Margaretha de Vos
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View article: Novel and optimized diagnostics for pediatric TB in endemic countries: NOD-pedFEND study protocol
Novel and optimized diagnostics for pediatric TB in endemic countries: NOD-pedFEND study protocol Open
View article: Comparison of the analytical and clinical sensitivities of 34 rapid antigen tests with prevalent SARS-CoV-2 variants of concern during the COVID-19 pandemic in the UK
Comparison of the analytical and clinical sensitivities of 34 rapid antigen tests with prevalent SARS-CoV-2 variants of concern during the COVID-19 pandemic in the UK Open
Antigen-detection rapid diagnostic tests (Ag-RDTs) have become a central pillar for the management of coronavirus disease worldwide due to their speed and ease of use and are now being developed for use in other emerging outbreaks. Like ot…
View article: Tongue Swab Xpert MTB/RIF Ultra Testing for Tuberculosis Using a Revised Consensus Protocol: A multi-country diagnostic accuracy study
Tongue Swab Xpert MTB/RIF Ultra Testing for Tuberculosis Using a Revised Consensus Protocol: A multi-country diagnostic accuracy study Open
Background Tongue swabs are a promising specimen for tuberculosis (TB) diagnosis. In a previous study using a consensus protocol, tongue swabs tested with Xpert MTB/RIF Ultra (Xpert Ultra, Cepheid, USA) outperformed sputum smear microscopy…
View article: Oral Swab Testing With Xpert MTB/RIF Ultra for the Diagnosis of Tuberculosis in Children Aged <5 Years in Uganda: An Exploratory Interim Analysis of Diagnostic Accuracy in the NOD-pedFEND Cohort
Oral Swab Testing With Xpert MTB/RIF Ultra for the Diagnosis of Tuberculosis in Children Aged <5 Years in Uganda: An Exploratory Interim Analysis of Diagnostic Accuracy in the NOD-pedFEND Cohort Open
Background Obtaining respiratory samples to diagnose tuberculosis in young children is challenging. Oral swabs are alternative noninvasive specimens for microbiology. Methods We conducted an interim prospective diagnostic accuracy evaluati…
View article: Head-to-head comparison of anterior nares and nasopharyngeal swabs for SARS-CoV-2 antigen detection in a community drive-through test centre in the UK
Head-to-head comparison of anterior nares and nasopharyngeal swabs for SARS-CoV-2 antigen detection in a community drive-through test centre in the UK Open
Objective To conduct a head-to-head diagnostic accuracy evaluation of anterior nares (AN) and nasopharyngeal (NP) swabs for SARS-CoV-2 antigen detection using two brands of rapid diagnostic tests (Ag-RDT). Methods Two prospective diagnosti…
View article: Optimal processing of tongue swab samples for <i>Mycobacterium tuberculosis</i> detection by the Xpert MTB/RIF Ultra assay
Optimal processing of tongue swab samples for <i>Mycobacterium tuberculosis</i> detection by the Xpert MTB/RIF Ultra assay Open
Tongue swabs represent a potential alternative to sputum as a sample type for detecting pulmonary tuberculosis (TB) with molecular diagnostic tests. The methods used to process tongue swabs for testing in the World Health Organization-reco…
View article: Diagnostic Accuracy of Tongue Swabs for Tuberculosis Using a Common Protocol for Xpert MTB/RIF Ultra Testing: A Multi-Country Assessment
Diagnostic Accuracy of Tongue Swabs for Tuberculosis Using a Common Protocol for Xpert MTB/RIF Ultra Testing: A Multi-Country Assessment Open
View article: Correction: Determining cost and placement decisions for moderate complexity NAATs for tuberculosis drug susceptibility testing
Correction: Determining cost and placement decisions for moderate complexity NAATs for tuberculosis drug susceptibility testing Open
[This corrects the article DOI: 10.1371/journal.pone.0290496.].
