Mareike Müller
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View article: Salt‐Responsive Switchable Block Copolymer Brushes with Antibacterial and Antifouling Properties
Salt‐Responsive Switchable Block Copolymer Brushes with Antibacterial and Antifouling Properties Open
A strategy for multifunctional biosurfaces exploiting multiblock copolymers and the antipolyelectrolyte effect is reported. Combining a polyzwitterionic/antifouling and a polycationic/antibacterial block with a central anchoring block for …
View article: Novel Zircaloy nanomaterials with antibacterial activity
Novel Zircaloy nanomaterials with antibacterial activity Open
The outcome of an implant procedure largely depends on the implant's surface properties. Biomaterials are now required to have surfaces with multifunctionality such as favorable tissue integration and the ability to combat bacterial adhesi…
View article: Artificial Intelligence at Universities: Impact on Grades, Student Experience, and Teaching
Artificial Intelligence at Universities: Impact on Grades, Student Experience, and Teaching Open
The rapid technological progress in artificial intelligence (AI) has placed universities in a field of tension in which regulation and the urgently needed teaching of AI skills must be balanced. The discussion often neglects the unique pos…
View article: 6‐Aryl‐Substituted Harmanium Derivatives as Light‐Up Probes for Fluorimetric DNA Detection and Staining of Eukaryotic Cells
6‐Aryl‐Substituted Harmanium Derivatives as Light‐Up Probes for Fluorimetric DNA Detection and Staining of Eukaryotic Cells Open
Nine 6‐aryl‐substituted harmanium derivatives were synthesized by Suzuki‐Miyaura coupling of 6‐bromoharmane with arylboronic acids and subsequent N 2‐benzylation. Depending on the substitution pattern of the aryl group the emission maxima …
View article: Photodynamic Eradication of Pseudomonas aeruginosa with Ru-Photosensitizers Encapsulated in Enzyme Degradable Nanocarriers
Photodynamic Eradication of Pseudomonas aeruginosa with Ru-Photosensitizers Encapsulated in Enzyme Degradable Nanocarriers Open
The development of new approaches for the treatment of the increasingly antibiotic-resistant pathogen Pseudomonas aeruginosa was targeted by enhancing the effect of local antimicrobial photodynamic therapy (aPDT) using poly(ethylene glycol…
View article: Fluorimetric Cell Analysis with 9‐Aryl‐Substituted Berberine Derivatives as DNA‐Targeting Fluorescent Probes
Fluorimetric Cell Analysis with 9‐Aryl‐Substituted Berberine Derivatives as DNA‐Targeting Fluorescent Probes Open
DNA‐sensitive fluorescent light‐up probes based on berberine are presented. This biogenic fluorophore was chosen as central unit to use its potential biocompatibility and its DNA‐binding properties. To provide predictable fluorescence quen…
View article: Monitoring Growth and Removal of Pseudomonas Biofilms on Cellulose-Based Fabrics
Monitoring Growth and Removal of Pseudomonas Biofilms on Cellulose-Based Fabrics Open
Biofilms are often tolerant towards routine cleaning and disinfection processes. As they can grow on fabrics in household or healthcare settings, resulting in odors and serious health problems, it is necessary to contain biofilms through e…
View article: Bare Eye Detection of Bacterial Enzymes of Pseudomonas aeruginosa with Polymer Modified Nanoporous Silicon Rugate Filters
Bare Eye Detection of Bacterial Enzymes of Pseudomonas aeruginosa with Polymer Modified Nanoporous Silicon Rugate Filters Open
The fabrication, characterization and application of a nanoporous Silicon Rugate Filter (pSiRF) loaded with an enzymatically degradable polymer is reported as a bare eye detection optical sensor for enzymes of pathogenic bacteria, which is…
View article: Ruthenium(II) Polypyridyl Complexes for Antimicrobial Photodynamic Therapy: Prospects for Application in Cystic Fibrosis Lung Airways
Ruthenium(II) Polypyridyl Complexes for Antimicrobial Photodynamic Therapy: Prospects for Application in Cystic Fibrosis Lung Airways Open
Antimicrobial photodynamic therapy (aPDT) depends on a variety of parameters notably related to the photosensitizers used, the pathogens to target and the environment to operate. In a previous study using a series of Ruthenium(II) polypyri…
View article: Impact of Surface Area on Sensitivity in Autonomously Reporting Sensing Hydrogel Nanomaterials for the Detection of Bacterial Enzymes
Impact of Surface Area on Sensitivity in Autonomously Reporting Sensing Hydrogel Nanomaterials for the Detection of Bacterial Enzymes Open
The rapid and selective detection of bacterial contaminations and bacterial infections in a non-laboratory setting using advanced sensing materials holds the promise to enable robust point-of-care tests and rapid diagnostics for applicatio…
View article: Effects of the Sex Steroid Hormone Estradiol on Biofilm Growth of Cystic Fibrosis Pseudomonas aeruginosa Isolates
Effects of the Sex Steroid Hormone Estradiol on Biofilm Growth of Cystic Fibrosis Pseudomonas aeruginosa Isolates Open
Women with cystic fibrosis (CF) have a significantly lower life expectancy compared to men, which is indicated by an earlier impairment of lung function due to chronic colonization with biofilm formed by Pseudomonas aeruginosa . There is g…
View article: Nanomedicine-based strategies to improve treatment of cutaneous leishmaniasis
Nanomedicine-based strategies to improve treatment of cutaneous leishmaniasis Open
Nanomedicine strategies were first adapted and successfully translated to clinical application for diseases, such as cancer and diabetes. These strategies would no doubt benefit unmet diseases needs as in the case of leishmaniasis. The lat…
View article: 9-Nitrobenzo[<i>b</i>]quinolizinium as a fluorogenic probe for the detection of nitroreductase <i>in vitro</i> and in <i>Escherichia coli</i>
9-Nitrobenzo[<i>b</i>]quinolizinium as a fluorogenic probe for the detection of nitroreductase <i>in vitro</i> and in <i>Escherichia coli</i> Open
The non-fluorescent 9-nitrobenzo[ b ]quinolizinium is readily reduced by nitroreductase to fluorescent reaction products whose formation depends on the reaction conditions.
