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View article: The clinicopathological PANOMEN-3 classification predicts pituitary adenoma prognosis: a real-world retrospective single center study of a surgically treated cohort
The clinicopathological PANOMEN-3 classification predicts pituitary adenoma prognosis: a real-world retrospective single center study of a surgically treated cohort Open
Introduction Pituitary adenomas (PAs) are generally benign neoplasms, though in rare cases may exhibit aggressive behavior. In 2024, the PANOMEN-3 workshop released a new clinical-pathological classification. The objective of this study wa…
View article: Primary Aortic Angiosarcoma: A Rare and Elusive Diagnosis. A Case Report and Review of the Literature
Primary Aortic Angiosarcoma: A Rare and Elusive Diagnosis. A Case Report and Review of the Literature Open
View article: OP0328 DISTINCT JOINT PATTERNS IN TREATMENT-NAÏVE RA ALSO CORRESPOND TO HISTOLOGICAL VARIATIONS
OP0328 DISTINCT JOINT PATTERNS IN TREATMENT-NAÏVE RA ALSO CORRESPOND TO HISTOLOGICAL VARIATIONS Open
View article: Advancing CNS tumor diagnostics with expanded DNA methylation-based classification
Advancing CNS tumor diagnostics with expanded DNA methylation-based classification Open
DNA methylation-based classification is integral to contemporary neuro-oncological diagnostics, as highlighted by the current World Health Organization (WHO) classification of central nervous system (CNS) tumors. We introduce the Heidelber…
View article: Location and amount of joint involvement differentiates rheumatoid arthritis into different clinical subsets
Location and amount of joint involvement differentiates rheumatoid arthritis into different clinical subsets Open
Background Rheumatoid arthritis (RA) is a heterogeneous disease. Patients vary in symptoms, prognosis and treatment response, demonstrating the need for a more refined taxonomy. Objective To identify distinct phenotypic subsets of RA patie…
View article: Residual pain and fatigue are affected by disease perception in rheumatoid arthritis in sustained clinical and ultrasound remission
Residual pain and fatigue are affected by disease perception in rheumatoid arthritis in sustained clinical and ultrasound remission Open
Objective Regardless of remission status, residual pain (RP) might persist in rheumatoid arthritis (RA). The aim of this study was to characterize RP, its perception, and patient-dependent features and to evaluate its possible association …
View article: MicroRNAs Expression Profile in MN1-Altered Astroblastoma
MicroRNAs Expression Profile in MN1-Altered Astroblastoma Open
Background/Objectives: Astroblastoma is a rare glial neoplasm more frequent in young female patients, with unclear clinical behaviors and outcomes. The diagnostic molecular alteration is a rearrangement of the Meningioma 1 (MN1) gene. Micr…
View article: Temporoparietal Fascia Flap (TPFF) in Extended Endoscopic Transnasal Skull Base Surgery: Clinical Experience and Systematic Literature Review
Temporoparietal Fascia Flap (TPFF) in Extended Endoscopic Transnasal Skull Base Surgery: Clinical Experience and Systematic Literature Review Open
Background and Objectives: The temporoparietal fascia flap (TPFF) has recently emerged as an option for skull base reconstruction in endoscopic transnasal surgery when vascularized nasal flaps are not available. This study provides a syste…
View article: LCM-RNAseq Highlights Intratumor Heterogeneity and a lncRNA Signature from Archival Tissues of GH-Secreting PitNETs
LCM-RNAseq Highlights Intratumor Heterogeneity and a lncRNA Signature from Archival Tissues of GH-Secreting PitNETs Open
Background: This study explores the potential for hidden variations within seemingly uniform regions of growth hormone-secreting pituitary neuroendocrine tumors (GH-PitNETs). We employed archived tissue samples using Laser Capture Microdis…
View article: A rare case of central nervous system pancreatoblastoma metastasis: illustrative case
A rare case of central nervous system pancreatoblastoma metastasis: illustrative case Open
