Martin Krueger
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View article: Optimism, sleep quality, physical activity, and cancer-related cognitive impairment in middle-to-older aged patients undergoing breast cancer treatment
Optimism, sleep quality, physical activity, and cancer-related cognitive impairment in middle-to-older aged patients undergoing breast cancer treatment Open
Results suggest that optimism and sleep quality may be associated with better cognitive function in BC patients in the post-surgical period. Interventions that improve optimistic expectancies and sleep quality may help to mitigate CRCI in …
View article: Impact of MEK Inhibition on Childhood RASopathy-Associated Hypertrophic Cardiomyopathy
Impact of MEK Inhibition on Childhood RASopathy-Associated Hypertrophic Cardiomyopathy Open
There is an unmet medical need to treat patients with severe hypertrophic cardiomyopathy leading to heart failure and death in children carrying pathogenic activating variants in the RAS/mitogen-activated protein kinase pathway. A retrospe…
View article: Author Correction: Specification of CNS macrophage subsets occurs postnatally in defined niches
Author Correction: Specification of CNS macrophage subsets occurs postnatally in defined niches Open
View article: Active integrins regulate white adipose tissue insulin sensitivity and brown fat thermogenesis
Active integrins regulate white adipose tissue insulin sensitivity and brown fat thermogenesis Open
Reorganization of the extracellular matrix is a prerequisite for healthy adipose tissue expansion, whereas fibrosis is a key feature of adipose dysfunction and inflammation. However, very little is known about the direct effects of impaire…
View article: Gradients in the mammalian cerebellar cortex enable Fourier-like transformation and improve storing capacity
Gradients in the mammalian cerebellar cortex enable Fourier-like transformation and improve storing capacity Open
Cerebellar granule cells (GCs) make up the majority of all neurons in the vertebrate brain, but heterogeneities among GCs and potential functional consequences are poorly understood. Here, we identified unexpected gradients in the biophysi…
View article: Non-pathological Chondrogenic Features of Valve Interstitial Cells in Normal Adult Zebrafish
Non-pathological Chondrogenic Features of Valve Interstitial Cells in Normal Adult Zebrafish Open
In the heart, unidirectional blood flow depends on proper heart valve function. As, in mammals, regulatory mechanisms of early heart valve and bone development are shown to contribute to adult heart valve pathologies, we used the animal mo…
View article: Effector T-cell trafficking between the leptomeninges and the cerebrospinal fluid
Effector T-cell trafficking between the leptomeninges and the cerebrospinal fluid Open
In multiple sclerosis, brain-reactive T cells invade the central nervous system (CNS) and induce a self-destructive inflammatory process. T-cell infiltrates are not only found within the parenchyma and the meninges, but also in the cerebro…
View article: OUP accepted manuscript
OUP accepted manuscript Open
The electrical contributor's site of earliest activation and intactness of posterior IACs affect PTF-V1 significantly by changing LA breakthrough sites independent from LA size. This should be considered for interpretation of el…
View article: Mesh structure-independent modeling of patient-specific atrial fiber orientation
Mesh structure-independent modeling of patient-specific atrial fiber orientation Open
The fiber orientation in the atria has a significant contribution to the electrophysiologic behavior of the heart and to the genesis of arrhythmia. Atrial fiber orientation has a direct effect on excitation propagation, activation patterns…
View article: Defective podocyte insulin signalling through p85-XBP1 promotes ATF6-dependent maladaptive ER-stress response in diabetic nephropathy
Defective podocyte insulin signalling through p85-XBP1 promotes ATF6-dependent maladaptive ER-stress response in diabetic nephropathy Open