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View article: Exposome, oxidative stress and inflammation in persons with multiple sclerosis: the EXPOSITION study protocol
Exposome, oxidative stress and inflammation in persons with multiple sclerosis: the EXPOSITION study protocol Open
The exposome represents the totality of external and internal exposures an individual encounters throughout life and plays a critical role in developing many chronic diseases, including multiple sclerosis (MS). MS is a multifactorial disea…
View article: Air pollution, nasal microbiota, and bronchiolitis: understanding their interplay through a multilevel approach
Air pollution, nasal microbiota, and bronchiolitis: understanding their interplay through a multilevel approach Open
Bronchiolitis is a severe acute lower respiratory tract condition in infants, with respiratory syncytial virus (RSV) infection being a leading cause. Despite extensive research, the factors influencing the severity of bronchiolitis remain …
View article: Linking antibiotic resistance genes in the vaginal microbiota to health-related behaviors and antibiotic awareness in reproductive-age women: a cross-sectional study
Linking antibiotic resistance genes in the vaginal microbiota to health-related behaviors and antibiotic awareness in reproductive-age women: a cross-sectional study Open
Introduction The vaginal microbiota (VMB), predominantly shaped by Lactobacillus species, plays a crucial role in maintaining vaginal health and preventing infections. However, its delicate balance is increasingly challenged by the widespr…
View article: Clustering of Exposome and Lifestyle Data to Support Differential Expression Analysis of Circulating miRNAs in Multiple Sclerosis
Clustering of Exposome and Lifestyle Data to Support Differential Expression Analysis of Circulating miRNAs in Multiple Sclerosis Open
Introduction:MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression post-transcriptionally and are influenced by various metabolic and environmental factors[1]. The functional exposome concept can be seen as a new strat…
View article: Insights from the EXPOSITION Study: Exposome-related microRNA Expression and Clinical Outcomes in People with multiple sclerosis
Insights from the EXPOSITION Study: Exposome-related microRNA Expression and Clinical Outcomes in People with multiple sclerosis Open
IntroductionMicroRNAs (miRNAs) are emerging as promising biomarkers of neuroinflammation and may capture the influence of lifestyle and environmental exposures in people with multiple sclerosis (pwMS). The EXPOSITION study[1] aims to eluci…
View article: Reducing enteric methane emission in dairy goats: impact of dietary inclusions of quebracho tannin extract on ruminal microbiota
Reducing enteric methane emission in dairy goats: impact of dietary inclusions of quebracho tannin extract on ruminal microbiota Open
Introduction Condensed tannins (CT) influence ruminal microbiota, feed digestibility, and methane emissions, yet their effects in goats are poorly understood. Methods This study evaluated the impact of dietary quebracho CT extract at 0%, 2…
View article: Dietary habits and vaginal environment: can a beneficial impact be expected?
Dietary habits and vaginal environment: can a beneficial impact be expected? Open
Introduction In reproductive-aged women, a vaginal microbiota dominated by several Lactobacillus species is crucial for maintaining vaginal health. Among the various factors affecting the composition of the vaginal ecosystem, the impact of…
View article: Red Blood Cell-derived Extracellular Vesicles enable Cisplatin and Cetuximab Synergistic Therapy against Triple-Negative Breast Cancer
Red Blood Cell-derived Extracellular Vesicles enable Cisplatin and Cetuximab Synergistic Therapy against Triple-Negative Breast Cancer Open
Triple-negative breast cancer is an aggressive breast cancer subtype characterized by the absence of human epidermal growth factor receptor 2, estrogen and progesterone receptors, limiting targeted therapy options. Cisplatin, a chemotherap…
View article: The impact of probiotic live yeast in a barley grain-based diet on rumen microbial communities, fermentation, and histology of artificially reared lambs
The impact of probiotic live yeast in a barley grain-based diet on rumen microbial communities, fermentation, and histology of artificially reared lambs Open
View article: The Effects of Animal, Collection Time, and Interval on the Microbiota Structure, Metabolism, and Degradative Potential of Rumen Fluid Inoculum Collected by Esophageal Probe from Hay-Fed Cows
The Effects of Animal, Collection Time, and Interval on the Microbiota Structure, Metabolism, and Degradative Potential of Rumen Fluid Inoculum Collected by Esophageal Probe from Hay-Fed Cows Open
