Marcus A. Lawson
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View article: Maternal viral infection causes global alterations in porcine fetal microglia
Maternal viral infection causes global alterations in porcine fetal microglia Open
Significance Mental health disorders account for approximately 14% of the worldwide burden of disease and affect people of all age groups and socioeconomic statuses. Prenatal exposure to maternal infection increases the risk of developing …
View article: Herring roe oil supplementation alters microglial cell gene expression and reduces peripheral inflammation after immune activation in a neonatal piglet model
Herring roe oil supplementation alters microglial cell gene expression and reduces peripheral inflammation after immune activation in a neonatal piglet model Open
View article: Inhibition of DNA Methylation With Zebularine Alters Lipopolysaccharide-Induced Sickness Behavior and Neuroinflammation in Mice
Inhibition of DNA Methylation With Zebularine Alters Lipopolysaccharide-Induced Sickness Behavior and Neuroinflammation in Mice Open
Activity of DNA methyltransferases (DNMTs), the enzymes that catalyze DNA methylation, is dynamically regulated in the brain. DNMT inhibitors alter DNA methylation globally in the brain and at individual neural plasticity-associated genes,…
View article: Butyrate and Dietary Soluble Fiber Improve Neuroinflammation Associated With Aging in Mice
Butyrate and Dietary Soluble Fiber Improve Neuroinflammation Associated With Aging in Mice Open
Aging results in chronic systemic inflammation that can alter neuroinflammation of the brain. Specifically, microglia shift to a pro-inflammatory phenotype predisposing them to hyperactivation upon stimulation by peripheral immune signals.…
View article: Glia- and tissue-specific changes in the Kynurenine Pathway after treatment of mice with lipopolysaccharide and dexamethasone
Glia- and tissue-specific changes in the Kynurenine Pathway after treatment of mice with lipopolysaccharide and dexamethasone Open
View article: Desipramine decreases expression of human and murine indoleamine-2,3-dioxygenases
Desipramine decreases expression of human and murine indoleamine-2,3-dioxygenases Open
View article: Immunomodulatory Factors Galectin-9 and Interferon-Gamma Synergize to Induce Expression of Rate-Limiting Enzymes of the Kynurenine Pathway in the Mouse Hippocampus
Immunomodulatory Factors Galectin-9 and Interferon-Gamma Synergize to Induce Expression of Rate-Limiting Enzymes of the Kynurenine Pathway in the Mouse Hippocampus Open
Elevated levels of circulating pro-inflammatory cytokines are associated with symptomology of several psychiatric disorders, notably major depressive disorder. Symptomology has been linked to inflammation/cytokine-dependent induction of th…
View article: Aging and peripheral lipopolysaccharide can modulate epigenetic regulators and decrease IL-1β promoter DNA methylation in microglia
Aging and peripheral lipopolysaccharide can modulate epigenetic regulators and decrease IL-1β promoter DNA methylation in microglia Open
View article: Differential Transcriptome Networks between IDO1-Knockout and Wild-Type Mice in Brain Microglia and Macrophages
Differential Transcriptome Networks between IDO1-Knockout and Wild-Type Mice in Brain Microglia and Macrophages Open
Microglia in the brain and macrophages in peripheral organs are cell types responsible for immune response to challenges. Indoleamine 2,3-dioxygenase 1 (IDO1) is an immunomodulatory enzyme of the tryptophan pathway that is expressed in the…
View article: Interactions between inflammatory mediators and corticosteroids regulate transcription of genes within the Kynurenine Pathway in the mouse hippocampus
Interactions between inflammatory mediators and corticosteroids regulate transcription of genes within the Kynurenine Pathway in the mouse hippocampus Open
View article: Microglia Transcriptome Changes in a Model of Depressive Behavior after Immune Challenge
Microglia Transcriptome Changes in a Model of Depressive Behavior after Immune Challenge Open
Depression symptoms following immune response to a challenge have been reported after the recovery from sickness. A RNA-Seq study of the dysregulation of the microglia transcriptome in a model of inflammation-associated depressive behavior…
View article: IL-4 Knock Out Mice Display Anxiety-Like Behavior
IL-4 Knock Out Mice Display Anxiety-Like Behavior Open
View article: Analytical workflow profiling gene expression in murine macrophages
Analytical workflow profiling gene expression in murine macrophages Open
Comprehensive and simultaneous analysis of all genes in a biological sample is a capability of RNA-Seq technology. Analysis of the entire transcriptome benefits from summarization of genes at the functional level. As a cellular response of…