Márcio W. Paixão
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View article: Synthesis of α-Amino Acids by ConPET-Mediated CO <sub>2</sub> Fixation into Amides
Synthesis of α-Amino Acids by ConPET-Mediated CO <sub>2</sub> Fixation into Amides Open
View article: Photoredox‐Catalyzed Synthesis of a Novel Class of Fluoroalkyl Pyrazolones
Photoredox‐Catalyzed Synthesis of a Novel Class of Fluoroalkyl Pyrazolones Open
A photoredox‐enabled strategy is developed for the regioselective synthesis of fluoroalkyl 2‐pyrazolin‐5‐ones via radical addition–cyclization cascades. This metal‐free approach enables the efficient incorporation of perfluoroalkyl and dif…
View article: Domino Upgrading of Hemicellulose Derivatives Using a Novel Magnetically Recoverable Mo(V)-Containing Heteropolyacid Catalyst
Domino Upgrading of Hemicellulose Derivatives Using a Novel Magnetically Recoverable Mo(V)-Containing Heteropolyacid Catalyst Open
View article: Selective Native N<sub>(in)</sub>–H Bond Activation in Peptides with Metallaphotocatalysis
Selective Native N<sub>(in)</sub>–H Bond Activation in Peptides with Metallaphotocatalysis Open
The development of chemical methods enabling site-selective incorporation of noncanonical amino acids into peptide backbones with precise functional tailoring remains a critical challenge. Particularly compelling is the use of underexplore…
View article: Selective Hydrogenation of HMF to DHMF Using Cationic Ru‐PNP Complex
Selective Hydrogenation of HMF to DHMF Using Cationic Ru‐PNP Complex Open
The advancement of biorefinery technology for converting non‐edible biomass into bio‐based fuels and chemicals, like 5‐hydroxymethylfurfural (HMF), is attracting considerable attention as a sustainable substitute for fossil‐based industria…
View article: Photocatalytic Synthesis of Difluorinated Glycoamino Acids and Neoglycopeptides via Hydrodifluoroacetamidation of Vinyl-C-glycosides
Photocatalytic Synthesis of Difluorinated Glycoamino Acids and Neoglycopeptides via Hydrodifluoroacetamidation of Vinyl-C-glycosides Open
A photocatalytic approach for the synthesis of difluorinated glycoamino acids and neoglycopeptides from bromodifluoroacetamides and sugar-derived olefins is presented. This method stands out because of its simplicity, atomic economy, and m…
View article: Visible Light‐Mediated Diastereoselective Synthesis of Novel Glycopeptide Mimetics
Visible Light‐Mediated Diastereoselective Synthesis of Novel Glycopeptide Mimetics Open
Herein, we introduce a mild and operationally simple visible‐light photochemistry protocol for the synthesis of novel glycopeptide mimetics. This method capitalizes on the reaction between 1,4‐dihydropyridine (DHP) containing amino acids a…
View article: Expanding the Chemical Space of Electrophilic β-Glycosyl β-Lactams through Photoinduced Diastereoselective Functionalization
Expanding the Chemical Space of Electrophilic β-Glycosyl β-Lactams through Photoinduced Diastereoselective Functionalization Open
Herein, we present a photoinduced diastereoselective C-3 functionalization of electrophilic β-glycosyl β-lactams. The developed protocol is simple, mild, and scalable and explores the use of 3-exomethylene β-lactams as reaction partners in…
View article: CCDC 2041734: Experimental Crystal Structure Determination
CCDC 2041734: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Synthesis, antioxidant activity, antimicrobial efficacy and molecular docking studies of 4-chloro-2-(1-(4-methoxyphenyl)-4,5-diphenyl-1<i>H</i>-imidazol-2-yl)phenol and its transition metal complexes
Synthesis, antioxidant activity, antimicrobial efficacy and molecular docking studies of 4-chloro-2-(1-(4-methoxyphenyl)-4,5-diphenyl-1<i>H</i>-imidazol-2-yl)phenol and its transition metal complexes Open
Herein, a one-pot synthesis of tetra-substituted imidazole, 4-chloro-2-(1-(4-methoxyphenyl)-4,5-diphenyl-1 H -imidazol-2-yl)phenol (HL), is reported by the reaction of benzil, 5-chlorosalicylaldehyde, ammonium acetate and anisidine.
