Rosa M. Andrade
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View article: Elucidating the Role of Toxoplasma gondii’s Mitochondrial Superoxide Dismutase
Elucidating the Role of Toxoplasma gondii’s Mitochondrial Superoxide Dismutase Open
Toxoplasma gondii is an Apicomplexan parasite that possesses a well-developed system of scavengers of reactive oxygen species (ROS). Among its components, T. gondii mitochondrial superoxide dismutase (TgSOD2) is essential, as predicted by …
View article: Gold(I) ion and the phosphine ligand are necessary for the anti- <i>Toxoplasma gondii</i> activity of auranofin
Gold(I) ion and the phosphine ligand are necessary for the anti- <i>Toxoplasma gondii</i> activity of auranofin Open
Auranofin, an FDA-approved drug for rheumatoid arthritis, has emerged as a promising antiparasitic medication in recent years. The gold(I) ion in auranofin is postulated to be responsible for its antiparasitic activity. Notably , aurothiom…
View article: Infection of a Nylon Foil Orbital Implant Due to Fusarium brachygibbosum and Lomentospora prolificans After Intranasal Methamphetamine Use
Infection of a Nylon Foil Orbital Implant Due to Fusarium brachygibbosum and Lomentospora prolificans After Intranasal Methamphetamine Use Open
The authors describe a case of nylon foil implant infection caused by Fusarium brachygibbosum , and Lomentospora prolificans following medial orbital wall fracture repair in the setting of postoperative nasal methamphetamine use. A 61-year…
View article: Chagas Disease Diagnostic Practices at Four Major Hospital Systems in California and Texas
Chagas Disease Diagnostic Practices at Four Major Hospital Systems in California and Texas Open
Background Chagas disease (CD) is a parasitic disease that affects ∼300 000 people living in the United States. CD leads to cardiac and/or gastrointestinal disease in up to 30% of untreated people. However, end-organ damage can be prevente…
View article: 742. Evaluation of Chagas Disease Diagnostic Testing Practices in Four Hospital Systems in California and Texas
742. Evaluation of Chagas Disease Diagnostic Testing Practices in Four Hospital Systems in California and Texas Open
Background Chagas disease (CD) is a neglected parasitic disease that affects >6 million people in the Americas, including >200,000 people in the United States (US). Medical provider knowledge of CD is key to decreasing morbidity and …
View article: Auranofin Resistance in Toxoplasma gondii Decreases the Accumulation of Reactive Oxygen Species but Does Not Target Parasite Thioredoxin Reductase
Auranofin Resistance in Toxoplasma gondii Decreases the Accumulation of Reactive Oxygen Species but Does Not Target Parasite Thioredoxin Reductase Open
Auranofin, a reprofiled FDA-approved drug originally designed to treat rheumatoid arthritis, has emerged as a promising anti-parasitic drug. It induces the accumulation of reactive oxygen species (ROS) in parasites, including Toxoplasma go…
View article: Auranofin resistance in<i>Toxoplasma gondii</i>decreases the accumulation of reactive oxygen species but does not target parasite thioredoxin reductase
Auranofin resistance in<i>Toxoplasma gondii</i>decreases the accumulation of reactive oxygen species but does not target parasite thioredoxin reductase Open
Auranofin, a reprofiled FDA-approved drug originally designed to treat rheumatoid arthritis, has emerged as a promising anti-parasitic drug. It induces the accumulation of reactive oxygen species (ROS) in parasites, including Toxoplasma go…
View article: Tracing the uptake of gold in Toxoplasma gondii using STEM-EDS
Tracing the uptake of gold in Toxoplasma gondii using STEM-EDS Open
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View article: Two key cathepsins, TgCPB and TgCPL, are targeted by the vinyl sulfone inhibitor K11777 in in vitro and in vivo models of toxoplasmosis
Two key cathepsins, TgCPB and TgCPL, are targeted by the vinyl sulfone inhibitor K11777 in in vitro and in vivo models of toxoplasmosis Open
Although toxoplasmosis is one of the most common parasitic infections worldwide, therapeutic options remain limited. Cathepsins, proteases that play key roles in the pathogenesis of toxoplasmosis and many other protozoan infections, are im…
View article: New drug target in protozoan parasites: the role of thioredoxin reductase
New drug target in protozoan parasites: the role of thioredoxin reductase Open
Amebiasis causes approximately 70,000 deaths annually and is the third cause of death due to parasites worldwide. It is treated primarily with metronidazole, which has adverse side effects, is mutagenic and carcinogenic, and emergence of r…