Margherita Malanchini
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View article: The developmental interplay between household chaos and educational achievement from age 9 through 16 years: A genetically sensitive study
The developmental interplay between household chaos and educational achievement from age 9 through 16 years: A genetically sensitive study Open
We tested whether associations between household chaos, which refers to confusion and disorganisation in family homes, and educational achievement are confounded by genetics and family socioeconomic status (SES). We modelled the developmen…
View article: How are children's perceptions of the home environment associated with a general psychopathology factor across childhood?
How are children's perceptions of the home environment associated with a general psychopathology factor across childhood? Open
Background Comorbidity and heterogeneity in psychiatric disorders may stem from a general psychopathology (p) factor influenced by both genetic and environmental factors. Although the relative contributions of these influences on psychopat…
View article: The Relationship Between Environmental Sensitivity and Common Mental-Health Problems in Adolescents and Adults: A Systematic Review and Meta-Analysis
The Relationship Between Environmental Sensitivity and Common Mental-Health Problems in Adolescents and Adults: A Systematic Review and Meta-Analysis Open
Environmental sensitivity is a personality trait reflecting individual differences in response to environmental influences. Although the link between common personality traits and psychopathology is well established, trait sensitivity is o…
View article: Author Correction: A meta-analysis of genetic effects associated with neurodevelopmental disorders and co-occurring conditions
Author Correction: A meta-analysis of genetic effects associated with neurodevelopmental disorders and co-occurring conditions Open
View article: The neurodevelopmental spectrum: phenotypic architecture, etiology, and predictive utility across development
The neurodevelopmental spectrum: phenotypic architecture, etiology, and predictive utility across development Open
Neurodevelopmental conditions are highly heritable, heterogeneous, and frequently co-occur with one another. Transdiagnostic dimensional approaches have advanced our understanding of psychiatric disorders and informed their classification,…
View article: The neurodevelopmental spectrum: phenotypic architecture, etiology, and predictive utility across development
The neurodevelopmental spectrum: phenotypic architecture, etiology, and predictive utility across development Open
Neurodevelopmental conditions are highly heritable, heterogeneous, and frequently co-occur with one another. Transdiagnostic dimensional approaches have advanced our understanding of psychiatric disorders and informed their classification,…
View article: Examining the association between cognitive ability and emotional problems across childhood using a genetically informative design: could there be a causal relationship?
Examining the association between cognitive ability and emotional problems across childhood using a genetically informative design: could there be a causal relationship? Open
Background Emotional problems co‐occur with difficulties in verbal and nonverbal cognitive ability, yet the pathways underlying their association remain poorly understood: It is unclear whether effects may be causal, and to what extent the…
View article: The developmental interplay between household chaos and educational achievement from age 9 through 16 years: A genetically sensitive study
The developmental interplay between household chaos and educational achievement from age 9 through 16 years: A genetically sensitive study Open
We tested whether associations between household chaos, which refers to confusion and disorganisation in family homes, and educational achievement are confounded by genetics and family socioeconomic status (SES). We modelled the developmen…
View article: Moving intelligence measurement online: adaptation and validation of the Polish version of the Pathfinder general cognitive ability test
Moving intelligence measurement online: adaptation and validation of the Polish version of the Pathfinder general cognitive ability test Open
View article: Specificity of polygenic scores for psychiatric disorders beyond transdiagnostic genetic risk (p)
Specificity of polygenic scores for psychiatric disorders beyond transdiagnostic genetic risk (p) Open
Importance: Polygenic scores are increasingly used to estimate genetic liability for psychiatric disorders. However, their limited specificity to the disorders for which they are derived limits their clinical and research utility. Objectiv…
View article: Disorder-specific genetic effects drive the associations between psychopathology and cognitive functioning
Disorder-specific genetic effects drive the associations between psychopathology and cognitive functioning Open
Background Cognitive functioning is a critical dimension of psychopathology that remains under-investigated. Because cognitive deficits often transcend diagnostic boundaries, it has been challenging to delineate specific relationships betw…
View article: Robust inference and widespread genetic correlates from a large-scale genetic association study of human personality
Robust inference and widespread genetic correlates from a large-scale genetic association study of human personality Open
Personality traits describe stable differences in how individuals think, feel, and behave and how they interact with and experience their social and physical environments. We assemble data from 46 cohorts including 611K-1.14M participants …
View article: Developmental pathways from childhood neurodevelopmental traits to early adolescent psychiatric dimensions: the role of environmental and lifestyle factors
Developmental pathways from childhood neurodevelopmental traits to early adolescent psychiatric dimensions: the role of environmental and lifestyle factors Open
ABCTRACT Objectives Transdiagnostic dimensional approaches have advanced our understanding of psychiatric comorbidity and developmental continuity, but have rarely been applied to investigate links between neurodevelopmental (e.g., attenti…
View article: Gene-environment interplay in internalising and externalising psychopathology in adolescence
Gene-environment interplay in internalising and externalising psychopathology in adolescence Open
A combination of genetic and environmental factors working in interplay is thought to underlie differences in symptoms of psychopathology between adolescents. Yet, studies that have investigated gene-environment interaction in isolated asp…
View article: From genetic disposition to academic achievement: The mediating role of non-cognitive skills across development
