Margaret Soucheray
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View article: <scp>ATG7</scp>(2) Interacts With Metabolic Proteins and Regulates Central Energy Metabolism
<span>ATG7</span>(2) Interacts With Metabolic Proteins and Regulates Central Energy Metabolism Open
Macroautophagy/autophagy is an essential catabolic process that targets a wide variety of cellular components including proteins, organelles, and pathogens. ATG7, a protein involved in the autophagy process, plays a crucial role in maintai…
View article: CRISPR-Cas9 screen of E3 ubiquitin ligases identifies TRAF2 and UHRF1 as regulators of HIV latency in primary human T cells
CRISPR-Cas9 screen of E3 ubiquitin ligases identifies TRAF2 and UHRF1 as regulators of HIV latency in primary human T cells Open
During HIV infection of CD4+ T cells, ubiquitin pathways are essential to viral replication and host innate immune response; however, the role of specific E3 ubiquitin ligases is not well understood. Proteomics analyses identified 116 sing…
View article: Proteomic and genetic analyses of influenza A viruses identify pan-viral host targets
Proteomic and genetic analyses of influenza A viruses identify pan-viral host targets Open
View article: SARS-CoV-2 variants evolve convergent strategies to remodel the host response
SARS-CoV-2 variants evolve convergent strategies to remodel the host response Open
View article: Impact of SARS-CoV-2 ORF6 and its variant polymorphisms on host responses and viral pathogenesis
Impact of SARS-CoV-2 ORF6 and its variant polymorphisms on host responses and viral pathogenesis Open
To assess the role of ORF6, and its recently emerged variant polymorphisms, on the host response to SARS-CoV-2 during infection using ORF6 mutant recombinant viruses.
View article: Supplementary Methods from Activation of the PD-1 Pathway Contributes to Immune Escape in EGFR-Driven Lung Tumors
Supplementary Methods from Activation of the PD-1 Pathway Contributes to Immune Escape in EGFR-Driven Lung Tumors Open
- PDF file 306K, MRI tumor volume quantification, lists for all the antibodies used in the experiments, gating method for Flow cytometry analysis, and supplementary references
View article: Supplementary Methods from Activation of the PD-1 Pathway Contributes to Immune Escape in EGFR-Driven Lung Tumors
Supplementary Methods from Activation of the PD-1 Pathway Contributes to Immune Escape in EGFR-Driven Lung Tumors Open
- PDF file 306K, MRI tumor volume quantification, lists for all the antibodies used in the experiments, gating method for Flow cytometry analysis, and supplementary references
View article: Supplementary Table 1 from Activation of the PD-1 Pathway Contributes to Immune Escape in EGFR-Driven Lung Tumors
Supplementary Table 1 from Activation of the PD-1 Pathway Contributes to Immune Escape in EGFR-Driven Lung Tumors Open
- PDF file 57K, Supplementary table and legend. Evaluation of the PD-L1 expression in tumor samples carrying EGFR mutations
View article: Supplementary Table 1 from Activation of the PD-1 Pathway Contributes to Immune Escape in EGFR-Driven Lung Tumors
Supplementary Table 1 from Activation of the PD-1 Pathway Contributes to Immune Escape in EGFR-Driven Lung Tumors Open
- PDF file 57K, Supplementary table and legend. Evaluation of the PD-L1 expression in tumor samples carrying EGFR mutations
View article: Data from Activation of the PD-1 Pathway Contributes to Immune Escape in EGFR-Driven Lung Tumors
Data from Activation of the PD-1 Pathway Contributes to Immune Escape in EGFR-Driven Lung Tumors Open
The success in lung cancer therapy with programmed death (PD)-1 blockade suggests that immune escape mechanisms contribute to lung tumor pathogenesis. We identified a correlation between EGF receptor (EGFR) pathway activation and a signatu…
