Marcus E. Raichle
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View article: The Knight Alzheimer Research Imaging (KARI) dataset: a comprehensive multimodal resource for exploring aging, preclinical, and symptomatic Alzheimer disease pathology
The Knight Alzheimer Research Imaging (KARI) dataset: a comprehensive multimodal resource for exploring aging, preclinical, and symptomatic Alzheimer disease pathology Open
Alzheimer disease (AD) remains a significant global public health challenge, requiring robust multimodal datasets to elucidate its prolonged preclinical phase, improve early detection, advance understanding of disease trajectories, and gui…
View article: Arousal as a universal embedding for spatiotemporal brain dynamics
Arousal as a universal embedding for spatiotemporal brain dynamics Open
Neural activity in awake organisms shows widespread, spatiotemporally diverse correlations with behavioural and physiological measurements1-4. We propose that this covariation reflects in part the structured, nonlinear dynamics of an under…
Hyperglycemia selectively increases cerebral non-oxidative glucose consumption without affecting blood flow Open
Multiple studies have shown that hyperglycemia increases the cerebral metabolic rate of glucose (CMRglc) in subcortical white matter. This observation remains unexplained. Using positron emission tomography (PET) and pancreatic glucose cla…
View article: Action-mode subnetworks for decision-making, action control, and feedback
Action-mode subnetworks for decision-making, action control, and feedback Open
The action-mode network (AMN) is a canonical functional brain network first identified using resting-state functional connectivity (RSFC). Based on animal and human data, we have proposed that AMN supports the brain’s action mode by contro…
View article: Stimulant medications affect arousal and reward, not attention
Stimulant medications affect arousal and reward, not attention Open
Prescription stimulants such as methylphenidate are being used by an increasing portion of the population, primarily children. These potent norepinephrine and dopamine reuptake inhibitors promote wakefulness, suppress appetite, enhance phy…
View article: The human brainstem’s red nucleus was upgraded to support goal-directed action
The human brainstem’s red nucleus was upgraded to support goal-directed action Open
The red nucleus, a large brainstem structure, coordinates limb movement for locomotion in quadrupedal animals. In humans, its pattern of anatomical connectivity differs from that of quadrupeds, suggesting a different purpose. Here, we appl…
View article: Disuse-driven plasticity in the human thalamus and putamen
Disuse-driven plasticity in the human thalamus and putamen Open
Subcortical plasticity has mainly been studied using invasive electrophysiology in animals. Here, we leverage precision functional mapping (PFM) to study motor plasticity in the human subcortex during 2 weeks of upper-extremity immobilizat…
ATP-sensitive potassium channels alter glycolytic flux to modulate cortical activity and sleep Open
Metabolism plays a key role in the maintenance of sleep/wake states. Brain lactate fluctuations are a biomarker of sleep/wake transitions, where increased interstitial fluid (ISF) lactate levels are associated with wakefulness and decrease…
View article: Prenatal social disadvantage is associated with alterations in functional networks at birth
Prenatal social disadvantage is associated with alterations in functional networks at birth Open
Childhood exposure to social disadvantage is a major risk factor for psychiatric disorders and poor developmental, educational, and occupational outcomes, presumably because adverse exposures alter the neurodevelopmental processes that con…
Hyperglycemia selectively increases cerebral non-oxidative glucose consumption without affecting blood flow Open
Multiple studies have shown that hyperglycemia increases the cerebral metabolic rate of glucose (CMRglc) in subcortical white matter. This observation remains unexplained. Using positron emission tomography (PET) and euinsulinaemic glucose…
View article: Psilocybin desynchronizes the human brain
Psilocybin desynchronizes the human brain Open
A single dose of psilocybin, a psychedelic that acutely causes distortions of space–time perception and ego dissolution, produces rapid and persistent therapeutic effects in human clinical trials 1–4 . In animal models, psilocybin induces …
View article: A novel spatiotemporal graph convolutional network framework for functional connectivity biomarkers identification of Alzheimer’s disease
