Marcus Gutmann
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View article: A Viral Neuraminidase-Specific Sensor for Taste-Based Detection of Influenza
A Viral Neuraminidase-Specific Sensor for Taste-Based Detection of Influenza Open
View article: Impurity profiling of PEGylated myristoyl diglyceride, DMG-PEG 2000, a functional excipient used in mRNA lipid nanoparticle formulations
Impurity profiling of PEGylated myristoyl diglyceride, DMG-PEG 2000, a functional excipient used in mRNA lipid nanoparticle formulations Open
Lipid nanoparticles have gained significant attention during the COVID-19 pandemic, particularly due to their role in mRNA vaccine delivery. However, their rapid advancement has outpaced the development of established harmonized protocols …
View article: Transglutaminase-catalyzed covalent anti-myostatin peptide depots
Transglutaminase-catalyzed covalent anti-myostatin peptide depots Open
View article: Beyond comparison: Brillouin microscopy and AFM-based indentation reveal divergent insights into the mechanical profile of the murine retina
Beyond comparison: Brillouin microscopy and AFM-based indentation reveal divergent insights into the mechanical profile of the murine retina Open
Mechanical tissue properties increasingly serve as pivotal phenotypic characteristics that are subject to change during development or pathological progression. The quantification of such material properties often relies on physical contac…
View article: PEGylated Recombinant <i>Aplysia punctata</i> Ink Toxin Depletes Arginine and Lysine and Inhibits the Growth of Tumor Xenografts
PEGylated Recombinant <i>Aplysia punctata</i> Ink Toxin Depletes Arginine and Lysine and Inhibits the Growth of Tumor Xenografts Open
In recent years, a novel treatment method for cancer has emerged, which is based on the starvation of tumors of amino acids like arginine. The deprivation of arginine in serum is based on enzymatic degradation and can be realized by argini…
View article: Beyond comparison: Brillouin microscopy and AFM-based indentation reveal divergent insights into the mechanical profile of the murine retina
Beyond comparison: Brillouin microscopy and AFM-based indentation reveal divergent insights into the mechanical profile of the murine retina Open
Mechanical tissue properties increasingly serve as pivotal phenotypic characteristics that are subject to change during development or pathological progression. The quantification of such material properties often relies on physical contac…
View article: Transglutaminase-Catalyzed Covalent Anti-Myostatin Peptide Depots
Transglutaminase-Catalyzed Covalent Anti-Myostatin Peptide Depots Open
View article: Visually distinguishing between tumor tissue and healthy tissue within ten minutes using proteolytic probes
Visually distinguishing between tumor tissue and healthy tissue within ten minutes using proteolytic probes Open
Fluorescence-emitting probes designed to detect furin, a biomarker protease that is upregulated in tumor tissue, simplifying complex diagnostic workflows and enabling tissue-conserving surgery through direct visual readout.
View article: Site-specific PEGylation of recombinant tissue-type plasminogen activator
Site-specific PEGylation of recombinant tissue-type plasminogen activator Open
View article: CCDC 2216856: Experimental Crystal Structure Determination
CCDC 2216856: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2216855: Experimental Crystal Structure Determination
CCDC 2216855: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2216858: Experimental Crystal Structure Determination
CCDC 2216858: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: PEGylated recombinant<i>Aplysia punctata</i>ink toxin depletes arginine and lysine and inhibits growth of tumor xenografts
PEGylated recombinant<i>Aplysia punctata</i>ink toxin depletes arginine and lysine and inhibits growth of tumor xenografts Open
In recent years, a novel treatment method for cancer emerged, which is based on the starvation of tumors of amino acids like arginine. The deprivation of arginine in serum is based on enzymatic degradation and can be realized by arginine d…
View article: Amber Light Control of Peptide Secondary Structure by a Perfluoroaromatic Azobenzene Photoswitch
Amber Light Control of Peptide Secondary Structure by a Perfluoroaromatic Azobenzene Photoswitch Open
The incorporation of photoswitches into the molecular structure of peptides and proteins enables their dynamic photocontrol in complex biological systems. Here, a perfluorinated azobenzene derivative triggered by amber light was site‐speci…
View article: Azobenzene derivatives with activity against drug‐resistant <i>Candida albicans</i> and <i>Candida auris</i>
Azobenzene derivatives with activity against drug‐resistant <i>Candida albicans</i> and <i>Candida auris</i> Open
