Pamela Leong
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View article: Investigating the impact of oral health on pregnancy and offspring outcomes: protocol for the Lifetime Impact of ORal heAlth (LIORA) cohort study
Investigating the impact of oral health on pregnancy and offspring outcomes: protocol for the Lifetime Impact of ORal heAlth (LIORA) cohort study Open
Introduction Oral health is a fundamental component of well-being, and is closely associated with overall health and quality of life. Oral health may also affect the next generation. The children of mothers with poor oral health are likely…
View article: Differential network analysis of oral microbiome metatranscriptomes identifies community scale metabolic restructuring in dental caries
Differential network analysis of oral microbiome metatranscriptomes identifies community scale metabolic restructuring in dental caries Open
Dental caries is a microbial disease and the most common chronic health condition, affecting nearly 3.5 billion people worldwide. In this study, we used a multiomics approach to characterize the supragingival plaque microbiome of 91 Austra…
View article: Cohort Profile: The Chongqing Longitudinal Twin Study (LoTiS)
Cohort Profile: The Chongqing Longitudinal Twin Study (LoTiS) Open
We aim to define the relative contribution of genetic factors and the environment to early onset illness of infancyhealth from and to birthidentify and to identify specific biomarkers and critical time points from pregnancy onwards for e…
View article: Epigenetic Influences on Neurodevelopment at 11 Years of Age: Protocol for the Longitudinal Peri/Postnatal Epigenetic Twins Study at 11 Years of Age (PETS@11)
Epigenetic Influences on Neurodevelopment at 11 Years of Age: Protocol for the Longitudinal Peri/Postnatal Epigenetic Twins Study at 11 Years of Age (PETS@11) Open
Neurodevelopment is sensitive to genetic and pre/postnatal environmental influences. These effects are likely mediated by epigenetic factors, yet current knowledge is limited. Longitudinal twin studies can delineate the link between geneti…
View article: THG volume 22 issue 6 Cover and Front matter
THG volume 22 issue 6 Cover and Front matter Open
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View article: Collecting biomarkers and biological samples in Australian primary schools: Insights from the field
Collecting biomarkers and biological samples in Australian primary schools: Insights from the field Open
There are increasing efforts to incorporate biology into our study of the social determinants of health. While there is increasing utilisation of biosocial methods in child health and health disparities research, protocols for collecting b…
View article: Genetic and Early-Life Environmental Influences on Dental Caries Risk: A Twin Study
Genetic and Early-Life Environmental Influences on Dental Caries Risk: A Twin Study Open
OBJECTIVES: To explore the relative contributions of genetic and environmental influences on dental caries risk and to investigate fetal and developmental risk factors for dental caries. METHODS: We recruited children from 250 twin pregnan…
View article: Supragingival Plaque Microbiome Ecology and Functional Potential in the Context of Health and Disease
Supragingival Plaque Microbiome Ecology and Functional Potential in the Context of Health and Disease Open
Oral health has substantial economic importance, with over $100 billion spent on dental care in the United States annually. The microbiome plays a critical role in oral health, yet remains poorly classified. To address the question of how …
View article: Etiology of Hypomineralized Second Primary Molars: A Prospective Twin Study
Etiology of Hypomineralized Second Primary Molars: A Prospective Twin Study Open
The etiology of hypomineralized second primary molars (HSPM) is unclear, but genetic and environmental factors have been proposed. The aim of this study was to investigate the relative contribution of genes and environment to the etiology …
View article: Supragingival plaque microbiome ecology and functional potential in the context of health and disease
Supragingival plaque microbiome ecology and functional potential in the context of health and disease Open
To address the question of how microbial diversity and function in the oral cavities of children relates to caries diagnosis, we surveyed the supragingival plaque biofilm microbiome in 44 juvenile twin pairs. Using shotgun sequencing, we c…
View article: Protocol for a longitudinal twin birth cohort study to unravel the complex interplay between early-life environmental and genetic risk factors in health and disease: the Chongqing Longitudinal Twin Study (LoTiS)
Protocol for a longitudinal twin birth cohort study to unravel the complex interplay between early-life environmental and genetic risk factors in health and disease: the Chongqing Longitudinal Twin Study (LoTiS) Open
Introduction Non-communicable diseases (NCD) now represent the major burden of adverse health in most countries. It is clear that much of the risk of such conditions begins very early in life, potentially in utero. Given their complex aeti…
View article: Community-based population-level interventions for promoting child oral health
Community-based population-level interventions for promoting child oral health Open
This review provides evidence of low certainty suggesting that community-based oral health promotion interventions that combine oral health education with supervised toothbrushing or professional preventive oral care can reduce dental cari…