Marcus Westerberg
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View article: Discriminative Ability of the Charlson Comorbidity Index for Long-Term Mortality in a General Population: Nationwide, Population-Based Study of 10 Million Adults in Sweden
Discriminative Ability of the Charlson Comorbidity Index for Long-Term Mortality in a General Population: Nationwide, Population-Based Study of 10 Million Adults in Sweden Open
The CCI discriminated risk of death best using a look-back period of at least 5 years and performed better in women than in men in most age groups. Our findings offer insights into both the practical utility of the CCI and the interpretati…
View article: Cohort Profile Update: The National Prostate Cancer Register of Sweden and PCBase
Cohort Profile Update: The National Prostate Cancer Register of Sweden and PCBase Open
View article: Urinary tract events after radical radiotherapy (RT) for prostate cancer according to pre‐RT International Prostate Symptom Score
Urinary tract events after radical radiotherapy (RT) for prostate cancer according to pre‐RT International Prostate Symptom Score Open
Objective To describe the risk of urinary tract events after radical radiotherapy (RT) according to pre‐RT (IPSS) overall and within subgroups of prostate volume, type of RT, and use of neoadjuvant androgen‐deprivation therapy (ADT), as me…
View article: Variation in fecal hemoglobin concentrations: Cross-sectional analysis of a screening trial and a screening program in Sweden
Variation in fecal hemoglobin concentrations: Cross-sectional analysis of a screening trial and a screening program in Sweden Open
Objectives To assess variation in fecal hemoglobin concentration according to year and season of fecal immunochemical test screening in Sweden, the detection rate of advanced neoplasia, and factors that could influence fecal immunochemical…
View article: Adaption of the Memorial Sloan Kettering Cancer Center Nomograms for the Prediction of Prostate Cancer–specific Death in Sweden: A Population-based Cohort Study
Adaption of the Memorial Sloan Kettering Cancer Center Nomograms for the Prediction of Prostate Cancer–specific Death in Sweden: A Population-based Cohort Study Open
View article: A comparison of comorbidity indices and estimates of life expectancy for men with prostate cancer
A comparison of comorbidity indices and estimates of life expectancy for men with prostate cancer Open
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View article: Prostate cancer incidence in Sweden before, during and after the COVID-19 pandemic. Population-based study
Prostate cancer incidence in Sweden before, during and after the COVID-19 pandemic. Population-based study Open
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View article: Radical Treatment for Prostate Cancer in Men With Limited Life Expectancy in Sweden
Radical Treatment for Prostate Cancer in Men With Limited Life Expectancy in Sweden Open
This cohort study compares rates of radical treatment for prostate cancer, despite current guideline recommendations that discourage its use for men with limited life expectancy, in Sweden and the US.
View article: Improved adherence to prostate cancer guidelines concomitant with public reporting. Nationwide population-based study
Improved adherence to prostate cancer guidelines concomitant with public reporting. Nationwide population-based study Open
Background: Swedish national guidelines provide evidence-based recommendations for standard of care; however, little is known about adherence to them. The aim of this study was to assess adherence to management guidelines for prostate canc…
View article: Functional outcomes after primary vs delayed robot-assisted radical prostatectomy following active surveillance
Functional outcomes after primary vs delayed robot-assisted radical prostatectomy following active surveillance Open
Background It is unknown if a period of active surveillance before prostatectomy for prostate cancer (PCa) worsens functional outcomes. The aim of this study was to compare functional outcomes after primary vs delayed robot-assisted radica…
View article: Incidence and prognostic implications of prostate-specific antigen persistence and relapse after radical prostatectomy: population-based study
Incidence and prognostic implications of prostate-specific antigen persistence and relapse after radical prostatectomy: population-based study Open
Background There has been a wide range in incidence of prostate-specific antigen (PSA) persistence and relapse after radical prostatectomy (RP) for prostate cancer (PCa). We aimed to describe incidence and prognostic implications of PSA pe…
View article: Assessment of variability in life expectancy in older men by use of new comorbidity indices. A nationwide population-based study
Assessment of variability in life expectancy in older men by use of new comorbidity indices. A nationwide population-based study Open
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View article: Target trial emulation using new comorbidity indices provided risk estimates comparable to a randomized trial
Target trial emulation using new comorbidity indices provided risk estimates comparable to a randomized trial Open
Adjustment for comorbidity using two new indices provided comparable risk of death from any cause in line with results of a RCT. Similar results were seen in a broader study population, more representative of clinical practice.
