Marcus J. Hines
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View article: Loss of MicroRNA29 expression in B cells and skin microbiota synergize to promote atopic dermatitis in mice 2581
Loss of MicroRNA29 expression in B cells and skin microbiota synergize to promote atopic dermatitis in mice 2581 Open
Description Our research focuses on the role of the microRNA(miR)29 family to regulate peripheral B cell survival and function. We hypothesized that mice with miR29-deficient B cells (B29KO) would have reduced B cell survival and heightene…
View article: Temporal Tracking of Plasma Cells<i>in vivo</i>Using J-chain CreERT2 Reporter System
Temporal Tracking of Plasma Cells<i>in vivo</i>Using J-chain CreERT2 Reporter System Open
Plasma cells (PCs) are essential for humoral immunity, as they are responsible for the production of antibodies and contribute to immunological memory. Despite their importance, differentiating between long-lived and short-lived PCs in viv…
View article: Disruption of the early-life microbiota alters Peyer’s patch development and germinal center formation in gastrointestinal-associated lymphoid tissue
Disruption of the early-life microbiota alters Peyer’s patch development and germinal center formation in gastrointestinal-associated lymphoid tissue Open
View article: Loss of microRNA-29 in B cells leads to atopic skin phenotype in mice
Loss of microRNA-29 in B cells leads to atopic skin phenotype in mice Open
Developing B cells are highly dependent on microRNA (miRNA) regulation. We have previously demonstrated the miR-29 family of miRNAs contributes to the regulation of B cell survival through fine-tuning of PTEN expression, a negative regulat…
View article: MicroRNA regulation of B cell receptor signaling
MicroRNA regulation of B cell receptor signaling Open
B lymphocytes play a central role in host immune defense. B cell receptor (BCR) signaling regulates survival, proliferation, and differentiation of B lymphocytes. Signaling through the BCR signalosome is a multi‐component cascade that is t…
View article: miR-29 Sustains B Cell Survival and Controls Terminal Differentiation via Regulation of PI3K Signaling
miR-29 Sustains B Cell Survival and Controls Terminal Differentiation via Regulation of PI3K Signaling Open
View article: B Cell Defects Observed in <i>Nod2</i> Knockout Mice Are a Consequence of a <i>Dock2</i> Mutation Frequently Found in Inbred Strains
B Cell Defects Observed in <i>Nod2</i> Knockout Mice Are a Consequence of a <i>Dock2</i> Mutation Frequently Found in Inbred Strains Open
Phenotypic differences among substrains of laboratory mice due to spontaneous mutations or pre-existing genetic variation confound the interpretation of targeted mutagenesis experiments and contribute to challenges with reproducibility acr…
View article: miRNAs Are Essential for the Regulation of the PI3K/AKT/FOXO Pathway and Receptor Editing during B Cell Maturation
miRNAs Are Essential for the Regulation of the PI3K/AKT/FOXO Pathway and Receptor Editing during B Cell Maturation Open