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View article: Implementation of infection prevention and control components in Italian hospitals based on a nationwide survey on behalf of INSIEME project
Implementation of infection prevention and control components in Italian hospitals based on a nationwide survey on behalf of INSIEME project Open
We aim to assess the state-of-the-art of Infection Prevention and Control (IPC) practices and their results in Italian healthcare facilities 6 years after the kick-off of the new National Plan for the Control of Antibiotic Resistance (PNCA…
View article: The Role of Prior HBV Infection and Resistance Mutations on the Efficacy of 3TC/DTG as a Maintenance Therapy
The Role of Prior HBV Infection and Resistance Mutations on the Efficacy of 3TC/DTG as a Maintenance Therapy Open
Lamivudine/dolutegravir (3TC/DTG) is effective and safe for most people with HIV infection (PWH) who are virologically suppressed, but specific individual’s characteristics, such as previous detection of archived resistance-associated muta…
View article: Inflatable penile prosthesis implantation performed by residents after a structured training pathway
Inflatable penile prosthesis implantation performed by residents after a structured training pathway Open
View article: Comparative effectiveness of echinocandins and liposomal amphotericin B for fluconazole-resistant <i>Candida parapsilosis</i> bloodstream infections
Comparative effectiveness of echinocandins and liposomal amphotericin B for fluconazole-resistant <i>Candida parapsilosis</i> bloodstream infections Open
Current therapeutic options for fluconazole-resistant Candida parapsilosis (FLZR-CP) bloodstream infections (BSI) are limited to echinocandins and liposomal amphotericin B (L-AmB). To the best of our knowledge, no real-world comparative ef…
View article: How I manage patients with New Delhi metallo-beta-lactamase and OXA-48-producing Enterobacterales infections: a practical approach
How I manage patients with New Delhi metallo-beta-lactamase and OXA-48-producing Enterobacterales infections: a practical approach Open
Purpose of review Infections caused by New Delhi metallo-β-lactamase (NDM) and OXA-48-producing Enterobacterales pose a critical threat due to increasing global prevalence and limited therapeutic options. This review provides an updated ov…
View article: Cost-Effectiveness Analysis of Aztreonam-Avibactam (ATM-AVI) Versus Colistin + Meropenem (COL + MER) for the Treatment of Infections Caused by Metallo-β-Lactamase (MBL)-Producing Enterobacterales in Italy
Cost-Effectiveness Analysis of Aztreonam-Avibactam (ATM-AVI) Versus Colistin + Meropenem (COL + MER) for the Treatment of Infections Caused by Metallo-β-Lactamase (MBL)-Producing Enterobacterales in Italy Open
Our analysis suggests that ATM-AVI is expected to be a cost-effective use of Italian healthcare resources for treating suspected metallo-β-lactamase-producing Enterobacterales, including complicated intra-abdominal infection and hospital-a…
View article: Surgical and functional outcomes of penoscrotal vaginoplasty in AMAB transgender patients: a comprehensive analysis of patient satisfaction and postoperative findings
Surgical and functional outcomes of penoscrotal vaginoplasty in AMAB transgender patients: a comprehensive analysis of patient satisfaction and postoperative findings Open
Aim: To evaluate surgical and functional outcomes of assigned male at birth (AMAB) transgender patients who received penoscrotal vaginoplasty at an Italian referral center. Methods: A retrospective analysis included AMAB transgender patien…
View article: The burden of infections caused by Metallo-Beta-LactamaseProducing Enterobacterales in Italy: epidemiology, outcomes, and management
The burden of infections caused by Metallo-Beta-LactamaseProducing Enterobacterales in Italy: epidemiology, outcomes, and management Open
Metallo-β-lactamase (MBL)-producing Enterobacterales represent a growing public health threat due to their intrinsic resistance to several antibiotics. In Italy, the burden of infections caused by these organisms has been steadily increasi…
View article: Persistent candidemia caused by different Candida species: Data from a multicenter contemporary cohort
Persistent candidemia caused by different Candida species: Data from a multicenter contemporary cohort Open
Persistent candidemia affects one in four patients with Candida BSI. Infections caused by Candida parapsilosis or Candida auris require individualized management, with early source control being essential to reduce the risk of persistence.
