Mareike Fauser
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View article: Improving computational models of deep brain stimulation through experimental calibration
Improving computational models of deep brain stimulation through experimental calibration Open
By reducing the uncertainties of the model, the accuracy in predicting neural activation is increased. The entire workflow is realized in open-source software, making it adaptable for other use cases, such as deep brain stimulation in huma…
View article: Subthalamic nucleus deep brain stimulation induces functional deficits in norepinephrinergic neurotransmission in a Parkinson’s disease model
Subthalamic nucleus deep brain stimulation induces functional deficits in norepinephrinergic neurotransmission in a Parkinson’s disease model Open
STN-DBS modulates striatal norepinephrinergic neurotransmission in a PD rat model. Additional behavioural studies are required to investigate the functional impact of this finding.
View article: Circadian variations influence anxiety-related behaviour, olfaction, and hedonic response in male Sprague–Dawley rats
Circadian variations influence anxiety-related behaviour, olfaction, and hedonic response in male Sprague–Dawley rats Open
This study demonstrates extensive circadian influences on nearly all parameters investigated, coupled with a significant reduction in data variability during the active phase. Emphasising the importance of aligning experimental timing with…
View article: Subthalamic nucleus but not entopeduncular nucleus deep brain stimulation enhances neurogenesis in the SVZ-olfactory bulb system of Parkinsonian rats
Subthalamic nucleus but not entopeduncular nucleus deep brain stimulation enhances neurogenesis in the SVZ-olfactory bulb system of Parkinsonian rats Open
Introduction Deep brain stimulation (DBS) is a highly effective treatment option in Parkinson’s disease. However, the underlying mechanisms of action, particularly effects on neuronal plasticity, remain enigmatic. Adult neurogenesis in the…
View article: Subthalamic nucleus deep brain stimulation does not alter growth factor expression in a rat model of stable dopaminergic deficiency
Subthalamic nucleus deep brain stimulation does not alter growth factor expression in a rat model of stable dopaminergic deficiency Open
STN-DBS does not increase growth factor expression when applied to a model of completed, severe dopaminergic deficiency in contrast to other studies in models of modest and ongoing dopaminergic degeneration. In healthy controls, STN-DBS do…
View article: Subthalamic nucleus deep brain stimulation induces nigrostriatal dopaminergic plasticity in a stable rat model of Parkinson’s disease
Subthalamic nucleus deep brain stimulation induces nigrostriatal dopaminergic plasticity in a stable rat model of Parkinson’s disease Open
Objective Deep brain stimulation (DBS) of the subthalamic nucleus (STN) has been a highly effective treatment option for middle to late stage Parkinson’s disease for decades. Though, the underlying mechanisms of action, particularly effect…
View article: Deep brain stimulation electrode modeling in rats
Deep brain stimulation electrode modeling in rats Open
Deep Brain Stimulation (DBS) is an efficacious treatment option for an increasing range of brain disorders. To enhance our knowledge about the mechanisms of action of DBS and to probe novel targets, basic research in animal models with DBS…
View article: Adult Neural Stem Cells from Midbrain Periventricular Regions Show Limited Neurogenic Potential after Transplantation into the Hippocampal Neurogenic Niche
Adult Neural Stem Cells from Midbrain Periventricular Regions Show Limited Neurogenic Potential after Transplantation into the Hippocampal Neurogenic Niche Open
The regulation of adult neural stem or progenitor cell (aNSC) proliferation and differentiation as an interplay of cell-intrinsic and local environmental cues remains in part unclear, impeding their role in putative regenerative therapies.…
View article: The software defined implantable modular platform (STELLA) for preclinical deep brain stimulation research in rodents
The software defined implantable modular platform (STELLA) for preclinical deep brain stimulation research in rodents Open
Context. Long-term deep brain stimulation (DBS) studies in rodents are of crucial importance for research progress in this field. However, most stimulation devices require jackets or large head-mounted systems which severely affect mobilit…
View article: Subthalamic nucleus deep brain stimulation induces sustained neurorestoration in the mesolimbic dopaminergic system in a Parkinson's disease model
Subthalamic nucleus deep brain stimulation induces sustained neurorestoration in the mesolimbic dopaminergic system in a Parkinson's disease model Open
Our data support sustained neurorestorative effects of STN-DBS not only in the nigrostriatal but also in the mesolimbic system as a potential factor mediating long-latency neuropsychiatric effects of STN-DBS in Parkinson's disease.
View article: Chronic–Progressive Dopaminergic Deficiency Does Not Induce Midbrain Neurogenesis
Chronic–Progressive Dopaminergic Deficiency Does Not Induce Midbrain Neurogenesis Open
Background: Consecutive adult neurogenesis is a well-known phenomenon in the ventricular–subventricular zone of the lateral wall of the lateral ventricles (V–SVZ) and has been controversially discussed in so-called “non-neurogenic” brain a…
View article: Catecholaminergic Innervation of Periventricular Neurogenic Regions of the Developing Mouse Brain
Catecholaminergic Innervation of Periventricular Neurogenic Regions of the Developing Mouse Brain Open
The major catecholamines-dopamine (DA) and norepinephrine (NE)-are not only involved in synaptic communication but also act as important trophic factors and might ultimately be involved in mammalian brain development. The catecholaminergic…
View article: Sleep Disturbances and Sleep Disordered Breathing Impair Cognitive Performance in Parkinson’s Disease
Sleep Disturbances and Sleep Disordered Breathing Impair Cognitive Performance in Parkinson’s Disease Open
Sleep apnea and other sleep disturbances impair cognitive performance in PD and should be evaluated in routine care, and treatment options such as continuous airway pressure therapy should be considered.
View article: Norepinephrine is a negative regulator of the adult periventricular neural stem cell niche
Norepinephrine is a negative regulator of the adult periventricular neural stem cell niche Open
The limited proliferative capacity of neuroprogenitor cells (NPCs) within the periventricular germinal niches (PGNs) located caudal of the subventricular zone (SVZ) of the lateral ventricles together with their high proliferation capacity …
View article: Dysphoria, dopaminergic medication and spatial memory in Parkinsons disease
Dysphoria, dopaminergic medication and spatial memory in Parkinsons disease Open
Depression is considered a potential risk factor for developing cognitive deficits and dementia during the progression of Parkinson’s disease (PD). Depression and dysthymia are also among the most frequent neuropsychiatric comorbidities, e…
View article: Accelerated Age-Dependent Hippocampal Volume Loss in Parkinson Disease With Mild Cognitive Impairment
Accelerated Age-Dependent Hippocampal Volume Loss in Parkinson Disease With Mild Cognitive Impairment Open
Background: Patients with Parkinson disease are at high risk of developing dementia. During the course of the disease, a substantial number of patients will experience a cognitive decline, indicating the dynamics of the underlying neuropat…
View article: Correlation of Quantitative Motor State Assessment Using a Kinetograph and Patient Diaries in Advanced PD: Data from an Observational Study
Correlation of Quantitative Motor State Assessment Using a Kinetograph and Patient Diaries in Advanced PD: Data from an Observational Study Open
The PKG has been shown to capture motor fluctuations in patients with advanced PD. The limited correlation of hour-to-hour diary and PKG recordings should be addressed in further studies.
View article: Intraindividual Variability of Nonmotor Fluctuations in Advanced Parkinson’s Disease
Intraindividual Variability of Nonmotor Fluctuations in Advanced Parkinson’s Disease Open
Nonmotor symptoms (NMS) fluctuate in conjunction with motor oscillations in advanced Parkinson's disease (PD), though little is known about the variability of NMS fluctuations in individual patients. We aimed to assess within-patient varia…