BACKGROUND Pancreatoblastoma is a malignant neoplasm of the pancreas, occurring usually in children and rarely in adults. Treatment consists of surgery with a variable combination of adjuvant therapies. Liver metastases are common, whereas…
View article: Morpho-phenotypic characterization of melanoma brain metastases immune microenvironment: A multicentre retrospective study
Morpho-phenotypic characterization of melanoma brain metastases immune microenvironment: A multicentre retrospective study Open
Introduction: The recent rise of immunotherapy for melanoma brain metastases (MBM) has enhanced the interest in characterizing the composition of local immune microenvironment. Despite the central nervous system (CNS) is well known for har…
View article: Cancer Frequency in <scp>MuSK</scp> Myasthenia Gravis and Histological Evidence of Paraneoplastic Etiology
Cancer Frequency in <span>MuSK</span> Myasthenia Gravis and Histological Evidence of Paraneoplastic Etiology Open
Cancer frequency in muscle‐specific kinase myasthenia gravis (MuSK‐MG) has not yet been explored and the mechanisms leading to the formation of MuSK IgG remain elusive. We aimed to explore cancer frequency in MuSK‐MG patients and to assess…
View article: LGG-33. NETWORK ANALYSIS INTEGRATING MICRORNAS AND CLINICAL DATA TO DETERMINE PROGNOSTIC OUTCOME IN PEDIATRIC LOW-GRADE GLIOMA PATIENTS
LGG-33. NETWORK ANALYSIS INTEGRATING MICRORNAS AND CLINICAL DATA TO DETERMINE PROGNOSTIC OUTCOME IN PEDIATRIC LOW-GRADE GLIOMA PATIENTS Open
BACKGROUND Low-grade pediatric gliomas (pLGGs) are the most common pediatric brain tumors. Surgical resection, when feasible, represents the standard of care. If complete resection cannot be achieved, disease progression occurs in about 30…
View article: Supplementary Figure S13 from The FKBP51s Splice Isoform Predicts Unfavorable Prognosis in Patients with Glioblastoma
Supplementary Figure S13 from The FKBP51s Splice Isoform Predicts Unfavorable Prognosis in Patients with Glioblastoma Open
Tumor volume and Immunophenotype of TME and peripheral blood. Graphical representation (linear regression) of flow cytometry data of TME (graphs on the left) and peripheral blood (graphs on the right). Significant results are underlined in…
View article: Supplementary Methods from The FKBP51s Splice Isoform Predicts Unfavorable Prognosis in Patients with Glioblastoma
Supplementary Methods from The FKBP51s Splice Isoform Predicts Unfavorable Prognosis in Patients with Glioblastoma Open
Details on plasmids, SiRNAs, antibodies, flow cytometry analysis, qPCR primers
View article: Supplementary Figure S6 from The FKBP51s Splice Isoform Predicts Unfavorable Prognosis in Patients with Glioblastoma
Supplementary Figure S6 from The FKBP51s Splice Isoform Predicts Unfavorable Prognosis in Patients with Glioblastoma Open
Analysis by qPCR of the mRNA levels of the stemness markers CD133, EPHA2, NANOG, OCT 3 and 4, SNAIL, SOX2, ZEB1 in GB138 and GB83 spheroids (grey), compared to correspondent cells grown in adhesion (black).
View article: Supplementary Figure S14 from The FKBP51s Splice Isoform Predicts Unfavorable Prognosis in Patients with Glioblastoma
Supplementary Figure S14 from The FKBP51s Splice Isoform Predicts Unfavorable Prognosis in Patients with Glioblastoma Open
Necrosis score and Immunophenotype of TME and peripheral blood. Graphical representation of flow cytometry data of TME (graphs on the left) and peripheral blood (graphs on the right) from primary tumors. Patient were divided into 3 groups,…
View article: Supplementary immunophenotyping from The FKBP51s Splice Isoform Predicts Unfavorable Prognosis in Patients with Glioblastoma
Supplementary immunophenotyping from The FKBP51s Splice Isoform Predicts Unfavorable Prognosis in Patients with Glioblastoma Open
This supplementary contains row data of immunophenotyping
View article: Table S3 from The FKBP51s Splice Isoform Predicts Unfavorable Prognosis in Patients with Glioblastoma
Table S3 from The FKBP51s Splice Isoform Predicts Unfavorable Prognosis in Patients with Glioblastoma Open
Tumor FKBP51-expression does not affect the counts of the indicated peripheral blood TAM phenotypes nor does it influence CD4 and CD8 T lymphocytes’ counts. Pearson r coefficient and p values are indicated for each variable.
