João S. Silva
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View article: Isolation and Characterization of Articular Cartilage-Derived Cells Obtained by Arthroscopic Cartilage Biopsy from Non-Osteoarthritic Patients
Isolation and Characterization of Articular Cartilage-Derived Cells Obtained by Arthroscopic Cartilage Biopsy from Non-Osteoarthritic Patients Open
Cartilage-derived migratory cells show great potential for autologous use in cartilage repair surgery. However, their collection through arthroscopic biopsy has not been previously reported in individuals without osteoarthritis. This study…
View article: T Cell Dysfunction in Cutaneous Leishmaniasis at Single-Cell Resolution
T Cell Dysfunction in Cutaneous Leishmaniasis at Single-Cell Resolution Open
Summary Background Cutaneous leishmaniasis (CL) is characterized by immune dysregulation that facilitates chronic infection. Objective To investigate the role of T cells in the immunopathology of CL by characterizing the immune landscape o…
View article: Biogenic silver nanoparticles produced by Trichoderma reesei inhibit SARS-CoV-2 infection, reduce lung viral load and ameliorate acute pulmonary inflammation
Biogenic silver nanoparticles produced by Trichoderma reesei inhibit SARS-CoV-2 infection, reduce lung viral load and ameliorate acute pulmonary inflammation Open
The COVID-19 pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), posed a significant global health challenge and still demands efforts to develop new therapies. In this study, we investigated the potential…
View article: SpiN-Tec: A T cell-based recombinant vaccine that is safe, immunogenic, and shows high efficacy in experimental models challenged with SARS-CoV-2 variants of concern
SpiN-Tec: A T cell-based recombinant vaccine that is safe, immunogenic, and shows high efficacy in experimental models challenged with SARS-CoV-2 variants of concern Open
The emergence of new SARS-CoV-2 variants of concern associated with waning immunity induced by natural infection or vaccines currently in use suggests that the COVID-19 pandemic will become endemic. Investing in new booster vaccines using …
View article: A quantitative Gidas-Ni-Nirenberg-type result for the $p$-Laplacian via integral identities
A quantitative Gidas-Ni-Nirenberg-type result for the $p$-Laplacian via integral identities Open
We prove a quantitative version of a Gidas-Ni-Nirenberg-type symmetry result involving the $p$-Laplacian. Quantitative stability is achieved here via integral identities based on the proof of rigidity established by J. Serra in 2013, which…
View article: Reprogramming of host energy metabolism mediated by the TNF-iNOS-HIF-1α axis plays a key role in host resistance to Plasmodium infection
Reprogramming of host energy metabolism mediated by the TNF-iNOS-HIF-1α axis plays a key role in host resistance to Plasmodium infection Open
Summary TNF has a dual effect in Plasmodium infection, bolstering the host’s immune defense while also triggering disease. Here, we show that TNF signaling hampers physical activity, food intake, and energy expenditure while enhancing gluc…
View article: Reprogramming of host energy metabolism mediated by the TNF-iNOS-HIF-1α axis plays a key role in host resistance to Plasmodium infection
Reprogramming of host energy metabolism mediated by the TNF-iNOS-HIF-1α axis plays a key role in host resistance to Plasmodium infection Open
Summary TNF has a dual effect in Plasmodium infection, bolstering the host’s immune defense while also triggering disease. Here, we show that TNF signaling hampers physical activity, food intake, and energy expenditure while enhancing gluc…
View article: Reprogramming of host energy metabolism mediated by the TNF-iNOS-HIF-1α axis plays a key role in host resistance to <i>Plasmodium</i> infection
Reprogramming of host energy metabolism mediated by the TNF-iNOS-HIF-1α axis plays a key role in host resistance to <i>Plasmodium</i> infection Open
Summary TNF has a dual effect in Plasmodium infection, bolstering the host’s immune defense while also triggering disease. Here, we show that TNF signaling hampers physical activity, food intake, and energy expenditure while enhancing gluc…
View article: Mycotoxins evaluation of total mixed ration (TMR) in bovine dairy farms: An update
Mycotoxins evaluation of total mixed ration (TMR) in bovine dairy farms: An update Open
The total mixed ration (TMR) is currently a widespread method to feed dairy cows. It is a mixture of raw fodder and concentrate feed that can be contaminated by several mycotoxins. The main aim of this paper was to provide a critical revie…
View article: Inulin prebiotic ameliorates type 1 diabetes dictating regulatory T cell homing via CCR4 to pancreatic islets and butyrogenic gut microbiota in murine model
