Mari Kamiya
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View article: Anti-centromere antibody positivity with coexisting idiopathic portal hypertension and primary biliary cholangitis progressing to limited cutaneous systemic sclerosis: a case report
Anti-centromere antibody positivity with coexisting idiopathic portal hypertension and primary biliary cholangitis progressing to limited cutaneous systemic sclerosis: a case report Open
This is the first documented case of hepatic and systemic microvascular impairment observed in an anti-centromere antibody-positive patient. The pathological evidence of endothelial damage in the liver suggests that the "idiopathic" label …
View article: TGF-β Coordinates Alanine Synthesis and Import for Myofibroblast Differentiation in Pulmonary Fibrosis
TGF-β Coordinates Alanine Synthesis and Import for Myofibroblast Differentiation in Pulmonary Fibrosis Open
Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease marked by aberrant fibroblast-to-myofibroblast differentiation, a process that requires metabolic reprogramming. We identify alanine as a critical metabolite th…
View article: Long-term outcome of a treat-to-target strategy in late-onset rheumatoid arthritis with chronic lung disease: 5-year results of a prospective observational study
Long-term outcome of a treat-to-target strategy in late-onset rheumatoid arthritis with chronic lung disease: 5-year results of a prospective observational study Open
Background Controlling disease activity and improving physical function would be more difficult in patients with late-onset rheumatoid arthritis (LORA) who have chronic lung disease (CLD) at baseline. Our aim was to evaluate 5-year outcome…
View article: A CD57+ cytotoxic CD8 T cell subset associated with fibrotic lung disease in systemic sclerosis
A CD57+ cytotoxic CD8 T cell subset associated with fibrotic lung disease in systemic sclerosis Open
Interstitial lung disease (ILD) is a major cause of morbidity and mortality in systemic sclerosis (SSc); however, the immunopathologic mechanisms driving lung disease in SSc are unclear. T cells have been implicated as a likely driver of l…
View article: Leukemia inhibitory factor (LIF) receptor amplifies pathogenic activation of fibroblasts in lung fibrosis
Leukemia inhibitory factor (LIF) receptor amplifies pathogenic activation of fibroblasts in lung fibrosis Open
Fibrosis drives end-organ damage in many diseases. However, clinical trials targeting individual upstream activators of fibroblasts, such as TGFβ, have largely failed. Here, we target the leukemia inhibitory factor receptor (LIFR) as an “a…
View article: Effectiveness and safety of treat-to-target strategy for methotrexate-naïve rheumatoid arthritis patients >75 years of age
Effectiveness and safety of treat-to-target strategy for methotrexate-naïve rheumatoid arthritis patients >75 years of age Open
Objectives To identify differences in effectiveness and safety of a treat-to-target (T2T) strategy comparing late-onset MTX-naïve RA patients (LORA) ≥75 or <75 years of age. Methods Treatment was adjusted to target low disease activity …
View article: Disease models of myositis: overview of cell culture and rodent systems
Disease models of myositis: overview of cell culture and rodent systems Open
Inflammatory myopathies (in short: myositis) display a heterogenic group of rare inflammatory diseases of the skeletal muscle and other organs such as lung, heart and skin. Patients typically display muscular weakness, wasting and a variab…
View article: Activation of CD8<sup>+</sup> T Cells in Chronic Obstructive Pulmonary Disease Lung
Activation of CD8<sup>+</sup> T Cells in Chronic Obstructive Pulmonary Disease Lung Open
Rationale: Despite the importance of inflammation in chronic obstructive pulmonary disease (COPD), the immune cell landscape in the lung tissue of patients with mild-moderate disease has not been well characterized at the single-cell and m…
View article: Muscle fiber necroptosis in pathophysiology of idiopathic inflammatory myopathies and its potential as target of novel treatment strategy
Muscle fiber necroptosis in pathophysiology of idiopathic inflammatory myopathies and its potential as target of novel treatment strategy Open
Idiopathic inflammatory myopathies (IIMs), which are a group of chronic and diverse inflammatory diseases, are primarily characterized by weakness in the proximal muscles that progressively leads to persistent disability. Current treatment…
View article: Apple-shaped obesity: A risky soil for cytokine-accelerated severity in COVID-19
Apple-shaped obesity: A risky soil for cytokine-accelerated severity in COVID-19 Open
