Explanipedia

Neuronal pSTAT1 hallmarks synaptic pathology in autoimmune encephalitis against intracellular antigens Open

Giovanni Di Liberto, Kristóf Égervári, Alberto Vogrig, Marianna Spatola, Margot Piccinno , et al. · 2025

Oligodendrocyte-derived IL-33 regulates self-reactive CD8+ T cells in CNS autoimmunity Open

Nicolas Fonta, Nathalie Pagé, Bogna Klimek, Margot Piccinno, Giovanni Di Liberto , et al. · 2025

In chronic inflammatory disorders of the central nervous system (CNS), tissue-resident self-reactive T cells perpetuate disease. The specific tissue factors governing the persistence and continuous differentiation of these cells remain und…

Persistent virus-specific and clonally expanded antibody-secreting cells respond to induced self-antigen in the CNS Open

Andreas Agrafiotis, Raphael Dizerens, Ilena Vincenti, Ingrid Wagner, Raphael Kuhn , et al. · 2023

Persistent virus-specific and clonally expanded antibody secreting cells respond to induced self antigen in the CNS Open

Andreas Agrafiotis, Raphael Dizerens, Ilena Vincenti, Ingrid Wagner, Raphael Kuhn , et al. · 2022

B cells contribute to the pathogenesis of both cellular- and humoral-mediated central nervous system (CNS) inflammatory diseases through a variety of mechanisms. In such conditions, B cells may enter the CNS parenchyma and contribute to lo…

Single-cell immune repertoire sequencing of B and T cells in murine models of infection and autoimmunity Open

Danielle Shlesinger, Kai‐Lin Hong, Ghazal Shammas, Nicolas Pagé, Ioana Sandu , et al. · 2022

Single-cell immune repertoire sequencing of B and T cells in murine models of infection and autoimmunity Open

Danielle Shlesinger, Kai‐Lin Hong, Ghazal Shammas, Nicolas Pagé, Ioana Sandu , et al. · 2022

Adaptive immune repertoires are composed by the ensemble of B and T cell receptors (BCR, TCR) within an individual and reflect both past and current immune responses. Recent advances in single-cell sequencing enable recovery of the complet…

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