View article: Supplementary Figures from Activation of the PD-1 Pathway Contributes to Immune Escape in EGFR-Driven Lung Tumors
Supplementary Figures from Activation of the PD-1 Pathway Contributes to Immune Escape in EGFR-Driven Lung Tumors Open
- PDF file 2020K, Supplementary figures 1-11. For the mouse experiments tumor bearing lungs were classified as mildly sick and severely sick based on the tumor burden as determined by right lung lobe weights. Oncogene induced immunosuppres…
View article: Data from Activation of the PD-1 Pathway Contributes to Immune Escape in EGFR-Driven Lung Tumors
Data from Activation of the PD-1 Pathway Contributes to Immune Escape in EGFR-Driven Lung Tumors Open
The success in lung cancer therapy with programmed death (PD)-1 blockade suggests that immune escape mechanisms contribute to lung tumor pathogenesis. We identified a correlation between EGF receptor (EGFR) pathway activation and a signatu…
View article: Supplementary Figures from Activation of the PD-1 Pathway Contributes to Immune Escape in EGFR-Driven Lung Tumors
Supplementary Figures from Activation of the PD-1 Pathway Contributes to Immune Escape in EGFR-Driven Lung Tumors Open
- PDF file 2020K, Supplementary figures 1-11. For the mouse experiments tumor bearing lungs were classified as mildly sick and severely sick based on the tumor burden as determined by right lung lobe weights. Oncogene induced immunosuppres…
View article: Supplementary Figure Legends from Activation of the PD-1 Pathway Contributes to Immune Escape in EGFR-Driven Lung Tumors
Supplementary Figure Legends from Activation of the PD-1 Pathway Contributes to Immune Escape in EGFR-Driven Lung Tumors Open
- PDF file 92K, Legends to supplementary figures 1-11
View article: Supplementary Figure Legends from Activation of the PD-1 Pathway Contributes to Immune Escape in EGFR-Driven Lung Tumors
Supplementary Figure Legends from Activation of the PD-1 Pathway Contributes to Immune Escape in EGFR-Driven Lung Tumors Open
- PDF file 92K, Legends to supplementary figures 1-11
View article: Supplemental Figure 1 from Cross-talk Signaling between HER3 and HPV16 E6 and E7 Mediates Resistance to PI3K Inhibitors in Head and Neck Cancer
Supplemental Figure 1 from Cross-talk Signaling between HER3 and HPV16 E6 and E7 Mediates Resistance to PI3K Inhibitors in Head and Neck Cancer Open
HPV(+) cell lines are less responsive to BKM120 and BEZ235 than HPV(-) cell lines
View article: Data from CXCR7 Reactivates ERK Signaling to Promote Resistance to EGFR Kinase Inhibitors in NSCLC
Data from CXCR7 Reactivates ERK Signaling to Promote Resistance to EGFR Kinase Inhibitors in NSCLC Open
Although EGFR mutant–selective tyrosine kinase inhibitors (TKI) are clinically effective, acquired resistance can occur by reactivating ERK. We show using in vitro models of acquired EGFR TKI resistance with a mesenchymal phenotype …
View article: Supplementary Figures S1-S6 from CXCR7 Reactivates ERK Signaling to Promote Resistance to EGFR Kinase Inhibitors in NSCLC
Supplementary Figures S1-S6 from CXCR7 Reactivates ERK Signaling to Promote Resistance to EGFR Kinase Inhibitors in NSCLC Open
Supplementary Figures
View article: Supplemental Figure 4 from Cross-talk Signaling between HER3 and HPV16 E6 and E7 Mediates Resistance to PI3K Inhibitors in Head and Neck Cancer
Supplemental Figure 4 from Cross-talk Signaling between HER3 and HPV16 E6 and E7 Mediates Resistance to PI3K Inhibitors in Head and Neck Cancer Open
HER3 blockade enhances the sensitivity of HPV(+) cell lines to BKM120
View article: Supplementary Table 1 from CXCR7 Reactivates ERK Signaling to Promote Resistance to EGFR Kinase Inhibitors in NSCLC
