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View article: A generic cell surface ligand system for studying cell–cell recognition
A generic cell surface ligand system for studying cell–cell recognition Open
Dose-response experiments are a mainstay of receptor biology studies and can reveal valuable insights into receptor function. Such studies of receptors that bind cell surface ligands are currently limited by the difficulty in manipulating …
View article: A generic cell surface ligand system for studying cell-cell recognition
A generic cell surface ligand system for studying cell-cell recognition Open
Dose-response experiments are a mainstay of receptor biology studies and can reveal valuable insights into receptor function. Such studies of receptors that bind cell surface ligands are currently limited by the difficulty in manipulating …
View article: Biophysical assay for tethered signaling reactions reveals tether-controlled activity for the phosphatase SHP-1
Biophysical assay for tethered signaling reactions reveals tether-controlled activity for the phosphatase SHP-1 Open
Tethering of the cytoplasmic tyrosine phosphatase SHP-1 to clustered receptors increases its activity 900-fold.
View article: Biophysical assay for tethered signaling reactions reveals tether-controlled activity for the phosphatase SHP-1
Biophysical assay for tethered signaling reactions reveals tether-controlled activity for the phosphatase SHP-1 Open
Tethered enzymatic reactions are ubiquitous in signalling networks but are poorly understood. Here, a novel mathematical analysis is established for tethered signalling reactions in surface plasmon resonance (SPR). Applying the method to t…