Marek Majdán
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View article: Anti-spike Antibody Response to Natural SARS-CoV-2 Infection
Anti-spike Antibody Response to Natural SARS-CoV-2 Infection Open
Objective To assess the immune response to natural SARS-CoV-2 infection, anti-spike antibody levels were investigated in a group of 1,348 unvaccinated individuals in Slovakia during the Alpha variant dominance. Methods Blood samples were u…
View article: A double-blind, placebo-controlled, randomized, multi-centre, phase III study of MLC901 (NeuroAiDTMII) for the treatment of cognitive impairment after mild traumatic brain injury
A double-blind, placebo-controlled, randomized, multi-centre, phase III study of MLC901 (NeuroAiDTMII) for the treatment of cognitive impairment after mild traumatic brain injury Open
Introduction About half of the world population will suffer from a traumatic brain injury (TBI) during their lifetime, of which about 90% of cases are mild TBI. Although up to 40% of adults with mild TBI experience persistent functional de…
View article: Suicides in Czech Republic, Slovakia, Hungary, and Poland in 1990–2019: Epidemiological Patterns and Trends in European and Global Context
Suicides in Czech Republic, Slovakia, Hungary, and Poland in 1990–2019: Epidemiological Patterns and Trends in European and Global Context Open
Death rates due to suicides have been declining in the analyzed countries, but some characteristics and trends when compared to global and regional estimates, such as substantially higher proportion of male suicides or high death rates amo…
View article: A DOUBLE-BLIND, PLACEBO-CONTROLLED, RANDOMIZED, MULTI-CENTRE, PHASE III STUDY OF MLC901 (NEUROAID II™) FOR THE TREATMENT OF COGNITIVE IMPAIRMENT AFTER MILD TRAUMATIC BRAIN INJURY
A DOUBLE-BLIND, PLACEBO-CONTROLLED, RANDOMIZED, MULTI-CENTRE, PHASE III STUDY OF MLC901 (NEUROAID II™) FOR THE TREATMENT OF COGNITIVE IMPAIRMENT AFTER MILD TRAUMATIC BRAIN INJURY Open
Introduction About half of the world population will suffer from a traumatic brain injury (TBI) during their lifetime, of which about 90% of cases are mild TBI. About 15-40% of adults with TBI experience persistent cognitive deficits, and …
View article: Secondary attack rate of COVID-19 in shared households in Slovakia
Secondary attack rate of COVID-19 in shared households in Slovakia Open
We found a high household secondary attack rate in two regions of Slovakia in the period when Alpha variant (B.1.1.7) of SARS-CoV-2 was dominant in the country. The results highlight the importance of monitoring transmission dynamics (Tab.…
View article: Impact of domiciliary administration of NSAIDs on COVID-19 hospital outcomes: an unCoVer analysis
Impact of domiciliary administration of NSAIDs on COVID-19 hospital outcomes: an unCoVer analysis Open
Background: Effective domiciliary treatment can be useful in the early phase of COVID-19 to limit disease progression, and pressure on hospitals. There are discrepant data on the use of non-steroidal anti-inflammatory drugs (NSAIDs). Aim o…
View article: The impact of the COVID-19 pandemic on the health and working conditions of nurses and its implications for policies: a cross-sectional study in Slovakia
The impact of the COVID-19 pandemic on the health and working conditions of nurses and its implications for policies: a cross-sectional study in Slovakia Open
Background Increased workload and of the health workforce (HW) strained the capacity to maintain essential health services (EHS) during the Coronavirus Disease 2019 (COVID-19) pandemic, while putting them at increased risk of COVID-19 and …
View article: Intramural Healthcare Consumption and Costs After Traumatic Brain Injury: A Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) Study
Intramural Healthcare Consumption and Costs After Traumatic Brain Injury: A Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) Study Open
Traumatic brain injury (TBI) is a global public health problem and a leading cause of mortality, morbidity, and disability. The increasing incidence combined with the heterogeneity and complexity of TBI will inevitably place a substantial …
View article: Association of Nonconcussive Repetitive Head Impacts and Intense Physical Activity With Levels of Phosphorylated Tau<sub>181</sub> and Total Tau in Plasma of Young Elite Soccer Players
Association of Nonconcussive Repetitive Head Impacts and Intense Physical Activity With Levels of Phosphorylated Tau<sub>181</sub> and Total Tau in Plasma of Young Elite Soccer Players Open
Importance Head impacts resulting in traumatic brain injury (TBI) lead to the elevation of phosphorylated tau protein (p-tau 181 ) in plasma. To our knowledge, this study is the first to investigate dynamics of p-tau 181 levels and the rat…
View article: International evidence-based guidelines on hypertension and type 2 diabetes mellitus: A systematic review
International evidence-based guidelines on hypertension and type 2 diabetes mellitus: A systematic review Open
This systematic review provides a high-quality, comprehensive summary of recommendations on hypertension (HT) and type 2 diabetes mellitus (T2DM), accentuating patient blood pressure, HbA1c levels, patterns of drug treatment, management, a…
View article: Joinpoint analysis of colorectal cancer trend in the Slovakia
Joinpoint analysis of colorectal cancer trend in the Slovakia Open
The situation of colorectal cancer trend in the Slovakia has improved compared to the previous period (1971-2001) (Tab. 4, Fig. 4, Ref. 34).
