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View article: Access to essential drugs for neglected tropical diseases in Italy: the case of Ivermectin
Access to essential drugs for neglected tropical diseases in Italy: the case of Ivermectin Open
View article: Schistosomiasis in migrants: bridging the gap in Italy’s treatment guidelines and access
Schistosomiasis in migrants: bridging the gap in Italy’s treatment guidelines and access Open
Schistosomiasis is a widespread disease that can cause serious health issues if not diagnosed and treated promptly. Fortunately, there is an effective and safe treatment available: praziquantel (PZQ). In countries with a high influx of mig…
View article: A general framework to support cost-efficient fecal egg count methods and study design choices for large-scale STH deworming programs–monitoring of therapeutic drug efficacy as a case study
A general framework to support cost-efficient fecal egg count methods and study design choices for large-scale STH deworming programs–monitoring of therapeutic drug efficacy as a case study Open
Background Soil-transmitted helminth (STH) control programs currently lack evidence-based recommendations for cost-efficient survey designs for monitoring and evaluation. Here, we present a framework to provide evidence-based recommendatio…
View article: A general framework to support cost-efficient fecal egg count method and study design choices for large-scale STH deworming programs – monitoring of therapeutic drug efficacy as a case study
A general framework to support cost-efficient fecal egg count method and study design choices for large-scale STH deworming programs – monitoring of therapeutic drug efficacy as a case study Open
Background Soil-transmitted helminth (STH) control programs currently lack evidence-based recommendations for cost-efficient survey designs for monitoring and evaluation. Here, we present a framework to provide evidence-based recommendatio…
View article: Egg excretion indicators for the measurement of soil-transmitted helminth response to treatment
Egg excretion indicators for the measurement of soil-transmitted helminth response to treatment Open
Background Periodic administration of anthelmintic drugs is a cost-effective intervention for morbidity control of soil-transmitted helminth (STH) infections. However, with programs expanding, drug pressure potentially selecting for drug-r…
View article: Individual responses to a single oral dose of albendazole indicate reduced efficacy against soil-transmitted helminths in an area with high drug pressure
Individual responses to a single oral dose of albendazole indicate reduced efficacy against soil-transmitted helminths in an area with high drug pressure Open
Background Albendazole (ALB) is administered annually to millions of children through global deworming programs targeting soil-transmitted helminths (STHs: Ascaris lumbricoides , Trichuris trichiura and hookworms, Necator americanus and An…
View article: In vitro copper oxide nanoparticle toxicity on intestinal barrier
In vitro copper oxide nanoparticle toxicity on intestinal barrier Open
The use of CuO nanoparticles (NPs) has increased greatly and their potential effects on human health need to be investigated. Differentiated Caco‐2 cells were treated from the apical (Ap) and the basolateral (Bl) compartment with different…
View article: An in-depth report of quality control on Kato-Katz and data entry in four clinical trials evaluating the efficacy of albendazole against soil-transmitted helminth infections
An in-depth report of quality control on Kato-Katz and data entry in four clinical trials evaluating the efficacy of albendazole against soil-transmitted helminth infections Open
In these trials, where staff was informed that QC would take place, minimal changes in study outcomes were reported following QC on FECs or data entry. Nevertheless, imposing QC did reduce the number of errors. Therefore, application of QC…
View article: World Gastroenterology Organisation Global Guidelines
World Gastroenterology Organisation Global Guidelines Open
Strongyloides stercoralis is a soil-transmitted helminth, but it has a unique life cycle that can be completed in the human host, in a process known as autoinfection. Worldwide, the burden of disease is substantial (300 to 400 million infe…
View article: Identifying thresholds for classifying moderate-to-heavy soil-transmitted helminth intensity infections for FECPAKG2, McMaster, Mini-FLOTAC and qPCR
Identifying thresholds for classifying moderate-to-heavy soil-transmitted helminth intensity infections for FECPAKG2, McMaster, Mini-FLOTAC and qPCR Open
The World Health Organization (WHO) has defined moderate-to-heavy intensity (M&HI) infections with soil-transmitted helminths (Ascaris lumbricoides, Trichuris trichiura and the two hookworms, Ancylostoma duodenale and Necator americanus) b…
View article: Piloting a surveillance system to monitor the global patterns of drug efficacy and the emergence of anthelmintic resistance in soil-transmitted helminth control programs: a Starworms study protocol
Piloting a surveillance system to monitor the global patterns of drug efficacy and the emergence of anthelmintic resistance in soil-transmitted helminth control programs: a Starworms study protocol Open
To eliminate soil-transmitted helminth (STH) infections as a public health problem, the administration of benzimidazole (BZ) drugs to children has recently intensified. But, as drug pressure increases, the development of anthelmintic drug …
View article: Therapeutic efficacy of albendazole against soil-transmitted helminthiasis in children measured by five diagnostic methods
Therapeutic efficacy of albendazole against soil-transmitted helminthiasis in children measured by five diagnostic methods Open
ClinicalTrials.gov NCT03465488.
