Marco Rusnati
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View article: Dual targeting of EphAs and KDR axis hampers VEGF-induced angiogenesis and glioma stem cell replication
Dual targeting of EphAs and KDR axis hampers VEGF-induced angiogenesis and glioma stem cell replication Open
Glioblastoma multiforme (GBM) is an aggressive and highly vascularized brain tumor with a poor prognosis and limited therapeutic options. Resistance to current treatments is largely driven by glioma stem-like cells (GSCs), a subpopulation …
View article: K5 polysaccharides inhibit SARS-CoV-2 infection by preventing spike-proteolytic priming
K5 polysaccharides inhibit SARS-CoV-2 infection by preventing spike-proteolytic priming Open
SARS-CoV-2 spike glycoprotein is a promising drug target due to its crucial role in viral infection. Heparin, a long linear polysaccharide that inhibits SARS-CoV-2 infection by acting on spike, has limited antiviral applications due to its…
View article: The accomplices: Heparan sulfates and N-glycans foster SARS-CoV-2 spike:ACE2 receptor binding and virus priming
The accomplices: Heparan sulfates and N-glycans foster SARS-CoV-2 spike:ACE2 receptor binding and virus priming Open
Although it is well established that the SARS-CoV-2 spike glycoprotein binds to the host cell ACE2 receptor to initiate infection, far less is known about the tissue tropism and host cell susceptibility to the virus. Differential expressio…
View article: Discovery of novel FGF trap small molecules endowed with anti-myeloma activity
Discovery of novel FGF trap small molecules endowed with anti-myeloma activity Open
Fibroblast growth factors (FGFs) act as proangiogenic and mitogenic cytokines in several cancers, including multiple myeloma (MM). Indeed, corrupted FGF autocrine and paracrine secretion induces an aberrant activation of the FGF receptor (…
View article: Validation of plasmonic-based biosensors for rapid and sensitive detection of rabbit hemorrhagic and foot-and-mouth disease viruses in biological samples
Validation of plasmonic-based biosensors for rapid and sensitive detection of rabbit hemorrhagic and foot-and-mouth disease viruses in biological samples Open
Biosensing technologies and monoclonal antibodies (MAbs) are gaining increasing importance as powerful tools in the field of virology. Surface plasmon resonance (SPR) is an optical biosensing technology already used in virus detection and …
View article: The accomplices: Heparan sulfates and N-glycans foster SARS-CoV-2 spike:ACE2 receptor binding and virus priming
The accomplices: Heparan sulfates and N-glycans foster SARS-CoV-2 spike:ACE2 receptor binding and virus priming Open
Although it is well established that the SARS-CoV-2 spike glycoprotein binds to the host cell ACE2 receptor to initiate infection, far less is known about the tissue tropism and host cell susceptibility to the virus. Differential expressio…
View article: Molecular Determinants of EphA2 and EphB2 Antagonism Enable the Design of Ligands with Improved Selectivity
Molecular Determinants of EphA2 and EphB2 Antagonism Enable the Design of Ligands with Improved Selectivity Open
With the aim of identifying novel antagonists selective for the EphA receptor family, a combined experimental and computational approach was taken to investigate the molecular basis of the recognition between a prototypical Eph-ephrin anta…
View article: Assessing the effect of protein corona formation in the process of EV surface engineering
Assessing the effect of protein corona formation in the process of EV surface engineering Open
To be profitably exploited in medicine, nanosized systems must be endowed with biocompatibility, targeting capability, the ability to evade the immune system, and resistance to clearance. Currently, biogenic nanoparticles, such as Extracel…
View article: Assessing the effect of protein corona formation in the process of EV surface engineering
Assessing the effect of protein corona formation in the process of EV surface engineering Open
To be profitably exploited in medicine, nanosized systems must be endowed with biocompatibility, targeting capability, the ability to evade the immune system, and resistance to clearance. Currently, biogenic nanoparticles, such as Extracel…
View article: Assessing the effect of protein corona formation in the process of EV surface engineering
Assessing the effect of protein corona formation in the process of EV surface engineering Open
To be profitably exploited in medicine as drug delivery carriers, nanosized systems should be endowed with essential properties, including high biocompatibility, stealth ability to escape the immune system, prolonged circulation lifetime, …
View article: Surface functionalization of extracellular vesicle nanoparticles with antibodies: a first study on the protein corona “variable”
Surface functionalization of extracellular vesicle nanoparticles with antibodies: a first study on the protein corona “variable” Open
Comparison between two edge cases of EVs modified with Cetuximab by chemisorption and physisorption methods: a first exploration of the protein corona “variable”.
