Marek Sanak
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View article: Effect of Aspirin Challenge on Innate Lymphoid Cells in Asthma Patients With Aspirin Hypersensitivity
Effect of Aspirin Challenge on Innate Lymphoid Cells in Asthma Patients With Aspirin Hypersensitivity Open
Previous studies confirmed increased group 2 innate lymphoid cell (ILC2s) count in nasal scrapings, alongside a reduced blood ILC2 count, in patients with nonsteroidal anti‐inflammatory drug‐exacerbated respiratory disease (N‐ERD) after in…
View article: Post-mortem diagnosis of malaria in decomposed and embalmed body
Post-mortem diagnosis of malaria in decomposed and embalmed body Open
The diagnosis of malaria during the autopsy of a decomposed corpse may prove challenging. Macroscopic changes are non-specific and may include, among others, cerebral oedema, pulmonary oedema, hepatosplenomegaly and, on occasion, the prese…
View article: Circulating B Lymphocyte Subsets in Patients with Systemic Lupus Erythematosus
Circulating B Lymphocyte Subsets in Patients with Systemic Lupus Erythematosus Open
Background/Objectives: Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the abnormal activation of autoreactive T and B cells, autoantibody production, complement activation, and immune-complex deposition, resul…
View article: Unique effect of aspirin on local 15‐oxo‐eicosatetraenoic acid synthesis in asthma patients with aspirin hypersensitivity
Unique effect of aspirin on local 15‐oxo‐eicosatetraenoic acid synthesis in asthma patients with aspirin hypersensitivity Open
Background Nonsteroidal anti‐inflammatory drugs–exacerbated respiratory disease (NSAIDs‐ERD) is characterized by altered arachidonic acid (AA) metabolism. Aspirin hypersensitivity is diagnosed using aspirin challenge, while induced sputum …
View article: Radiomultiomics: quantitative CT clusters of severe asthma associated with multiomics
Radiomultiomics: quantitative CT clusters of severe asthma associated with multiomics Open
Background Lung quantitative computed tomography (qCT) severe asthma clusters have been reported, but their replication and underlying disease mechanisms are unknown. We identified and replicated qCT clusters of severe asthma in two indepe…
View article: Role of Plasma Angiopoietin-1 and VEGF Levels as Potential Biomarkers in Chronic Central Serous Chorioretinopathy with Macular Neovascularization
Role of Plasma Angiopoietin-1 and VEGF Levels as Potential Biomarkers in Chronic Central Serous Chorioretinopathy with Macular Neovascularization Open
To evaluate the plasma levels of angiopoietin-1 and vascular endothelial growth factor (VEGF) and their association with macular neovascularization (MNV) in patients with chronic central serous chorioretinopathy (cCSC). Correlations betwee…
View article: Dissecting the importance and origin of circulating myokines in gastric cancer cachexia
Dissecting the importance and origin of circulating myokines in gastric cancer cachexia Open
Background Some experimental data suggest that myokines may play an important role in developing cancer-associated cachexia (CAC), but their relevance in humans remains poorly explored. In our study, we tested the hypothesis that circulati…
View article: Aspirin hypersensitivity diagnostic index (<scp>AHDI</scp>): In vitro test for diagnosing of N‐<scp>ERD</scp> based on urinary 15‐oxo‐<scp>ETE</scp> and <scp>LTE<sub>4</sub></scp> excretion
Aspirin hypersensitivity diagnostic index (<span>AHDI</span>): In vitro test for diagnosing of N‐<span>ERD</span> based on urinary 15‐oxo‐<span>ETE</span> and <span>LTE<sub>4</sub></span> excretion Open
Background 15‐oxo‐eicosatetraenoic acid (15‐oxo‐ETE), is a product of arachidonic acid (AA) metabolism in the 15‐lipoxygenase‐1 (15‐LOX‐1) pathway. 15‐oxo‐ETE was overproduced in the nasal polyps of patients with nonsteroidal anti‐inflamma…
View article: Circulating Anti-Endothelial Cell Antibodies in Patients with Geographic Atrophy Related to Dry Age-Related Macular Degeneration
Circulating Anti-Endothelial Cell Antibodies in Patients with Geographic Atrophy Related to Dry Age-Related Macular Degeneration Open
Background and Objectives: Age-related macular degeneration (AMD) is one of the leading causes of central vision loss among elderly patients, and its dry form accounts for the majority of cases. Although several causes and mechanisms for t…
View article: Circulating Anti-endothelial Cell Antibodies in Patients with Geographic Atrophy Related to Dry Age-Related Macular Degeneration
Circulating Anti-endothelial Cell Antibodies in Patients with Geographic Atrophy Related to Dry Age-Related Macular Degeneration Open
