Marek Majewski
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View article: Exome sequencing points to pathogenic ATM variants in gastric cancer
Exome sequencing points to pathogenic ATM variants in gastric cancer Open
Gastric cancer (GC) is a leading cause of cancer-related deaths worldwide. While most cases result from the cumulative risk of common genetic variants, a smaller proportion shows a monogenic etiology. We used germline exome sequencing data…
View article: First genome-wide association study reveals immune-mediated aetiopathology in idiopathic achalasia
First genome-wide association study reveals immune-mediated aetiopathology in idiopathic achalasia Open
Background Idiopathic achalasia (IA) is characterised by the degeneration of neurons in the myenteric plexus leading to an irreversible impaired oesophageal function. Although immune-mediated mechanisms have been proposed, the underlying a…
View article: AI-Based Facial Analysis vs Self-Report: A Pilot Study Using Insights From Pre-Procedural Psychological Tests
AI-Based Facial Analysis vs Self-Report: A Pilot Study Using Insights From Pre-Procedural Psychological Tests Open
BACKGROUND Aesthetic procedures aligning with societal beauty standards are gaining popularity, often driven by unrealistic beauty ideals. However, these treatments frequently disappoint individuals with low self-esteem and distorted self-…
View article: The impact of Body Mass Index (BMI) on mortality rates in patients with severe burns
The impact of Body Mass Index (BMI) on mortality rates in patients with severe burns Open
There is an increase in the number of obese patients in burn units. Obesity is strongly associated with metabolic syndrome and chronic diseases, including cardiovascular and gastrointestinal disorders and diabetes. However, there is eviden…
View article: How Toll-like Receptor 9 Plays a Key Role in the Development of Gastric Cancer and Is Linked to Epstein–Barr Virus Infection
How Toll-like Receptor 9 Plays a Key Role in the Development of Gastric Cancer and Is Linked to Epstein–Barr Virus Infection Open
The relationship between Toll-like receptor 9 (TLR-9) signaling and its involvement with Epstein–Barr virus (EBV) in gastric cancer (GC) is complex and currently under study. This research intended to understand TLR-9’s role in certain T a…
View article: Data from Loss of Optineurin Drives Cancer Immune Evasion via Palmitoylation-Dependent IFNGR1 Lysosomal Sorting and Degradation
Data from Loss of Optineurin Drives Cancer Immune Evasion via Palmitoylation-Dependent IFNGR1 Lysosomal Sorting and Degradation Open
Mutations in IFN and MHC signaling genes endow immunotherapy resistance. Patients with colorectal cancer infrequently exhibit IFN and MHC signaling gene mutations and are generally resistant to immunotherapy. In exploring the integrity of …
View article: Data from Loss of Optineurin Drives Cancer Immune Evasion via Palmitoylation-Dependent IFNGR1 Lysosomal Sorting and Degradation
Data from Loss of Optineurin Drives Cancer Immune Evasion via Palmitoylation-Dependent IFNGR1 Lysosomal Sorting and Degradation Open
Mutations in IFN and MHC signaling genes endow immunotherapy resistance. Patients with colorectal cancer infrequently exhibit IFN and MHC signaling gene mutations and are generally resistant to immunotherapy. In exploring the integrity of …
View article: Supplementary Data from Loss of Optineurin Drives Cancer Immune Evasion via Palmitoylation-Dependent IFNGR1 Lysosomal Sorting and Degradation
Supplementary Data from Loss of Optineurin Drives Cancer Immune Evasion via Palmitoylation-Dependent IFNGR1 Lysosomal Sorting and Degradation Open
Supplementary Figure S1-9 and Supplementary Tables S1-8
View article: Supplementary Data from Loss of Optineurin Drives Cancer Immune Evasion via Palmitoylation-Dependent IFNGR1 Lysosomal Sorting and Degradation
Supplementary Data from Loss of Optineurin Drives Cancer Immune Evasion via Palmitoylation-Dependent IFNGR1 Lysosomal Sorting and Degradation Open
Supplementary Figure S1-9 and Supplementary Tables S1-8
View article: Supplementary Figure Legends from miR-508 Defines the Stem-like/Mesenchymal Subtype in Colorectal Cancer
Supplementary Figure Legends from miR-508 Defines the Stem-like/Mesenchymal Subtype in Colorectal Cancer Open
This file contains figure legends corresponding to supplementary figures.