View article: Diagnostic performance of a single and duplicate Kato-Katz, Mini-FLOTAC, FECPAKG2 and qPCR for the detection and quantification of soil-transmitted helminths in three endemic countries
Diagnostic performance of a single and duplicate Kato-Katz, Mini-FLOTAC, FECPAKG2 and qPCR for the detection and quantification of soil-transmitted helminths in three endemic countries Open
ClinicalTrials.gov NCT03465488.
View article: Cytotoxic and proinflammatory responses induced by ZnO nanoparticles in in vitro intestinal barrier
Cytotoxic and proinflammatory responses induced by ZnO nanoparticles in in vitro intestinal barrier Open
ZnO nanoparticles (NPs) are widely used nowadays, thus the gastrointestinal exposure to ZnO NPs is likely to be relevant and the effects on the intestinal barrier should be investigated. Polarized Caco‐2 cells were exposed from the apical …
View article: Correction: Modification and optimization of the FECPAKG2 protocol for the detection and quantification of soil-transmitted helminth eggs in human stool
Correction: Modification and optimization of the FECPAKG2 protocol for the detection and quantification of soil-transmitted helminth eggs in human stool Open
[This corrects the article DOI: 10.1371/journal.pntd.0006655.].
View article: Comprehensive evaluation of stool-based diagnostic methods and benzimidazole resistance markers to assess drug efficacy and detect the emergence of anthelmintic resistance: A Starworms study protocol
Comprehensive evaluation of stool-based diagnostic methods and benzimidazole resistance markers to assess drug efficacy and detect the emergence of anthelmintic resistance: A Starworms study protocol Open
The trial was retrospectively registered the 7th of March 2018 on Clinicaltrials.gov (ID: NCT03465488).
View article: Modification and optimization of the FECPAKG2 protocol for the detection and quantification of soil-transmitted helminth eggs in human stool
Modification and optimization of the FECPAKG2 protocol for the detection and quantification of soil-transmitted helminth eggs in human stool Open
[This corrects the article DOI: 10.1371/journal.pntd.0006655.].
