Margaret Johnson
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View article: Lung Transplant Outcomes Following Treatment of Pre‐Transplant MAC Pulmonary Infection
Lung Transplant Outcomes Following Treatment of Pre‐Transplant MAC Pulmonary Infection Open
Background Treating Mycobacterium avium complex (MAC) infection pre‐lung transplant (LT) can be challenging to treat, given prolonged therapy and side effects. The impact of pre‐transplant MAC treatment on recurrence and outcomes post‐LT r…
View article: Patient Characteristics and Reasons for Switching to Bictegravir/Emtricitabine/Tenofovir Alafenamide: A Retrospective Cohort From a Large Urban HIV Clinic
Patient Characteristics and Reasons for Switching to Bictegravir/Emtricitabine/Tenofovir Alafenamide: A Retrospective Cohort From a Large Urban HIV Clinic Open
View article: A qualitative study of Yorùbá culture and the utilisation of modern dental services for oral health
A qualitative study of Yorùbá culture and the utilisation of modern dental services for oral health Open
The interrogation of Yorùbá orature suggests oral aesthetics have spiritual connotations for life and wellness, which makes oral self-care practices a routine part of the daily lives of the community. Modern dentistry programmes and practi…
View article: The Role of Healthy Relationships and Social Connectivity in the Mediterranean Lifestyle: An Umbrella Review of Reviews
The Role of Healthy Relationships and Social Connectivity in the Mediterranean Lifestyle: An Umbrella Review of Reviews Open
Introduction Social connectivity and interpersonal relationships underpin all aspects of lifestyle. As part of a broader research collaboration on the Mediterranean lifestyle, we examined existing evidence on social connectivity patterns i…
View article: Severe acute respiratory syndrome coronavirus-2 antibody prevalence in adults with HIV
Severe acute respiratory syndrome coronavirus-2 antibody prevalence in adults with HIV Open
Objectives: To measure severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) antibody seroprevalence within a cohort of adults with HIV and correlate demographics with response rates to SARS CoV-2 vaccination. Design: Initial vaccin…
View article: A Bayesian hierarchical framework for fusion of remote sensing data: An example with solar-induced fluorescence
A Bayesian hierarchical framework for fusion of remote sensing data: An example with solar-induced fluorescence Open
Solar-induced chlorophyll fluorescence (SIF) has emerged as an effective indicator of vegetation productivity and plant health. The global quantification of SIF and its associated uncertainties yields many important capabilities, including…
View article: Caregiver burden in lung transplantation: A review
Caregiver burden in lung transplantation: A review Open
View article: National Survey of Sexual Attitudes and Lifestyles, 2010-2012: Secure Access
National Survey of Sexual Attitudes and Lifestyles, 2010-2012: Secure Access Open
The British National Surveys of Sexual Attitudes and Lifestyles, or Natsal, are among the largest and most detailed studies of sexual behaviour in the world. Three Natsal surveys have taken place to date: Natsal-1 in 1990-1991 (avai…
View article: Major Depressive Disorder and Driving Behavior Among Older Adults
Major Depressive Disorder and Driving Behavior Among Older Adults Open
Importance Depression and antidepressant use are independently associated with crash risk among older drivers. However, it is unclear what factors impact daily driving that increase safety risk for drivers with depression. Objective To exa…
View article: Exploring the cascade of mental healthcare among people with <scp>HIV</scp> experiencing depressive symptoms in the UK and Ireland: The <scp>POPPY</scp> study
Exploring the cascade of mental healthcare among people with <span>HIV</span> experiencing depressive symptoms in the UK and Ireland: The <span>POPPY</span> study Open
Introduction Depressive symptoms are highly prevalent among people with HIV, which can negatively impact HIV‐related outcomes. We explore the cascade of mental healthcare for people with HIV experiencing depressive symptoms. Methods People…
View article: Unlocking the potential of digital therapeutics: The need for consistent and granular inclusion in drug compendia for managed care
Unlocking the potential of digital therapeutics: The need for consistent and granular inclusion in drug compendia for managed care Open
The field of digital therapeutics (DTx), software programs that prevent, manage, and treat medical conditions, continues to grow. DTx offers new treatment options and has the potential to close gaps in care caused by unmet patient needs, p…
View article: Footprints of innate immune activity during HIV-1 reservoir cell evolution in early-treated infection
Footprints of innate immune activity during HIV-1 reservoir cell evolution in early-treated infection Open
Antiretroviral treatment (ART) initiation during the early stages of HIV-1 infection is associated with a higher probability of maintaining drug-free viral control during subsequent treatment interruptions, for reasons that remain unclear.…
View article: Estimating the household secondary attack rate and serial interval of COVID-19 using social media
Estimating the household secondary attack rate and serial interval of COVID-19 using social media Open
View article: MAVMET trial: maraviroc and/or metformin for metabolic dysfunction associated fatty liver disease in adults with suppressed HIV
MAVMET trial: maraviroc and/or metformin for metabolic dysfunction associated fatty liver disease in adults with suppressed HIV Open
Objective: Metabolic dysfunction associated fatty liver disease (MAFLD) is over-represented in people with HIV (PWH). Maraviroc (MVC) and/or metformin (MET) may reduce MAFLD by influencing inflammatory pathways and fatty acid metabolism. D…
View article: Skilled Nursing and Inpatient Rehabilitation Facility Use by Medicare Fee-for-Service Beneficiaries Discharged Home After a Stroke: Findings From the COMPASS Trial
Skilled Nursing and Inpatient Rehabilitation Facility Use by Medicare Fee-for-Service Beneficiaries Discharged Home After a Stroke: Findings From the COMPASS Trial Open
