Marcus Ng
YOU?
Author Swipe
View article: Machine Learning–Based Cognitive Assessment With The Autonomous Cognitive Examination: Randomized Controlled Trial
Machine Learning–Based Cognitive Assessment With The Autonomous Cognitive Examination: Randomized Controlled Trial Open
Background The rising prevalence of dementia necessitates a scalable solution to cognitive assessments. The Autonomous Cognitive Examination (ACoE) is a foundational cognitive test for the phenotyping of cognitive symptoms across the prima…
View article: Inter-Rater Reliability of EEG-Based Encephalopathy Grading
Inter-Rater Reliability of EEG-Based Encephalopathy Grading Open
Purpose: Visual EEG Confusion Assessment Method-Severity (VE-CAM-S) quantifies encephalopathy severity based on electroencephalography features. This study evaluated inter-rater reliability among experts using the VE-CAM-S scale. Methods: …
View article: Expert-Level Detection of Epilepsy Markers in EEG on Short and Long Timescales
Expert-Level Detection of Epilepsy Markers in EEG on Short and Long Timescales Open
SpikeNet2 offers expert-level accuracy in both event-level spike detection and EEG-level classification, while significantly reducing false positives. Its dual functionality and robust performance across diverse datasets make it a promisin…
View article: The Rapid Online Cognitive Assessment for the Detection of Neurocognitive Disorder: Open-Label Study
The Rapid Online Cognitive Assessment for the Detection of Neurocognitive Disorder: Open-Label Study Open
Background The rising prevalence of dementia necessitates a scalable solution to cognitive screening. Paper-based cognitive screening examinations are well-validated but minimally scalable. If a digital cognitive screening examination coul…
View article: 0875 Age-Related Increase of Circannual Correlation Between Day Length and Severe Seizures
0875 Age-Related Increase of Circannual Correlation Between Day Length and Severe Seizures Open
Introduction Recent work at Earth’s extreme poles in the northern and southern hemispheres has shown a significant correlation between increasing day length (i.e. solar time and severe seizures across the year with higher frequency during …
View article: Optimization of Existing RNA Visualization Methods Reveals Novel Dendritic mRNA Dynamics
Optimization of Existing RNA Visualization Methods Reveals Novel Dendritic mRNA Dynamics Open
Background: Spatial-temporal control of mRNA translation in dendrites is important for synaptic plasticity. In response to pre-synaptic stimuli, local mRNA translation can be rapidly triggered near stimulated synapses to supply the necessa…
View article: Perspective: Hippocampal theta rhythm as a potential vestibuloacoustic biomarker of anxiety
Perspective: Hippocampal theta rhythm as a potential vestibuloacoustic biomarker of anxiety Open
Anxiety disorders are the most common mental illnesses — afflicting 19% of Americans every year and 31% within their lifetimes — yet diagnoses remain based on symptom checklists because existing technologies have yet to produce biomarkers …
View article: Trends of antiseizure medication utilization among pregnant people in four Canadian provinces from 1998 to 2023; a study from the Canadian mother-child cohort active surveillance initiative (CAMCCO)
Trends of antiseizure medication utilization among pregnant people in four Canadian provinces from 1998 to 2023; a study from the Canadian mother-child cohort active surveillance initiative (CAMCCO) Open
Background Epilepsy management during pregnancy is crucial for both the mother and fetus. The use of antiseizure medications (ASMs) during pregnancy requires careful consideration due to their potential effects on maternal and fetal health…
View article: Commentary on stimulus‐induced arousal with transient electroencephalographic improvement distinguishes nonictal from ictal generalized periodic discharges
Commentary on stimulus‐induced arousal with transient electroencephalographic improvement distinguishes nonictal from ictal generalized periodic discharges Open
Here we critique recent arguments proposing to distinguish ictal from non‐ictal generalized periodic discharges (GPDs) based on etiology and stimulation response, arguing that these are unreliable. We advocate for an empirical approach to …
View article: The Rapid Online Cognitive Assessment
The Rapid Online Cognitive Assessment Open
INTRODUCTION Paper-based screening examinations are well-validated but minimally scalable. If a DCA replicate paper-based screening, it would improve scalability while benefiting from their extensive validation. METHODS We developed and ev…
View article: The challenges of treating status epilepticus in rural Canada
The challenges of treating status epilepticus in rural Canada Open
Though unified by challenges in the treatment of status epilepticus (SE), rural Canada is simultaneously massive and diverse, spanning the Pacific, Atlantic, and Arctic Oceans. According to the national statistical agency, the most rural j…
