Explanipedia

Fibromuscular Dysplasia and Spontaneous Cervical Artery Dissection Open

Ahmad Nehme, Liqi Shu, Marion Boulanger, Junpeng Ma, Salter Arms , et al. · 2025

Importance Fibromuscular dysplasia (FMD) is found in 6 to 14% of patients with spontaneous cervical artery dissection (SCEAD) and may be associated with recurrent SCEAD. Objective To evaluate the correlates of FMD in patients with SCEAD an…

Mechanical thrombectomy vs intravenous rt-PA in medium vessel occlusions: real-world data from the Italian SITS registry Open

Matteo Farè, Elisa Bianchi, Giulia Benina, Giulia Ricci Lucchi, Martina Mercenari , et al. · 2025

Background Recent randomized trials have questioned the benefit of endovascular therapy (EVT) for medium vessel occlusion (MeVO) stroke, but data from clinical practice are limited. This study aimed to assess the effectiveness and safety o…

The role of neurology in the development of community healthcare within the Italian national health service. The position of the Italian society of neurology (SIN) Open

Pietro Ferrara, Vincenzo Andreone, Fabio Bandini, Massimo Del Sette, Marco Longoni , et al. · 2025

Exploring the Role of Diabetes in ALS: A Population-Based Cohort Study Open

Ilaria Martinelli, Giulia Gianferrari, Roberta Santarelli, Elisabetta Zucchi, Cecilia Simonini , et al. · 2025

Type 2 diabetes mellitus (T2DM) as a comorbidity in amyotrophic lateral sclerosis (ALS) has sparked interest for its potential impact on disease expression and prognosis. In this retrospective cohort study, we investigated the prevalence a…

Mechanical Thrombectomy in Prestroke Disability: Data From the Italian Endovascular Stroke Registry Open

Andrea Naldi, Federico D’Agata, Giovanni Pracucci, Valentina Saia, Roberto Cavallo , et al. · 2025

BACKGROUND: The benefits and safety of mechanical thrombectomy (MT) in patients with prestroke disability, classified as modified Rankin Scale (mRS) score of 3 to 4, and anterior circulation stroke remain uncertain. This study aims to eval…

Phenotypical Characterization of C9ALS Patients from the Emilia Romagna Registry of ALS: A Retrospective Case–Control Study Open

Andrea Ghezzi, Giulia Gianferrari, Elisa Baldassarri, Elisabetta Zucchi, Ilaria Martinelli , et al. · 2025

Background/Objectives: C9ORF72 expansion is associated with significant phenotypic heterogeneity. This study aimed to characterize the clinical features of C9ALS patients from the Emilia Romagna ALS registry (ERRALS) and compare them with …

Efficacy and tolerability of low versus standard daily doses of antiseizure medications in newly diagnosed focal epilepsy. A multicenter, randomized, single‐blind, non‐inferiority trial (<span>STANDLOW</span>) Open

Giorgia Giussani, Elisa Bianchi, Edoardo Carlando, Jacopo C. DiFrancesco, Payam Tabaee Damavandi , et al. · 2025

Objective The STANDLOW trial investigated whether first‐line antiseizure monotherapy with low doses has a similar efficacy to standard doses, but with fewer adverse events, improved quality of life, and reduced costs for the National Healt…

Predictors of Stroke Recurrence After Initial Diagnosis of Cervical Artery Dissection Open

Daniel Mandel, Liqi Shu, Christopher Chang, N JACK, Christopher R. Leon Guerrero , et al. · 2024

Objective Patients with cervical artery dissection (CAD) are at increased ischemic stroke risk. We aimed to identify characteristics that are associated with increased risk of ischemic stroke following initial presentation of CAD and to ev…

Mechanical Thrombectomy in Ischemic Stroke with a Large Infarct Core: A Meta-Analysis of Randomized Controlled Trials Open

Michele Romoli, Lucia Princiotta Cariddi, Marco Longoni, Gianluca Stufano, Sebastiano Giacomozzi , et al. · 2024

