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View article: Development and Mechanical Testing of Synthetic 3D-Printed Models of Healthy and Metastatic Vertebrae
Development and Mechanical Testing of Synthetic 3D-Printed Models of Healthy and Metastatic Vertebrae Open
Experimental characterisation of ex vivo specimens is limited by specimen availability and high costs, whereas 3D printing provides a cost-effective alternative for producing multiple replicas. This study aimed to develop a methodology for…
View article: Can Multi‐Vertebral CT‐Based Finite Element Models Accurately Predict Strains? An In Vitro Validation Study
Can Multi‐Vertebral CT‐Based Finite Element Models Accurately Predict Strains? An In Vitro Validation Study Open
Many proposed FE models to predict the vertebral risk of fracture consider single vertebrae only, neglecting the role of the intervertebral discs in load transmission and distribution across vertebrae. Inclusion of the intervertebral discs…
View article: Intervertebral disc degeneration increases surface strain on metastatic vertebrae in compression and flexion but not in torsion
Intervertebral disc degeneration increases surface strain on metastatic vertebrae in compression and flexion but not in torsion Open
Despite the fundamental role of intervertebral discs (IVDs) in the biomechanics of the spine, their condition has never been considered among the possible factors affecting the mechanical behaviour of metastatic vertebrae. The structure of…
View article: Comparing the predictions of CT-based subject-specific finite element models of human metastatic vertebrae with digital volume correlation measurements
Comparing the predictions of CT-based subject-specific finite element models of human metastatic vertebrae with digital volume correlation measurements Open
View article: Improved primary stability and load transfer of a customized osseointegrated transfemoral prosthesis compared to a commercial one
Improved primary stability and load transfer of a customized osseointegrated transfemoral prosthesis compared to a commercial one Open
View article: Degeneration of the nucleus pulposus affects the internal volumetric strains and failure location of adjacent human metastatic vertebral bodies
Degeneration of the nucleus pulposus affects the internal volumetric strains and failure location of adjacent human metastatic vertebral bodies Open
Intervertebral disc (IVD) degeneration is suspected to affect the distribution of stress and strain near the vertebral endplates and in the underlying bone. This scenario is worsened by the presence of metastatic lesions on the vertebrae (…
View article: Microstructure of the human metastatic vertebral body
Microstructure of the human metastatic vertebral body Open
Introduction Bone spinal metastases disrupt the bone homeostasis, inducing a local imbalance in the bone formation and/or resorption, with consequent loss of the structural optimisation of the vertebrae and increase of the risk of fracture…
View article: Fabrication of hierarchically porous trabecular bone replicas via 3D printing with high internal phase emulsions (HIPEs)
Fabrication of hierarchically porous trabecular bone replicas via 3D printing with high internal phase emulsions (HIPEs) Open
Combining emulsion templating with additive manufacturing enables the production of inherently porous scaffolds with multiscale porosity. This approach incorporates interconnected porous materials, providing a structure that supports cell …
View article: Short humeral stem in total shoulder arthroplasty does not jeopardize primary implant stability
Short humeral stem in total shoulder arthroplasty does not jeopardize primary implant stability Open
View article: Advantages of customization of osseointegrated implants in transfemoral amputees: a comparative analysis of surgical planning
Advantages of customization of osseointegrated implants in transfemoral amputees: a comparative analysis of surgical planning Open
View article: Identification of a lumped-parameter model of the intervertebral joint from experimental data
Identification of a lumped-parameter model of the intervertebral joint from experimental data Open
Through predictive simulations, multibody models can aid the treatment of spinal pathologies by identifying optimal surgical procedures. Critical to achieving accurate predictions is the definition of the intervertebral joint. The joint po…
View article: Data-driven image mechanics (D2IM): A deep learning approach to predict displacement and strain fields from undeformed X-ray tomography images – Evaluation of bone mechanics
Data-driven image mechanics (D2IM): A deep learning approach to predict displacement and strain fields from undeformed X-ray tomography images – Evaluation of bone mechanics Open
The recent advent of deep learning (DL) has enabled data-driven models to pave the way for the full exploitation of rich image datasets from which physics can be learnt. Here we propose a novel data-driven image mechanics (D2IM) approach t…
View article: Reliable in vitro method for the evaluation of the primary stability and load transfer of transfemoral prostheses for osseointegrated implantation
Reliable in vitro method for the evaluation of the primary stability and load transfer of transfemoral prostheses for osseointegrated implantation Open
Osseointegrated transfemoral prostheses experience aseptic complications with an incidence between 3% and 30%. The main aseptic risks are implant loosening, adverse bone remodeling, and post-operative periprosthetic fractures. Implant loos…
View article: Multi-vertebral CT-based FE models implementing linear isotropic population-based material properties for the intervertebral discs cannot accurately predict strains
Multi-vertebral CT-based FE models implementing linear isotropic population-based material properties for the intervertebral discs cannot accurately predict strains Open