Objectives: To examine the effect of a comprehensive transitional care model on the use of skilled nursing facility (SNF) and inpatient rehabilitation facility (IRF) care in the 12 months after acute care discharge home following stroke; a…
View article: Improving sexual health through partner notification: the LUSTRUM mixed-methods research Programme including RCT of accelerated partner therapy
Improving sexual health through partner notification: the LUSTRUM mixed-methods research Programme including RCT of accelerated partner therapy Open
Background Sexually transmitted infections disproportionately affect young people and men who have sex with men. Chlamydia is Britain’s most common sexually transmitted infection. Partner notification is a key intervention to reduce transm…
View article: Long-term efficacy and safety of a treatment strategy for HIV infection using protease inhibitor monotherapy: 8-year routine clinical care follow-up from a randomised, controlled, open-label pragmatic trial (PIVOT)
Long-term efficacy and safety of a treatment strategy for HIV infection using protease inhibitor monotherapy: 8-year routine clinical care follow-up from a randomised, controlled, open-label pragmatic trial (PIVOT) Open
View article: National Survey of Sexual Attitudes and Lifestyles, 2010-2012: Biological Data: Secure Access
National Survey of Sexual Attitudes and Lifestyles, 2010-2012: Biological Data: Secure Access Open
The British National Surveys of Sexual Attitudes and Lifestyles, or Natsal, are among the largest and most detailed studies of sexual behaviour in the world. Three Natsal surveys have taken place to date: Natsal-1 in 1990-1991 (avai…
View article: A rapid systematic review of breakthrough pain definitions and descriptions
A rapid systematic review of breakthrough pain definitions and descriptions Open
Background Breakthrough pain is common in life-limiting conditions and at end-of-life. Despite over 30 years of study, there is little consensus regarding the definition and characteristics of breakthrough pain. Objective This study aims t…
View article: Issue Information
Issue Information Open
View article: Association of age at antiretroviral therapy initiation with CD4+ : CD8+ ratio recovery among virally suppressed people with HIV
Association of age at antiretroviral therapy initiation with CD4+ : CD8+ ratio recovery among virally suppressed people with HIV Open
Objective: To investigate the association of age at antiretroviral therapy (ART) initiation with CD4 + : CD8 + T-cell ratio in virally suppressed people with HIV on long-term ART, and to characterize potential CD4 + : CD8 + ratio recovery …
View article: Eyeglasses and risk of COVID-19 transmission—analysis of the Virus Watch Community Cohort study
Eyeglasses and risk of COVID-19 transmission—analysis of the Virus Watch Community Cohort study Open
View article: The changing contributory role to infections of work, public transport, shopping, hospitality and leisure activities throughout the SARS-CoV-2 pandemic in England and Wales
The changing contributory role to infections of work, public transport, shopping, hospitality and leisure activities throughout the SARS-CoV-2 pandemic in England and Wales Open
Background Understanding how non-household activities contributed to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections under different levels of national health restrictions is vital. Methods Among adult Virus Watch p…
View article: 58 Cognitive and Brain Reserve Predict a Decline in Adverse Driving Behaviors Among Cognitively Normal Older Adults
58 Cognitive and Brain Reserve Predict a Decline in Adverse Driving Behaviors Among Cognitively Normal Older Adults Open
Objective: Daily driving behavior is ultimate measure of cognitive functioning requiring multiple cognitive domains working synergistically to complete this complex instrumental activity of daily living. As the world’s population continues…
View article: Medication and Road Test Performance Among Cognitively Healthy Older Adults
Medication and Road Test Performance Among Cognitively Healthy Older Adults Open
Importance Older adults are increasingly prescribed medications that have adverse effects. Prior studies have found a higher risk of motor vehicle crashes to be associated with certain medication use. Objective To determine whether specifi…
View article: Deprivation, essential and non-essential activities and SARS-CoV-2 infection following the lifting of national public health restrictions in England and Wales
Deprivation, essential and non-essential activities and SARS-CoV-2 infection following the lifting of national public health restrictions in England and Wales Open
Background: Individuals living in deprived areas in England and Wales undertook essential activities more frequently and experienced higher rates of SARS-CoV-2 infection than less deprived communities during periods of restrictions aimed a…
View article: Anticholinergic medications associated with falls and frailty in people with <scp>HIV</scp>
Anticholinergic medications associated with falls and frailty in people with <span>HIV</span> Open
Background Anticholinergic medications (ACMs) are associated with poorer age‐related outcomes, including falls and frailty. We investigate associations between ACM use and recurrent falls and frailty among older (aged ≥50 years) people wit…
View article: Differential impacts of road diets on driving behavior among older adults with and without preclinical Alzheimer’s pathology
Differential impacts of road diets on driving behavior among older adults with and without preclinical Alzheimer’s pathology Open
View article: Long-term effects on subclinical cardiovascular disease of switching from boosted protease inhibitors to dolutegravir
Long-term effects on subclinical cardiovascular disease of switching from boosted protease inhibitors to dolutegravir Open
Background In the NEAT022 trial, switching from boosted PIs (PI/r) to dolutegravir in people with HIV (PWH) with high cardiovascular risk decreased plasma lipids, soluble CD14 and adiponectin, and showed consistent favourable, although non…
View article: Neuropsychiatric Symptoms and Alzheimer Disease Biomarkers Independently Predict Progression to Incident Cognitive Impairment
Neuropsychiatric Symptoms and Alzheimer Disease Biomarkers Independently Predict Progression to Incident Cognitive Impairment Open