Rumen fluid (RF) is the greatest source of uncontrolled inter-assay variations in in vitro digestibility tests. This study aimed to investigate the effect of donor cow (DC) individual variability, time relative to feeding, and weekly sampl…
View article: Breast cancer patient-derived organoids for the investigation of patient-specific tumour evolution
Breast cancer patient-derived organoids for the investigation of patient-specific tumour evolution Open
View article: Anti-chlamydial activity of vaginal fluids: new evidence from an in vitro model
Anti-chlamydial activity of vaginal fluids: new evidence from an in vitro model Open
Introduction We assessed the in vitro anti-chlamydial activity of fresh vaginal secretions, deciphering the microbial and metabolic components able to counteract Chlamydia trachomatis viability. Methods Forty vaginal samples were collected…
View article: Chlamydia trachomatis and Neisseria gonorrhoeae rectal infections: Interplay between rectal microbiome, HPV infection and Torquetenovirus
Chlamydia trachomatis and Neisseria gonorrhoeae rectal infections: Interplay between rectal microbiome, HPV infection and Torquetenovirus Open
Men having sex with men (MSM) represent a key population, in which sexually transmitted rectal infections (STIs) caused by Chlamydia trachomatis (CT), Neisseria gonorrhoeae (NG) and high-risk HPV (HR-HPV) are very common and linked to sign…
View article: Polypharmacy, drug-drug interactions, anticholinergic burden and cognitive outcomes: a snapshot from a community-dwelling sample of older men and women in northern Italy
Polypharmacy, drug-drug interactions, anticholinergic burden and cognitive outcomes: a snapshot from a community-dwelling sample of older men and women in northern Italy Open
View article: Bovine Colostrum Supplementation in Rabbit Diet Modulates Gene Expression of Cytokines, Gut–Vascular Barrier, and Red-Ox-Related Molecules in the Gut Wall
Bovine Colostrum Supplementation in Rabbit Diet Modulates Gene Expression of Cytokines, Gut–Vascular Barrier, and Red-Ox-Related Molecules in the Gut Wall Open
Rabbits, pivotal in the EU as livestock, pets, and experimental animals, face bacterial infection challenges, prompting a quest for alternatives to curb antibiotic resistance. Bovine colostrum (BC), rich in immunoregulatory compounds, anti…
View article: Adherence to Mediterranean diet is inversely associated with depressive symptoms in older women: findings from the NutBrain Study
Adherence to Mediterranean diet is inversely associated with depressive symptoms in older women: findings from the NutBrain Study Open
Data on the association of the Mediterranean diet (MD) with depressive symptoms in older people at high risk of depression are scarce. This study aimed to investigate the cross-sectional association of the adherence to the MD and its compo…
View article: Investigating the individual and joint effects of socioeconomic status and lifestyle factors on mild cognitive impairment in older Italians living independently in the community: results from the NutBrain study
Investigating the individual and joint effects of socioeconomic status and lifestyle factors on mild cognitive impairment in older Italians living independently in the community: results from the NutBrain study Open
Trial registration number NCT04461951, date of registration July 7, 2020 (retrospectively registered, ClinicalTrials.gov).
View article: Longitudinal Changes of Ocular Surface Microbiome in Patients Undergoing Hemopoietic Stem Cell Transplant (HSCT)
Longitudinal Changes of Ocular Surface Microbiome in Patients Undergoing Hemopoietic Stem Cell Transplant (HSCT) Open
Purpose: To evaluate changes in the ocular surface microbiome (OSM) between pre- and post-haemopoietic stem cell transplant (HSCT) in the same patient, and to assess the potential impact of these changes in ocular graft-versus-host disease…
View article: Polypharmacy, drug-drug interactions, anticholinergic burden and cognitive outcomes: a snapshot from a community-dwelling sample of older men and women in northern Italy
Polypharmacy, drug-drug interactions, anticholinergic burden and cognitive outcomes: a snapshot from a community-dwelling sample of older men and women in northern Italy Open
Introduction Polypharmacy (PP) use is very common in older people and may lead to anticholinergic burdens that affect cognitive impairment. We aimed to determine the occurrence of PP, drug-drug interactions (DDIs) and anticholinergic burde…
View article: Impact of increasing dietary concentrations of quebracho tannins on the ruminal and fecal microbiota of dairy goats
Impact of increasing dietary concentrations of quebracho tannins on the ruminal and fecal microbiota of dairy goats Open
