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View article: A multiomics resource of B cell activation helps decipher disease pathogenesis 4355
A multiomics resource of B cell activation helps decipher disease pathogenesis 4355 Open
Description Most genetic variants that confer risk of complex immune-mediated diseases (IMD) affect gene regulation in specific cell types. Their target genes and focus cell types are often unknown, partially because some effects are hidde…
View article: Functional genomics deciphers pathogenic B cell dynamics in lupus bone marrow 3662
Functional genomics deciphers pathogenic B cell dynamics in lupus bone marrow 3662 Open
Description Systemic lupus erythematosus (SLE) is an autoimmune disease involving immune and non-immune cells, with complex pathogenesis and limited therapies. Dysregulated B cells, particularly double-negative 2 (DN2) B cells (CD19?, CD27…
View article: ABC transporters knockout in Aedes aegypti induces upregulation of paralogous genes, avoiding resistance development to Bacillus thuringiensis Cry toxins
ABC transporters knockout in Aedes aegypti induces upregulation of paralogous genes, avoiding resistance development to Bacillus thuringiensis Cry toxins Open
ABC transporters are membrane proteins that modulate the insecticidal activity of Bacillus thuringiensis Cry toxins by acting as receptors in the gut epithelium of insect larvae. However, their role as Cry receptors in dipteran species rem…
View article: A multi-omics resource of B cell activation reveals genetic mechanisms for immune-mediated diseases
A multi-omics resource of B cell activation reveals genetic mechanisms for immune-mediated diseases Open
Most genetic variants that confer risk of complex immune-mediated diseases (IMDs) affect gene regulation in specific cell types. Their target genes and focus cell types are often unknown, partially because some effects are hidden in untest…
View article: Functional genomics implicates natural killer cells in the pathogenesis of ankylosing spondylitis
Functional genomics implicates natural killer cells in the pathogenesis of ankylosing spondylitis Open
View article: History of tuberculosis disease is associated with genetic regulatory variation in Peruvians
History of tuberculosis disease is associated with genetic regulatory variation in Peruvians Open
A quarter of humanity is estimated to have been exposed to Mycobacterium tuberculosis ( Mtb ) with a 5–10% risk of developing tuberculosis (TB) disease. Variability in responses to Mtb infection could be due to host or pathogen heterogenei…
View article: Functional genomics implicates natural killer cells in the pathogenesis of ankylosing spondylitis
Functional genomics implicates natural killer cells in the pathogenesis of ankylosing spondylitis Open
Objective Multiple lines of evidence indicate that ankylosing spondylitis (AS) is a lymphocyte-driven disease. However, which lymphocyte populations are critical in AS pathogenesis is not known. In this study, we aimed to identify the key …
View article: History of tuberculosis disease is associated with genetic regulatory variation in Peruvians
History of tuberculosis disease is associated with genetic regulatory variation in Peruvians Open
A quarter of humanity is estimated to be latently infected with Mycobacterium tuberculosis ( Mtb ) with a 5-10% risk of developing tuberculosis (TB) disease. Variability in responses to Mtb infection could be due to host or pathogen hetero…
View article: A hotspot for posttranslational modifications on the androgen receptor dimer interface drives pathology and anti-androgen resistance
A hotspot for posttranslational modifications on the androgen receptor dimer interface drives pathology and anti-androgen resistance Open
Mutations of the androgen receptor (AR) associated with prostate cancer and androgen insensitivity syndrome may profoundly influence its structure, protein interaction network, and binding to chromatin, resulting in altered transcription s…
View article: Aedes aegypti Strain Subjected to Long-Term Exposure to Bacillus thuringiensis svar. israelensis Larvicides Displays an Altered Transcriptional Response to Zika Virus Infection
Aedes aegypti Strain Subjected to Long-Term Exposure to Bacillus thuringiensis svar. israelensis Larvicides Displays an Altered Transcriptional Response to Zika Virus Infection Open
Bacillus thuringiensis svar. israelensis (Bti) larvicides are effective in controlling Aedes aegypti; however, the effects of long-term exposure need to be properly evaluated. We established an Ae. aegypti strain that has been treated with…
View article: SARS-CoV-2-specific T cell responses in patients with multisystem inflammatory syndrome in children
SARS-CoV-2-specific T cell responses in patients with multisystem inflammatory syndrome in children Open
View article: Whole Genome Sequencing Analysis of Bacillus thuringiensis GR007 Reveals Multiple Pesticidal Protein Genes
Whole Genome Sequencing Analysis of Bacillus thuringiensis GR007 Reveals Multiple Pesticidal Protein Genes Open
Bacillus thuringiensis ( Bt ) are soil ubiquitous bacteria. They produce a great variability of insecticidal proteins, where certain of these toxins are used worldwide for pest control. Through their adaptation to diverse ecosystems, certa…