Background/Objectives: Endovascular treatment (EVT) is recommended for acute ischemic stroke due to large-vessel occlusion (LVO) and an Alberta Stroke Program Early CT Score (ASPECTS) ≥ 6. Randomized controlled trials (RCTs) have recently …

Association between procedural time and outcome in unsuccessful mechanical thrombectomy for acute ischemic stroke: analysis from the Italian Registry of Endovascular Treatment in Acute Stroke Open

Fabrizio Sallustio, Ettore Nicolini, Valentina Saia, Giovanni Pracucci, Alfredo Paolo Mascolo , et al. · 2024

Predictors of futile recanalization in nonagenarians treated with mechanical thrombectomy: a multi-center observational study Open

Lucio D’Anna, Giovanni Merlino, Michele Romoli, Liqun Zhang, Caterina Del Regno , et al. · 2024

Stress hyperglycemia is associated with futile recanalization in patients with anterior large vessel occlusion undergoing mechanical thrombectomy Open

Giovanni Merlino, Michele Romoli, Raffaele Ornello, Matteo Foschi, Caterina Del Regno , et al. · 2024

Introduction: Mechanical thrombectomy (MT) is the standard treatment for acute ischemic stroke (AIS) due to anterior large vessel occlusion (LVO). Despite successful recanalization, some patients remain disabled after 3 months. Mechanisms …

Impact of Sex on Thrombectomy Outcomes in Ischemic Stroke: A Propensity Score‐Matched Study, Systematic Review, and Meta‐Analysis Open

Michele Romoli, Soma Banerjee, Francesco Cordici, Kyriakos Lobotesis, Marco Longoni , et al. · 2024

Background Women are underrepresented in stroke thrombectomy trials, and the impact of sex differences in outcomes after stroke thrombectomy is unclear. We performed a multicenter propensity matching study to define sex‐related differences…

Effect of tauroursodeoxycholic acid on survival and safety in amyotrophic lateral sclerosis: a retrospective population-based cohort study Open

Elisabetta Zucchi, Umberto M. Musazzi, Guido Fedele, Ilaria Martinelli, Giulia Gianferrari , et al. · 2023

Insight into Elderly ALS Patients in the Emilia Romagna Region: Epidemiological and Clinical Features of Late-Onset ALS in a Prospective, Population-Based Study Open

Giulia Gianferrari, Ilaria Martinelli, Cecilia Simonini, Elisabetta Zucchi, Nicola Fini , et al. · 2023

Few studies have focused on elderly (>80 years) amyotrophic lateral sclerosis (ALS) patients, who represent a fragile subgroup generally not included in clinical trials and often neglected because they are more difficult to diagnose and ma…

Anti-LGI1 encephalitis following COVID-19 vaccination: a case series Open

Gian Maria Asioli, Lorenzo Muccioli, Valentina Barone, Sebastiano Giacomozzi, Símone Rossi , et al. · 2022

Sex differences in outcome after thrombectomy for acute ischemic stroke. A propensity score-matched study Open

Ilaria Casetta, Enrico Fainardi, Giovanni Pracucci, Valentina Saia, Fabrizio Sallustio , et al. · 2022

Background and purpose We sought to investigate whether there are gender differences in clinical outcome after stroke due to large vessel occlusion (LVO) after mechanical thrombectomy (EVT) in a large population of real-world patients. Met…

Epidemiological, Clinical and Genetic Features of ALS in the Last Decade: A Prospective Population-Based Study in the Emilia Romagna Region of Italy Open

Giulia Gianferrari, Ilaria Martinelli, Elisabetta Zucchi, Cecilia Simonini, Nicola Fini , et al. · 2022

Increased incidence rates of amyotrophic lateral sclerosis (ALS) have been recently reported across various Western countries, although geographic and temporal variations in terms of incidence, clinical features and genetics are not fully …

Drip-and-ship toward mothership model for mechanical thrombectomy during COVID-19 pandemic: a retrospective analysis Open

Matteo Paolucci, Sara Biguzzi, Francesco Cordici, Michele Romoli, Mattia Altini , et al. · 2022