Vertebral fractures prediction in clinics lacks of accuracy. The most used scores have limitations in distinguishing between subjects at risk or not. Finite element (FE) models generated from computed tomography (CT) of these patients may …
View article: Validation of homogenized finite element models of human metastatic vertebrae using digital volume correlation
Validation of homogenized finite element models of human metastatic vertebrae using digital volume correlation Open
The incidence of vertebral fragility fracture is increased by the presence of preexisting pathologies such as metastatic disease. Computational tools could support the fracture prediction and consequently the decision of the best medical t…
View article: The role of bone metastases on the mechanical competence of human vertebrae
The role of bone metastases on the mechanical competence of human vertebrae Open
Spine is the most common site for bone metastases. The evaluation of the mechanical competence and failure location in metastatic vertebrae is a biomechanical and clinical challenge. Little is known about the failure behaviour of vertebrae…
View article: Bone metastases do not affect the measurement uncertainties of a global digital volume correlation algorithm
Bone metastases do not affect the measurement uncertainties of a global digital volume correlation algorithm Open
Introduction: Measurement uncertainties of Digital Volume Correlation (DVC) are influenced by several factors, like input images quality, correlation algorithm, bone type, etc. However, it is still unknown if highly heterogeneous trabecula…
View article: Experimental validation of a subject-specific finite element model of lumbar spine segment using digital image correlation
Experimental validation of a subject-specific finite element model of lumbar spine segment using digital image correlation Open
Pathologies such as cancer metastasis and osteoporosis strongly affect the mechanical properties of the vertebral bone and increase the risk of fragility fractures. The prediction of the fracture risk with a patient-specific model, directl…
View article: Rapid In Situ Detection of THC and CBD in <i>Cannabis sativa</i> L. by 1064 nm Raman Spectroscopy
Rapid In Situ Detection of THC and CBD in <i>Cannabis sativa</i> L. by 1064 nm Raman Spectroscopy Open
The need to find a rapid and worthwhile technique for the in situ detection of the content of delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) in Cannabis sativa L. is an ever-increasing problem in the forensic field. Among …
View article: Effects Induced by Osteophytes on the Strain Distribution in the Vertebral Body Under Different Loading Configurations
Effects Induced by Osteophytes on the Strain Distribution in the Vertebral Body Under Different Loading Configurations Open
The mechanical consequences of osteophytes are not completely clear. We aimed to understand whether and how the presence of an osteophyte perturbs strain distribution in the neighboring bone. The scope of this study was to evaluate the mec…
View article: Global and local characterization explains the different mechanisms of failure of the human ribs
Global and local characterization explains the different mechanisms of failure of the human ribs Open
View article: MicroFE models of porcine vertebrae with induced bone focal lesions: Validation of predicted displacements with digital volume correlation
MicroFE models of porcine vertebrae with induced bone focal lesions: Validation of predicted displacements with digital volume correlation Open
View article: Type, size, and position of metastatic lesions explain the deformation of the vertebrae under complex loading conditions
Type, size, and position of metastatic lesions explain the deformation of the vertebrae under complex loading conditions Open
These results highlight the relevance of the size and location of the lytic lesion, which are marginally considered in the current clinical scoring systems, in driving the spinal biomechanical instability. The strong correlation with the b…
View article: A novel approach to evaluate the effects of artificial bone focal lesion on the three-dimensional strain distributions within the vertebral body
A novel approach to evaluate the effects of artificial bone focal lesion on the three-dimensional strain distributions within the vertebral body Open
The spine is the first site for incidence of bone metastasis. Thus, the vertebrae have a high potential risk of being weakened by metastatic tissues. The evaluation of strength of the bone affected by the presence of metastases is fundamen…
View article: Experimental study exploring the factors that promote rib fragility in the elderly
Experimental study exploring the factors that promote rib fragility in the elderly Open
Rib fractures represent a common injury type due to blunt chest trauma, affecting hospital stay and mortality especially in elderly patients. Factors promoting rib fragility, however, are little investigated. The purpose of this in vitro s…
View article: Load-sharing biomechanics of lumbar fixation and fusion with pedicle subtraction osteotomy
Load-sharing biomechanics of lumbar fixation and fusion with pedicle subtraction osteotomy Open
View article: Correlation between the mechanical properties of the metastatic vertebrae and the features of the lesions
Correlation between the mechanical properties of the metastatic vertebrae and the features of the lesions Open
View article: Development and validation of a subject-specific finite element model of pathological lumbar spine
Development and validation of a subject-specific finite element model of pathological lumbar spine Open
View article: Body Anthropometry and Bone Strength Conjointly Determine the Risk of Hip Fracture in a Sideways Fall
Body Anthropometry and Bone Strength Conjointly Determine the Risk of Hip Fracture in a Sideways Fall Open
View article: Hierarchical chitinous matrices byssus-inspired with mechanical properties tunable by Fe(III) and oxidation
Hierarchical chitinous matrices byssus-inspired with mechanical properties tunable by Fe(III) and oxidation Open