannabinoids and psychotropic drugs
Green rush and red warnings: Retrospective chart review of adverse events of interactions between cannabinoids and psychotropic drugs Open
Aim Our objective was to systematically assess the prevalence and clinical features of adverse events related to interactions between cannabinoids and psychotropic drugs through a retrospective chart review. Methodology 1586 adverse event …
View article: Drugs with glutamate-based mechanisms of action in psychiatry
Drugs with glutamate-based mechanisms of action in psychiatry Open
Psychopharmacotherapy of major psychiatric disorders is mostly based on drugs that modulate serotonergic, dopaminergic, or noradrenergic neurotransmission, either by inhibiting their reuptake or by acting as agonists or antagonists on spec…
View article: Divergent pattern of functional connectivity within the dorsal attention network differentiates schizophrenia and bipolar disorder patients
Divergent pattern of functional connectivity within the dorsal attention network differentiates schizophrenia and bipolar disorder patients Open
Introduction Schizophrenia (SZ) and bipolar disorder (BD) share common clinical features, symptoms, and neurocognitive deficits, which results in common misdiagnosis. Recently, it has been suggested that alterations within brain networks a…
View article: Insulin Resistance, Temperament and Personality Traits Are Associated with Anhedonia in a Transdiagnostic Sample
Insulin Resistance, Temperament and Personality Traits Are Associated with Anhedonia in a Transdiagnostic Sample Open
Anhedonia constitutes a core symptom of major depressive disorder (MDD) mediating the ultimate goal of MDD treatment: functional remission. Anhedonia is also present in other clinical populations, including patients with chronic pain. Rece…
View article: Interactions between grapefruit juice and psychotropic medications: an update of the literature and an original case series
Interactions between grapefruit juice and psychotropic medications: an update of the literature and an original case series Open
The impact of GJ on CYP 3A4 appears to be the critical mechanism for the majority of GJ-to-psychopharmacotherapy interactions described in human studies or case reports. However, there are studies and cases of patients clearly showing that…
View article: Clinical and pharmacological factors influencing serum clozapine and norclozapine levels
Clinical and pharmacological factors influencing serum clozapine and norclozapine levels Open
Background: Clozapine (CLO) is a very effective antipsychotic, whose use is associated with dose-dependent risk of complications. Due to high interindividual variability in CLO metabolism, there is a need to identify factors affecting the …
View article: New Light on Prions: Putative Role of PrPc in Pathophysiology of Mood Disorders
New Light on Prions: Putative Role of PrPc in Pathophysiology of Mood Disorders Open
Mood disorders are highly prevalent and heterogenous mental illnesses with devastating rates of mortality and treatment resistance. The molecular basis of those conditions involves complex interplay between genetic and environmental factor…
View article: Cariprazine augmentation of clozapine in schizophrenia—a retrospective chart review
Cariprazine augmentation of clozapine in schizophrenia—a retrospective chart review Open
The aim of our study was to evaluate the efficacy of cariprazine augmentation of clozapine in treatment-resistant schizophrenia in a retrospective chart review. Among 916 medical records of schizophrenia patients, we identified 12 individu…
View article: Consolidating evidence on the role of insulin resistance in major depressive disorder
Consolidating evidence on the role of insulin resistance in major depressive disorder Open
Purpose of review The circular interactions between type 2 diabetes (TMD2) and major depressive disorder (MDD) are well documented but the understanding of their mechanisms has only recently gained more clarity. Latest research indicates, …
View article: TED—trazodone effectiveness in depression: a naturalistic study of the effeciveness of trazodone in extended release formulation compared to SSRIs in patients with a major depressive disorder
TED—trazodone effectiveness in depression: a naturalistic study of the effeciveness of trazodone in extended release formulation compared to SSRIs in patients with a major depressive disorder Open
Introduction: Selective serotonin reuptake inhibitors (SSRIs) are the most often used medications to treat major depressive disorder (MDD). Despite their effectiveness in reducing depressive symptoms, several issues are associated with the…
View article: Depression, anxiety, insomnia and interleukins in the early postpartum period
Depression, anxiety, insomnia and interleukins in the early postpartum period Open
Background Some new mothers have been shown to suffer from anxiety and depression associated with insomnia during the postpartum period. Our study assessed the impact of demographic, psychopathological, and biochemical factors on the incid…
View article: Harder, better, faster, stronger? Retrospective chart review of adverse events of interactions between adaptogens and antidepressant drugs
Harder, better, faster, stronger? Retrospective chart review of adverse events of interactions between adaptogens and antidepressant drugs Open
Aim: We aimed to systematically evaluate the prevalence and clinical characteristics of adverse events associated with the adaptogens and antidepressant drug interactions in a retrospective chart review. Methodology: A total of 1,816 repor…