Supplementary Table 1 from CXCR7 Reactivates ERK Signaling to Promote Resistance to EGFR Kinase Inhibitors in NSCLC Open
Supplementary Table 1
View article: Supplementary Figures S1-S6 from CXCR7 Reactivates ERK Signaling to Promote Resistance to EGFR Kinase Inhibitors in NSCLC
Supplementary Figures S1-S6 from CXCR7 Reactivates ERK Signaling to Promote Resistance to EGFR Kinase Inhibitors in NSCLC Open
Supplementary Figures
View article: Data from Endothelin-1–Mediated Drug Resistance in <i>EGFR</i>-Mutant Non-Small Cell Lung Carcinoma
Data from Endothelin-1–Mediated Drug Resistance in <i>EGFR</i>-Mutant Non-Small Cell Lung Carcinoma Open
Progression on therapy in non-small cell lung carcinoma (NSCLC) is often evaluated radiographically, however, image-based evaluation of said therapies may not distinguish disease progression due to intrinsic tumor drug resistance or ineffi…
View article: Supplemental Figure 2 from Cross-talk Signaling between HER3 and HPV16 E6 and E7 Mediates Resistance to PI3K Inhibitors in Head and Neck Cancer
Supplemental Figure 2 from Cross-talk Signaling between HER3 and HPV16 E6 and E7 Mediates Resistance to PI3K Inhibitors in Head and Neck Cancer Open
Pan-phospho-RTK profiling identifies HER3 to be hyper-phosphorylated after BYL719 treatment in HPV(+) cell lines
View article: Supplemental Figure 4 from Cross-talk Signaling between HER3 and HPV16 E6 and E7 Mediates Resistance to PI3K Inhibitors in Head and Neck Cancer
Supplemental Figure 4 from Cross-talk Signaling between HER3 and HPV16 E6 and E7 Mediates Resistance to PI3K Inhibitors in Head and Neck Cancer Open
HER3 blockade enhances the sensitivity of HPV(+) cell lines to BKM120
View article: Supplementary Figures from Efficacy of BET Bromodomain Inhibition in Kras-Mutant Non–Small Cell Lung Cancer
Supplementary Figures from Efficacy of BET Bromodomain Inhibition in Kras-Mutant Non–Small Cell Lung Cancer Open
Supplementary Figures - PDF file 770K, Supplementary Figure 1. JQ1 treatment induces apoptosis proliferation arrest in a subset of NSCLC cells Supplementary Figure 2. JQ1 treatment promotes a depletion of 57kDa MYC in a time dependent mann…
View article: Supplementary Materials and Methods from Endothelin-1–Mediated Drug Resistance in <i>EGFR</i>-Mutant Non-Small Cell Lung Carcinoma
Supplementary Materials and Methods from Endothelin-1–Mediated Drug Resistance in <i>EGFR</i>-Mutant Non-Small Cell Lung Carcinoma Open
Supplementary Materials and Methods
View article: Supplementary Table 1 from CXCR7 Reactivates ERK Signaling to Promote Resistance to EGFR Kinase Inhibitors in NSCLC
Supplementary Table 1 from CXCR7 Reactivates ERK Signaling to Promote Resistance to EGFR Kinase Inhibitors in NSCLC Open
Supplementary Table 1
View article: Supplementary Figure Legend from Endothelin-1–Mediated Drug Resistance in <i>EGFR</i>-Mutant Non-Small Cell Lung Carcinoma
Supplementary Figure Legend from Endothelin-1–Mediated Drug Resistance in <i>EGFR</i>-Mutant Non-Small Cell Lung Carcinoma Open
Supplementary Figure Legend
View article: Supplementary Figure Legends from CXCR7 Reactivates ERK Signaling to Promote Resistance to EGFR Kinase Inhibitors in NSCLC
Supplementary Figure Legends from CXCR7 Reactivates ERK Signaling to Promote Resistance to EGFR Kinase Inhibitors in NSCLC Open
Supplementary Figure Legends
View article: Supplemental Figure 3 from Cross-talk Signaling between HER3 and HPV16 E6 and E7 Mediates Resistance to PI3K Inhibitors in Head and Neck Cancer
Supplemental Figure 3 from Cross-talk Signaling between HER3 and HPV16 E6 and E7 Mediates Resistance to PI3K Inhibitors in Head and Neck Cancer Open
Blockade of the PI3K pathway with BKM120 or BEZ235 increases HER3/AKT signaling