View article: Rapid eye movement sleep and epilepsy: exploring interactions and therapeutic prospects
Rapid eye movement sleep and epilepsy: exploring interactions and therapeutic prospects Open
Summary While research interest in the relationship between sleep and epilepsy is growing, it primarily centres on the effects of non‐rapid eye movement (NREM) sleep in favouring seizures. Nonetheless, a noteworthy aspect is the observatio…
View article: Circannual seizure provocation as the day lengthens in the northern and southern hemispheres
Circannual seizure provocation as the day lengthens in the northern and southern hemispheres Open
Circannual status epilepticus (SE) patterns in communities near Earth's poles best test the hypothesis that SE susceptibility varies with light exposure because these communities are routinely subject to large changes in annual light expos…
View article: Residual Seizure Rate of Intermittent Inpatient EEG Compared to a Continuous EEG Model
Residual Seizure Rate of Intermittent Inpatient EEG Compared to a Continuous EEG Model Open
Background: Subclinical seizures are common in hospitalized patients and require electroencephalography (EEG) for detection and intervention. At our institution, continuous EEG (cEEG) is not available, but intermittent EEGs are subject to …
View article: P.078 Desynchronization in high-definition transcranial direct current stimulation of refractory status epilepticus
P.078 Desynchronization in high-definition transcranial direct current stimulation of refractory status epilepticus Open
Background: Recently, we showed cathodal high-definition transcranial direct current stimulation (HD-tDCS) inhibits spikes in refractory status epilepticus (RSE) patients. We sought to characterize relative power changes within regional fr…
View article: P.002 Increased epileptiform activity during N2 and slow wave sleep in Alzheimer’s Disease
P.002 Increased epileptiform activity during N2 and slow wave sleep in Alzheimer’s Disease Open
Background: Recent evidence shows that epileptiform activity (EA) in sleep can present early in Alzheimer’s Disease (AD) with faster cognitive decline. Existing literature examining sleep, AD and seizures is mostly qualitative. We conducte…
View article: Antiseizure medication use during pregnancy and neonatal growth outcomes: A systematic review and meta‐analysis
Antiseizure medication use during pregnancy and neonatal growth outcomes: A systematic review and meta‐analysis Open
Aims We aimed to systematically synthesize the current published literature on neonatal growth outcomes associated with antiseizure medication (ASM) use during pregnancy. Methods We searched seven databases, from inception to 23 March 2022…
View article: Do Epilepsy Patients with Cognitive Impairment Have Alzheimer’s Disease-like Brain Metabolism?
Do Epilepsy Patients with Cognitive Impairment Have Alzheimer’s Disease-like Brain Metabolism? Open
Although not classically considered together, there is emerging evidence that Alzheimer’s disease (AD) and epilepsy share a number of features and that each disease predisposes patients to developing the other. Using machine learning, we h…
View article: Development of Expert-Level Classification of Seizures and Rhythmic and Periodic Patterns During EEG Interpretation
Development of Expert-Level Classification of Seizures and Rhythmic and Periodic Patterns During EEG Interpretation Open
This study provides Class II evidence that among patients with epilepsy or critical illness undergoing EEG monitoring, SPaRCNet can differentiate (IIIC) patterns from non-IIIC events and expert neurophysiologists.
View article: Interrater Reliability of Expert Electroencephalographers Identifying Seizures and Rhythmic and Periodic Patterns in EEGs
Interrater Reliability of Expert Electroencephalographers Identifying Seizures and Rhythmic and Periodic Patterns in EEGs Open
This study provides Class II evidence that an independent expert review reliably identifies ictal-interictal injury continuum patterns on EEG compared with expert consensus.
View article: Measuring expertise in identifying interictal epileptiform discharges
Measuring expertise in identifying interictal epileptiform discharges Open
Objective . Interictal epileptiform discharges on EEG are integral to diagnosing epilepsy. However, EEGs are interpreted by readers with and without specialty training, and there is no accepted method to assess skill in interpretation. We …
View article: 0174 The Odds Ratio Product as a Marker of Sleep Homeostasis
0174 The Odds Ratio Product as a Marker of Sleep Homeostasis Open
Introduction Classic EEG markers of sleep homeostasis (process S) usually study the level and amount of slow wave activity (SWA). In recent years, the odds ratio product (ORP) has been described as a novel quantitative measure of sleep dep…