Markus Müller
YOU?
Author Swipe
View article: Coherent information as a mixed-state topological order parameter of fermions
Coherent information as a mixed-state topological order parameter of fermions Open
Quantum error correction protects quantum information against decoherence, provided the noise strength remains below a critical threshold. This threshold marks the critical point for the decoding phase transition. Here, we connect this tra…
View article: Quantum Circuit Discovery for Fault-Tolerant Logical State Preparation with Reinforcement Learning
Quantum Circuit Discovery for Fault-Tolerant Logical State Preparation with Reinforcement Learning Open
The realization of large-scale quantum computers requires not only quantum error correction but also fault-tolerant (FT) operations to handle errors that propagate into harmful errors. Recently, flag-based protocols have been introduced th…
View article: Selective Chemical Manipulation of Mannosyl‐ and Galactosyl‐Queuosine in tRNAs of Living Cells
Selective Chemical Manipulation of Mannosyl‐ and Galactosyl‐Queuosine in tRNAs of Living Cells Open
Queuosine is a hypermodified nucleoside found in the anticodon loop of tRNAs decoding the amino acids His, Asn, Tyr, and Asp. In tRNA Tyr , the homoallylic 2‐hydroxyl group of the cyclopentene ring carries an additional β‐galactose, while …
View article: Optimized measurement-free and fault-tolerant quantum error correction for neutral atoms
Optimized measurement-free and fault-tolerant quantum error correction for neutral atoms Open
A major challenge in performing quantum error correction (QEC) is implementing reliable measurements and conditional feed-forward operations. In quantum computing platforms supporting unconditional qubit resets, or a constant supply of fre…
View article: Molecular rotors are loud, highly photostable, NIR/SWIR-active molecular optoacoustic contrast agents
Molecular rotors are loud, highly photostable, NIR/SWIR-active molecular optoacoustic contrast agents Open
Optoacoustic or photoacoustic imaging (PA) combines optical excitation with acoustic readout, for non-invasive in vivo imaging at up to several centimetres' penetration depth, and down to micron resolution. Conceptually, many chromophore t…
View article: Robust Bisulfite‐Free Single‐Molecule Real‐Time Sequencing of Methyldeoxycytidine Based on a Novel hpTet3 Enzyme
Robust Bisulfite‐Free Single‐Molecule Real‐Time Sequencing of Methyldeoxycytidine Based on a Novel hpTet3 Enzyme Open
In addition to the four canonical nucleosides dA, dG, dC and T, genomic DNA contains the additional base 5‐methyldeoxycytidine (mdC). The presence of this methylated cytidine nucleoside in promoter regions or gene bodies significantly affe…
View article: A Phosphotriester‐Masked Dideoxy‐cGAMP Derivative as a Cell‐Permeable STING Agonist
A Phosphotriester‐Masked Dideoxy‐cGAMP Derivative as a Cell‐Permeable STING Agonist Open
2′,3′‐Cyclic GMP‐AMP (cGAMP) is a cyclic dinucleotide second messenger in which guanosine and adenosine are connected by one 3′‐5′ and one 2′‐5′ phosphodiester linkage. It is formed in the cytosol upon detection of pathogenic DNA by the en…
View article: Accurate optimal quantum error correction thresholds from coherent information
Accurate optimal quantum error correction thresholds from coherent information Open
Quantum error correcting (QEC) codes protect quantum information from decoherence as long as error rates fall below critical error thresholds. In general, obtaining thresholds implies simulating the QEC procedure using, in general, subopti…
View article: Partitioning behavior of short DNA fragments in polymer/salt aqueous two‐phase systems
Partitioning behavior of short DNA fragments in polymer/salt aqueous two‐phase systems Open
The development of liquid biopsy as a minimally invasive technique for tumor profiling has created a need for efficient biomarker extraction systems from body fluids. The analysis of circulating cell‐free DNA (cfDNA) is especially promisin…
View article: Ideal efficacy photoswitches for TRPC4/5 channels harness high potency for spatiotemporally-resolved control of TRPC function in live tissues
Ideal efficacy photoswitches for TRPC4/5 channels harness high potency for spatiotemporally-resolved control of TRPC function in live tissues Open
Directly probing the endogenous biological roles of target proteins with high spatial and temporal resolution, as non-invasively and reproducibly as possible, is a shared conceptual goal for research across many fields, as well as for targ…
View article: Merged Molecular Switches Excel as Optoacoustic Dyes: Azobenzene–Cyanines Are Loud and Photostable NIR Imaging Agents
Merged Molecular Switches Excel as Optoacoustic Dyes: Azobenzene–Cyanines Are Loud and Photostable NIR Imaging Agents Open
Optoacoustic (or photoacoustic) imaging promises micron‐resolution noninvasive bioimaging with much deeper penetration (>cm) than fluorescence. However, optoacoustic imaging of enzyme activity would require loud, photostable, NIR‐absorbing…
View article: Efficient Tandem Copper‐Catalyzed Click Synthesis of Multisugar‐Modified Oligonucleotides
Efficient Tandem Copper‐Catalyzed Click Synthesis of Multisugar‐Modified Oligonucleotides Open
Nucleic acids in the form of siRNA, antisense oligonucleotides or mRNA are currently explored as new promising modalities in the pharmaceutical industry. Particularly, the success of mRNA‐vaccines against SARS‐CoV‐2, along with the success…
View article: Synthesis and Structure Elucidation of Glutamyl-Queuosine
Synthesis and Structure Elucidation of Glutamyl-Queuosine Open
Queuosine is one of the most complex hypermodified RNA nucleosides found in the Wobble position of tRNAs. In addition to Queuosine itself, several further modified derivatives are known, where the cyclopentene ring structure is additionall…
