Marcus Couey
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View article: Elastic scattering spectroscopy for intraoperative oral cancer mucosal margin guidance: Initial results from a 104 patient cohort
Elastic scattering spectroscopy for intraoperative oral cancer mucosal margin guidance: Initial results from a 104 patient cohort Open
The ESS device demonstrated high sensitivity and appropriate specificity when differentiating benign from malignant tissue. Discriminant ability increased when samples were pooled within patients, informing future protocols for evaluating …
View article: 680 Multi-parametric assessment of the immune response to a trio immunotherapy in patients with recurrent or metastatic head and neck squamous cell carcinoma
680 Multi-parametric assessment of the immune response to a trio immunotherapy in patients with recurrent or metastatic head and neck squamous cell carcinoma Open
Background Our group developed a strategy for generating an 'off-the-shelf' multivalent proteasome-blocked autophagosome vaccine that contains proteins for many genes commonly overexpressed in adenocarcinoma and squamous cell cancers. This…
View article: Immune‐related adverse events are associated with improved response, progression‐free survival, and overall survival for patients with head and neck cancer receiving immune checkpoint inhibitors
Immune‐related adverse events are associated with improved response, progression‐free survival, and overall survival for patients with head and neck cancer receiving immune checkpoint inhibitors Open
Background The authors hypothesized that patients developing immune‐related adverse events (irAEs) while receiving immune checkpoint inhibition (ICI) for recurrent/metastatic head and neck cancer (HNC) would have improved oncologic outcome…
View article: Neoadjuvant immunoradiotherapy results in high rate of complete pathological response and clinical to pathological downstaging in locally advanced head and neck squamous cell carcinoma
Neoadjuvant immunoradiotherapy results in high rate of complete pathological response and clinical to pathological downstaging in locally advanced head and neck squamous cell carcinoma Open
Background Checkpoint inhibitors targeting programmed death receptor-1 (PD-1) have been tested in the neoadjuvant setting for the treatment of locoregionally advanced head and neck squamous cell carcinoma (HNSCC); however, response rates a…
View article: Additional file 1 of The REASON score: an epigenetic and clinicopathologic score to predict risk of poor survival in patients with early stage oral squamous cell carcinoma
Additional file 1 of The REASON score: an epigenetic and clinicopathologic score to predict risk of poor survival in patients with early stage oral squamous cell carcinoma Open
Additional file 1: Table S1. Functional network analysis (GO). Differentially methylated pathways (adjusted p-value
View article: 443 An immunotherapy trio in advanced HNSCC for coordinated B and T cell antigen response
443 An immunotherapy trio in advanced HNSCC for coordinated B and T cell antigen response Open
Background Outcomes for recurrent or metastatic (R/M) head and neck squamous cell carcinoma (HNSCC) are dismal and responses to anti-PD-1 appear best in tumors with PD-1+ T cells in proximity to PD-L1+ cells, arguing that improved outcome …
View article: Computed tomography-guided 3D printed patient-specific regional anesthesia
Computed tomography-guided 3D printed patient-specific regional anesthesia Open
Classic anesthetic techniques for the inferior alveolar nerve, lingual nerve, and long buccal nerve blockade are achieved by estimating the intended location for anesthetic deposition based on palpation, inspection, and subsequent correlat…
View article: Modified karapandzic flap with radial forearm free flap to reconstruct a large composite upper lip and palate defect: Case report and anatomic study
Modified karapandzic flap with radial forearm free flap to reconstruct a large composite upper lip and palate defect: Case report and anatomic study Open
Functional reconstruction of a combined upper lip and palatal defect presents surgical challenges that differ from either type of defect in isolation. While useful in obtaining tissue coverage for large defects, free flaps lack the ability…
View article: Delayed immune-related events (DIRE) after discontinuation of immunotherapy: diagnostic hazard of autoimmunity at a distance
Delayed immune-related events (DIRE) after discontinuation of immunotherapy: diagnostic hazard of autoimmunity at a distance Open
As immunotherapy indications expand into the curative setting, often with brief exposure and potentially sequenced with multimodality treatments, it will be necessary to recognize an emerging diagnostic complex, which we have termed delaye…
View article: Large Draining Focal Fibrous Hyperplasia Secondary to Periapical Granuloma
Large Draining Focal Fibrous Hyperplasia Secondary to Periapical Granuloma Open
Periapical granuloma is a pathological diagnosis associated clinically and radiographically with a nonvital tooth and a periapical radiolucency, respectively. It is frequently seen as a sequela of long-standing pulpal necrosis. Often times…