Background and Objectives: Age-related macular degeneration (AMD) is one of the major causes of central vision loss in the older age group and its dry form accounts for the majority of cases. Although several causes and mechanisms for the …
View article: Serum IL-17 and TNFα as prognostic biomarkers in systemic sclerosis patients: a prospective study
Serum IL-17 and TNFα as prognostic biomarkers in systemic sclerosis patients: a prospective study Open
Recent reports have demonstrated that endothelial injury is critical in the pathogenesis of systemic sclerosis (SSc) and is associated with increased levels of circulating inflammatory biomarkers. This study aims to analyze the serum conce…
View article: Activity of granulomatosis with polyangiitis and its correlation with mTOR phosphoproteomics in neutrophils
Activity of granulomatosis with polyangiitis and its correlation with mTOR phosphoproteomics in neutrophils Open
Introduction Granulomatosis with polyangiitis (GPA) is a small vessel vasculitis with a complex pathomechanism. Organ damage in GPA is also mediated by extracellular trap formation (NETosis). We analyzed the functional status of phosphopro…
View article: Low levels of endogenous anabolic androgenic steroids in females with severe asthma taking corticosteroids
Low levels of endogenous anabolic androgenic steroids in females with severe asthma taking corticosteroids Open
Rationale Patients with severe asthma are dependent upon treatment with high doses of inhaled corticosteroids (ICS) and often also oral corticosteroids (OCS). The extent of endogenous androgenic anabolic steroid (EAAS) suppression in asthm…
View article: Association between clinical features and course of systemic sclerosis and serum interleukin-8, vascular endothelial growth factor, basic fibroblast growth factor, and interferon alpha
Association between clinical features and course of systemic sclerosis and serum interleukin-8, vascular endothelial growth factor, basic fibroblast growth factor, and interferon alpha Open
The SSc group was characterized by higher serum concentrations of bFGF and IFN-α compared to healthy controls. Patients treated with cyclophosphamide or receiving higher systemic steroid doses, thus suffering from a more severe disease typ…
View article: Comprehensive Analysis of Circular RNAs in Endothelial Cells
Comprehensive Analysis of Circular RNAs in Endothelial Cells Open
Non-coding RNAs constitute a heterogeneous group of molecules that lack the ability to encode proteins but retain the potential ability to influence cellular processes through a regulatory mechanism. Of these proteins, microRNAs, long non-…
View article: Peripheral biomarkers for predicting sputum eosinophilia in nonsteroidal anti‐inflammatory drug‐exacerbated respiratory disease
Peripheral biomarkers for predicting sputum eosinophilia in nonsteroidal anti‐inflammatory drug‐exacerbated respiratory disease Open
The data that support the findings of this study are available from the corresponding author upon reasonable request. Data S1 Please note: The publisher is not responsible for the content or functionality of any supporting information supp…
View article: Oropharyngeal Microbiota Clusters in Children with Asthma or Wheeze Associate with Allergy, Blood Transcriptomic Immune Pathways, and Exacerbation Risk
Oropharyngeal Microbiota Clusters in Children with Asthma or Wheeze Associate with Allergy, Blood Transcriptomic Immune Pathways, and Exacerbation Risk Open
Rationale: Children with preschool wheezing or school-age asthma are reported to have airway microbial imbalances. Objectives: To identify clusters in children with asthma or wheezing using oropharyngeal microbiota profiles. Methods: Oroph…
View article: The role of inflammation in anxiety and depression in the European U-BIOPRED asthma cohorts
The role of inflammation in anxiety and depression in the European U-BIOPRED asthma cohorts Open
The current study suggests that severe asthma patients are associated with higher levels of anxiety and depression, and inflammatory responses may underlie this comorbid condition.
View article: The association of STAT4 single nucleotide polymorphisms with thrombotic manifestations in a cohort of patients with autoimmune diseases and antiphospholipid antibodies
The association of STAT4 single nucleotide polymorphisms with thrombotic manifestations in a cohort of patients with autoimmune diseases and antiphospholipid antibodies Open
Objective To assess the association of genetic polymorphisms of signal transducer and activator of transcription ( STAT ) 4 with thrombotic manifestations in patients with autoimmune diseases, including antiphospholipid syndrome (APS). Met…