View article: Diagnostic Accuracy of LiquidArray MTB-XDR VER 1.0 for the Detection of <i>Mycobacterium tuberculosis</i> Complex, Fluoroquinolone, Amikacin, Ethambutol, and Linezolid Susceptibility
Diagnostic Accuracy of LiquidArray MTB-XDR VER 1.0 for the Detection of <i>Mycobacterium tuberculosis</i> Complex, Fluoroquinolone, Amikacin, Ethambutol, and Linezolid Susceptibility Open
Background Drug susceptibility testing (DST) is essential for starting people on effective tuberculosis (TB) regimens. No published data exist for the high-throughput LiquidArray MTB-XDR (LA-XDR) test, which detects Mycobacterium tuberculo…
View article: Diagnostic accuracy of LiquidArray MTB-XDR VER1.0 for the detection of Mycobacterium tuberculosis complex, fluoroquinolone, amikacin, ethambutol, and linezolid susceptibility
Diagnostic accuracy of LiquidArray MTB-XDR VER1.0 for the detection of Mycobacterium tuberculosis complex, fluoroquinolone, amikacin, ethambutol, and linezolid susceptibility Open
Drug susceptibility testing (DST) is essential for effectively starting people on effective tuberculosis (TB) regimens. No accuracy data exists for the new high-throughput LiquidArray MTB-XDR (LA-XDR) test, which detects Mycobacterium tube…
View article: Optimal processing of tongue swab samples for Mycobacterium tuberculosis detection by the Xpert MTB/RIF Ultra assay
Optimal processing of tongue swab samples for Mycobacterium tuberculosis detection by the Xpert MTB/RIF Ultra assay Open
Tongue swabs represent a potential alternative to sputum as a sample type for detecting pulmonary tuberculosis (TB) using molecular diagnostic tests. The methods used to process tongue swabs for testing in the WHO-recommended Xpert MTB/RIF…
View article: Xpert MTB/RIF Ultra testing from tongue swabs – Diluted SR method v1
Xpert MTB/RIF Ultra testing from tongue swabs – Diluted SR method v1 Open
This standard operating procedure (SOP) outlines the methodology for processing dry dorsum tongue swabs with Xpert MTB/RIF Ultra (Ultra) (Cepheid, Sunnyvale, CA). The procedure is intended as a consensus protocol for clinical evidence gene…
View article: Consensus standard operating procedure for collection of tongue swabs for TB diagnostics v1
Consensus standard operating procedure for collection of tongue swabs for TB diagnostics v1 Open
This standard operating procedure (SOP) outlines the methodology for the collection of tongue swabs for subsequent testing of tuberculosis molecular assays that require a dry swab as input material.
View article: Accuracy of cobas MTB and MTB-RIF/INH for Detection of Mycobacterium tuberculosis and Drug Resistance
Accuracy of cobas MTB and MTB-RIF/INH for Detection of Mycobacterium tuberculosis and Drug Resistance Open
This study evaluated the performance of cobas MTB and cobas MTB-RIF/INH for the diagnosis of tuberculosis and detection of rifampicin (RIF) and isoniazid (INH) resistance. Adults presenting with pulmonary tuberculosis symptoms were recruit…
View article: Diagnostic accuracy of tongue swab testing on two automated tuberculosis diagnostic platforms, Cepheid Xpert MTB/RIF Ultra and Molbio Truenat MTB Ultima
Diagnostic accuracy of tongue swab testing on two automated tuberculosis diagnostic platforms, Cepheid Xpert MTB/RIF Ultra and Molbio Truenat MTB Ultima Open
Tongue dorsum swabbing is a potential alternative to sputum collection for tuberculosis (TB) testing. Previous studies showed that Cepheid Xpert MTB/RIF Ultra (Xpert Ultra) can detect Mycobacterium tuberculosis DNA on tongue swabs stored i…
View article: Bedaquiline resistance in patients with drug-resistant tuberculosis in Cape Town, South Africa: a retrospective longitudinal cohort study
Bedaquiline resistance in patients with drug-resistant tuberculosis in Cape Town, South Africa: a retrospective longitudinal cohort study Open
Doris Duke Charitable Foundation, US National Institute of Allergy and Infectious Diseases, South African Medical Research Council, National Research Foundation, Research Foundation Flanders, Stellenbosch University Faculty of Medicine Hea…
View article: Tongue swab testing on two automated tuberculosis diagnostic platforms, Cepheid Xpert® MTB/RIF Ultra and Molbio Truenat® MTB Ultima
Tongue swab testing on two automated tuberculosis diagnostic platforms, Cepheid Xpert® MTB/RIF Ultra and Molbio Truenat® MTB Ultima Open
Tongue dorsum swabbing is a potential alternative to sputum collection for tuberculosis (TB) testing. Previous studies showed that Cepheid Xpert® MTB/RIF Ultra (Xpert Ultra) can detect Mycobacterium tuberculosis (MTB) DNA in tongue swabs s…
View article: Determining cost and placement decisions for moderate complexity NAATs for tuberculosis drug susceptibility testing
Determining cost and placement decisions for moderate complexity NAATs for tuberculosis drug susceptibility testing Open
Background Access to drug resistant testing for tuberculosis (TB) remains a challenge in high burden countries. Recently, the World Health Organization approved the use of several moderate complexity automated nucleic acid amplification te…
View article: Impact of a multi-disease integrated screening and diagnostic model for COVID-19, TB, and HIV in Lesotho