View article: Colonoscopy findings after increasing two‐stool faecal immunochemical test (FIT) cut‐off: Cross‐sectional analysis of the SCREESCO randomized trial
Colonoscopy findings after increasing two‐stool faecal immunochemical test (FIT) cut‐off: Cross‐sectional analysis of the SCREESCO randomized trial Open
Background We determined the impact of an increased two‐stool faecal immunochemical test (FIT) cut‐off on colonoscopy positivity and relative sensitivity and specificity in the randomized controlled screening trial screening of Swedish col…
View article: Risk of prostate cancer death in men diagnosed with prostate cancer at cystoprostatectomy. A nationwide population-based study
Risk of prostate cancer death in men diagnosed with prostate cancer at cystoprostatectomy. A nationwide population-based study Open
Background and aims: One out of three men who undergo cystoprostatectomy for bladder cancer is diagnosed with incidental prostate cancer (PCa) at histopathological examination. Many of these men are PSA tested as part of their follow-up, b…
View article: Colorectal cancer screening with fecal immunochemical testing or primary colonoscopy: inequities in diagnostic yield
Colorectal cancer screening with fecal immunochemical testing or primary colonoscopy: inequities in diagnostic yield Open
Background Socioeconomic inequalities in the uptake of colorectal cancer screening are well documented, but the implications on inequities in health gain remain unclear. Methods Sixty-year-olds were randomly recruited from the Swedish popu…
View article: Patient-reported Side Effects 1 Year After Radical Prostatectomy or Radiotherapy for Prostate Cancer: A Register-based Nationwide Study
Patient-reported Side Effects 1 Year After Radical Prostatectomy or Radiotherapy for Prostate Cancer: A Register-based Nationwide Study Open
View article: Development and validation of a multi-dimensional diagnosis-based comorbidity index that improves prediction of death in men with prostate cancer: Nationwide, population-based register study
Development and validation of a multi-dimensional diagnosis-based comorbidity index that improves prediction of death in men with prostate cancer: Nationwide, population-based register study Open
Assessment of comorbidity is crucial for confounding adjustment and prediction of mortality in register-based studies, but the commonly used Charlson comorbidity index is not sufficiently predictive. We aimed to develop a multidimensional …
View article: The role of endoscopist adenoma detection rate in in sex differences in colonoscopy findings: cross-sectional analysis of the SCREESCO randomized controlled trial
The role of endoscopist adenoma detection rate in in sex differences in colonoscopy findings: cross-sectional analysis of the SCREESCO randomized controlled trial Open
This study provides no evidence that endoscopist skill measured by ADR underlies the sex difference in adenoma detection at colonoscopy. This study has trial number NCT02078804 and is registered with ClinicalTrials.gov.
View article: Survival trend in men with de novo metastatic prostate cancer after the introduction of doublet therapy. Nationwide population-based cohort study
Survival trend in men with de novo metastatic prostate cancer after the introduction of doublet therapy. Nationwide population-based cohort study Open
View article: Survival Trend in Individuals With De Novo Metastatic Prostate Cancer After the Introduction of Doublet Therapy
Survival Trend in Individuals With De Novo Metastatic Prostate Cancer After the Introduction of Doublet Therapy Open
Importance Recently, life-prolonging treatments for patients with advanced prostate cancer have been introduced in clinical practice. Objective To investigate if the introduction of doublet therapy is associated with changes in survival on…
View article: Design considerations for observational studies of drugs for advanced cancer
Design considerations for observational studies of drugs for advanced cancer Open
Post-authorisation studies complement the clinical development programme of a drug by studying larger, more diverse populations over a longer time than studies of the programme and can rely on secondary use of routinely collected patient d…
View article: Estimation in discrete time coarsened multivariate longitudinal models
Estimation in discrete time coarsened multivariate longitudinal models Open
We consider the analysis of longitudinal data of multiple types of events where some of the events are observed on a coarser level (e.g. grouped) at some time points during the follow-up, for example, when certain events, such as disease p…
View article: The role of endoscopist adenoma detection rate in in sex differences in colonoscopy findings: cross-sectional analysis of the SCREESCO randomized controlled trial
The role of endoscopist adenoma detection rate in in sex differences in colonoscopy findings: cross-sectional analysis of the SCREESCO randomized controlled trial Open
Fewer adenomas are detected at colonoscopy in women compared to men and failure to detect adenomas and sessile serrated polyps is associated with an increased risk of post-colonoscopy colorectal cancer. The aim of this study was to investi…
View article: Choice of imputation method for missing metastatic status affected estimates of metastatic prostate cancer incidence
Choice of imputation method for missing metastatic status affected estimates of metastatic prostate cancer incidence Open
View article: Diagnostic activity impacts lifetime risk of prostate cancer diagnosis more strongly than life expectancy
Diagnostic activity impacts lifetime risk of prostate cancer diagnosis more strongly than life expectancy Open
The main aim of the study was to determine the impact of diagnostic activity and life expectancy on the lifetime risk of a prostate cancer diagnosis. We used a state transition simulation model based on Swedish population-based data to sim…
View article: Endoscopist Characteristics and Polyp Detection in Colonoscopy: Cross-Sectional Analyses of Screening of Swedish Colons
Endoscopist Characteristics and Polyp Detection in Colonoscopy: Cross-Sectional Analyses of Screening of Swedish Colons Open
View article: Watch out for sticky diagnosis bias in older men with prostate cancer
Watch out for sticky diagnosis bias in older men with prostate cancer Open
View article: Real World Outcomes in Patients With Metastatic, Castration-Resistant Prostate Cancer Treated With Radium-223 in Routine Clinical Practice in Sweden
Real World Outcomes in Patients With Metastatic, Castration-Resistant Prostate Cancer Treated With Radium-223 in Routine Clinical Practice in Sweden Open