Marek Behr
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View article: Computational Model of Coronary Arteries with In-Stent Restenosis: Mutual Influence of Hemodynamics, Growth Mechanics and Pharmacokinetics
Computational Model of Coronary Arteries with In-Stent Restenosis: Mutual Influence of Hemodynamics, Growth Mechanics and Pharmacokinetics Open
Despite advances in stent technology, in-stent restenosis remains a critical challenge following percutaneous coronary intervention. In this work, we propose a comprehensive fluid-solid computational model to simulate restenosis after drug…
View article: Quantifying data needs in surrogate modeling for flow fields in two-dimensional stirred tanks with physics-informed neural networks
Quantifying data needs in surrogate modeling for flow fields in two-dimensional stirred tanks with physics-informed neural networks Open
Stirred tanks are vital in chemical and biotechnological processes, particularly as bioreactors. Although computational fluid dynamics (CFD) is widely used to model the flow in stirred tanks, its high computational cost$-$especially in mul…
View article: Experimental Investigation of the Applicability of the Stress‐Based and Strain‐Based Hemolysis Models for Short‐Term Stress Peaks Typical for Rotary Blood Pumps
Experimental Investigation of the Applicability of the Stress‐Based and Strain‐Based Hemolysis Models for Short‐Term Stress Peaks Typical for Rotary Blood Pumps Open
Background Although flow simulations have become more accurate, hemolysis prediction models still show large deviations from measured values in blood‐carrying devices. To develop and validate more accurate models, specific hemolysis experi…
View article: A continuum chemo‐mechano‐biological model for in‐stent restenosis with consideration of hemodynamic effects
A continuum chemo‐mechano‐biological model for in‐stent restenosis with consideration of hemodynamic effects Open
The occurrence of in‐stent restenosis following percutaneous coronary intervention highlights the need for the creation of computational tools that can extract pathophysiological insights and optimize interventional procedures on a patient…
View article: An Ising Machine Formulation for Design Updates in Topology Optimization of Flow Channels
An Ising Machine Formulation for Design Updates in Topology Optimization of Flow Channels Open
Topology optimization is an essential tool in computational engineering, for example, to improve the design and efficiency of flow channels. At the same time, Ising machines, including digital or quantum annealers, have been used as effici…
View article: Two‐phase flows simulations in a space‐time framework for injection molding applications: Comparison with experimental results
Two‐phase flows simulations in a space‐time framework for injection molding applications: Comparison with experimental results Open
High‐resolution numerical simulations of the injection molding process are crucial for precise process and part behavior prediction and tool fabrication. However, the complex flow behavior with high shear rates, rapid cooling as well as th…
View article: Eulerian formulation of the tensor-based morphology equations for strain-based blood damage modeling
Eulerian formulation of the tensor-based morphology equations for strain-based blood damage modeling Open
The development of blood-handling medical devices, such as ventricular assist devices, requires the analysis of their biocompatibility. Among other aspects, this includes hemolysis, i.e., red blood cell damage. For this purpose, computatio…
View article: In-silico Analysis of Hemodynamic Indicators in Idealized Stented Coronary Arteries for Varying Stent Indentation
In-silico Analysis of Hemodynamic Indicators in Idealized Stented Coronary Arteries for Varying Stent Indentation Open
In this work, we investigate the effects of stent indentation on hemodynamic indicators in stented coronary arteries. Our aim is to assess in-silico risk factors for in-stent restenosis (ISR) and thrombosis after stent implantation. The pr…
View article: In silico reproduction of the pathophysiology of in-stent restenosis
In silico reproduction of the pathophysiology of in-stent restenosis Open
The occurrence of in-stent restenosis following percutaneous coronary intervention highlights the need for the creation of computational tools that can extract pathophysiological insights and optimize interventional procedures on a patient…
View article: Multiphase Flow Simulation of Blow-by and Fuel-in-Oil Dilution via the Piston Ring Pack Using the CFD Level-Set Method
Multiphase Flow Simulation of Blow-by and Fuel-in-Oil Dilution via the Piston Ring Pack Using the CFD Level-Set Method Open
Modern diesel engines temporarily use a very late post-injection in the combustion cycle to either generate heat for a diesel particulate filter regeneration or purge a lean NOx trap. In some configurations, unburned fuel is left at the cy…
View article: Using Bayesian optimization for warpage compensation in injection molding
Using Bayesian optimization for warpage compensation in injection molding Open
In injection molding, shrinkage and warpage lead to a deformation of the produced parts with respect to the cavity shape. One method to mitigate this effect is to adapt the cavity shape to the expected deformation. This deformation can be …
View article: A model hierarchy for predicting the flow in stirred tanks with physics-informed neural networks
A model hierarchy for predicting the flow in stirred tanks with physics-informed neural networks Open
This paper explores the potential of Physics-Informed Neural Networks (PINNs) to serve as Reduced Order Models (ROMs) for simulating the flow field within stirred tank reactors (STRs). We solve the two-dimensional stationary Navier-Stokes …
View article: High‐resolution numerical simulations of polymer injection molding: Analysis of mesh size and refinement
High‐resolution numerical simulations of polymer injection molding: Analysis of mesh size and refinement Open
Accurate and high‐resolution numerical simulations are crucial for preventing manufacturing defects during polymer injection molding. However, achieving efficient and precise simulations in this field remains a subject of ongoing research.…
View article: Exploring the Influence of Parametrized Pulsatility on Left Ventricular Washout under LVAD Support: A Computational Study Using Reduced-Order Models
Exploring the Influence of Parametrized Pulsatility on Left Ventricular Washout under LVAD Support: A Computational Study Using Reduced-Order Models Open
Medical therapy for patients with severe heart disease often relies on left ventricular assist devices (LVADs). It is an ongoing topic of research how complications like stagnation and thrombosis can be prevented by using artificial pulsat…
View article: Computational modeling of in-stent restenosis: Pharmacokinetic and pharmacodynamic evaluation
Computational modeling of in-stent restenosis: Pharmacokinetic and pharmacodynamic evaluation Open
Persistence of the pathology of in-stent restenosis even with the advent of drug-eluting stents warrants the development of highly resolved in silico models. These computational models assist in gaining insights into the transient biochemi…
View article: Numerical Analysis and Reduced‐Order Modeling of Plastic Profile Extrusion Processes
Numerical Analysis and Reduced‐Order Modeling of Plastic Profile Extrusion Processes Open
We present the data‐driven standardized non‐intrusive reduced‐order modeling strategy, sniROM, applied in context of plastics profile extrusion. After a brief introduction to the process and the governing physics, we give a short overview …
View article: Time‐continuous and time‐discontinuous space‐time finite elements for advection‐diffusion problems
Time‐continuous and time‐discontinuous space‐time finite elements for advection‐diffusion problems Open
We construct four variants of space‐time finite element discretizations based on linear tensor‐product and simplex‐type finite elements. The resulting discretizations are continuous in space, and continuous or discontinuous in time. In a f…
View article: Development and validation of a novel<i>in-vivo</i>vascular injury score for prediction of in-stent restenosis
Development and validation of a novel<i>in-vivo</i>vascular injury score for prediction of in-stent restenosis Open
Background Despite optimizations of coronary stenting technology, a residual risk of in-stent restenosis (ISR) remains. Vessel wall injury has important impact on the development of ISR. While injury can be assessed in histology, there is …