Marek Ostrowski
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View article: IUC24428-85 Real-world effectiveness of ipilimumab plus nivolumab in second-line in patients with metastatic clear cell renal cell carcinoma (mccRCC) based on prior receipt of PD-1/L1 inhibitors
IUC24428-85 Real-world effectiveness of ipilimumab plus nivolumab in second-line in patients with metastatic clear cell renal cell carcinoma (mccRCC) based on prior receipt of PD-1/L1 inhibitors Open
Background Previous phase 3 studies have established that the addition of PD-1/L1 inhibitors (PD-1/L1i) to a tyrosine kinase inhibitor (TKI) after progression on prior anti-PD-1/L1 therapy does not yield additional benefit over single-agen…
View article: IUC24429-86 Real-world use of bone-modifying agents (BMA) in patients with metastatic castration-resistant prostate cancer (mCRPC) in the United States
IUC24429-86 Real-world use of bone-modifying agents (BMA) in patients with metastatic castration-resistant prostate cancer (mCRPC) in the United States Open
Background Most patients with prostate cancer experience symptomatic skeletal events, leading to increased morbidity and mortality. BMAs have been approved since 2007 and recommended in mCRPC to prevent SSEs in patients with bone metastase…
View article: Quality Control And Preparation Of Acoustic Survey Data For Treatment By Spatial Analysis Techniques. Experiences From Using Integrated Visualization Software Tools
Quality Control And Preparation Of Acoustic Survey Data For Treatment By Spatial Analysis Techniques. Experiences From Using Integrated Visualization Software Tools Open
No abstracts are to be cited without prior reference to the author.Based on real survey data, cases are presented of the common data preparation steps, which are required for bringing the voluminous acoustic survey data into a form amenabl…
View article: An object-based approach to integration of software to support management and reporting of marine ecosystem survey data
An object-based approach to integration of software to support management and reporting of marine ecosystem survey data Open
No abstracts are to be cited without prior reference to the author.An object-based software to support distributed databases and data reporting from combined fisheries and environmental surveys is presented. The key abstraction of this sys…
View article: PB1312 “The Doctor Says So” - Patient Values and Preferences Regarding Resumption of Oral Anticoagulation after Gastrointestinal Bleeding
PB1312 “The Doctor Says So” - Patient Values and Preferences Regarding Resumption of Oral Anticoagulation after Gastrointestinal Bleeding Open
Conclusion(s):When developing a RAM for HA-bleeding, we determined that each bleeding site had different risk factors.Based on these findings, site-specific bleeding RAMs may be better for use in clinical practice and research than all-sit…
View article: Comparative Intra‐Subject Analysis of Gene Expression and Protein Abundance of Major and Minor Drug Metabolizing Enzymes in Healthy Human Jejunum and Liver
Comparative Intra‐Subject Analysis of Gene Expression and Protein Abundance of Major and Minor Drug Metabolizing Enzymes in Healthy Human Jejunum and Liver Open
First pass metabolism by phase I and phase II enzymes in the intestines and liver is a major determinant of the oral bioavailability of many drugs. Several studies analyzed expressions of major drug‐metabolizing enzymes (DMEs), such as CYP…
View article: Immunosuppressant Adherence Factors Differentiating Compliant and Non-Compliant Kidney Transplant Recipients
Immunosuppressant Adherence Factors Differentiating Compliant and Non-Compliant Kidney Transplant Recipients Open
The purpose of this study is to find out the psychological factor characteristic of non-adherence patients. The study population comprised kidney transplant recipients aged between 18 and 82 years at least 3 months post-transplant who volu…
View article: Welfare and Self-Assessment in Patients after Aesthetic and Reconstructive Treatments
Welfare and Self-Assessment in Patients after Aesthetic and Reconstructive Treatments Open
In the last decade, there has been a noticeable increase in the interest in aesthetic and corrective surgery regardless of a patient’s age. Both aesthetical and practical considerations are a motivation for patients undergoing plastic surg…
View article: The Arterial Anastomosis Between Deep Inferior Epigastric Artery and Small Polar Renal Artery in Kidney Transplantation: A Case Report
The Arterial Anastomosis Between Deep Inferior Epigastric Artery and Small Polar Renal Artery in Kidney Transplantation: A Case Report Open
The presence of multiple renal arteries is the most common form of vascular anomalies found in donor kidneys. In rare cases, small renal polar arteries may be found. They can be anastomosed with deep inferior epigastric arteries, resulting…
View article: Assessment of Oxidative Stress Markers in Hypothermic Preservation of Transplanted Kidneys
Assessment of Oxidative Stress Markers in Hypothermic Preservation of Transplanted Kidneys Open
Ischemia-reperfusion injury (IRI) after renal transplantation is a complex biochemical process. The first component is an ischemic phase during kidney storage. The second is reperfusion, the main source of oxidative stress. This study aime…
View article: The Role of Endothelins, IL-18, and NGAL in Kidney Hypothermic Machine Perfusion
The Role of Endothelins, IL-18, and NGAL in Kidney Hypothermic Machine Perfusion Open
Ischemia-reperfusion injury (IRI) occurring after renal transplantation is a complex biochemical process that can be monitored by specific biomarkers. The roles of those are not yet fully elucidated. The aim of this study was to analyze th…
