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View article: High Prevalence of Potential Molecular Therapeutic Targets in Poorly Differentiated Thyroid Carcinoma
High Prevalence of Potential Molecular Therapeutic Targets in Poorly Differentiated Thyroid Carcinoma Open
Poorly differentiated thyroid carcinoma (PDTC) is a rare thyroid cancer with aggressive clinical course and peculiar clinical/pathological characteristics but lacking effective therapeutic options, when surgery is not curative. We aimed at…
View article: Diagnosis and grading of adrenal cortical carcinoma
Diagnosis and grading of adrenal cortical carcinoma Open
The 5th edition of the WHO classification of endocrine and neuroendocrine tumors represents a significant advancement in the diagnostic approach to adrenocortical carcinoma (ACC), integrating novel molecular insights with established histo…
View article: Differential expression profiles of immunoregulatory genes in anaplastic thyroid carcinomas with a coexistent papillary carcinoma component
Differential expression profiles of immunoregulatory genes in anaplastic thyroid carcinomas with a coexistent papillary carcinoma component Open
View article: OC36 - Analysis of predictive factors of malignancy in adrenal masses: findings from a large single-center surgical cohort
OC36 - Analysis of predictive factors of malignancy in adrenal masses: findings from a large single-center surgical cohort Open
Background/Introduction Risk stratification for malignancy in adrenal masses is crucial to either avoid unnecessary surgery or reduce the risk of missing aggressive lesions. Purpose This study aims to investigate predictors of malignancy i…
View article: Figure S5 from AREG and EREG Are Predictive Biomarkers of Response to EGFR Inhibition in Gastroesophageal Cancer
Figure S5 from AREG and EREG Are Predictive Biomarkers of Response to EGFR Inhibition in Gastroesophageal Cancer Open
Evaluation of the expression of EGFR and HER2 in cetuximab sensitive vs resistant cells.
View article: Figure S9 from AREG and EREG Are Predictive Biomarkers of Response to EGFR Inhibition in Gastroesophageal Cancer
Figure S9 from AREG and EREG Are Predictive Biomarkers of Response to EGFR Inhibition in Gastroesophageal Cancer Open
Overall survival according AREG or EREG overexpression in ACRG cohort.
View article: Figure S1 from AREG and EREG Are Predictive Biomarkers of Response to EGFR Inhibition in Gastroesophageal Cancer
Figure S1 from AREG and EREG Are Predictive Biomarkers of Response to EGFR Inhibition in Gastroesophageal Cancer Open
Features of the analyzed models.
View article: Data from AREG and EREG Are Predictive Biomarkers of Response to EGFR Inhibition in Gastroesophageal Cancer
Data from AREG and EREG Are Predictive Biomarkers of Response to EGFR Inhibition in Gastroesophageal Cancer Open
EGFR is a potential therapeutic target in gastroesophageal cancer. However, negative results from several phase II/III clinical trials have hindered the approval of EGFR inhibitors for treating gastroesophageal adenocarcinoma. Preclinical …
View article: Figure S8 from AREG and EREG Are Predictive Biomarkers of Response to EGFR Inhibition in Gastroesophageal Cancer
Figure S8 from AREG and EREG Are Predictive Biomarkers of Response to EGFR Inhibition in Gastroesophageal Cancer Open
Overall survival according HER3 expression in the COG cohort.
View article: Figure S3 from AREG and EREG Are Predictive Biomarkers of Response to EGFR Inhibition in Gastroesophageal Cancer
Figure S3 from AREG and EREG Are Predictive Biomarkers of Response to EGFR Inhibition in Gastroesophageal Cancer Open
Evaluation of apoptosis and cell cycle upon cetuximab treatment.
View article: Figure S6 from AREG and EREG Are Predictive Biomarkers of Response to EGFR Inhibition in Gastroesophageal Cancer
Figure S6 from AREG and EREG Are Predictive Biomarkers of Response to EGFR Inhibition in Gastroesophageal Cancer Open
AREG and EREG RNAscope staining and quantification.
View article: Figure S2 from AREG and EREG Are Predictive Biomarkers of Response to EGFR Inhibition in Gastroesophageal Cancer
Figure S2 from AREG and EREG Are Predictive Biomarkers of Response to EGFR Inhibition in Gastroesophageal Cancer Open
Cross‐sensitivity of GEA primary cells among EGFR targeting drugs.
View article: Figure S10 from AREG and EREG Are Predictive Biomarkers of Response to EGFR Inhibition in Gastroesophageal Cancer
Figure S10 from AREG and EREG Are Predictive Biomarkers of Response to EGFR Inhibition in Gastroesophageal Cancer Open
Evaluation of EGFR pathway activation.
View article: Figure S7 from AREG and EREG Are Predictive Biomarkers of Response to EGFR Inhibition in Gastroesophageal Cancer
Figure S7 from AREG and EREG Are Predictive Biomarkers of Response to EGFR Inhibition in Gastroesophageal Cancer Open
H‐score correlation between the pathologists for AREG, EREG, and HER3 biomarkers.