View article: Review of the 2017 WHO Guideline: Preventive chemotherapy to control soil-transmitted helminth infections in at-risk population groups. An opportunity lost in translation
Review of the 2017 WHO Guideline: Preventive chemotherapy to control soil-transmitted helminth infections in at-risk population groups. An opportunity lost in translation Open
View article: The optimal timing of post-treatment sampling for the assessment of anthelminthic drug efficacy against Ascaris infections in humans
The optimal timing of post-treatment sampling for the assessment of anthelminthic drug efficacy against Ascaris infections in humans Open
View article: Side Benefits of Mass Drug Administration for Lymphatic Filariasis on Strongyloides stercoralis Prevalence on Pemba Island, Tanzania
Side Benefits of Mass Drug Administration for Lymphatic Filariasis on Strongyloides stercoralis Prevalence on Pemba Island, Tanzania Open
Strongyloides stercoralis , although endemic in many countries, is not included in helminth control programs. Few data are available on the prevalence and morbidity linked to this infection. We compared data from two studies conducted in 1…
View article: Efficacy and safety of tribendimidine, tribendimidine plus ivermectin, tribendimidine plus oxantel pamoate, and albendazole plus oxantel pamoate against hookworm and concomitant soil-transmitted helminth infections in Tanzania and Côte d'Ivoire: a randomised, controlled, single-blinded, non-inferiority trial
Efficacy and safety of tribendimidine, tribendimidine plus ivermectin, tribendimidine plus oxantel pamoate, and albendazole plus oxantel pamoate against hookworm and concomitant soil-transmitted helminth infections in Tanzania and Côte d'Ivoire: a randomised, controlled, single-blinded, non-inferiority trial Open
View article: Screening, diagnosis and management of human cysticercosis and <i>Taenia solium</i> taeniasis: technical recommendations by the <scp>COHEMI</scp> project study group
Screening, diagnosis and management of human cysticercosis and <i>Taenia solium</i> taeniasis: technical recommendations by the <span>COHEMI</span> project study group Open
Neurocysticercosis, the central nervous system's localised form of cysticercosis, is considered to be the leading cause of epilepsy in the developing world. In Europe, the disease is mainly imported and affects both immigrants and travelle…
View article: IN VITRO TOXICOLOGICAL EFFECTS OF FUMONISIN B1 ALONE AND COMBINED WITH OTHER MYCOTOXINS
IN VITRO TOXICOLOGICAL EFFECTS OF FUMONISIN B1 ALONE AND COMBINED WITH OTHER MYCOTOXINS Open
Mycotoxins, secondary metabolites produced by moulds, mainly Aspergillus spp., Fusarium spp. and Penicillium spp., are common contaminants of food and feed. The aim of this project was to evaluate: (i) the potential endocrine disruptor eff…
View article: Building a global schistosomiasis alliance: an opportunity to join forces to fight inequality and rural poverty
Building a global schistosomiasis alliance: an opportunity to join forces to fight inequality and rural poverty Open
View article: The molecular speciation of soil-transmitted helminth eggs collected from school children across six endemic countries
The molecular speciation of soil-transmitted helminth eggs collected from school children across six endemic countries Open
Our study indicates that STH infections in humans are predominantly caused by human STH species. They also suggest that zoonotic transmission occurs on a local scale.
View article: StrongNet: An International Network to Improve Diagnostics and Access to Treatment for Strongyloidiasis Control
StrongNet: An International Network to Improve Diagnostics and Access to Treatment for Strongyloidiasis Control Open
StrongNet: An International Network to Improve Diagnostics and Access to Treatment for Strongyloidiasis Control
View article: In vitro toxicity of beauvericin alone and combined with fumonisin B1 or deoxynivalenol on Caco-2 cells
In vitro toxicity of beauvericin alone and combined with fumonisin B1 or deoxynivalenol on Caco-2 cells Open
Beauvericin (BEA) is a mycotoxin produced by Fusarium species, frequently occurring in cereal grains in combination with fumonisin B1 (FB1) and deoxynivalenol (DON). The aim of this study was to evaluate the in vitro toxic effects of BEA a…
View article: Efficacy and reinfection with soil-transmitted helminths 18-weeks post-treatment with albendazole-ivermectin, albendazole-mebendazole, albendazole-oxantel pamoate and mebendazole
Efficacy and reinfection with soil-transmitted helminths 18-weeks post-treatment with albendazole-ivermectin, albendazole-mebendazole, albendazole-oxantel pamoate and mebendazole Open
View article: The fill-FLOTAC and the mini-FLOTAC kit.
The fill-FLOTAC and the mini-FLOTAC kit. Open
View article: Mass Administration of Ivermectin for the Elimination of Onchocerciasis Significantly Reduced and Maintained Low the Prevalence of Strongyloides stercoralis in Esmeraldas, Ecuador
Mass Administration of Ivermectin for the Elimination of Onchocerciasis Significantly Reduced and Maintained Low the Prevalence of Strongyloides stercoralis in Esmeraldas, Ecuador Open
Periodic mass distribution of ivermectin had a significant impact on the prevalence of strongyloidiasis, less on trichuriasis and apparently no effect on ascariasis and hookworm infections.