A novel spatiotemporal graph convolutional network framework for functional connectivity biomarkers identification of Alzheimer’s disease Open
Background Functional connectivity (FC) biomarkers play a crucial role in the early diagnosis and mechanistic study of Alzheimer’s disease (AD). However, the identification of effective FC biomarkers remains challenging. In this study, we …
The brain’s cingulo-opercular action-mode network Open
The brain is always intrinsically active, utilizing energy at high rates, while moving between global functional modes. Awake brain modes are tied to corresponding behavioral states. During goal-directed behavior, the brain enters an actio…
The brainstem’s red nucleus was evolutionarily upgraded to support goal-directed action Open
The red nucleus is a large brainstem structure that coordinates limb movement for locomotion in quadrupedal animals (Basile et al., 2021). The humans red nucleus has a different pattern of anatomical connectivity compared to quadrupeds, su…
View article: Arousal as a universal embedding for spatiotemporal brain dynamics
Arousal as a universal embedding for spatiotemporal brain dynamics Open
Neural activity in awake organisms shows widespread and spatiotemporally diverse correlations with behavioral and physiological measurements. We propose that this covariation reflects in part the dynamics of a unified, multidimensional aro…
View article: Disuse-driven plasticity in the human thalamus and putamen
Disuse-driven plasticity in the human thalamus and putamen Open
Motor adaptation in cortico-striato-thalamo-cortical loops has been studied mainly in animals using invasive electrophysiology. Here, we leverage functional neuroimaging in humans to study motor circuit plasticity in the human subcortex. W…
View article: Psilocybin desynchronizes brain networks
Psilocybin desynchronizes brain networks Open
1 Summary The relationship between the acute effects of psychedelics and their persisting neurobiological and psychological effects is poorly understood. Here, we tracked brain changes with longitudinal precision functional mapping in heal…
View article: Science
Science Open
The asymmetric α-addition of relatively nonpolar hydrocarbon substrates, such as allyl and aryl groups, to aldehydes and ketones remains a largely unsolved problem in organic synthesis, despite the wide potential utility of direct routes t…
Targeted neurostimulation reverses a spatiotemporal biomarker of treatment-resistant depression Open
Major depressive disorder (MDD) is widely hypothesized to result from disordered communication across brain-wide networks. Yet, prior resting-state-functional MRI (rs-fMRI) studies of MDD have studied zero-lag temporal synchrony (functiona…
View article: Deep learning-based polygenic risk analysis for Alzheimer’s disease prediction
Deep learning-based polygenic risk analysis for Alzheimer’s disease prediction Open
Background The polygenic nature of Alzheimer’s disease (AD) suggests that multiple variants jointly contribute to disease susceptibility. As an individual’s genetic variants are constant throughout life, evaluating the combined effects of …
Brain aerobic glycolysis and resilience in Alzheimer disease Open
The distribution of brain aerobic glycolysis (AG) in normal young adults correlates spatially with amyloid-beta (Aβ) deposition in individuals with symptomatic and preclinical Alzheimer disease (AD). Brain AG decreases with age, but the fu…
View article: A mind-body interface alternates with effector-specific regions in motor cortex
A mind-body interface alternates with effector-specific regions in motor cortex Open
SUMMARY Primary motor cortex (M1) has been thought to form a continuous somatotopic homunculus extending down precentral gyrus from foot to face representations 1,2 . The motor homunculus has remained a textbook pillar of functional neuroa…
Acute hyper- and hypoglycemia uncouples the metabolic cooperation between glucose and lactate to disrupt sleep Open
The sleep-wake cycle is a master regulator of metabolic and neuronal activity and when altered, can have profound effects on metabolic health and disease. Although consideration is given to how fluctuations in blood glucose affect peripher…
Brain aerobic glycolysis and resilience in Alzheimer disease Open
The distribution of brain aerobic glycolysis (AG) in normal young adults correlates spatially with amyloid-beta (Aβ) deposition in individuals with dementia of the Alzheimer type (DAT) and asymptomatic individuals with brain amyloid deposi…