Impact of a multi-disease integrated screening and diagnostic model for COVID-19, TB, and HIV in Lesotho Open
The surge of the COVID-19 pandemic challenged health services globally, and in Lesotho, the HIV and tuberculosis (TB) services were similarly affected. Integrated, multi-disease diagnostic services were proposed solutions to mitigate these…
View article: Comparison of the analytical and clinical sensitivity of thirty-four rapid antigen tests with prevalent SARS-CoV-2 variants of concern during the COVID-19 pandemic in the UK
Comparison of the analytical and clinical sensitivity of thirty-four rapid antigen tests with prevalent SARS-CoV-2 variants of concern during the COVID-19 pandemic in the UK Open
Antigen-detection rapid diagnostic tests (Ag-RDTs) have become a central pillar for the management of COVID-19 worldwide due to their speed and ease of use, and are now being developed for use in other emerging outbreaks. Like other viruse…
View article: Evaluating diagnostic tests during outbreaks: challenges and lessons learnt from COVID-19
Evaluating diagnostic tests during outbreaks: challenges and lessons learnt from COVID-19 Open
View article: To Test or Not? Xpert MTB/RIF as an Alternative to Smear Microscopy to Guide Line Probe Assay Testing for Drug-Resistant Tuberculosis
To Test or Not? Xpert MTB/RIF as an Alternative to Smear Microscopy to Guide Line Probe Assay Testing for Drug-Resistant Tuberculosis Open
Xpert MTB/RIF (Xpert) revolutionized tuberculosis (TB) diagnosis. Laboratory decision making on whether widely-used reflex drug susceptibility assays (MTBDR plus , first-line resistance; MTBDR sl , second-line) are conducted is based on sm…
View article: Diagnostic performance of four lateral flow immunoassays for COVID-19 antibodies in Peruvian population
Diagnostic performance of four lateral flow immunoassays for COVID-19 antibodies in Peruvian population Open
Serological assays have been used in seroprevalence studies to inform the dynamics of COVID-19. Lateral flow immunoassay (LFIA) tests are a very practical technology to use for this objective; however, one of their challenges may be variab…
View article: Performance of rapid antigen tests in identifying Omicron BA.4 and BA.5 infections in South Africa
Performance of rapid antigen tests in identifying Omicron BA.4 and BA.5 infections in South Africa Open
Accuracy of tested rapid antigen tests that target the nucleocapsid SARS-CoV-2 protein, were not adversely affected by BA.4 and BA.5 Omicron sub-variants.
View article: Multicenter Diagnostic Evaluation of OnSite COVID-19 Rapid Test (CTK Biotech) among Symptomatic Individuals in Brazil and the United Kingdom
Multicenter Diagnostic Evaluation of OnSite COVID-19 Rapid Test (CTK Biotech) among Symptomatic Individuals in Brazil and the United Kingdom Open
Evaluating rapid diagnostic tests in diverse populations is essential to improving diagnostic responses as it gives an indication of the accuracy in real-world scenarios. In the case of rapid diagnostic testing within this pandemic, latera…
View article: Diagnostic performance of GENEDIA W and ActiveXpress+ COVID-19 antigens tests among symptomatic individuals in Peru and The United Kingdom
Diagnostic performance of GENEDIA W and ActiveXpress+ COVID-19 antigens tests among symptomatic individuals in Peru and The United Kingdom Open
Objectives In order to generate independent performance data regarding accuracy of COVID-19 antigen-based rapid diagnostic tests (Ag-RDTs), prospective diagnostic evaluation studies across multiple sites are required to evaluate their perf…
View article: Head-to-head comparison of nasal and nasopharyngeal sampling using SARS-CoV-2 rapid antigen testing in Lesotho
Head-to-head comparison of nasal and nasopharyngeal sampling using SARS-CoV-2 rapid antigen testing in Lesotho Open
Objectives To assess the real-world diagnostic performance of nasal and nasopharyngeal swabs for SD Biosensor STANDARD Q COVID-19 Antigen Rapid Diagnostic Test (Ag-RDT). Methods Individuals ≥5 years with COVID-19 compatible symptoms or his…
View article: Designing molecular diagnostics for current tuberculosis drug regimens
Designing molecular diagnostics for current tuberculosis drug regimens Open
Diagnostic development must occur in parallel with drug development to ensure the longevity of new treatment compounds. Despite an increasing number of novel and repurposed anti-tuberculosis compounds and regimens, there remains a large nu…
View article: Diagnostic performance of lateral flow immunoassays for COVID-19 antibodies in Peruvian population
Diagnostic performance of lateral flow immunoassays for COVID-19 antibodies in Peruvian population Open
Background Serological assays have been used in seroprevalence studies to inform the dynamics of COVID-19. Lateral flow immunoassay (LFIA) tests are a very practical technology to use for this objective; however, one of their challenges ma…
View article: Performance of Rapid Antigen Tests in Identifying Omicron Ba.4 and Ba.5 Infections in South Africa
Performance of Rapid Antigen Tests in Identifying Omicron Ba.4 and Ba.5 Infections in South Africa Open