Explanipedia

Public and Healthcare Professional Attitudes Towards Risk‐Stratified Bowel Screening: A Qualitative Study Using an Info‐Comic Book Open

Horacio A. Miles, Una Macleod, David Weller, Joanne‐Marie Cairns · 2025

Background Screening for bowel cancer (colorectal cancer, CRC) is well established in many high‐income countries. There has been considerable interest in moving towards risk‐based bowel screening to increase the efficiency and effectivenes…

Internet and telephone intervention to support patients discontinuing long-term antidepressants in primary care: the REDUCE research programme including RCT Open

Tony Kendrick, Beth Stuart, Hannah Bowers, Mahboobeh Haji Sadeghi, Page Hl , et al. · 2025

Background There is significant concern about increasing long-term antidepressant use in Western countries, much of which is not evidence-based. Median duration of treatment is more than 2 years in the United Kingdom, and more than 10% of …

Are there inequalities in ovarian cancer diagnosis and treatment in England? A population-based study Open

Benjamin Pickwell‐Smith, Lewis W. Paton, Ireneous N Soyiri, Michael Lind, Una Macleod · 2025

In this large cohort of patients with ovarian cancer in England, we demonstrated that patients from more deprived areas are less likely to receive surgery or chemotherapy and wait longer to commence treatment. Further research is needed to…

GP referral to rapid diagnostic centres for non-specific cancer symptoms: a qualitative study Open

Caroline White, Spencer Robinson, Una Macleod, Charlotte Kelly · 2025

Background Diagnosing cancer can be challenging, especially when patients present to GPs with serious, but non-specific symptoms. Rapid diagnostic centres (RDCs) have been introduced in England as diagnostic pathways for patients with non-…

Internet and Telephone Support for Discontinuing Long-Term Antidepressants Open

Tony Kendrick, Beth Stuart, Hannah Bowers, Mahboobeh Haji Sadeghi, Page Hl , et al. · 2024

Importance There is significant concern regarding increasing long-term antidepressant treatment for depression beyond an evidence-based duration. Objective To determine whether adding internet and telephone support to a family practitioner…

Are There Inequalities in Ovarian Cancer Diagnosis and Treatment in England? A Population-Based Study Open

Benjamin Pickwell‐Smith, Lewis W. Paton, Ireneous N Soyiri, Michael Lind, Una Macleod · 2024

Where are the inequalities in colorectal cancer care in a country with universal healthcare? A systematic review and narrative synthesis Open

Benjamin Pickwell‐Smith, Katie Spencer, Mahboobeh Haji Sadeghi, Sarah Greenley, Michael Lind , et al. · 2024

Objective Patients diagnosed with colorectal cancer living in more deprived areas experience worse survival than those in more affluent areas. Those living in more deprived areas face barriers to accessing timely, quality healthcare. These…

Where are the inequalities in ovarian cancer care in a country with universal healthcare? A systematic review and narrative synthesis Open

Benjamin Pickwell‐Smith, Sarah Greenley, Michael Lind, Una Macleod · 2023

Ovarian cancer treatments differed between socioeconomic groups despite the availability of universal healthcare. Further research is needed to understand why, though suggested reasons include patient choice, health literacy, and financial…

Challenges and opportunities for cervical screening in women over the age of 50 years: a qualitative study Open

Alison Bravington, Hong Chen, Judith Dyson, Lesley Jones, Christopher Dalgliesh , et al. · 2022

Background Cervical cancer is a preventable disease. Cases in women age >50 years are predicted to rise by 60% in the next two decades, yet this group are less likely to attend for screening than younger women. Aim To seek novel solutions …

Translating qualitative data into intervention content using the Theoretical Domains Framework and stakeholder co-design: a worked example from a study of cervical screening attendance in older women Open

Alison Bravington, Hong Chen, Judith Dyson, Lesley Jones, Christopher Dalgliesh , et al. · 2022

A qualitative exploration of women's perspectives and acceptability of including new cancer awareness information in all‐clear breast or cervical screening results Open

Olufikayo Bamidele, Trish Green, Sara Tookey, Julie Walabyeki, Una Macleod · 2022

