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View article: Implantation Success, Electrical Performance, and Safety of an active fixation stylet-driven lead for LBBAP in Clinical Practice: A Multicenter Experience
Implantation Success, Electrical Performance, and Safety of an active fixation stylet-driven lead for LBBAP in Clinical Practice: A Multicenter Experience Open
View article: Investigating aging trajectories and determinants in Northern Italy through the Novara cohort study
Investigating aging trajectories and determinants in Northern Italy through the Novara cohort study Open
View article: Second-Generation Antipsychotics Induce Metabolic Disruption in Adipose Tissue-Derived Mesenchymal Stem Cells Through an aPKC-Dependent Pathway
Second-Generation Antipsychotics Induce Metabolic Disruption in Adipose Tissue-Derived Mesenchymal Stem Cells Through an aPKC-Dependent Pathway Open
Metabolic syndrome (MetS) is a cluster of metabolic abnormalities, including visceral obesity, dyslipidemia, and insulin resistance. In this regard, visceral white adipose tissue (vWAT) plays a critical role, influencing energy metabolism,…
View article: The Novara Cohort Study: Rationale, Objective and Preliminary Findings From an Italian Ageing Cohort Study
The Novara Cohort Study: Rationale, Objective and Preliminary Findings From an Italian Ageing Cohort Study Open
Background The Novara Cohort Study (NCS) is the first multidisciplinary cohort study on aging in Northern Italy. It is designed to explore aging trajectories and health outcomes in the general population. This study involves the collection…
View article: Targeting lysine-specific demethylase 1 (KDM1A/LSD1) impairs colorectal cancer tumorigenesis by affecting cancer cells stemness, motility, and differentiation
Targeting lysine-specific demethylase 1 (KDM1A/LSD1) impairs colorectal cancer tumorigenesis by affecting cancer cells stemness, motility, and differentiation Open
View article: UPO Biobank: The Challenge of Integrating Biobanking into the Academic Environment to Support Translational Research
UPO Biobank: The Challenge of Integrating Biobanking into the Academic Environment to Support Translational Research Open
Biobanks are driving motors of precision and personalized medicine by providing high-quality biological material/data through the standardization and harmonization of their collection, preservation, and distribution. UPO Biobank was establ…
View article: Extracellular vesicles from human plasma for biomarkers discovery: Impact of anticoagulants and isolation techniques
Extracellular vesicles from human plasma for biomarkers discovery: Impact of anticoagulants and isolation techniques Open
Extracellular vesicles (EVs) isolated from plasma are increasingly recognized as promising circulating biomarkers for disease discovery and progression, as well as for therapeutic drug delivery. The scientific community underlined the nece…
View article: Risk factors and control of hospital acquired infections: a comparison between Wikipedia and scientific literature
Risk factors and control of hospital acquired infections: a comparison between Wikipedia and scientific literature Open
Background: nowadays Wikipedia is one of the main on-line sources of general information. It contains several items about nosocomial infections and their prevention, together of items on virtually every scientific topic.
This study aims t…
View article: Dissecting the Mechanism of Action of Spiperone—A Candidate for Drug Repurposing for Colorectal Cancer
Dissecting the Mechanism of Action of Spiperone—A Candidate for Drug Repurposing for Colorectal Cancer Open
Approximately 50% of colorectal cancer (CRC) patients still die from recurrence and metastatic disease, highlighting the need for novel therapeutic strategies. Drug repurposing is attracting increasing attention because, compared to tradit…
View article: Psychotropic Drugs Show Anticancer Activity by Disrupting Mitochondrial and Lysosomal Function
Psychotropic Drugs Show Anticancer Activity by Disrupting Mitochondrial and Lysosomal Function Open
Background and Purpose: Drug repositioning is a promising strategy for discovering new therapeutic strategies for cancer therapy. We investigated psychotropic drugs for their antitumor activity because of several epidemiological stu…
View article: P2928External implantable defibrillator as a bridge to reimplant after explant for infection: experience from two centers
P2928External implantable defibrillator as a bridge to reimplant after explant for infection: experience from two centers Open
Background: Arrhythmias and conduction abnormalities are not uncommon in patients with cardiac amyloidosis (CA).The loss of atrial kick and impaired ventricular filling from atrial fibrillation/flutter (AF/FL) in patients with CA often lea…