View article: High prevalence of potential molecular therapeutic targets in poorly differentiated thyroid carcinoma
High prevalence of potential molecular therapeutic targets in poorly differentiated thyroid carcinoma Open
Poorly differentiated thyroid carcinoma (PDTC) is a rare thyroid cancer with aggressive clinical course and peculiar clinical/pathological characteristics but lacking effective therapeutic options, when surgery is not curative.We aimed at …
View article: AREG and EREG Are Predictive Biomarkers of Response to EGFR Inhibition in Gastroesophageal Cancer
AREG and EREG Are Predictive Biomarkers of Response to EGFR Inhibition in Gastroesophageal Cancer Open
EGFR is a potential therapeutic target in gastroesophageal cancer. However, negative results from several phase II/III clinical trials have hindered the approval of EGFR inhibitors for treating gastroesophageal adenocarcinoma. Preclinical …
View article: Controversies in <scp>NEN</scp> : An <scp>ENETS</scp> position statement on the endoscopic management of localised gastric, duodenal and rectal neuroendocrine neoplasms
Controversies in <span>NEN</span> : An <span>ENETS</span> position statement on the endoscopic management of localised gastric, duodenal and rectal neuroendocrine neoplasms Open
Gastric, duodenal and rectal neuroendocrine tumours (NETs) are increasingly detected due to advances in endoscopic imaging. While international guidelines provide criteria for endoscopic management, several aspects remain controversial due…
View article: Impact and Reproducibility of In-House Targeted Next-Generation Sequencing Biomarker Testing in Non–Small-Cell Lung Cancer
Impact and Reproducibility of In-House Targeted Next-Generation Sequencing Biomarker Testing in Non–Small-Cell Lung Cancer Open
View article: Prognostic impact of fibrosclerotic changes in non-papillary, non-anaplastic, follicular cell-derived thyroid carcinomas
Prognostic impact of fibrosclerotic changes in non-papillary, non-anaplastic, follicular cell-derived thyroid carcinomas Open
View article: <i>TERT</i> Expression and Clinical Outcome in Pulmonary Carcinoids
<i>TERT</i> Expression and Clinical Outcome in Pulmonary Carcinoids Open
PURPOSE The clinical course of pulmonary carcinoids ranges from indolent to fatal disease, suggesting that specific molecular alterations drive progression toward the fully malignant state. A similar spectrum of clinical phenotypes occurs …
View article: Contact-based transfer of thymidylate promotes collective tumor growth
Contact-based transfer of thymidylate promotes collective tumor growth Open
Summary Sustained cell proliferation is a fundamental hallmark of cancer, yet its mechanism remains elusive, particularly in context of heterogenous tumor organization, intercellular interactions, and metabolite exchanges. In this study, w…
View article: Pathology of Adrenocortical Carcinoma and Malignant Pheochromocytoma
Pathology of Adrenocortical Carcinoma and Malignant Pheochromocytoma Open
Adrenocortical carcinoma (ACC) and pheochromocytoma (PHEO) are the two most prevalent primary malignancies in the adrenal gland. ACC diagnosis relies on multiparametric scoring systems or diagnostic algorithms that are endorsed by the WHO …
View article: Assessment of the current and emerging criteria for the histopathological classification of lung neuroendocrine tumours in the lungNENomics project
Assessment of the current and emerging criteria for the histopathological classification of lung neuroendocrine tumours in the lungNENomics project Open
This study suggests that the mitotic criteria can be complemented by manual or automated assessment of Ki-67 or PHH3 protein expression, but these markers do not significantly improve the prognostic value of the current classification, as …
View article: Polyoxometalate exerts broad-spectrum activity against human respiratory viruses hampering viral entry
Polyoxometalate exerts broad-spectrum activity against human respiratory viruses hampering viral entry Open
Human respiratory viruses have an enormous impact on national health systems, societies, and economy due to the rapid airborne transmission and epidemic spread of such pathogens, while effective specific antiviral drugs to counteract infec…
View article: Germline NGS targeted analysis in adult patients with sporadic adrenocortical carcinoma
Germline NGS targeted analysis in adult patients with sporadic adrenocortical carcinoma Open
View article: Actionable Non-Small Cell Lung Cancer Mutation Identification by Comprehensive Genomic Profiling for Clinical Trial Enrollment: The European Program for the Routine Testing of Patients with Advanced Lung Cancer (Epropa)
Actionable Non-Small Cell Lung Cancer Mutation Identification by Comprehensive Genomic Profiling for Clinical Trial Enrollment: The European Program for the Routine Testing of Patients with Advanced Lung Cancer (Epropa) Open
View article: Diagnostic Utility of a Modified Reticulin Algorithm in Pediatric Adrenocortical Neoplasms
Diagnostic Utility of a Modified Reticulin Algorithm in Pediatric Adrenocortical Neoplasms Open
Pediatric adrenocortical neoplasms (ACNs) are extremely rare tumors in contrast to their adult counterparts. Distinguishing benign from malignant is challenging based on pure morphologic grounds. Previously, 2 scoring systems were proposed…
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Cover Image Open
View article: Optimising Radioligand Therapy for Patients with Gastro-Entero-Pancreatic Neuroendocrine Tumours: Expert Opinion from an Italian Multidisciplinary Group
Optimising Radioligand Therapy for Patients with Gastro-Entero-Pancreatic Neuroendocrine Tumours: Expert Opinion from an Italian Multidisciplinary Group Open
View article: Updates on lung neuroendocrine neoplasm classification
Updates on lung neuroendocrine neoplasm classification Open
Lung neuroendocrine neoplasms (NENs) are a heterogeneous group of pulmonary neoplasms showing different morphological patterns and clinical and biological characteristics. The World Health Organisation (WHO) classification of lung NENs has…