View article: The diagnostic value of dual-phase SPECT/CT scintigraphy based on transport kinetics of 99mTc-sestamibi confirmed with histopathological findings in patients with secondary hyperparathyroidism — practical consideration
The diagnostic value of dual-phase SPECT/CT scintigraphy based on transport kinetics of 99mTc-sestamibi confirmed with histopathological findings in patients with secondary hyperparathyroidism — practical consideration Open
For SHP patients evaluated with SPECT/CT PPS accumulation type I is a weak premise for surgeon to find parathyroid pathology. Only persistent 99mTc-sestamibi accumulation in both phases - equivocal with accumulation type II - effectively d…
View article: Acid-Base Balance Disorders During Kidney Preservation in Cold Ischemia
Acid-Base Balance Disorders During Kidney Preservation in Cold Ischemia Open
We concluded that kidney storage in cold ischemia is associated with organ acidosis independent of preservation method and that SH is correlated with significantly bigger acidosis than storage in PP, which is an important procedure removin…
View article: Data for: Acid-base balance disorders during kidney preservation in cold ischemia
Data for: Acid-base balance disorders during kidney preservation in cold ischemia Open
citations associated with article
View article: Transplantation of a Kidney With Duplicated Ureter Harvested From a Donor With Vascular Anomaly in the Form of Double Inferior Vena Cava: A Case Report
Transplantation of a Kidney With Duplicated Ureter Harvested From a Donor With Vascular Anomaly in the Form of Double Inferior Vena Cava: A Case Report Open
During the organ procurement procedure, a surgeon encounters anatomic anomalies not very often but also not uncommonly. These changes may put the success of the transplant into question. Despite the thorough diagnosis of the potential dono…
View article: Estimation of Parameters of Parathyroid Glands Using Particle Swarm Optimization and Multivariate Generalized Gaussian Function Mixture
Estimation of Parameters of Parathyroid Glands Using Particle Swarm Optimization and Multivariate Generalized Gaussian Function Mixture Open
The paper introduces a fitting method for Single-Photon Emission Computed Tomography (SPECT) images of parathyroid glands using generalized Gaussian function for quantitative assessment of preoperative parathyroid SPECT/CT scintigraphy res…
View article: Effect of Multidrug-Resistant 1 (MDR1) and CYP3A4*1B Polymorphisms on Cyclosporine-Based Immunosuppressive Therapy in Renal Transplant Patients
Effect of Multidrug-Resistant 1 (MDR1) and CYP3A4*1B Polymorphisms on Cyclosporine-Based Immunosuppressive Therapy in Renal Transplant Patients Open
BACKGROUND Immunosuppressive drugs such as cyclosporine A (CsA) are characterized by a narrow therapeutic range and high interindividual pharmacokinetic variations. Therefore, the effective monitoring of drug serum level is crucial for suc…
View article: Correlation Between Stem and Progenitor Cells Number and Immune Response in Patients After Allogeneic Kidney Transplant
Correlation Between Stem and Progenitor Cells Number and Immune Response in Patients After Allogeneic Kidney Transplant Open
BACKGROUND Stem and progenitor cells are of great interest in all medical procedures involving tissue regeneration. There is a consensus that the use of stem cells after solid organ transplantation may play a role in tissue repair and in i…
View article: Protein abundance of clinically relevant drug transporters in the human liver and along the intestine: a comparative analysis in paired tissue specimens
Protein abundance of clinically relevant drug transporters in the human liver and along the intestine: a comparative analysis in paired tissue specimens Open
Background: The bioavailability of orally administered drugs is markedly affected by the expression and function of metabolizing enzymes and drug transporters both in the liver and the gastrointestinal tract. The study revises and compleme…
View article: Clinically Relevant Multidrug Transporters Are Regulated by microRNAs along the Human Intestine
Clinically Relevant Multidrug Transporters Are Regulated by microRNAs along the Human Intestine Open
Intestinal drug transporters are crucial determinants for absorption and oral bioavailability of drugs. In healthy tissue donors, a recent study revealed profound discrepancies between mRNA expression and protein abundance as well as diffe…
View article: Semi-quantitative method for the assessment of focal lesions in parathyroid scintigraphy with relation to histopathology: a prospective study
Semi-quantitative method for the assessment of focal lesions in parathyroid scintigraphy with relation to histopathology: a prospective study Open
The washout technique in pre-operative 99mTc-MIBI scintigraphy is effective in detecting lesions of the parathyroid (cancer, adenoma, hyperplasia, normal tissue of the parathyroid). Parathyroid cancers in semi-quantitative analysis were ch…
View article: Zagadnienia prawdy i poprawności a retoryka w dyskursie medialnym
Zagadnienia prawdy i poprawności a retoryka w dyskursie medialnym Open
Following Niklas Luhmann, the author assumes that communication creates social systems. The system therefore influences the nature of communication. The impact of rhetoric on media discourse can be understood as a result of the strategy ad…
View article: Abdominal hernia repair surgery with the new injectable polymer biomaterials
Abdominal hernia repair surgery with the new injectable polymer biomaterials Open
1Clinic of General and Transplantation Surgery, Pomeranian Medical University, Szczecin Head of Clinic: prof. Marek Ostrowski, MD, PhD 2Division of Biomaterials and Microbiological Technologies, West Pomeranian University of Technology, Sz…