Marco Andrea Riva
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View article: Restoring Balance: The Role of Omega-3 Polyunsaturated Fatty Acids on the Gut–Brain Axis and Other Interconnected Biological Pathways to Improve Depression
Restoring Balance: The Role of Omega-3 Polyunsaturated Fatty Acids on the Gut–Brain Axis and Other Interconnected Biological Pathways to Improve Depression Open
Major depressive disorder (MDD) is a complex, multifactorial condition involving dysregulation across immune, neural, and metabolic systems. Omega-3 polyunsaturated fatty acids (n-3 PUFAs), particularly eicosapentaenoic acid (EPA) and doco…
View article: Inflammatory status along the brain-liver axis in animals vulnerable to prenatal stress: sex-related implications for stress-induced comorbidities
Inflammatory status along the brain-liver axis in animals vulnerable to prenatal stress: sex-related implications for stress-induced comorbidities Open
View article: Structural Magnetic Resonance Imaging and Genome-Wide Transcriptional Profiling Reveal Intergenerational Vulnerability in a Mouse Model of Preconceptional Stress
Structural Magnetic Resonance Imaging and Genome-Wide Transcriptional Profiling Reveal Intergenerational Vulnerability in a Mouse Model of Preconceptional Stress Open
Antenatal depression, affecting 10–20% of pregnancies worldwide, represents a major public health concern due to its association with maternal suicide, obstetric complications, and long-term neurodevelopmental and psychiatric vulnerability…
View article: Exposure to early-life stress uncovers shared biological signatures underlying vulnerability in the habenula and insular cortex of male and female adult rats
Exposure to early-life stress uncovers shared biological signatures underlying vulnerability in the habenula and insular cortex of male and female adult rats Open
Early-life stress (ELS) is a well-known risk factor for the development of several mental disorders later in life. The effect of ELS can be twofold: resilient individuals adapt by perceiving stress as minimal, while vulnerable ones struggl…
View article: Prenatal Stress Rewires the Gut–Brain Axis: Long-Term, Sex-Specific Effects on Microbiota, Intestinal Barrier, and Hippocampal Inflammation
Prenatal Stress Rewires the Gut–Brain Axis: Long-Term, Sex-Specific Effects on Microbiota, Intestinal Barrier, and Hippocampal Inflammation Open
Background: The gut microbiota and the gut epithelium play a central role in maintaining systemic and brain homeostasis from early life. Stressful experiences during sensitive developmental windows can disrupt this balance, increasing long…
View article: Sex-dependent preventive effects of prenatal N-acetyl-cysteine on neuronal, emotional and metabolic dysfunctions following exposure to maternal high-fat diet in mice
Sex-dependent preventive effects of prenatal N-acetyl-cysteine on neuronal, emotional and metabolic dysfunctions following exposure to maternal high-fat diet in mice Open
View article: 506. MAPPING PERIPHERAL MOLECULAR MECHANISMS ASSOCIATED WITH LONG-LASTING EFFECTS OF EARLY LIFE STRESS: A TRANSCRIPTOMIC SET-BASED APPROACH
506. MAPPING PERIPHERAL MOLECULAR MECHANISMS ASSOCIATED WITH LONG-LASTING EFFECTS OF EARLY LIFE STRESS: A TRANSCRIPTOMIC SET-BASED APPROACH Open
Background Exposure to adversities in early life may leave long-lasting neurobiological alterations, increasing the risk of developing mental disorders in later life. Emerging evidence has suggested that stress in early life can interfere …
View article: Impact of brain redox biomarkers on the emotional and cognitive-related states in male and female adolescent rats: A descriptive analysis
Impact of brain redox biomarkers on the emotional and cognitive-related states in male and female adolescent rats: A descriptive analysis Open
Redox imbalance can affect several processes within the brain (e.g., synaptic plasticity, neurotransmitters release and their related pathways), leading to altered emotional and cognitive states. These effects can be particularly detriment…
View article: IUPHAR review – Novel therapeutic targets for schizophrenia treatment: A translational perspective
IUPHAR review – Novel therapeutic targets for schizophrenia treatment: A translational perspective Open
View article: Understanding, predicting, and treating depression in pregnancy to improve mothers' and offspring's mental health outcomes: The HappyMums study
Understanding, predicting, and treating depression in pregnancy to improve mothers' and offspring's mental health outcomes: The HappyMums study Open
View article: IMMUNOMETABOLIC FEATURES MAPPING CLINICAL DOMAINS IN STRESS RELATED PSYCHIATRIC DISORDERS: IMPLICATIONS FOR PERSONALIZED INTERVENTIONS
IMMUNOMETABOLIC FEATURES MAPPING CLINICAL DOMAINS IN STRESS RELATED PSYCHIATRIC DISORDERS: IMPLICATIONS FOR PERSONALIZED INTERVENTIONS Open
It is well known that one third of depressed patients do not respond to two or more antidepressant treatments and the majority has a chronic or intermittent disease course, experiencing recurrent relapses, or developing physical comorbidit…
View article: EXPOSURE TO CHRONIC STRESS IMPAIRS MOTIVATION AND SOCIABILITY IN RATS: RESTORATIVE PROPERTIES OF CHRONIC LURASIDONE TREATMENT
EXPOSURE TO CHRONIC STRESS IMPAIRS MOTIVATION AND SOCIABILITY IN RATS: RESTORATIVE PROPERTIES OF CHRONIC LURASIDONE TREATMENT Open
Background Stress is one of the most important factors for the etiology of mental disorders. On these bases, exposure to stress is used to investigate neurobiological mechanisms associated with specific psychopathologic mechanisms and to e…
View article: THE RECOVERY EFFECT OF STEM CELLS AND KAMPO MEDICINE KAMIKIHITO ON SOCIAL BEHAVIOR DYSFUNCTIONS IN REFRACTORY PSYCHIATRIC DISORDERS
THE RECOVERY EFFECT OF STEM CELLS AND KAMPO MEDICINE KAMIKIHITO ON SOCIAL BEHAVIOR DYSFUNCTIONS IN REFRACTORY PSYCHIATRIC DISORDERS Open
Background The brain pathophysiology of social dysfunctions in depression and autism spectrum disorder are complex, and there is a growing need to understand the relevant neuronal circuit alterations and to find direct and effective treatm…