View article: Can We Lower the Burden of Antimicrobial Resistance (AMR) in Heavily Immunocompromised Patients? A Narrative Review and Call to Action
Can We Lower the Burden of Antimicrobial Resistance (AMR) in Heavily Immunocompromised Patients? A Narrative Review and Call to Action Open
Effective antibiotics are a cornerstone of treatment for heavily immunocompromised patients such as those undergoing cancer treatment or transplantation procedures, as these patients are at particularly high risk of adverse outcomes from i…
View article: Correction: Bacteremic nosocomial pneumonia caused by Gram-negative bacilli: results from the nationwide ALARICO study in Italy
Correction: Bacteremic nosocomial pneumonia caused by Gram-negative bacilli: results from the nationwide ALARICO study in Italy Open
View article: AMRrounds: susceptibility to the new tetracycline-derivative eravacycline of New Delhi metallo-β-lactamase-producing <i>Klebsiella pneumoniae</i> complex
AMRrounds: susceptibility to the new tetracycline-derivative eravacycline of New Delhi metallo-β-lactamase-producing <i>Klebsiella pneumoniae</i> complex Open
View article: Three Autochthonous Cases of Amoebic Liver Abscess Clustered in a Small Village of Tuscany (Central Italy), a Non-Endemic Area
Three Autochthonous Cases of Amoebic Liver Abscess Clustered in a Small Village of Tuscany (Central Italy), a Non-Endemic Area Open
Amebiasis is a rare condition in industrialised countries but is epidemiologically growing. Clinical manifestations may range from asymptomatic to invasive disease. An amebic abscess can be the result of extraintestinal amebiasis, and it i…
View article: A Head-to-Head Comparison Between [18F]Fluorodeoxyglucose ([18F]FDG) Positron Emission Tomography/Computed Tomography (PET/CT) and 99mTechnetium-Hexamethylpropylene Amine Oxime (HMPAO)-Labeled Leukocyte Scintigraphy in a Case Series of Patients with Suspected Vascular Prosthesis Infection: To Trust Is Good, but to Check Is Better
A Head-to-Head Comparison Between [18F]Fluorodeoxyglucose ([18F]FDG) Positron Emission Tomography/Computed Tomography (PET/CT) and 99mTechnetium-Hexamethylpropylene Amine Oxime (HMPAO)-Labeled Leukocyte Scintigraphy in a Case Series of Patients with Suspected Vascular Prosthesis Infection: To Trust Is Good, but to Check Is Better Open
Background: Prosthetic vascular graft infection (PVGI) is a serious complication associated with vascular prostheses. Nuclear medicine techniques, including [18F]fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) …
View article: Impact of multidrug resistance in cancer patients with bloodstream infections caused by Gram-negative bacilli: results from a multicentre study
Impact of multidrug resistance in cancer patients with bloodstream infections caused by Gram-negative bacilli: results from a multicentre study Open
Objective To evaluate the impact of multidrug resistance (MDR) on the mortality of cancer patients with bloodstream infection (BSI) by Gram-negative bacilli (GNB). Patients and methods This was a prospective observational multicentre study…
View article: Carbapenemase type and mortality in blood-stream infections caused by carbapenemase-producing enterobacterales: a multicenter retrospective cohort study
Carbapenemase type and mortality in blood-stream infections caused by carbapenemase-producing enterobacterales: a multicenter retrospective cohort study Open
View article: 2 - Pudendal nerve block, pulsed-radiofrequency and sacral neuromodulation: Description of a diagnostic–therapeutic pathway for chronic pelvic pain associated with pudendal neuralgia
2 - Pudendal nerve block, pulsed-radiofrequency and sacral neuromodulation: Description of a diagnostic–therapeutic pathway for chronic pelvic pain associated with pudendal neuralgia Open
View article: Postoperative risk of infection with klebsiella in adults – a retrospective case–control study
Postoperative risk of infection with klebsiella in adults – a retrospective case–control study Open
A multi-variable model incorporating klebsiella colonization status and clinical factors can accurately predict klebsiella infections in elective surgery patients. This model can select high-risk patients, enhancing the efficiency of phase…
View article: FUNCTIONAL, SURGICAL AND SATISFACTION OUTCOMES OF MODIFIED CORPOROPLASTY FOR PENILE CURVATURE: AN UPDATE
FUNCTIONAL, SURGICAL AND SATISFACTION OUTCOMES OF MODIFIED CORPOROPLASTY FOR PENILE CURVATURE: AN UPDATE Open
Objectives Nesbit corporoplasty is a surgical tecnique proposed to correct congenital (CPC) or acquired (APC penile curvature. A modified corporoplasty was proposed in 2005 in Turin by Rolle. Aim of the study is to assess functional, surgi…
View article: SURGICAL, FUNCTIONAL, AND SATISFACTION OUTCOMES AFTER IMPLANTATION OF THE NEW RIGICON INFLA 10® THREE-PIECE INFLATABLE PROSTHESIS FOR THE TREATMENT OF ERECTILE DYSFUNCTION