From genetic disposition to academic achievement: The mediating role of non-cognitive skills across development Open
Genetic effects on academic achievement are likely to capture environmental, developmental, and psychological processes. How these processes contribute to translating genetic dispositions into observed academic achievement remains critical…
View article: The Genetic Specificity of Cognitive Tests After Controlling for General Cognitive Ability
The Genetic Specificity of Cognitive Tests After Controlling for General Cognitive Ability Open
Diverse tests of cognitive abilities correlate about 0.30 phenotypically and about 0.60 genetically. Their phenotypic overlap defines general cognitive ability (g), driven largely by genetic overlap. Consequently, much of our understanding…
View article: Exploring the specific predictive ability of multiple domains of spatial ability on STEM educational outcomes
Exploring the specific predictive ability of multiple domains of spatial ability on STEM educational outcomes Open
Research has implicated spatial ability as a robust predictor of aptitude, interest, and choice in STEM education and career pursuits. We address three under-explored questions regarding the role of spatial ability in STEM. First, can spat…
View article: The genetic specificity of specific cognitive abilities after controlling for general cognitive ability
The genetic specificity of specific cognitive abilities after controlling for general cognitive ability Open
Diverse cognitive abilities correlate about 0.30 phenotypically and about 0.60 genetically. Their phenotypic overlap defines general cognitive ability (g), driven largely by genetic overlap. Consequently, much of our understanding of the g…
View article: Exploring the role of telomere length in the efficacy of an exercise intervention for vascular cognitive impairment: a 12‐month randomised controlled trial substudy
Exploring the role of telomere length in the efficacy of an exercise intervention for vascular cognitive impairment: a 12‐month randomised controlled trial substudy Open
Background Subcortical ischemic vascular cognitive impairment (SIVCI) is the most common form of vascular cognitive impairment. Exercise is a potentially effective intervention for SIVCI. However, the mechanisms through which exercise prom…
View article: Mathematics interest, self-efficacy, and anxiety predict STEM career choice in emerging adulthood
Mathematics interest, self-efficacy, and anxiety predict STEM career choice in emerging adulthood Open
To examine the combined effects of maths anxiety (MA), maths self-efficacy (MSE), and maths interest (MI) on STEM career choice, we analysed self-report data from 7908 Twins Early Development Study participants, collected at ages 16 (MSE, …
View article: Examining the association between cognitive ability and emotional problems across childhood using a genetically informative design: Could there be a causal relationship?
Examining the association between cognitive ability and emotional problems across childhood using a genetically informative design: Could there be a causal relationship? Open
Background: Emotional problems co-occur with difficulties in verbal and non-verbal cognitive performance, yet the pathways underlying their association remain poorly understood: It is unclear whether effects may be causal, and to what exte…
View article: Telomere length and cognitive changes in 7,877 older UK adults of European ancestry
Telomere length and cognitive changes in 7,877 older UK adults of European ancestry Open
Background Telomere length (TL) has been linked to cognitive function, decline and dementia. This study aimed to explore whether both measured TL and genetic disposition for TL predict dimensions of cognitive performance in a longitudinal …
View article: Gene-environment correlation: the role of family environment in academic development
Gene-environment correlation: the role of family environment in academic development Open
Academic achievement is partly heritable and highly polygenic. However, genetic effects on academic achievement are not independent of environmental processes. We investigated whether aspects of the family environment mediated genetic effe…
View article: Genetic associations between non-cognitive skills and academic achievement over development
Genetic associations between non-cognitive skills and academic achievement over development Open
View article: How are children’s perceptions of the home environment associated with a general psychopathology factor across childhood?
How are children’s perceptions of the home environment associated with a general psychopathology factor across childhood? Open
Background Comorbidity and heterogeneity in psychiatric disorders may stem from a general psychopathology (p) factor influenced by both genetic and environmental factors. Although the relative contributions of these influences on psychopat…
View article: Multi-polygenic score prediction of mathematics, reading, and language abilities independent of general cognitive ability
Multi-polygenic score prediction of mathematics, reading, and language abilities independent of general cognitive ability Open
View article: Exploring the genetic prediction of academic underachievement and overachievement
Exploring the genetic prediction of academic underachievement and overachievement Open
Academic underachievement refers to school performance which falls below expectations. Focusing on the pivotal first stage of education, we explored a quantitative measure of underachievement using genomically predicted achievement delta (…
View article: Maths motivation predicts STEM career choice in young adults better than maths anxiety
Maths motivation predicts STEM career choice in young adults better than maths anxiety Open
As the UK experiences a widening skills gap in Science, Technology, Engineering and Maths (STEM) fields, understanding the psychological underpinnings of STEM career choices is increasingly critical. Here, we examined the joint role of mat…
View article: Multi-polygenic score prediction of mathematics, reading, and language abilities independent of general cognitive ability
Multi-polygenic score prediction of mathematics, reading, and language abilities independent of general cognitive ability Open
Specific cognitive abilities (SCA) correlate genetically about 0.50, which underpins general cognitive ability (g), but it also means that there is considerable genetic specificity. If g is not controlled, then genomic prediction of specif…
View article: Gene-environment correlation: The role of family environment in academic development
Gene-environment correlation: The role of family environment in academic development Open
Academic achievement is partly heritable and highly polygenic. However, genetic effects on academic achievement are not independent of environmental processes. We investigated whether aspects of the family environment mediated genetic effe…