While women perceived this approach as acceptable, it is pertinent to note the potential of the new cancer information to stimulate anxiety and potentially widen inequalities by excluding non-attenders at screening programmes. Specific com…

Geographical distance and reduced access to palliative radiotherapy: systematic review and meta-analysis Open

Chandini Parsan Chand, Sarah Greenley, Una Macleod, Michael Lind, Rachel Barton , et al. · 2022

Background Palliative radiotherapy (PRT) is an effective way of reducing symptoms caused by advanced incurable cancer. Several studies have investigated factors that contribute to inequalities in access to PRT; distance to a radiotherapy c…

Translating Qualitative Data into Intervention Content Using the Theoretical Domains Framework and Stakeholder Co-Design: A Worked Example from a Study of Cervical Screening Attendance in Older Women Open

Alison Bravington, Hong Chen, Judith Dyson, Lesley Jones, Christopher Dalgleish , et al. · 2021

Background: Previous screening interventions have demonstrated a series of features related to social determinants which have increased uptake in targeted populations, including the assessment of health beliefs and barriers to screening at…

The PEOPLE-HULL Study: improving help-seeking for lung symptoms in Hull Open

Liz Mitchell, Una Macleod, Julie Walabyeki · 2021

A cluster randomised trial of a Needs Assessment Tool for adult Cancer patients and their carers (NAT-C) in primary care: A feasibility study Open

Joseph Clark, Elvis Amoakwa, Alexandra Wright‐Hughes, John Blenkinsopp, David C. Currow , et al. · 2021

Background People with cancer often have unidentified symptoms and social care needs. The Needs Assessment Tool-Cancer (NAT-C) is a validated, structured method of assessing patient/carer concerns and prompting action, to address unmet nee…

Yorkshire Lung Screening Trial (YLST): protocol for a randomised controlled trial to evaluate invitation to community-based low-dose CT screening for lung cancer versus usual care in a targeted population at risk Open

Philip Crosbie, Rhian Gabe, Irene Simmonds, Martyn Kennedy, Suzanne Rogerson , et al. · 2020

Introduction Lung cancer is the world’s leading cause of cancer death. Low-dose computed tomography (LDCT) screening reduced lung cancer mortality by 20% in the US National Lung Screening Trial. Here, we present the Yorkshire Lung Screenin…

REDUCE (Reviewing long-term antidepressant use by careful monitoring in everyday practice) internet and telephone support to people coming off long-term antidepressants: protocol for a randomised controlled trial Open

Tony Kendrick, Adam W A Geraghty, Hannah Bowers, Beth Stuart, Geraldine Leydon , et al. · 2020

Background Around one in ten adults take antidepressants for depression in England, and their long-term use is increasing. Some need them to prevent relapse, but 30–50% could possibly stop them without relapsing and avoid adverse effects a…

63 Systematic review of prognostic variables associated with mortality in adult patients with heart failure Open

Sophie Hancock, Anna Oriani, Miriam J. Johnson, Una Macleod, Amy Gadoud · 2020

Background Heart failure is a serious life limiting condition and patients can have a high symptom burden, reduced quality of life and increased unscheduled hospital admissions. Despite guidance advocating a palliative care approach in adv…

‘Unpacking’ pathways to lymphoma and myeloma diagnosis: Do experiences align with the Model of Pathways to Treatment? Findings from a UK qualitative study with patients and relatives Open

Debra Howell, Ruth I. Hart, Alexandra Smith, Una Macleod, Russell Patmore , et al. · 2020

Objectives To explore alignment of experiences before lymphoma and myeloma diagnosis with the appraisal, help seeking and diagnostic intervals in the Model of Pathways to Treatment (MPT). Design A qualitative study using in-depth semistruc…

Non-attendance at urgent referral appointments for suspected cancer: a qualitative study to gain understanding from patients and GPs Open

Laura Jefferson, Karl Atkin, Rebecca Sheridan, Steven Oliver, Una Macleod , et al. · 2019