SURGICAL, FUNCTIONAL, AND SATISFACTION OUTCOMES AFTER IMPLANTATION OF THE NEW RIGICON INFLA 10® THREE-PIECE INFLATABLE PROSTHESIS FOR THE TREATMENT OF ERECTILE DYSFUNCTION Open
Objectives To evaluate functional and satisfaction outcomes of Rigicon Infla 10® and compare with the most widely implanted inflatable prostheses. Methods 15 consecutive ED patients in waiting list for a three-pieces implant (Group 1). All…
View article: Role of liposomal amphotericin B in intensive care unit: an expert opinion paper
Role of liposomal amphotericin B in intensive care unit: an expert opinion paper Open
Introduction Invasive fungal infections (IFI) are frequent in patients admitted to the intensive care unit (ICU). The use of first-line antifungals like triazoles or echinocandins may be limited by the global spread of multi-drug resistanc…
View article: The S862C amino acid change in CpMrr1 confers fluconazole resistance in <i>Candida parapsilosis</i>
The S862C amino acid change in CpMrr1 confers fluconazole resistance in <i>Candida parapsilosis</i> Open
Background Candida parapsilosis is an opportunistic pathogen with increasing rates of resistance to fluconazole and voriconazole. Recently, in an outbreak at the Azienda Ospedaliero-Universitaria Pisana, a new amino acid substitution, S862…
View article: P23. Development of phage therapy in Italy for the treatment of difficult-to-treat bacterial infections
P23. Development of phage therapy in Italy for the treatment of difficult-to-treat bacterial infections Open
Background Difficult-to-treat bacterial infections represent a significant public health issue.1 Phage therapy is emerging as a promising strategy to be combined with antibiotic treatment for their eradication.2 In Italy, the demand for th…
View article: P17. Clinical value of genotypic resistance test on proviral HIV-DNA in people living with HIV and detectable viremia
P17. Clinical value of genotypic resistance test on proviral HIV-DNA in people living with HIV and detectable viremia Open
Background The clinical impact of HIV genotypic resistance test (GRT) on peripheral blood mononuclear cells (PBMCs) in people with HIV (PWH) and low-level, detectable HIV-RNA, is still debated. Methods An observational, retrospective, mono…
View article: P22. Risk factors for carbapenem-resistant <i>Acinetobacter baumannii</i> bloodstream infections among colonized patients: a prospective observational study
P22. Risk factors for carbapenem-resistant <i>Acinetobacter baumannii</i> bloodstream infections among colonized patients: a prospective observational study Open
Background To identify predictors of bloodstream infections (BSI) caused by carbapenem-resistant Acinetobacter baumannii (CRAB) among patients with colonization by the same organism. Methods Observational, prospective study including conse…
View article: Real-World Use, Effectiveness, and Safety of Intravenous Fosfomycin: The FORTRESS Study
Real-World Use, Effectiveness, and Safety of Intravenous Fosfomycin: The FORTRESS Study Open
View article: Patologie respiratorie croniche ad esordio nel primo anno di vita: dal sospetto alla diagnosi
Patologie respiratorie croniche ad esordio nel primo anno di vita: dal sospetto alla diagnosi Open
View article: Phenotypic and Molecular Characterization of Pyomelanin-Producing Acinetobacter baumannii ST2Pas;ST1816/ST195Oxf Causing the First European Nosocomial Outbreak
Phenotypic and Molecular Characterization of Pyomelanin-Producing Acinetobacter baumannii ST2Pas;ST1816/ST195Oxf Causing the First European Nosocomial Outbreak Open
Acinetobacter baumannii is one of the most successful and feared nosocomial pathogens. A. baumannii is considered a global threat in the healthcare setting, mainly owing to its ability to acquire multidrug resistance phenotypes. The A. bau…
View article: Current role of ceftobiprole in the treatment of hospital-acquired and community-acquired pneumonia: expert opinion based on literature and real-life experiences
Current role of ceftobiprole in the treatment of hospital-acquired and community-acquired pneumonia: expert opinion based on literature and real-life experiences Open
Ceftobiprole represents a valid option for the patients with CAP and HAP. Its main advantages include its broad spectrum of activity, making it a valuable therapeutic choice for treating polymicrobial infections, and its favorable safety p…
View article: Safety of ceftobiprole in patients with impaired renal, hepatic or immune function: A multinational retrospective hospital chart review (RETRACE study)
Safety of ceftobiprole in patients with impaired renal, hepatic or immune function: A multinational retrospective hospital chart review (RETRACE study) Open
Overall, no new safety concerns related to ceftobiprole use in real-world patients with severe renal impairment, hepatic impairment or immunocompromised status were identified.