Increasing resistance against antimycotic drugs challenges anti‐infective therapies today and contributes to the mortality of infections by drug‐resistant Candida species and strains. Therefore, novel antifungal agents are needed. A promis…
View article: Synthesis and Biological Evaluation of Flavonoid‐Cinnamic Acid Amide Hybrids with Distinct Activity against Neurodegeneration in Vitro and in Vivo
Synthesis and Biological Evaluation of Flavonoid‐Cinnamic Acid Amide Hybrids with Distinct Activity against Neurodegeneration in Vitro and in Vivo Open
Flavonoids are polyphenolic natural products and have shown significant potential as disease‐modifying agents against neurodegenerative disorders like Alzheimer's disease (AD), with activities even in vivo. Hybridization of the natural pro…
View article: Merging bioresponsive release of insulin-like growth factor I with 3D printable thermogelling hydrogels
Merging bioresponsive release of insulin-like growth factor I with 3D printable thermogelling hydrogels Open
3D printing of biomaterials enables spatial control of drug incorporation during automated manufacturing. This study links bioresponsive release of the anabolic biologic, insulin-like growth factor-I (IGF-I) in response to matrix metallopr…
View article: Merging bioresponsive release of insulin-like growth factor I with 3D printable thermogelling hydrogels
Merging bioresponsive release of insulin-like growth factor I with 3D printable thermogelling hydrogels Open
3D printing of biomaterials enables spatial control of drug incorporation during automated manufacturing. This study links bioresponsive release of the anabolic biologic, insulin-like growth factor-I (IGF-I) in response to matrix metallopr…
View article: From Thermogelling Hydrogels toward Functional Bioinks: Controlled Modification and Cytocompatible Crosslinking
From Thermogelling Hydrogels toward Functional Bioinks: Controlled Modification and Cytocompatible Crosslinking Open
Hydrogels are key components in bioink formulations to ensure printability and stability in biofabrication. In this study, a well‐known Diels‐Alder two‐step post‐polymerization modification approach is introduced into thermogelling diblock…
View article: Biomechanical and Biological Performances of Diels-Alder Crosslinked Thermogelling Bioink
Biomechanical and Biological Performances of Diels-Alder Crosslinked Thermogelling Bioink Open
Hydrogels are key components in bioink formulations to ensure printability and stability in biofabrication. In this study a well-known post-polymerization modification approach is introduced into thermogelling diblock copolymers, comprisin…
View article: Metabolic Glycoengineering in hMSC-TERT as a Model for Skeletal Precursors by Using Modified Azide/Alkyne Monosaccharides
Metabolic Glycoengineering in hMSC-TERT as a Model for Skeletal Precursors by Using Modified Azide/Alkyne Monosaccharides Open
Metabolic glycoengineering enables a directed modification of cell surfaces by introducing target molecules to surface proteins displaying new features. Biochemical pathways involving glycans differ in dependence on the cell type; therefor…
View article: Biomechanical and Biological Performances of Diels-Alder Crosslinked Thermogelling Bioink
Biomechanical and Biological Performances of Diels-Alder Crosslinked Thermogelling Bioink Open
Hydrogels are key components in bioink formulations to ensure printability and stability in biofabrication. In this study a well-known post-polymerization modification approach is introduced into thermogelling diblock copolymers, comprisin…
View article: Beschreibung der ersten Studienphase des Forschungsprojekts MobiStaR
Beschreibung der ersten Studienphase des Forschungsprojekts MobiStaR Open
View article: Mobilisation Intensiv-Pflegebedürftiger durch einen neuen Standard in der adaptiven Robotik
Mobilisation Intensiv-Pflegebedürftiger durch einen neuen Standard in der adaptiven Robotik Open
View article: Functionalization of cells, extracellular matrix components and proteins for therapeutic application
Functionalization of cells, extracellular matrix components and proteins for therapeutic application Open
Glycosylation is a biochemical process leading to the formation of glycoconjugates by linking glycans (carbohydrates) to proteins, lipids and various small molecules. The glycans are formed by one or more monosaccharides that are covalentl…
View article: Water‐Soluble Triarylborane Chromophores for One‐ and Two‐Photon Excited Fluorescence Imaging of Mitochondria in Cells
Water‐Soluble Triarylborane Chromophores for One‐ and Two‐Photon Excited Fluorescence Imaging of Mitochondria in Cells Open
Three water‐soluble tetracationic quadrupolar chromophores comprising two three‐coordinate boron π‐acceptor groups bridged by thiophene‐containing moieties were synthesised for biological imaging applications. Compound 3 containing the bul…