View article: Satisfaction with Health Care Services in the Adult Population of the Federation of Bosnia and Herzegovina during the COVID-19 Pandemic
Satisfaction with Health Care Services in the Adult Population of the Federation of Bosnia and Herzegovina during the COVID-19 Pandemic Open
Background and Objectives: Patient satisfaction with health care can influence health care-seeking behavior in relation to both minor or major health problems or influence communication and compliance with medical advice, which is especial…
View article: Epidemiological Patterns of Hypertension and Type 2 Diabetes Mellitus in the Socialist Republic of Vietnam: an Ecological Study
Epidemiological Patterns of Hypertension and Type 2 Diabetes Mellitus in the Socialist Republic of Vietnam: an Ecological Study Open
Background: Hypertension and type 2 diabetes mellitus belong to the most costly chronic diseases worldwide. The Socialist Republic of Vietnam is a country with a high burden of communicable and non-communicable diseases, with hypertension …
View article: Population Perspectives on Impact of the COVID-19 Pandemic on Essential Health Services—Behavioral Insights from the Federation of Bosnia and Herzegovina
Population Perspectives on Impact of the COVID-19 Pandemic on Essential Health Services—Behavioral Insights from the Federation of Bosnia and Herzegovina Open
The aim of this study was to analyze the impact of the COVID-19 pandemic on patterns of use of essential health services (EHS), health-seeking behaviors, and population health and wellbeing in the Federation of Bosnia and Herzegovina (FBiH…
View article: Non-concussive Repetitive Head Impacts and Intense Physical Activity Elevate pT181-Tau and pT181/total-Tau in Plasma of Young Adults
Non-concussive Repetitive Head Impacts and Intense Physical Activity Elevate pT181-Tau and pT181/total-Tau in Plasma of Young Adults Open
IMPORTANCE Head impacts resulting in traumatic brain injury (TBI) lead to elevation of phosphorylated tau protein in plasma, the biomarkers for patients with acute and chronic TBI. Dynamics of phosphorylated tau protein level (pTau) and ra…
View article: Associations of pre-existing comorbidities and COVID-19 in-hospital mortality: an unCoVer analyses
Associations of pre-existing comorbidities and COVID-19 in-hospital mortality: an unCoVer analyses Open
Background Accumulated evidence on risk factors for adverse COVID-19 outcomes revealed that old age and male sex are main associates, next to pre-existing comorbidities, as analysed from scattered single cohorts of hospitalised COVID-19 pa…
View article: 1.S. Preparing for the unexpected
1.S. Preparing for the unexpected Open
This abstract has been withdrawn
View article: Cervical cancer rates in relation to the Roma population distribution in Slovakia in 2013 – 2020
Cervical cancer rates in relation to the Roma population distribution in Slovakia in 2013 – 2020 Open
Background Globally, more than 300 000 women die due to cervical cancer (CC) each year despite its high preventability and treatability in its early stages. This study aimed to analyse CC rates at the regional level in Slovakia from 2013 t…
View article: Disruptions of cytological screening procedures due to the COVID-19 pandemic in Slovakia
Disruptions of cytological screening procedures due to the COVID-19 pandemic in Slovakia Open
Background During the COVID-19 pandemic, most settings experienced healthcare service disruptions. The majority of cytological screening procedures were postponed to focus on assisting patients infected with COVID-19. In this study, we aim…
View article: Investigating feasibility of 2021 WHO protocol for cervical cancer screening in underscreened populations: PREvention and SCReening Innovation Project Toward Elimination of Cervical Cancer (PRESCRIP-TEC)
Investigating feasibility of 2021 WHO protocol for cervical cancer screening in underscreened populations: PREvention and SCReening Innovation Project Toward Elimination of Cervical Cancer (PRESCRIP-TEC) Open
Background High-risk human papillomavirus (hrHPV) testing has been recommended by the World Health Organization as the primary screening test in cervical screening programs. The option of self-sampling for this screening method can potenti…
View article: Health care utilization and outcomes in older adults after Traumatic Brain Injury: A CENTER-TBI study
Health care utilization and outcomes in older adults after Traumatic Brain Injury: A CENTER-TBI study Open
The rate of impairment and disability following TBI in older adults is substantial, and poorer outcomes across domains are associated with worse preinjury health. Nonetheless, a considerable number of patients fully or partially returns to…
View article: Randomised, double-blind, placebo-controlled study investigating Safety and efficAcy of MLC901 in post-traUmatic bRAin Injury: the SAMURAI study protocol
Randomised, double-blind, placebo-controlled study investigating Safety and efficAcy of MLC901 in post-traUmatic bRAin Injury: the SAMURAI study protocol Open
Introduction Traumatic brain injury (TBI) is a leading cause of death in young adults globally and 90% of cases are mild TBI. Treatment to facilitate recovery after TBI is needed. Traditional medicine MLC901 (NeuroAiD II) with neuroprotect…
View article: Additional file 2 of Methodological considerations in injury burden of disease studies across Europe: a systematic literature review
Additional file 2 of Methodological considerations in injury burden of disease studies across Europe: a systematic literature review Open
Additional file 2. Data extraction form.