Maren Pfirrmann
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View article: The Phenotypical and Functional Effect of PGE2 on Human Macrophages
The Phenotypical and Functional Effect of PGE2 on Human Macrophages Open
Prostaglandin E2 (PGE2) is one important immunosuppressive factor within the tumor microenvironment (TME). Signaling through E‐prostanoid receptor type 2 (EP2) and EP4, PGE2 promotes suppressive immune cell phenotypes and impairs antitumor…
View article: Potential of Heparan Sulphate Mimetics Integrated Into Collagen Scaffolds for Enhanced Skin Wound Healing
Potential of Heparan Sulphate Mimetics Integrated Into Collagen Scaffolds for Enhanced Skin Wound Healing Open
Optimal healing of full‐thickness skin wounds remains a clinical challenge. While current skin substitutes aid burn wound management, there is still a need to effectively minimize scarring. Therefore, we developed type I collagen scaffolds…
View article: Biomolecule Conjugation Strategy for HAGM Cryogels to Create 3D Immune Niches that Induce Multifunctional T Cells
Biomolecule Conjugation Strategy for HAGM Cryogels to Create 3D Immune Niches that Induce Multifunctional T Cells Open
Recently, biomaterials have emerged as tools to activate and expand T cells in the context of cancer immunotherapy. Most designs accommodate T cells with a stimulatory two-dimensional (2D) environment. In contrast, three-dimensional (3D) s…
View article: Effect of Hyaluronan in Collagen Biomaterials on Human Macrophages and Fibroblasts In Vitro
Effect of Hyaluronan in Collagen Biomaterials on Human Macrophages and Fibroblasts In Vitro Open
In adults, scars are formed after deep skin wound injuries like burns. However, the fetal microenvironment allows for scarless skin regeneration. One component that is abundantly present in the fetal extracellular matrix is hyaluronan (HA)…
View article: A surgically optimized intraoperative poly(I:C)-releasing hydrogel prevents cancer recurrence
A surgically optimized intraoperative poly(I:C)-releasing hydrogel prevents cancer recurrence Open
Recurrences frequently occur following surgical removal of primary tumors. In many cancers, adjuvant therapies have limited efficacy. Surgery provides access to the tumor microenvironment, creating an opportunity for local therapy, in part…
View article: Report on the <scp>FEBS‐IUBMB‐ENABLE</scp> 1st International Molecular Biosciences <scp>PhD</scp> and Postdoc Conference
Report on the <span>FEBS‐IUBMB‐ENABLE</span> 1st International Molecular Biosciences <span>PhD</span> and Postdoc Conference Open
The FEBS‐IUBMB‐ENABLE 1st International Molecular Biosciences PhD and Postdoc Conference was held in Seville, Spain, from the 16–18th of November 2022. Nearly 300 participants from all over the globe were welcomed by the host institution, …
View article: S859 GENOME‐WIDE CRISPR‐CAS9 SCREEN REVEALS SYNTHETIC LETHALITY OF WNT PATHWAY ACTIVATION AND ASPARAGINASE IN DRUG‐RESISTANT ACUTE LEUKEMIAS
S859 GENOME‐WIDE CRISPR‐CAS9 SCREEN REVEALS SYNTHETIC LETHALITY OF WNT PATHWAY ACTIVATION AND ASPARAGINASE IN DRUG‐RESISTANT ACUTE LEUKEMIAS Open
Background: Intensification of asparaginase‐based therapy has improved outcomes for several subtypes of acute leukemia, but the development of treatment resistance has a poor prognosis, and effective therapeutic options are lacking for man…
View article: Synthetic Lethality of Wnt Pathway Activation and Asparaginase in Drug-Resistant Acute Leukemias
Synthetic Lethality of Wnt Pathway Activation and Asparaginase in Drug-Resistant Acute Leukemias Open
View article: PRC2 loss induces chemoresistance by repressing apoptosis in T cell acute lymphoblastic leukemia
PRC2 loss induces chemoresistance by repressing apoptosis in T cell acute lymphoblastic leukemia Open
The tendency of mitochondria to undergo or resist BCL2-controlled apoptosis (so-called mitochondrial priming) is a powerful predictor of response to cytotoxic chemotherapy. Fully exploiting this finding will require unraveling the molecula…
View article: Synthetic Lethality of Wnt Pathway Activation and Asparaginase in Drug-Resistant Acute Leukemias
Synthetic Lethality of Wnt Pathway Activation and Asparaginase in Drug-Resistant Acute Leukemias Open
SUMMARY Resistance to asparaginase, an antileukemic enzyme that depletes asparagine, is a common clinical problem. Using a genome-wide CRISPR/Cas9 screen, we found a synthetic lethal interaction between Wnt pathway activation and asparagin…