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View article: High‐Sensitivity Cardiac Troponin T and Cognitive Function Over 12 Months After Stroke—Results of the DEMDAS Study
High‐Sensitivity Cardiac Troponin T and Cognitive Function Over 12 Months After Stroke—Results of the DEMDAS Study Open
Background Subclinical myocardial injury in form of hs‐cTn (high‐sensitivity cardiac troponin) levels has been associated with cognitive impairment and imaging markers of cerebral small vessel disease (SVD) in population‐based and cardiova…
View article: Similarity between structural and proxy estimates of brain connectivity
Similarity between structural and proxy estimates of brain connectivity Open
Functional magnetic resonance and diffusion weighted imaging have so far made a major contribution to delineation of the brain connectome at the macroscale. While functional connectivity (FC) was shown to be related to structural connectiv…
View article: Sex differences of vascular brain lesions in patients with atrial fibrillation
Sex differences of vascular brain lesions in patients with atrial fibrillation Open
Objective To examine sex differences in prevalence, volume and distribution of vascular brain lesions on MRI among patients with atrial fibrillation (AF). Methods In this cross-sectional analysis, we included 1743 patients with AF (27% wom…
View article: Cerebral small vessel disease burden and cognitive and functional outcomes after stroke: A multicenter prospective cohort study
Cerebral small vessel disease burden and cognitive and functional outcomes after stroke: A multicenter prospective cohort study Open
Introduction It remains unknown whether the global small vessel disease (SVD) burden predicts post‐stroke outcomes. Methods In a prospective multicenter study of 666 ischemic and hemorrhagic stroke patients, we quantified magnetic resonanc…
View article: Cognitive Improvement After Kidney Transplantation Is Associated With Structural and Functional Changes on MRI
Cognitive Improvement After Kidney Transplantation Is Associated With Structural and Functional Changes on MRI Open
Background. Several studies have reported improved cognitive outcomes after kidney transplantation, but most studies either did not include controls or lacked extensive neuroimaging. In addition, there is uncertainty whether kidney donatio…
View article: Safety and efficacy of epigallocatechin gallate in multiple system atrophy (PROMESA): a randomised, double-blind, placebo-controlled trial
Safety and efficacy of epigallocatechin gallate in multiple system atrophy (PROMESA): a randomised, double-blind, placebo-controlled trial Open
BACKGROUND Multiple system atrophy is a rare neurodegenerative disease characterised by aggregation of \\textgreeka-synuclein in oligodendrocytes and neurons. The polyphenol epigallocatechin gallate inhibits \\textgreeka-synuclein aggregat…
View article: Decreased CSF Levels of ß-Amyloid in Patients With Cortical Superficial Siderosis
Decreased CSF Levels of ß-Amyloid in Patients With Cortical Superficial Siderosis Open
Background: Cortical superficial siderosis (cSS) represents a key neuroimaging marker of cerebral amyloid angiopathy (CAA) that is associated with intracranial hemorrhages and cognitive impairment. Nevertheless, the association between cSS…
View article: Automated analysis of whole brain vasculature using machine learning
Automated analysis of whole brain vasculature using machine learning Open
SUMMARY Tissue clearing methods enable imaging of intact biological specimens without sectioning. However, reliable and scalable analysis of such large imaging data in 3D remains a challenge. Towards this goal, we developed a deep learning…
View article: Harmonizing brain magnetic resonance imaging methods for vascular contributions to neurodegeneration
Harmonizing brain magnetic resonance imaging methods for vascular contributions to neurodegeneration Open
Introduction Many consequences of cerebrovascular disease are identifiable by magnetic resonance imaging (MRI), but variation in methods limits multicenter studies and pooling of data. The European Union Joint Program on Neurodegenerative …
View article: <i>In vivo</i> widefield calcium imaging of the mouse cortex for analysis of network connectivity in health and brain disease
<i>In vivo</i> widefield calcium imaging of the mouse cortex for analysis of network connectivity in health and brain disease Open
The organization of brain areas in functionally connected networks, their dynamic changes, and perturbations in disease states are subject of extensive investigations. Research on functional networks in humans predominantly uses functional…
View article: Fourth European stroke science workshop
Fourth European stroke science workshop Open
Lake Eibsee, Garmisch-Partenkirchen, 16 to 18 November, 2017: The European Stroke Organisation convened >120 stroke experts from 21 countries to discuss latest results and hot topics in clinical, translational and basic stroke research. Si…
View article: Arterial branching and basal ganglia lacunes: A study in pure small vessel disease
Arterial branching and basal ganglia lacunes: A study in pure small vessel disease Open
Introduction Lacunes are defined morphologically by size and location, but radiological characteristics alone may be unable to distinguish small vessel disease aetiology from alternative mechanisms. We investigated the branching order of a…
View article: METACOHORTS for the study of vascular disease and its contribution to cognitive decline and neurodegeneration: An initiative of the Joint Programme for Neurodegenerative Disease Research
METACOHORTS for the study of vascular disease and its contribution to cognitive decline and neurodegeneration: An initiative of the Joint Programme for Neurodegenerative Disease Research Open
Dementia is a global problem and major target for health care providers. Although up to 45% of cases are primarily or partly due to cerebrovascular disease, little is known of these mechanisms or treatments because most dementia research s…