View article: Supplementary Figure S15 from The FKBP51s Splice Isoform Predicts Unfavorable Prognosis in Patients with Glioblastoma
Supplementary Figure S15 from The FKBP51s Splice Isoform Predicts Unfavorable Prognosis in Patients with Glioblastoma Open
ITSS score and Immunophenotype of TME and peripheral blood. Graphical representation of flow cytometry data of TME (graphs on the left) and peripheral blood (graphs on the right) from primary tumors. Patient were divided into 3 groups, ITS…
View article: Supplementary immunophenotyping from The FKBP51s Splice Isoform Predicts Unfavorable Prognosis in Patients with Glioblastoma
Supplementary immunophenotyping from The FKBP51s Splice Isoform Predicts Unfavorable Prognosis in Patients with Glioblastoma Open
This supplementary contains row data of immunophenotyping
View article: Supplementary Figure S5 from The FKBP51s Splice Isoform Predicts Unfavorable Prognosis in Patients with Glioblastoma
Supplementary Figure S5 from The FKBP51s Splice Isoform Predicts Unfavorable Prognosis in Patients with Glioblastoma Open
Cytokine levels in the sera from the two patients’ groups. Beyond the nominal p-values, the adjusted p-values by FDR method are also calculated and reported.
View article: Supplementary Figure S15 from The FKBP51s Splice Isoform Predicts Unfavorable Prognosis in Patients with Glioblastoma
Supplementary Figure S15 from The FKBP51s Splice Isoform Predicts Unfavorable Prognosis in Patients with Glioblastoma Open
ITSS score and Immunophenotype of TME and peripheral blood. Graphical representation of flow cytometry data of TME (graphs on the left) and peripheral blood (graphs on the right) from primary tumors. Patient were divided into 3 groups, ITS…
View article: Supplementary Methods from The FKBP51s Splice Isoform Predicts Unfavorable Prognosis in Patients with Glioblastoma
Supplementary Methods from The FKBP51s Splice Isoform Predicts Unfavorable Prognosis in Patients with Glioblastoma Open
Details on plasmids, SiRNAs, antibodies, flow cytometry analysis, qPCR primers
View article: Supplementary Figure S7 from The FKBP51s Splice Isoform Predicts Unfavorable Prognosis in Patients with Glioblastoma
Supplementary Figure S7 from The FKBP51s Splice Isoform Predicts Unfavorable Prognosis in Patients with Glioblastoma Open
(a) Macrophage gating by CD45. (b) Representative flow cytometry histograms of CD163/FKBP51s expression on: M0 (no coculture), top; CD45-gated macrophages in cocultures with adherent GB138 (CC GB138), medium; or with spheroids GB138 (CC GB…
View article: Table S2 from The FKBP51s Splice Isoform Predicts Unfavorable Prognosis in Patients with Glioblastoma
Table S2 from The FKBP51s Splice Isoform Predicts Unfavorable Prognosis in Patients with Glioblastoma Open
Tumor FKBP51-expression does not affect the composition of TME in CD163 or HLA- DR-TAMs nor does it influence tumor HLA-DR expression. Pearson r coefficient and p values are indicated for each variable.
View article: Supplementary Figure S9 from The FKBP51s Splice Isoform Predicts Unfavorable Prognosis in Patients with Glioblastoma
Supplementary Figure S9 from The FKBP51s Splice Isoform Predicts Unfavorable Prognosis in Patients with Glioblastoma Open
Callosal infiltration and Immunophenotype of TME and peripheral blood. Graphical representation of flow cytometry data of TME (graphs on the left) and peripheral blood (graphs on the right) from primary tumors (upper) and recurrences (lowe…
View article: FIGURE 2 from The FKBP51s Splice Isoform Predicts Unfavorable Prognosis in Patients with Glioblastoma
FIGURE 2 from The FKBP51s Splice Isoform Predicts Unfavorable Prognosis in Patients with Glioblastoma Open
FKBP5 splicing in GBM tumors sustains STAT3 activation and is accompanied by systemic tolerogenic immune condition. A, Left, IB of GB138 cell transfected with Flag-FKBP51, Flag-FKBP51s or correspondent EV as control. The spliced FKB…
View article: Table S3 from The FKBP51s Splice Isoform Predicts Unfavorable Prognosis in Patients with Glioblastoma
Table S3 from The FKBP51s Splice Isoform Predicts Unfavorable Prognosis in Patients with Glioblastoma Open
Tumor FKBP51-expression does not affect the counts of the indicated peripheral blood TAM phenotypes nor does it influence CD4 and CD8 T lymphocytes’ counts. Pearson r coefficient and p values are indicated for each variable.
View article: Supplementary Figure S10 from The FKBP51s Splice Isoform Predicts Unfavorable Prognosis in Patients with Glioblastoma
Supplementary Figure S10 from The FKBP51s Splice Isoform Predicts Unfavorable Prognosis in Patients with Glioblastoma Open
ADC values and Immunophenotype of TME and peripheral blood. Graphical representation (linear regression) of flow cytometry data of TME (graphs on the left) and peripheral blood (graphs on the right) from primary tumors and recurrences. Sig…