Marek Dynowski
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View article: Data from Next-Generation Sequencing Analysis and Algorithms for PDX and CDX Models
Data from Next-Generation Sequencing Analysis and Algorithms for PDX and CDX Models Open
Patient-derived xenograft (PDX) and circulating tumor cell–derived explant (CDX) models are powerful methods for the study of human disease. In cancer research, these methods have been applied to multiple questions, including the study of …
View article: Supplementary Figure 1 from Next-Generation Sequencing Analysis and Algorithms for PDX and CDX Models
Supplementary Figure 1 from Next-Generation Sequencing Analysis and Algorithms for PDX and CDX Models Open
Overview of data processing pipeline.
View article: Supplementary Table 1 from Next-Generation Sequencing Analysis and Algorithms for PDX and CDX Models
Supplementary Table 1 from Next-Generation Sequencing Analysis and Algorithms for PDX and CDX Models Open
Mapping percentages for RNA-sequencing datasets.
View article: Supplementary Figure 3 from Next-Generation Sequencing Analysis and Algorithms for PDX and CDX Models
Supplementary Figure 3 from Next-Generation Sequencing Analysis and Algorithms for PDX and CDX Models Open
Differences in fold change between primary tumour and CDXF1 before and after processing using Xenome.
View article: Supplementary Table 1 from Next-Generation Sequencing Analysis and Algorithms for PDX and CDX Models
Supplementary Table 1 from Next-Generation Sequencing Analysis and Algorithms for PDX and CDX Models Open
Mapping percentages for RNA-sequencing datasets.
View article: Data from Next-Generation Sequencing Analysis and Algorithms for PDX and CDX Models
Data from Next-Generation Sequencing Analysis and Algorithms for PDX and CDX Models Open
Patient-derived xenograft (PDX) and circulating tumor cell–derived explant (CDX) models are powerful methods for the study of human disease. In cancer research, these methods have been applied to multiple questions, including the study of …
View article: Supplementary Figure 1 from Next-Generation Sequencing Analysis and Algorithms for PDX and CDX Models
Supplementary Figure 1 from Next-Generation Sequencing Analysis and Algorithms for PDX and CDX Models Open
Overview of data processing pipeline.
View article: Supplementary Figure 3 from Next-Generation Sequencing Analysis and Algorithms for PDX and CDX Models
Supplementary Figure 3 from Next-Generation Sequencing Analysis and Algorithms for PDX and CDX Models Open
Differences in fold change between primary tumour and CDXF1 before and after processing using Xenome.
View article: Supplementary Figure 2 from Next-Generation Sequencing Analysis and Algorithms for PDX and CDX Models
Supplementary Figure 2 from Next-Generation Sequencing Analysis and Algorithms for PDX and CDX Models Open
Variant Allele Frequencies for the CDXF1 model.
View article: Supplementary Figure 2 from Next-Generation Sequencing Analysis and Algorithms for PDX and CDX Models
Supplementary Figure 2 from Next-Generation Sequencing Analysis and Algorithms for PDX and CDX Models Open
Variant Allele Frequencies for the CDXF1 model.
View article: Tumour infiltrating B cells discriminate checkpoint blockade-induced responses
Tumour infiltrating B cells discriminate checkpoint blockade-induced responses Open
Our exploratory translational study provides new insights on the mechanistic role of B cells in anti-melanoma immunity during treatment with ICB. Additionally, we support pre-treatment B cell tumour infiltration as a promising prognostic b…
View article: Resurrection of a functional phosphatidylinositol transfer protein from a pseudo-Sec14 scaffold by directed evolution
Resurrection of a functional phosphatidylinositol transfer protein from a pseudo-Sec14 scaffold by directed evolution Open
Proteins of the Sec14 superfamily regulate phosphoinositide signaling, and dysfunction of individual members of this superfamily results in a variety of human diseases. This study uses a directed evolution approach as a novel prism through…
View article: Optic disc detection in the presence of strong technical artifacts
Optic disc detection in the presence of strong technical artifacts Open
The inspection of retinal fundus pictures taken by a fundus camera is one of the key procedures for diagnosing a wide range of diseases like diabetic retinopathy, hypertension or hypercranial pressure. The detection of the optic disc (OD) …
View article: Next-Generation Sequencing Analysis and Algorithms for PDX and CDX Models
Next-Generation Sequencing Analysis and Algorithms for PDX and CDX Models Open
Patient-derived xenograft (PDX) and circulating tumor cell–derived explant (CDX) models are powerful methods for the study of human disease. In cancer research, these methods have been applied to multiple questions, including the study of …
View article: Design, Implementation and Operation of a Reading Center Platform for Clinical Studies
Design, Implementation and Operation of a Reading Center Platform for Clinical Studies Open
Clinical reading centers provide expertise for consistent, centralized analysis of medical data gathered in a distributed context. Accordingly, appropriate software solutions are required for the involved communication and data management …
View article: Inositol Polyphosphate Binding Specificity of the Jasmonate Receptor Complex
Inositol Polyphosphate Binding Specificity of the Jasmonate Receptor Complex Open
Inositol polyphosphate binding specificity of the jasmonate receptor is largely determined by the F-box protein COI1.
View article: Human Vision–Motivated Algorithm Allows Consistent Retinal Vessel Classification Based on Local Color Contrast for Advancing General Diagnostic Exams
Human Vision–Motivated Algorithm Allows Consistent Retinal Vessel Classification Based on Local Color Contrast for Advancing General Diagnostic Exams Open
Our study demonstrates that vessel classification based on local color contrast can cope with inter- or intraimage lightness variability and allows consistent AVR calculation. We offer an open-source implementation of this method upon requ…