Marcus Hortmann
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View article: An artificial intelligence-driven 3D-vectorcardiography technique for non-invasive prediction of obstructive coronary artery disease: a prospective study
An artificial intelligence-driven 3D-vectorcardiography technique for non-invasive prediction of obstructive coronary artery disease: a prospective study Open
Cardiovascular disease, particularly coronary artery disease (CAD), is the leading cause of death in industrialized nations. Invasive coronary angiography is the diagnostic gold standard for ischemic heart disease but is costly, and comple…
View article: Medical History of Coronary Artery Disease and Time to Electrocardiogram in the Emergency Department: A Real-Life, Single-Center, Retrospective Analysis
Medical History of Coronary Artery Disease and Time to Electrocardiogram in the Emergency Department: A Real-Life, Single-Center, Retrospective Analysis Open
Background: Timely acquisition of 12-lead Electrocardiogram (ECG) in the emergency department (ED) is crucial and recommended by current guidelines. Objectives: To evaluate the association of medical history of coronary artery disease (hCA…
View article: Dual-Pathway Antithrombotic Therapy in Patients With Atrial Fibrillation After Percutaneous Coronary Intervention in Stable Coronary Artery Disease: A Single-Center, Single-Operator, Retrospective Cohort Study
Dual-Pathway Antithrombotic Therapy in Patients With Atrial Fibrillation After Percutaneous Coronary Intervention in Stable Coronary Artery Disease: A Single-Center, Single-Operator, Retrospective Cohort Study Open
Background: There is limited data evaluating the prescription practices for antithrombotic therapy in patients with atrial fibrillation (AF) following elective percutaneous coronary intervention (PCI). Objective: This single-center, single…
View article: Evaluation of Serum Serotonin as a Biomarker for Myocardial Infarction and Ischemia/Reperfusion Injury
Evaluation of Serum Serotonin as a Biomarker for Myocardial Infarction and Ischemia/Reperfusion Injury Open
Background: Activated platelets release serotonin during acute myocardial infarction (AMI), aggravating myocardial damage and ischemia/reperfusion (I/R) injury. However, serum serotonin and its potential role as a biomarker for myocardial …
View article: Influence of extracorporeal membrane oxygenation on serum microRNA expression
Influence of extracorporeal membrane oxygenation on serum microRNA expression Open
Objective To date, no biomarkers have been established to predict haematological complications and outcomes of extracorporeal membrane oxygenation (ECMO). The aim of this study was to investigate the expression of a panel of microRNAs (miR…
View article: Extracellular HtrA2 Induces Apoptosis in Human Umbilical Vein Endothelial Cells
Extracellular HtrA2 Induces Apoptosis in Human Umbilical Vein Endothelial Cells Open
The serine protease high-temperature-required protein A2 (HtrA2) has been identified as a key intracellular molecule promoting apoptosis in cells during ischemia reperfusion (IR) injury. IR injury in ST-segment elevation myocardial infarct…
View article: Inflammation in acute coronary syndrome: Expression of TLR2 mRNA is increased in platelets of patients with ACS
Inflammation in acute coronary syndrome: Expression of TLR2 mRNA is increased in platelets of patients with ACS Open
Our results suggest elevated TLR2 mRNA expression in platelets as a biomarker reflecting the underlying inflammation in ACS and possibly severity of coronary atherosclerosis. Platelet TLR2 may represent a link between inflammation and athe…
View article: Digital PCR for Quantifying Circulating MicroRNAs in Acute Myocardial Infarction and Cardiovascular Disease
Digital PCR for Quantifying Circulating MicroRNAs in Acute Myocardial Infarction and Cardiovascular Disease Open
Circulating serum microRNAs (miRNAs) have shown promise as biomarkers for the cardiovascular disease and acute myocardial infarction (AMI), being released from the cardiovascular cells into the circulation. Circulating miRNAs are highly st…
View article: The mitochondria-targeting peptide elamipretide diminishes circulating HtrA2 in ST-segment elevation myocardial infarction
The mitochondria-targeting peptide elamipretide diminishes circulating HtrA2 in ST-segment elevation myocardial infarction Open
Background: The extent of myocardial damage in patients with ST-segment elevation myocardial infarction (STEMI) depends on both the time to reperfusion as well as injury induced by ischaemia–reperfusion resulting in a cascade of cellular a…
View article: Direct factor IXa inhibition with the RNA-aptamer pegnivacogin reduces platelet reactivity in vitro and residual platelet aggregation in patients with acute coronary syndromes
Direct factor IXa inhibition with the RNA-aptamer pegnivacogin reduces platelet reactivity in vitro and residual platelet aggregation in patients with acute coronary syndromes Open
Background: Residual platelet reactivity is a predictor of poor prognosis in patients with acute coronary syndromes (ACSs) undergoing percutaneous coronary intervention. Thrombin is a major platelet activator and upon initiation of the coa…