View article: Restorative properties of chronic lurasidone treatment on emotional dysfunction in rats exposed to chronic unavoidable stress: A role for medial prefrontal cortex - nucleus accumbens network
Restorative properties of chronic lurasidone treatment on emotional dysfunction in rats exposed to chronic unavoidable stress: A role for medial prefrontal cortex - nucleus accumbens network Open
View article: Emotional dysregulation following prenatal stress is associated with altered prefrontal cortex responsiveness to an acute challenge in adolescence
Emotional dysregulation following prenatal stress is associated with altered prefrontal cortex responsiveness to an acute challenge in adolescence Open
View article: Chronic treatment with the antipsychotic lurasidone modulates the neuroinflammatory changes associated with the vulnerability to chronic mild stress exposure in female rats
Chronic treatment with the antipsychotic lurasidone modulates the neuroinflammatory changes associated with the vulnerability to chronic mild stress exposure in female rats Open
View article: Definition, assessment and treatment of cognitive impairment associated with schizophrenia: expert opinion and practical recommendations
Definition, assessment and treatment of cognitive impairment associated with schizophrenia: expert opinion and practical recommendations Open
A considerable proportion of patients with schizophrenia perform below population norms on standardized neuropsychological tests, and the performance of those performing within normal range is lower than predicted based on parental educati…
View article: Transcriptomic profiles in major depressive disorder: the role of immunometabolic and cell-cycle-related pathways in depression with different levels of inflammation
Transcriptomic profiles in major depressive disorder: the role of immunometabolic and cell-cycle-related pathways in depression with different levels of inflammation Open
View article: Early life adversities, psychopathologies and novel pharmacological strategies
Early life adversities, psychopathologies and novel pharmacological strategies Open
Exposure to adversities during early life stages (early life adversities - ELA), ranging from pregnancy to adolescence, represents a major risk factor for the vulnerability to mental disorders. Hence, it is important to understand the mole…
View article: Inflammation and immune system pathways as biological signatures of adolescent depression—the IDEA-RiSCo study
Inflammation and immune system pathways as biological signatures of adolescent depression—the IDEA-RiSCo study Open
View article: N-acetylcysteine counteracts increased brain excitatory/inhibitory balance following maternal high-fat diet and restores emotional and cognitive profiles in adult mouse offspring
N-acetylcysteine counteracts increased brain excitatory/inhibitory balance following maternal high-fat diet and restores emotional and cognitive profiles in adult mouse offspring Open
Introduction High-fat diet (HFD) consumption during pregnancy can shape fetal brain development, increasing susceptibility to mental disorders. Nevertheless, the mechanisms underlying these negative outcomes remain unclear. Objectives We h…
View article: Dissecting the Long-Term Effect of Stress Early in Life on FKBP5: The Role of miR-20b-5p and miR-29c-3p
Dissecting the Long-Term Effect of Stress Early in Life on FKBP5: The Role of miR-20b-5p and miR-29c-3p Open
Exposure to early-life stress (ELS) has been related to an increased susceptibility to psychiatric disorders later in life. Although the molecular mechanisms underlying this association are still under investigation, glucocorticoid signali…
View article: Lurasidone treatment in adolescence prevents the pro-inflammatory status in the prefrontal cortex of adult rats exposed to prenatal stress
Lurasidone treatment in adolescence prevents the pro-inflammatory status in the prefrontal cortex of adult rats exposed to prenatal stress Open
View article: Prenatal N-acetyl-cysteine prevents Behavioural and hippocampal disruptions of maternal high-fat diet in adult mice
Prenatal N-acetyl-cysteine prevents Behavioural and hippocampal disruptions of maternal high-fat diet in adult mice Open
View article: Ketogenic diet prevents social dysfunctions and improves stress resilience in a preclinical model of prenatal stress exposure
Ketogenic diet prevents social dysfunctions and improves stress resilience in a preclinical model of prenatal stress exposure Open
View article: N-acetyl-cysteine prevents hippocampal excitatory/inhibitory imbalance, cognitive impairments and metabolic alterations in a mouse model of maternal obesity
N-acetyl-cysteine prevents hippocampal excitatory/inhibitory imbalance, cognitive impairments and metabolic alterations in a mouse model of maternal obesity Open
View article: Exposure to prenatal stress and long-lasting effect in the offspring: focus on the alteration in colon-associated bacteria and intestinal barrier
Exposure to prenatal stress and long-lasting effect in the offspring: focus on the alteration in colon-associated bacteria and intestinal barrier Open
View article: Neuroinflammation and hepatic inflammatory processes heighten vulnerability to psychopathology in adolescent rats exposed to stress early in life
Neuroinflammation and hepatic inflammatory processes heighten vulnerability to psychopathology in adolescent rats exposed to stress early in life Open
View article: Long-term transcriptomic changes in the ventral hippocampus and liver of adult rats exposed to prenatal stress
Long-term transcriptomic changes in the ventral hippocampus and liver of adult rats exposed to prenatal stress Open
View article: Effect of prenatal stress exposure on early longitudinal hippocampal neurodevelopmental trajectories in males and females
Effect of prenatal stress exposure on early longitudinal hippocampal neurodevelopmental trajectories in males and females Open