View article: Virtual Drug Repositioning as a Tool to Identify Natural Small Molecules That Synergize with Lumacaftor in F508del-CFTR Binding and Rescuing
Virtual Drug Repositioning as a Tool to Identify Natural Small Molecules That Synergize with Lumacaftor in F508del-CFTR Binding and Rescuing Open
Cystic fibrosis is a hereditary disease mainly caused by the deletion of the Phe 508 (F508del) of the cystic fibrosis transmembrane conductance regulator (CFTR) protein that is thus withheld in the endoplasmic reticulum and rapidly degrade…
View article: Prevention of Herpesviridae Infections by Cationic PEGylated Carbosilane Dendrimers
Prevention of Herpesviridae Infections by Cationic PEGylated Carbosilane Dendrimers Open
Infections caused by viruses from the Herpesviridae family produce some of the most prevalent transmitted diseases in the world, constituting a serious global public health issue. Some of the virus properties such as latency and the appear…
View article: Metabolic Soft Spot and Pharmacokinetics: Functionalization of C-3 Position of an Eph–Ephrin Antagonist Featuring a Bile Acid Core as an Effective Strategy to Obtain Oral Bioavailability in Mice
Metabolic Soft Spot and Pharmacokinetics: Functionalization of C-3 Position of an Eph–Ephrin Antagonist Featuring a Bile Acid Core as an Effective Strategy to Obtain Oral Bioavailability in Mice Open
UniPR129, an L-β-homotryptophan conjugate of the secondary bile acid lithocholic acid (LCA), acts as an effective protein-protein interaction (PPI) inhibitor of the Eph–ephrin system but suffers from a poor oral bioavailability in mice. To…
View article: The binding of heparin to spike glycoprotein inhibits SARS-CoV-2 infection by three mechanisms
The binding of heparin to spike glycoprotein inhibits SARS-CoV-2 infection by three mechanisms Open
Heparin, a naturally occurring glycosaminoglycan, has been found to have antiviral activity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative virus of COVID-19. To elucidate the mechanistic basis for the a…
View article: HIV-1 Tat and Heparan Sulfate Proteoglycans Orchestrate the Setup of in Cis and in Trans Cell-Surface Interactions Functional to Lymphocyte Trans-Endothelial Migration
HIV-1 Tat and Heparan Sulfate Proteoglycans Orchestrate the Setup of in Cis and in Trans Cell-Surface Interactions Functional to Lymphocyte Trans-Endothelial Migration Open
HIV-1 transactivating factor Tat is released by infected cells. Extracellular Tat homodimerizes and engages several receptors, including integrins, vascular endothelial growth factor receptor 2 (VEGFR2) and heparan sulfate proteoglycan (HS…
View article: A Bittersweet Computational Journey among Glycosaminoglycans
A Bittersweet Computational Journey among Glycosaminoglycans Open
Glycosaminoglycans (GAGs) are linear polysaccharides. In proteoglycans (PGs), they are attached to a core protein. GAGs and PGs can be found as free molecules, associated with the extracellular matrix or expressed on the cell membrane. The…
View article: Mechanism of inhibition of SARS-CoV-2 infection by the interaction of the spike glycoprotein with heparin
Mechanism of inhibition of SARS-CoV-2 infection by the interaction of the spike glycoprotein with heparin Open
Heparin has been found to have antiviral activity against SARS-CoV-2. Here, by means of sliding window docking, molecular dynamics simulations and biochemical assays, we investigate the binding mode of heparin to the virus spike glycoprote…
View article: Three-fold mechanism of inhibition of SARS-CoV-2 infection by the interaction of the spike glycoprotein with heparin
Three-fold mechanism of inhibition of SARS-CoV-2 infection by the interaction of the spike glycoprotein with heparin Open
Heparin has been found to have antiviral activity against SARS-CoV-2. Here, by means of sliding window docking, molecular dynamics simulations and biochemical assays, we investigate the binding mode of heparin to the virus spike glycoprote…
View article: Recent Strategic Advances in CFTR Drug Discovery: An Overview
Recent Strategic Advances in CFTR Drug Discovery: An Overview Open
Cystic fibrosis transmembrane conductance regulator (CFTR)-rescuing drugs have already transformed cystic fibrosis (CF) from a fatal disease to a treatable chronic condition. However, new-generation drugs able to bind CFTR with higher spec…
View article: Identification of amino acid residues critical for the B cell growth-promoting activity of HIV-1 matrix protein p17 variants
Identification of amino acid residues critical for the B cell growth-promoting activity of HIV-1 matrix protein p17 variants Open
Our findings pave the way for identifying the receptor(s) responsible for B cell proliferation and offer new opportunities to identify novel treatment strategies in combating HIV-related NHL.