View article: Divergent Functionalization of Styrenes via Radical/Polar Crossover with CO<sub>2</sub> and Sodium Sulfinates
Divergent Functionalization of Styrenes via Radical/Polar Crossover with CO<sub>2</sub> and Sodium Sulfinates Open
Sulfones and carboxylic acids are prominent motifs widely present in the chemical structure of agrochemicals, pharmaceuticals and many other highly valuable compounds. Herein, we describe a conjunctive strategy for the precise installation…
View article: Decoding the Role of Melatonin Structure on Plasmodium falciparum Human Malaria Parasites Synchronization Using 2-Sulfenylindoles Derivatives
Decoding the Role of Melatonin Structure on Plasmodium falciparum Human Malaria Parasites Synchronization Using 2-Sulfenylindoles Derivatives Open
Melatonin acts to synchronize the parasite’s intraerythrocytic cycle by triggering the phospholipase C-inositol 1,4,5-trisphosphate (PLC-IP3) signaling cascade. Compounds with an indole scaffold impair in vitro proliferation of blood-stage…
View article: RECENT APPLICATIONS OF THE ORGANIC PHOTOCATALYST 1,2,3,5-TETRAKIS(CARBAZOL-9-YL)-4,6-DICIANOBENZENE IN CHEMICAL TRANSFORMATIONS
RECENT APPLICATIONS OF THE ORGANIC PHOTOCATALYST 1,2,3,5-TETRAKIS(CARBAZOL-9-YL)-4,6-DICIANOBENZENE IN CHEMICAL TRANSFORMATIONS Open
Ruthenium and iridium polypyridine complexes are among the most employed photocatalysts described in literature. The broad applicability is due to the redox potentials and long half-life times of the excited state which these molecules pre…
View article: Cover Feature: Electrochemical Installation of CFH<sub>2</sub>−, CF<sub>2</sub>H−, CF<sub>3</sub>−, and Perfluoroalkyl Groups into Small Organic Molecules (Chem. Rec. 9/2021)
Cover Feature: Electrochemical Installation of CFH<sub>2</sub>−, CF<sub>2</sub>H−, CF<sub>3</sub>−, and Perfluoroalkyl Groups into Small Organic Molecules (Chem. Rec. 9/2021) Open
The cover picture displays fluoroalkyl radicals as reactive intermediates in the electrochemical (per)fluoroalkylation and representative examples of electrochemically fluoroalkylated small molecules. The installation of fluoroalkyl moieti…
View article: Direct access to tetrasubstituted cyclopentenyl scaffolds through a diastereoselective isocyanide-based multicomponent reaction
Direct access to tetrasubstituted cyclopentenyl scaffolds through a diastereoselective isocyanide-based multicomponent reaction Open
Simple and available reagents are combined in this new three-component isocyanide-based multicomponent reaction providing an interesting and straightforward way to prepare complex and highly functionalized cyclopentenyl rings.
View article: Post-synthetic functionalization of tryptophan protected peptide sequences through indole (C-2) photocatalytic alkylation
Post-synthetic functionalization of tryptophan protected peptide sequences through indole (C-2) photocatalytic alkylation Open
Mild and efficient C–H functionalization of tryptophan and of tryptophan-containing peptides with activated α-bromo-carbonyl compounds under visible-light irradiation is described.