Condensed tannins may reduce enteric methane emissions in dairy goats by acting on feed digestibility and promoting microbial community composition shifts. We assessed the impact on the ruminal and fecal microbiota of a dietary integration…
View article: Diversity and Co-Occurrence Pattern Analysis of Cecal and Jejunal Microbiota in Two Rabbit Breeds
Diversity and Co-Occurrence Pattern Analysis of Cecal and Jejunal Microbiota in Two Rabbit Breeds Open
This study aimed to evaluate the productive performance and microbiota variation in the jejunum and cecum of two rabbit breeds with different growth rates. This study was carried out on Native Middle-Egypt Breed (NMER) and Giant Flanders (…
View article: Genomic Characterization of Mycoplasma arginini Isolated from a Housefly on a Dairy Farm and Comparison with Isolates from Bovine Milk and Lung Tissue
Genomic Characterization of Mycoplasma arginini Isolated from a Housefly on a Dairy Farm and Comparison with Isolates from Bovine Milk and Lung Tissue Open
It is critical to control the spread of bovine mastitis caused by Mycoplasma spp., as this disease can be highly contagious and have a severe economic impact on affected dairies. A better understanding of possible transmission routes is cr…
View article: A comparison between Greengenes, SILVA, RDP, and NCBI reference databases in four published microbiota datasets
A comparison between Greengenes, SILVA, RDP, and NCBI reference databases in four published microbiota datasets Open
Inaccurate bacterial taxonomic assignment in 16S-based microbiota experiments could have deleterious effects on research results, as all downstream analyses heavily rely on the accurate assessment of microbial taxonomy: a bias in the choic…
View article: Nutrition, gUT Microbiota, and BRain AgINg: the NutBrain Study (NutBrain)
Nutrition, gUT Microbiota, and BRain AgINg: the NutBrain Study (NutBrain) Open
The NutBrain Study is a multidisciplinary research project that incorporates modern and advanced technologies (i.e microbiome and neuroimaging) into traditional epidemiologic design study aimed to address key questions about the role of mo…
View article: Nutrition, gUT Microbiota, and BRain AgINg: the NutBrain Study (NutBrain)
Nutrition, gUT Microbiota, and BRain AgINg: the NutBrain Study (NutBrain) Open
The NutBrain Study is a multidisciplinary research project that incorporates modern and advanced technologies (i.e microbiome and neuroimaging) into traditional epidemiologic design study aimed to address key questions about the role of mo…
View article: Bovine Colostrum Supplementation Modulates the Intestinal Microbial Community in Rabbits
Bovine Colostrum Supplementation Modulates the Intestinal Microbial Community in Rabbits Open
BC is a nutraceutical that can modulate intestinal microbiota. This study investigates the effects of BC diet supplementation on luminal and mucosa-associated microbiota in the jejunum, caecum, and colon of rabbits. Twenty-one New Zealand …
View article: Gut microbiota dysbiosis in Parkinson disease: A systematic review and pooled analysis
Gut microbiota dysbiosis in Parkinson disease: A systematic review and pooled analysis Open
Background and purpose The role of the gut microbiome in the pathogenesis of Parkinson disease (PD) is under intense investigation, and the results presented are still very heterogeneous. These discrepancies arise not only from the highly …
View article: Torquetenovirus in pregnancy: Correlation with vaginal microbiome, metabolome and pro-inflammatory cytokines
Torquetenovirus in pregnancy: Correlation with vaginal microbiome, metabolome and pro-inflammatory cytokines Open
Torquetenovirus (TTV) is a negative sense, single-stranded DNA virus present in many body fluids of apparently healthy individuals. At present, it is considered a non-pathogenic endogenous virus. TTV can be detected in the vagina of pregna…
View article: Conjoined Genes as Common Events in Childhood Acute Lymphoblastic Leukemia
Conjoined Genes as Common Events in Childhood Acute Lymphoblastic Leukemia Open
Acute lymphoblastic leukemia (ALL) is the most frequent childhood cancer. For the last three decades, conventional cytogenetic and molecular approaches allowed the identification of genetic abnormalities having prognostic and therapeutic r…
View article: Gardnerella vaginalis clades in pregnancy: New insights into the interactions with the vaginal microbiome
Gardnerella vaginalis clades in pregnancy: New insights into the interactions with the vaginal microbiome Open
Gardnerella vaginalis (GV) is an anaerobic bacterial species involved in the pathogenesis of bacterial vaginosis (BV), a condition of vaginal dysbiosis associated with adverse pregnancy outcomes. GV strains are categorized into four clades…