Background The 2-week-wait urgent referral policy in the UK has sought to improve cancer outcomes by accelerating diagnosis and treatment. However, around 5–7% of symptomatic referred patients cancel or do not attend their hospital appoint…

Perceived colorectal cancer candidacy and the role of candidacy in colorectal cancer screening Open

Annemieke Bikker, Sara Macdonald, Kathryn A. Robb, Ellie Conway, Susan Browne , et al. · 2019

Screening is a well-established tool to advance earlier cancer diagnosis. We used Davison’s concept of ‘candidacy’ to explore how individuals draw on collectively constructed images of ‘typical’ colorectal cancer (CRC) sufferers, or ‘candi…

Patient non-attendance at urgent referral appointments for suspected cancer and its links to cancer diagnosis and one year mortality: A cohort study of patients referred on the Two Week Wait pathway Open

Rebecca Sheridan, Steven Oliver, Geoff Hall, Victoria Allgar, P Melling , et al. · 2019

Non-attendance at urgent referral appointments for suspected cancer involves a minority of patients but happens in predictable groups. Cancer diagnosis was less likely in non-attending patients but these patients had worse early mortality …

An integrated understanding of the complex drivers of emergency presentations and admissions in cancer patients: Qualitative modelling of secondary-care health professionals’ experiences and views Open

Hong Chen, Julie Walabyeki, Miriam J. Johnson, Elaine Boland, Julie Seymour , et al. · 2019

The number of cancer-related emergency presentations and admissions has been steadily increasing in the UK. Drivers of this phenomenon are complex, multifactorial and interlinked. The main objective of this study was to understand the comp…

Facilitated group work for people with long-term conditions: a systematic review of benefits from studies of group-work interventions Open

Margaret Jackson, Daniel Jones, Judith Dyson, Una Macleod · 2019

Background About 15.4 million people in the UK live with a long-term condition. Of the health and social care spend, 70% is invested in caring for this population. Evidence suggests that group-work interventions offer patient support, impr…

146 A cluster randomised feasibility trial (cRCT) to test the routine use of the needs assessment tool: cancer (NAT:C) in primary care to reduce unmet patient and carer needs and determine the feasibility of a definitive trial Open

Miriam J. Johnson, Elvis Amoakwa, Victoria Allgar, John Blenkinsopp, David C. Currow , et al. · 2019

Background People with cancer commonly have distressing symptoms and unidentified palliative care needs. The Needs Assessment Tool:Cancer (NAT:-C) is a validated tool to improve needs-based access to palliative care. Aims To assess the fea…

Lung cancer symptom appraisal among people with chronic obstructive pulmonary disease: A qualitative interview study Open

Yvonne Cunningham, Sally Wyke, Kevin G. Blyth, Douglas Rigg, Sara Macdonald , et al. · 2019

Objective The incidence of lung cancer is four times higher in people with chronic obstructive pulmonary disease (COPD) compared with the general population. Promotion of a shorter time from symptom onset to presentation is one potential s…

Disease-related factors affecting timely lymphoma diagnosis: a qualitative study exploring patient experiences Open

Debra Howell, Ruth I. Hart, Alexandra Smith, Una Macleod, Russell Patmore , et al. · 2019

Background Expediting cancer diagnosis is widely perceived as one way to improve patient outcomes. Evidence indicates that lymphoma diagnosis is often delayed, yet understanding of issues influencing this is incomplete. Aim To explore pati…

Time intervals from first symptom to diagnosis for head and neck cancers: An analysis of linked patient reports and medical records from the UK Open

Victoria Allgar, Steven Oliver, Hong Chen, Osaretin Oviasu, Miriam J. Johnson , et al. · 2019

These data improve understanding of the intervals from first symptom recognition to HNC diagnosis and provide preliminary evidence to identify targets to reduce overall time to diagnosis.

Making sense of bodily sensations: Do shared cancer narratives influence symptom appraisal? Open

Sara Macdonald, Elaine Conway, Annemieke Bikker, Susan Browne, Kathryn A. Robb , et al. · 2019

Identifying potentially inappropriate prescribing in older people with dementia: a systematic review Open

Deborah Hukins, Una Macleod, Jason W Boland · 2019

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