Inulin prebiotic ameliorates type 1 diabetes dictating regulatory T cell homing via CCR4 to pancreatic islets and butyrogenic gut microbiota in murine model Open
Gut dysbiosis is linked to type 1 diabetes mellitus (T1D). Inulin (INU), a prebiotic, modulates the gut microbiota, promoting beneficial bacteria that produce essential short-chain fatty acids for immune regulation. However, how INU affect…
View article: Blimp-1 signaling pathways in T lymphocytes is essential to control the Trypanosoma cruzi infection-induced inflammation
Blimp-1 signaling pathways in T lymphocytes is essential to control the Trypanosoma cruzi infection-induced inflammation Open
In many infectious diseases, the pathogen-induced inflammatory response could result in protective immunity that should be regulated to prevent tissue damage and death. In fact, in Trypanosoma cruzi infection, the innate immune and the inf…
View article: Boundary controllability of the Korteweg-de Vries equation: The Neumann case
Boundary controllability of the Korteweg-de Vries equation: The Neumann case Open
This article gives a necessary first step to understanding the critical set phenomenon for the Korteweg-de Vries (KdV) equation posed on interval $[0,L]$ considering the Neumann boundary conditions with only one control input. We showed th…
View article: Mannose-Binding Lectins as Potent Antivirals against SARS-CoV-2
Mannose-Binding Lectins as Potent Antivirals against SARS-CoV-2 Open
The SARS-CoV-2 entry into host cells is mainly mediated by the interactions between the viral spike protein (S) and the ACE-2 cell receptor, which are highly glycosylated. Therefore, carbohydrate binding agents may represent potential cand…
View article: Rigidity of free boundary minimal disks in mean convex three-manifolds
Rigidity of free boundary minimal disks in mean convex three-manifolds Open
The purpose of this article is study rigidity of free boundary minimal two-disks that locally maximize the modified Hawking mass on a Riemannian three-manifold with positive lower bound on its scalar curvature and mean convex boundary. Ass…
View article: Parasite Detection in Visceral Leishmaniasis Samples by Dye-Based qPCR Using New Gene Targets of Leishmania infantum and Crithidia
Parasite Detection in Visceral Leishmaniasis Samples by Dye-Based qPCR Using New Gene Targets of Leishmania infantum and Crithidia Open
Visceral leishmaniasis (VL) is a neglected disease considered a serious public health problem, especially in endemic countries. Several studies have discovered monoxenous trypanosomatids (Leptomonas and Crithidia) in patients with VL. In d…
View article: Data from IL17 Promotes Mammary Tumor Progression by Changing the Behavior of Tumor Cells and Eliciting Tumorigenic Neutrophils Recruitment
Data from IL17 Promotes Mammary Tumor Progression by Changing the Behavior of Tumor Cells and Eliciting Tumorigenic Neutrophils Recruitment Open
The aggressiveness of invasive ductal carcinoma (IDC) of the breast is associated with increased IL17 levels. Studying the role of IL17 in invasive breast tumor pathogenesis, we found that metastatic primary tumor-infiltrating T lymphocyte…
View article: Supplementary Materials, Figures S1-4, Table S1 from IL17 Promotes Mammary Tumor Progression by Changing the Behavior of Tumor Cells and Eliciting Tumorigenic Neutrophils Recruitment
Supplementary Materials, Figures S1-4, Table S1 from IL17 Promotes Mammary Tumor Progression by Changing the Behavior of Tumor Cells and Eliciting Tumorigenic Neutrophils Recruitment Open
Supplementary Materials, Figures S1-4, Table S1: Supplementary materials and methods Supplementary Fig. S1. Treatment with anti-IL-17 antibodies inhibits the growth of murine TC-1 tumors. Supplementary Fig. S2. Blockade of IL-17 does not a…
View article: Data from IL17 Promotes Mammary Tumor Progression by Changing the Behavior of Tumor Cells and Eliciting Tumorigenic Neutrophils Recruitment
Data from IL17 Promotes Mammary Tumor Progression by Changing the Behavior of Tumor Cells and Eliciting Tumorigenic Neutrophils Recruitment Open
The aggressiveness of invasive ductal carcinoma (IDC) of the breast is associated with increased IL17 levels. Studying the role of IL17 in invasive breast tumor pathogenesis, we found that metastatic primary tumor-infiltrating T lymphocyte…
View article: Supplementary Materials, Figures S1-4, Table S1 from IL17 Promotes Mammary Tumor Progression by Changing the Behavior of Tumor Cells and Eliciting Tumorigenic Neutrophils Recruitment
Supplementary Materials, Figures S1-4, Table S1 from IL17 Promotes Mammary Tumor Progression by Changing the Behavior of Tumor Cells and Eliciting Tumorigenic Neutrophils Recruitment Open
Supplementary Materials, Figures S1-4, Table S1: Supplementary materials and methods Supplementary Fig. S1. Treatment with anti-IL-17 antibodies inhibits the growth of murine TC-1 tumors. Supplementary Fig. S2. Blockade of IL-17 does not a…