Marek Weiler
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View article: In Vitro Calcification of Bioprosthetic Heart Valves: Method Validation by Comparative Heart Valve Calcification Testing
In Vitro Calcification of Bioprosthetic Heart Valves: Method Validation by Comparative Heart Valve Calcification Testing Open
Background A major reason for the failure of bioprosthetic heart valves is calcification. Various pretreatment methods are developed to reduce the calcification behavior. The effectiveness of these methods has so far been investigated in e…
Possible Association of Nrf2/ARE and NFκB Response to Osteoblast Function in Spheroid Culture Induced by Low-Intensity Pulsed Ultrasound (LIPUS) Open
This study suggests that LIPUS may have NFκB-downregulating, limited ARE-raising effects in combination with sulforaphane, and elevating osteoblast mineralization three-dimensionally. Thus, LIPUS could be useful for treating fractures in c…
Polymeric Microbubble Shell Engineering: Microporosity as a Key Factor to Enhance Ultrasound Imaging and Drug Delivery Performance Open
Microbubbles (MB) are widely used as contrast agents for ultrasound (US) imaging and US‐enhanced drug delivery. Polymeric MB are highly suitable for these applications because of their acoustic responsiveness, high drug loading capability,…
View article: In vitro calcification of bioprosthetic heart valves: test method validation on prosthetic heart valves
In vitro calcification of bioprosthetic heart valves: test method validation on prosthetic heart valves Open
A major reason for the failure of bioprosthetic heart valves is calcification. Various pretreatment methods are developed to reduce the calcification behavior. The effectiveness of these methods has so far been investigated in expensive an…
CCL2 chemokine inhibition primes the tumor vasculature for improved nanomedicine delivery and efficacy Open
Blood vessel functionality is crucial for efficient tumor-targeted drug delivery. Heterogeneous distribution and perfusion of angiogenic blood vessels contribute to suboptimal accumulation of (nano-) therapeutics in tumors and metastases. …
Predicting localised corrosion and mechanical performance of a PEO surface modified rare earth magnesium alloy for implant use through in-silico modelling Open
In this study, the influence of a plasma electrolytic oxidation (PEO) surface treatment on a medical-grade WE43-based magnesium alloy is examined through an experimental and computational framework that considers the effects of localised c…
View article: Nonspherical ultrasound microbubbles
Nonspherical ultrasound microbubbles Open
Surface tension provides microbubbles (MB) with a perfect spherical shape. Here, we demonstrate that MB can be engineered to be nonspherical, endowing them with unique features for biomedical applications. Anisotropic MB were generated via…
Physiological Mineralization during In Vitro Osteogenesis in a Biomimetic Spheroid Culture Model Open
Bone health-targeting drug development strategies still largely rely on inferior 2D in vitro screenings. We aimed at developing a scaffold-free progenitor cell-based 3D biomineralization model for more physiological high-throughput screeni…
Theranostic Trigger‐Responsive Carbon Monoxide‐Generating Microbubbles Open
Carbon monoxide (CO) is a gaseous signaling molecule that modulates inflammation, cell survival, and recovery after myocardial infarction. However, handling and dosing of CO as a compressed gas are difficult. Here, light‐triggerable and ma…
Shelf-Life Evaluation and Lyophilization of PBCA-Based Polymeric Microbubbles Open
Poly(n-butyl cyanoacrylate) microbubbles (PBCA-MB) are extensively employed for functional and molecular ultrasound (US) imaging, as well as for US-mediated drug delivery. To facilitate the use of PBCA-MB as a commercial platform for biome…
In vivo evaluation of riboflavin receptor targeted fluorescent USPIO in mice with prostate cancer xenografts Open
Riboflavin (Rf) receptors bind and translocate Rf and its phosphorylated forms (e.g. flavin mononucleotide, FMN) into cells where they mediate various cellular metabolic pathways. Previously, we showed that FMN-coated ultrasmall superparam…