View article: Merged molecular switches excel as optoacoustic dyes: azobenzene-cyanines are loud and photostable NIR imaging agents
Merged molecular switches excel as optoacoustic dyes: azobenzene-cyanines are loud and photostable NIR imaging agents Open
Optoacoustic imaging, also known as photoacoustic imaging, promises micron-resolution noninvasive imaging in biology at much deeper penetration (>cm) depths than e.g. fluorescence. However, the loud, photostable, NIR-absorbing molecular co…
View article: Fault-Tolerant Code Switching Protocols for Near-Term Quantum Processors
Fault-Tolerant Code Switching Protocols for Near-Term Quantum Processors Open
Topological color codes are widely acknowledged as promising candidates for fault-tolerant quantum computing. Neither a two-dimensional nor a three-dimensional topology, however, can provide a universal gate set $\{$H, T, CNOT$\}$, with th…
View article: Strategies for practical advantage of fault-tolerant circuit design in noisy trapped-ion quantum computers
Strategies for practical advantage of fault-tolerant circuit design in noisy trapped-ion quantum computers Open
Raw data for figures showing experimental and simulation data
View article: Third‐Generation Sequencing of Epigenetic DNA
Third‐Generation Sequencing of Epigenetic DNA Open
The discovery of epigenetic bases has revolutionised the understanding of disease and development. Among the most studied epigenetic marks are cytosines covalently modified at the 5 position. In order to gain insight into their biological …
View article: Third‐Generation Sequencing of Epigenetic DNA
Third‐Generation Sequencing of Epigenetic DNA Open
The discovery of epigenetic bases has revolutionised the understanding of disease and development. Among the most studied epigenetic marks are cytosines covalently modified at the 5 position. In order to gain insight into their biological …
View article: Click Chemistry Enables Rapid Amplification of Full-Length Reverse Transcripts for Long-Read Third Generation Sequencing
Click Chemistry Enables Rapid Amplification of Full-Length Reverse Transcripts for Long-Read Third Generation Sequencing Open
Here we describe the development of a novel click chemistry-based method for the generation and amplification of full-length cDNA libraries from total RNA, while avoiding the need for problematic template-switching (TS) reactions. Compared…
View article: Suppression of SARS‐CoV‐2 Replication with Stabilized and Click‐Chemistry Modified siRNAs
Suppression of SARS‐CoV‐2 Replication with Stabilized and Click‐Chemistry Modified siRNAs Open
The emergence of more transmissible or aggressive variants of SARS‐CoV‐2 requires the development of antiviral medication that is quickly adjustable to evolving viral escape mutations. Here we report the synthesis of chemically stabilized …
View article: BTDAzo: A Photoswitchable TRPC5 Channel Activator**
BTDAzo: A Photoswitchable TRPC5 Channel Activator** Open
Photoswitchable reagents can be powerful tools for high‐precision biological control. TRPC5 is a Ca 2+ ‐permeable cation channel with distinct tissue‐specific roles, from synaptic function to hormone regulation. Reagents giving spatiotempo…
View article: BTDAzo: A Photoswitchable TRPC5 Channel Activator**
BTDAzo: A Photoswitchable TRPC5 Channel Activator** Open
Photoswitchable reagents can be powerful tools for high‐precision biological control. TRPC5 is a Ca 2+ ‐permeable cation channel with distinct tissue‐specific roles, from synaptic function to hormone regulation. Reagents giving spatiotempo…
View article: Drug screen in iPSC-Neurons identifies nucleoside analogs as inhibitors of (G4C2)n expression in C9orf72 ALS/FTD
Drug screen in iPSC-Neurons identifies nucleoside analogs as inhibitors of (G4C2)n expression in C9orf72 ALS/FTD Open
An intronic (G4C2)n expansion in C9orf72 causes amyotrophic lateral sclerosis and frontotemporal dementia primarily through gain-of-function mechanisms: the accumulation of sense and antisense repeat RNA foci and dipeptide repeat (DPR) pro…
View article: Epigenetic Anti‐Cancer Treatment With a Stabilized Carbocyclic Decitabine Analogue
Epigenetic Anti‐Cancer Treatment With a Stabilized Carbocyclic Decitabine Analogue Open
5‐Aza‐2’‐deoxycytidine (Decitabine, AzadC) is a nucleoside analogue, which is in clinical use to treat patients with myelodysplastic syndrome or acute myeloid leukemia. Its mode of action is unusual because the compound is one of the few d…
View article: BTDAzo - a photoswitchable TRPC5 channel activator
BTDAzo - a photoswitchable TRPC5 channel activator Open
Photoswitchable reagents to modulate protein activity are powerful tools for high-spatiotemporal-precision control over endogenous biological functions. TRPC5 is a Ca2+-permeable cation channel with distinct tissue-specific roles, ranging …
View article: Epigenetic anti-cancer treatment with a stabilized carbocyclic Decitabine analogue
Epigenetic anti-cancer treatment with a stabilized carbocyclic Decitabine analogue Open
5-Aza-2’-deoxycytidine (Decitabine, AzadC) is a nucleoside analogue, which is in clinical use to treat patients with myelodysplastic syndrome or acute myeloid leukemia. Its mode of action is unusual because the compound is one of the few d…
View article: Intragenomic Decarboxylation of 5‐Carboxy‐2′‐deoxycytidine
Intragenomic Decarboxylation of 5‐Carboxy‐2′‐deoxycytidine Open
Cellular DNA is composed of four canonical nucleosides (dA, dC, dG and T), which form two Watson–Crick base pairs. In addition, 5‐methylcytosine (mdC) may be present. The methylation of dC to mdC is known to regulate transcriptional activi…