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View article: Potential asthma biomarkers identified by nontargeted proteomics of extracellular vesicles in exhaled breath condensate
Potential asthma biomarkers identified by nontargeted proteomics of extracellular vesicles in exhaled breath condensate Open
Proteomics of EBC-EVs has enabled the identification of potential diagnostic biomarkers for BA and COPD. "Breathomics" of EBC-EVs offers a promising noninvasive approach for diagnosis and phenotyping of respiratory diseases.
View article: NHERF2 as a Novel Biomarker for Distinguishing MAC Pulmonary Disease from Tuberculosis Based on Proteome Analysis of Serum Extracellular Vesicles
NHERF2 as a Novel Biomarker for Distinguishing MAC Pulmonary Disease from Tuberculosis Based on Proteome Analysis of Serum Extracellular Vesicles Open
Nontuberculous mycobacterial pulmonary disease (NTM-PD), mainly caused by Mycobacterium avium complex (MAC), and pulmonary tuberculosis (TB) are emerging health problems worldwide. However, because their clinical features are often similar…
View article: Analysis of Factors That Promote Awareness of Breast MRI Surveillance for Carriers of Hereditary Breast Cancer Risk Genes ( <i>BRCA1/2</i>)
Analysis of Factors That Promote Awareness of Breast MRI Surveillance for Carriers of Hereditary Breast Cancer Risk Genes ( <i>BRCA1/2</i>) Open
By enhancing the acquisition of knowledge about HBOC and raising awareness of breast MRI surveillance, it is expected that discussions towards building a robust system will deepen.
View article: SFTPB in serum extracellular vesicles as a biomarker of progressive pulmonary fibrosis
SFTPB in serum extracellular vesicles as a biomarker of progressive pulmonary fibrosis Open
Progressive pulmonary fibrosis (PPF), defined as the worsening of various interstitial lung diseases (ILDs), currently lacks useful biomarkers. To identify novel biomarkers for early detection of patients at risk of PPF, we performed a pro…
View article: Galectin-10 in serum extracellular vesicles reflects asthma pathophysiology
Galectin-10 in serum extracellular vesicles reflects asthma pathophysiology Open
Novel BMs such as Gal10 from serum EVs reflect disease pathophysiology in BA and may represent a new target for liquid biopsy approaches.
View article: Data-driven patient stratification and drug target discovery by using medical information and serum proteome data of idiopathic pulmonary fibrosis patients
Data-driven patient stratification and drug target discovery by using medical information and serum proteome data of idiopathic pulmonary fibrosis patients Open
Medical information is valuable information obtained from humans regarding the phenotype of diseases. Omics data is informative to understand diseases at biomolecular level. We aimed to detect patient stratification patterns in a data-driv…
View article: Latent inter-organ mechanism of idiopathic pulmonary fibrosis unveiled by a generative computational approach
Latent inter-organ mechanism of idiopathic pulmonary fibrosis unveiled by a generative computational approach Open
Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive disease characterized by complex lung pathogenesis affecting approximately three million people worldwide. While the molecular and cellular details of the IPF mechanism is em…
View article: Disease Network Constructor: a Pathway Extraction and Visualization
Disease Network Constructor: a Pathway Extraction and Visualization Open
Mohammad Golam Sohrab, Khoa Duong, Goran Topić, Masami Ikeda, Nozomi Nagano, Yayoi Natsume-Kitatani, Masakata Kuroda, Mari Itoh, Hiroya Takamura. Proceedings of the 61st Annual Meeting of the Association for Computational Linguistics (Volu…
View article: Next-generation proteomics of serum extracellular vesicles combined with single-cell RNA sequencing identifies MACROH2A1 associated with refractory COVID-19
Next-generation proteomics of serum extracellular vesicles combined with single-cell RNA sequencing identifies MACROH2A1 associated with refractory COVID-19 Open
Background The coronavirus disease 2019 (COVID-19) pandemic is widespread; however, accurate predictors of refractory cases have not yet been established. Circulating extracellular vesicles, involved in many pathological processes, are ide…
View article: Integrative Network Modeling Highlights the Crucial Roles of Rho-GDI Signaling Pathway in the Progression of non-Small Cell Lung Cancer
Integrative Network Modeling Highlights the Crucial Roles of Rho-GDI Signaling Pathway in the Progression of non-Small Cell Lung Cancer Open
Non-small cell lung cancer (NSCLC) is the most prevalent form of lung cancer and a leading cause of cancer-related deaths worldwide. Using an integrative approach, we analyzed a publicly available merged NSCLC transcriptome dataset using m…
View article: Data-driven patient stratification and drug target discovery by using medical information and serum proteome data of idiopathic pulmonary fibrosis patients
Data-driven patient stratification and drug target discovery by using medical information and serum proteome data of idiopathic pulmonary fibrosis patients Open
Medical information is valuable information obtained from humans regarding the phenotype of diseases. Omics data is informative to understand diseases at biomolecular level. We aimed to detect patient stratification patterns in a data-driv…
View article: Data-driven patient stratification and drug target discovery by using medical information and serum proteome data of idiopathic pulmonary fibrosis patients
Data-driven patient stratification and drug target discovery by using medical information and serum proteome data of idiopathic pulmonary fibrosis patients Open
Medical information is valuable information obtained from humans regarding the phenotype of diseases. Omics data is informative to understand diseases at biomolecular level. We aimed to detect patient stratification patterns in a data-driv…
View article: Integrative Analysis Reveals Common and Unique Roles of Tetraspanins in Fibrosis and Emphysema
Integrative Analysis Reveals Common and Unique Roles of Tetraspanins in Fibrosis and Emphysema Open
While both chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF) are multifactorial disorders characterized by distinct clinical and pathological features, their commonalities and differences have not been fu…
View article: Sphingomyelin Deacylase, the Enzyme Involved in the Pathogenesis of Atopic Dermatitis, Is Identical to the β-Subunit of Acid Ceramidase
Sphingomyelin Deacylase, the Enzyme Involved in the Pathogenesis of Atopic Dermatitis, Is Identical to the β-Subunit of Acid Ceramidase Open
A ceramide deficiency in the stratum corneum (SC) is an essential etiologic factor for the dry and barrier-disrupted skin of patients with atopic dermatitis (AD). Previously, we reported that sphingomyelin (SM) deacylase, which hydrolyzes …
View article: Metabolomic analysis of fibrotic mice combined with public RNA‐Seq human lung data reveal potential diagnostic biomarker candidates for lung fibrosis
Metabolomic analysis of fibrotic mice combined with public RNA‐Seq human lung data reveal potential diagnostic biomarker candidates for lung fibrosis Open
Idiopathic pulmonary fibrosis (IPF) is a severe lung disease with poor survival that warrants early and precise diagnosis for timely therapeutic intervention. Despite accumulating genomic, transcriptomic, proteomic, and lipidomic data on I…
View article: The TargetMine Data Warehouse: Enhancement and Updates
The TargetMine Data Warehouse: Enhancement and Updates Open
Biological data analysis is the key to new discoveries in disease biology and drug discovery. The rapid proliferation of high-throughput 'omics' data has necessitated a need for tools and platforms that allow the researchers to combine and…
View article: Objective Predictive Score as a Feasible Biomarker for Short-term Survival in TerminalIy Ill Patients with Cancer
Objective Predictive Score as a Feasible Biomarker for Short-term Survival in TerminalIy Ill Patients with Cancer Open
Our scoring system might enable the assessment of prognostication with higher accuracy in a terminal care setting.