View article: Supplementary Tables from miR-508 Defines the Stem-like/Mesenchymal Subtype in Colorectal Cancer
Supplementary Tables from miR-508 Defines the Stem-like/Mesenchymal Subtype in Colorectal Cancer Open
This file contains supplementary tables 1-7 and the main information was described as follows. Table S1. All primers for real time PCR assay. Table S2. Differentially expressed genes between mesenchymal subtype and other non stem-like. Tab…
View article: Supplementary Tables from miR-508 Defines the Stem-like/Mesenchymal Subtype in Colorectal Cancer
Supplementary Tables from miR-508 Defines the Stem-like/Mesenchymal Subtype in Colorectal Cancer Open
This file contains supplementary tables 1-7 and the main information was described as follows. Table S1. All primers for real time PCR assay. Table S2. Differentially expressed genes between mesenchymal subtype and other non stem-like. Tab…
View article: Data from IL33 Promotes Colon Cancer Cell Stemness via JNK Activation and Macrophage Recruitment
Data from IL33 Promotes Colon Cancer Cell Stemness via JNK Activation and Macrophage Recruitment Open
The expression and biological role of IL33 in colon cancer is poorly understood. In this study, we show that IL33 is expressed by vascular endothelial cells and tumor cells in the human colon cancer microenvironment. Administration of huma…
View article: Supplementary Methods from miR-508 Defines the Stem-like/Mesenchymal Subtype in Colorectal Cancer
Supplementary Methods from miR-508 Defines the Stem-like/Mesenchymal Subtype in Colorectal Cancer Open
This file contains methods which were not included in the main text.
View article: Supplementary Figures from miR-508 Defines the Stem-like/Mesenchymal Subtype in Colorectal Cancer
Supplementary Figures from miR-508 Defines the Stem-like/Mesenchymal Subtype in Colorectal Cancer Open
This file contains supplementary figures 1-7 and the main information was described as follows. Fig. S1. Differential microRNA and mRNA profiles in the stem-like/EMT subtype of CRC in TCGA. Fig. S2. Role of miR-506 family in the control of…
View article: Data from miR-508 Defines the Stem-like/Mesenchymal Subtype in Colorectal Cancer
Data from miR-508 Defines the Stem-like/Mesenchymal Subtype in Colorectal Cancer Open
Colorectal cancer includes an invasive stem-like/mesenchymal subtype, but its genetic drivers, functional, and clinical relevance are uncharacterized. Here we report the definition of an altered miRNA signature defining this subtype that i…
View article: Data from IL33 Promotes Colon Cancer Cell Stemness via JNK Activation and Macrophage Recruitment
Data from IL33 Promotes Colon Cancer Cell Stemness via JNK Activation and Macrophage Recruitment Open
The expression and biological role of IL33 in colon cancer is poorly understood. In this study, we show that IL33 is expressed by vascular endothelial cells and tumor cells in the human colon cancer microenvironment. Administration of huma…
View article: Supplementary Information from IL33 Promotes Colon Cancer Cell Stemness via JNK Activation and Macrophage Recruitment
Supplementary Information from IL33 Promotes Colon Cancer Cell Stemness via JNK Activation and Macrophage Recruitment Open
It contains 5 figures and 3 tables
View article: Supplementary Figures from miR-508 Defines the Stem-like/Mesenchymal Subtype in Colorectal Cancer
Supplementary Figures from miR-508 Defines the Stem-like/Mesenchymal Subtype in Colorectal Cancer Open
This file contains supplementary figures 1-7 and the main information was described as follows. Fig. S1. Differential microRNA and mRNA profiles in the stem-like/EMT subtype of CRC in TCGA. Fig. S2. Role of miR-506 family in the control of…
View article: Supplementary Methods from miR-508 Defines the Stem-like/Mesenchymal Subtype in Colorectal Cancer
Supplementary Methods from miR-508 Defines the Stem-like/Mesenchymal Subtype in Colorectal Cancer Open
This file contains methods which were not included in the main text.
View article: Supplementary Information from IL33 Promotes Colon Cancer Cell Stemness via JNK Activation and Macrophage Recruitment
Supplementary Information from IL33 Promotes Colon Cancer Cell Stemness via JNK Activation and Macrophage Recruitment Open
It contains 5 figures and 3 tables
View article: Data from miR-508 Defines the Stem-like/Mesenchymal Subtype in Colorectal Cancer
Data from miR-508 Defines the Stem-like/Mesenchymal Subtype in Colorectal Cancer Open
Colorectal cancer includes an invasive stem-like/mesenchymal subtype, but its genetic drivers, functional, and clinical relevance are uncharacterized. Here we report the definition of an altered miRNA signature defining this subtype that i…
View article: Supplementary Figure Legends from miR-508 Defines the Stem-like/Mesenchymal Subtype in Colorectal Cancer
Supplementary Figure Legends from miR-508 Defines the Stem-like/Mesenchymal Subtype in Colorectal Cancer Open
This file contains figure legends corresponding to supplementary figures.
View article: Could Toll-like Receptor 2 Serve as Biomarker to Detect Advanced Gastric Cancer?
Could Toll-like Receptor 2 Serve as Biomarker to Detect Advanced Gastric Cancer? Open
Gastric cancer is one of the five most common types of cancer worldwide. Due to the heterogeneous course and the involvement of many risk factors, its treatment and diagnosis is an important challenge for modern medicine. Recent studies ha…
View article: Microbiota and the Immune System—Actors in the Gastric Cancer Story
Microbiota and the Immune System—Actors in the Gastric Cancer Story Open
Gastric cancer remains one of the most commonly diagnosed cancers in the world, with a relatively high mortality rate. Due to the heterogeneous course of the disease, its diagnosis and treatment are limited and difficult, and it is associa…