View article: Green asymmetric synthesis of epoxypeptidomimetics and evaluation as human cathepsin K inhibitors
Green asymmetric synthesis of epoxypeptidomimetics and evaluation as human cathepsin K inhibitors Open
View article: C(<i>sp</i><sup>3</sup>)−C(<i>sp</i><sup>3</sup>) Cross‐Coupling of Alkyl Bromides and Ethers Mediated by Metal and Visible Light Photoredox Catalysis
C(<i>sp</i><sup>3</sup>)−C(<i>sp</i><sup>3</sup>) Cross‐Coupling of Alkyl Bromides and Ethers Mediated by Metal and Visible Light Photoredox Catalysis Open
We report a C( sp 3 )−C( sp 3 ) cross‐coupling of alkyl bromides and alkyl chlorides with ethers by dual photoredox‐nickel catalysis. The catalytic system comprises of the organic photocatalyst 1,2,3,5‐tetrakis(carbazol‐9‐yl)‐4,6‐dicyanobe…
View article: CCDC 1946000: Experimental Crystal Structure Determination
CCDC 1946000: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Metal-Free Photoinduced Hydroalkylation Cascade Enabled by an Electron-Donor-Acceptor Complex
Metal-Free Photoinduced Hydroalkylation Cascade Enabled by an Electron-Donor-Acceptor Complex Open
A metal- and catalyst-free photoinduced radical cascade hydroalkylation of 1,7-enynes has been disclosed. The process is triggered by a SET event involving a photoexcited electron-donor-aceptor complex between NHPI ester and Hantzsch ester…
View article: Metal-Free Photoinduced Hydroalkylation Cascade Enabled by an Electron-Donor-Acceptor Complex
Metal-Free Photoinduced Hydroalkylation Cascade Enabled by an Electron-Donor-Acceptor Complex Open
A metal- and catalyst-free photoinduced radical cascade hydroalkylation of 1,7-enynes has been disclosed. The process is triggered by a SET event involving a photoexcited electron-donor-aceptor complex between NHPI ester and Hantzsch ester…
View article: CCDC 1950467: Experimental Crystal Structure Determination
CCDC 1950467: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1950466: Experimental Crystal Structure Determination
CCDC 1950466: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1950465: Experimental Crystal Structure Determination
CCDC 1950465: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: RECENTES APLICAÇÕES DO ORGANOFOTOCATALISADOR 1,2,3,5-TETRAQUIS(CARBAZOL-9-IL)-4,6- DICIANOBENZENO EM TRANSFORMAÇÕES QUÍMICAS
RECENTES APLICAÇÕES DO ORGANOFOTOCATALISADOR 1,2,3,5-TETRAQUIS(CARBAZOL-9-IL)-4,6- DICIANOBENZENO EM TRANSFORMAÇÕES QUÍMICAS Open
RECENT APPLICATIONS OF THE ORGANIC PHOTOCATALYST 1,2,3,5-TETRAKIS(CARBAZOL-9-YL)- 4,6-DICIANOBENZENE IN CHEMICAL TRANSFORMATIONS. Ruthenium and iridium polypyridine complexes are among the most employed photocatalysts described in literatu…
View article: Green One-Pot Asymmetric Synthesis of Peptidomimetics via Sequential Organocatalyzed Aziridination and Passerini Multicomponent Reaction
Green One-Pot Asymmetric Synthesis of Peptidomimetics via Sequential Organocatalyzed Aziridination and Passerini Multicomponent Reaction Open
Peptidomimetics containing an aziridine moiety have been reported as potent cysteine protease inhibitors. In this sense, the development of stereoselective and sustainable synthetic strategies to obtain three-membered N-heterocyclic compou…
View article: CCDC 1873659: Experimental Crystal Structure Determination
CCDC 1873659: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1873945: Experimental Crystal Structure Determination
CCDC 1873945: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Design of a Helical-Stabilized, Cyclic, and Nontoxic Analogue of the Peptide Cm-p5 with Improved Antifungal Activity
Design of a Helical-Stabilized, Cyclic, and Nontoxic Analogue of the Peptide Cm-p5 with Improved Antifungal Activity Open
Following the information obtained by a rational design study, a cyclic and helical-stabilized analogue of the peptide Cm-p5 was synthetized. The cyclic monomer showed an increased activity in vitro against Candida albicans and C…
View article: Ugi reaction-derived prolyl peptide catalysts grafted on the renewable polymer polyfurfuryl alcohol for applications in heterogeneous enamine catalysis
Ugi reaction-derived prolyl peptide catalysts grafted on the renewable polymer polyfurfuryl alcohol for applications in heterogeneous enamine catalysis Open
The multicomponent synthesis of prolyl pseudo-peptide catalysts using the Ugi reaction with furfurylamines or isocyanides is described. The incorporation of such a polymerizable furan handle enabled the subsequent polymerization of the pep…