View article: Antimicrobial Photodynamic Therapy: Latest Developments with a Focus on Combinatory Strategies
Antimicrobial Photodynamic Therapy: Latest Developments with a Focus on Combinatory Strategies Open
Antimicrobial photodynamic therapy (aPDT) has become a fundamental tool in modern therapeutics, notably due to the expanding versatility of photosensitizers (PSs) and the numerous possibilities to combine aPDT with other antimicrobial trea…
View article: Disproportionate mitral regurgitation as a predictor of functional outcomes following edge-to-edge repair with the MitraClip system
Disproportionate mitral regurgitation as a predictor of functional outcomes following edge-to-edge repair with the MitraClip system Open
Aims The concept of disproportionate mitral regurgitation (MR) was recently from the analysis of the results of two large randomized trials that compared edge-to-edge repair with the MitraClip system and optimal medical treatment alone in …
View article: A Dimethylaminophenyl‐Substituted Naphtho[1,2‐<i>b</i>]quinolizinium as a Multicolor NIR Probe for the Fluorimetric Detection of Intracellular Nucleic Acids and Proteins
A Dimethylaminophenyl‐Substituted Naphtho[1,2‐<i>b</i>]quinolizinium as a Multicolor NIR Probe for the Fluorimetric Detection of Intracellular Nucleic Acids and Proteins Open
The dye 3‐(4‐( N , N ‐dimethylamino)phenyl)naphtho[ 1,2‐b ]quinolizinium was synthesized by means of a Suzuki–Miyaura reaction in good yield, and its binding properties with duplex DNA, quadruplex DNA (G4‐DNA), RNA, and bovine serum albumi…
View article: Drug Release from Thermo‐Responsive Polymer Brush Coatings to Control Bacterial Colonization and Biofilm Growth on Titanium Implants
Drug Release from Thermo‐Responsive Polymer Brush Coatings to Control Bacterial Colonization and Biofilm Growth on Titanium Implants Open
Despite decades of biomedical advances, the colonization of implant devices with bacterial biofilms is still a leading cause of implant failure. Clearly, new strategies and materials that suppress both initial and later stage bacterial col…
View article: Quantitative E. coli Enzyme Detection in Reporter Hydrogel-Coated Paper Using a Smartphone Camera
Quantitative E. coli Enzyme Detection in Reporter Hydrogel-Coated Paper Using a Smartphone Camera Open
There is a growing demand for rapid and sensitive detection approaches for pathogenic bacteria that can be applied by non-specialists in non-laboratory field settings. Here, the detection of the typical E. coli enzyme β-glucuronidase using…
View article: Enhancing DPCD in Liquid Products by Mechanical Inactivation Effects: Assessment of Feasibility
Enhancing DPCD in Liquid Products by Mechanical Inactivation Effects: Assessment of Feasibility Open
The enhancement of standard dense phase carbon dioxide (DPCD) pasteurization by additional mechanical effects was assessed in this work. These effects were induced during pasteurization by the sudden depressurization in a narrow minitube. …
View article: Colorimetric and Fluorimetric DNA Detection with a Hydroxystyryl–Quinolizinium Photoacid and Its Application for Cell Imaging
Colorimetric and Fluorimetric DNA Detection with a Hydroxystyryl–Quinolizinium Photoacid and Its Application for Cell Imaging Open
The combination of styryl dye properties with the acidity and strong photoacidity of the 2,2′‐[(1′′‐hydroxy‐4′′‐methyl‐( E )‐2′′,6′′‐phenylene)]‐bisquinolizinium enables the detection of DNA by distinct absorption and emission color change…
View article: Encapsulation of Autoinducer Sensing Reporter Bacteria in Reinforced Alginate-Based Microbeads
Encapsulation of Autoinducer Sensing Reporter Bacteria in Reinforced Alginate-Based Microbeads Open
Quorum sensing, in which bacteria communities use signaling molecules for inter- and intracellular communication, has been intensively studied in recent decades. In order to fabricate highly sensitive easy-to-handle point of care biosensor…
View article: Isolated Reporter Bacteria in Supramolecular Hydrogel Microwell Arrays
Isolated Reporter Bacteria in Supramolecular Hydrogel Microwell Arrays Open
The combination of supramolecular hydrogels formed by low molecular weight gelator self-assembly via noncovalent interactions within a scaffold derived from polyethylene glycol (PEG) affords an interesting approach to immobilize fully func…