Applying Telemedicine for Stroke Remote Diagnosis: the TeleStroke System Open

Angelo Croatti, Marco Longoni, Sara Montagna · 2022

The Genetic Landscape of Patent Foramen Ovale: A Systematic Review Open

Matteo Paolucci, Chiara Vincenzi, Michele Romoli, Giulia Amico, Isabella Ceccherini , et al. · 2021

Patent Foramen Ovale (PFO) is a common postnatal defect of cardiac atrial septation. A certain degree of familial aggregation has been reported. Animal studies suggest the involvement of the Notch pathway and other cardiac transcription fa…

The benefit of a short-stay neurological observation unit in the COVID-19 era Open

Matteo Paolucci, Sara Biguzzi, Chiara Bomprezzi, Francesco Cordici, Flavio Di Stasio , et al. · 2021

Shift from drip-and-ship towards mothership model for mechanical thrombectomy during COVID-19 pandemic: A retrospective analysis of a stroke network performances Open

Matteo Paolucci, Maria Ruggiero, Vanni Agnoletti, Maurizio Menarini, Raffaella Francesconi , et al. · 2021

Stroke network performance during the first COVID-19 pandemic stage: A meta-analysis based on stroke network models Open

Michele Romoli, Paolo Eusebi, Stefano Forlivesi, Mauro Gentile, Fabrizio Giammello , et al. · 2021

Background The effect of the COVID pandemic on stroke network performance is unclear, particularly with consideration of drip&ship vs. mothership models. Aims We systematically reviewed and meta-analyzed variations in stroke admissions, ra…

Fulminant case of multiple sclerosis (marburg variant) with atypical MRI presentation Open

Luca Mancinelli, Yerma Bartolini, Maria Lia Cataldi, Chiara Bomprezzi, Alessia Tomassini , et al. · 2021

Marburg type is a rare variant of Multiple Sclerosis (MS) characterized by a severe and progressive course/evolution leading to exitus in few months. Its radiological presentation commonly raises suspicion of a malignancy, often requiring …

Anesthetics management strategy for endovascular treatment of acute ischemic stroke. A proposal for anesthetic approach Open

Emanuele Russo, Daniele Bellantonio, Marco Benni, Emiliano Gamberini, Alessandro Circelli , et al. · 2021

GEAcute ischemic stroke is one of the leading causes of death and long-term disability for adults. Endovascular therapy is the standard of care for severe acute ischemic stroke, caused by large-vessel occlusion in the anterior circulation;…

Impact of COVID-19 pandemic on acute stroke care: facing an epidemiological paradox with a paradigm shift Open

Matteo Paolucci, Sara Biguzzi, Francesco Cordici, Enrico Maria Lotti, Simonetta Morresi , et al. · 2020

Reperfusion strategies in stroke due to isolated cervical internal carotid artery occlusion: systematic review and treatment comparison Open

Michele Romoli, Maria Giulia Mosconi, Patrizia Pierini, Andrea Alberti, Michele Venti , et al. · 2020

Introduction Despite intravenous thrombolysis (IVT) and endovascular treatment (EVT) have been demonstrated effective in acute ischemic stroke (AIS) due to large vessel occlusions, there are still no conclusive data to guide treatment in s…

Functional and radiological outcomes after bridging therapy versus direct thrombectomy in stroke patients with unknown onset Open

Manuel Cappellari, Valentina Saia, Giovanni Pracucci, Fabrizio Sallustio, Roberto Gandini , et al. · 2020

Background and purpose The aim was to assess functional and radiological outcomes after bridging therapy (intravenous thrombolysis plus mechanical thrombectomy) versus direct mechanical thrombectomy (MT) in unknown onset stroke patients. M…

Thrombolysis and bridging therapy in patients with acute ischaemic stroke and Covid‐19 Open

Manuel Cappellari, Andrea Zini, Davide Sangalli, Anna Cavallini, Monica Reggiani , et al. · 2020

Background and purpose Comorbidity of acute ischaemic stroke with Covid‐19 is a challenging condition, potentially influencing the decision of whether to administer intravenous thrombolysis (IVT). We aimed to assess the 1‐month outcome in …

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