Obesity has been recognized as one of the most significant risk factors for the deterioration and mortality associated with COVID-19, but the significance of obesity itself differs among ethnicity. Multifactored analysis of our single inst…
View article: Apple-shaped obesity; a risky soil for cytokine-accelerated severity in COVID-19
Apple-shaped obesity; a risky soil for cytokine-accelerated severity in COVID-19 Open
Obesity is one of the most significant risk factors for the deterioration and mortality associated with COVID-19 [1]. A certain proportion of COVID-19 patients experience marked elevations of inflammatory mediators, termed “cytokine storm”…
View article: Amelioration of inflammatory myopathies by glucagon‐like peptide‐1 receptor agonist via suppressing muscle fibre necroptosis
Amelioration of inflammatory myopathies by glucagon‐like peptide‐1 receptor agonist via suppressing muscle fibre necroptosis Open
Background As glucocorticoids induce muscle atrophy during the treatment course of polymyositis (PM), novel therapeutic strategy is awaited that suppresses muscle inflammation but retains muscle strength. We recently found that injured mus…
View article: Arterial and Venous Thrombosis Complicated in COVID-19: A Retrospective Single Center Analysis in Japan
Arterial and Venous Thrombosis Complicated in COVID-19: A Retrospective Single Center Analysis in Japan Open
Background: Thrombosis is a characteristic complication in coronavirus disease 2019 (COVID-19). Since coagulopathy has been observed over the entire clinical course, thrombosis might be a clue to understanding the specific pathology in COV…
View article: Factors associated with normal physical function in patients with rheumatoid arthritis of different ages
Factors associated with normal physical function in patients with rheumatoid arthritis of different ages Open
Background To investigate factors associated with normal physical function of middle-aged (55-64), old (65-74) or very old (75-84) patients with rheumatoid arthritis (RA). Methods Data from RA patients in the National Database of Rheumatic…
View article: SAT-190 COMPREHENSIVE ANALYSIS OF URINARY AMINOPEPTIDASE ACTIVITIES FOR INVESTIGATING PROGNOSTIC MARKERS TO PREDICT THE PROGRESSION OF CHRONIC KIDNEY DISEASE
SAT-190 COMPREHENSIVE ANALYSIS OF URINARY AMINOPEPTIDASE ACTIVITIES FOR INVESTIGATING PROGNOSTIC MARKERS TO PREDICT THE PROGRESSION OF CHRONIC KIDNEY DISEASE Open
Renal prognosis is better correlated with the degree of tubulointerstitial damage than with that of glomerular injury (J Am Soc Nephrol. 2006: 17: 17–25), therefore a biomarker for tubular damage is important to predict chronic kidney dise…
View article: A new in vitro model of polymyositis reveals CD8+ T cell invasion into muscle cells and its cytotoxic role
A new in vitro model of polymyositis reveals CD8+ T cell invasion into muscle cells and its cytotoxic role Open
Objectives The hallmark histopathology of PM is the presence of CD8+ T cells in the non-necrotic muscle cells. The aim of this study was to clarify the pathological significance of CD8+ T cells in muscle cells. Methods C2C12 cells were tra…
View article: Allergic bronchopulmonary aspergillosis in a patient with rheumatoid arthritis under adalimumab therapy: a case report
Allergic bronchopulmonary aspergillosis in a patient with rheumatoid arthritis under adalimumab therapy: a case report Open
A 77-year-old woman with a 15-year history of rheumatoid arthritis (RA) was admitted to our hospital because of a wet cough that persisted for 1 month. The patient had been taking methotrexate (MTX) and adalimumab (ADA) for the past 3 year…
View article: Acute Tubulointerstitial Nephritis Associated with Infliximab in a Patient with Crohn's Disease
Acute Tubulointerstitial Nephritis Associated with Infliximab in a Patient with Crohn's Disease Open
We report the findings of a 46-year-old man, who presented with fever and renal dysfunction while undergoing treatment for Crohn's disease with infliximab (IFX). Remittent fever and renal dysfunction with urinary casts developed and lasted…
View article: IgG4-Related Sialoadenitis with a Skin Lesion and Multiple Mononeuropathies Suggesting Coexistent Cryoglobulinemic Vasculitis
IgG4-Related Sialoadenitis with a Skin Lesion and Multiple Mononeuropathies Suggesting Coexistent Cryoglobulinemic Vasculitis Open
A 68-year-old man was admitted because of weakness of the left leg, dysesthesiae of the extremities and bilateral lower extremity purpura. A neurological examination showed mononeuritis multiplex with laboratory evidence of hypocomplemente…
View article: Atherosclerotic and hemorrhagic diseases in a patient with primary immune deficiency
Atherosclerotic and hemorrhagic diseases in a patient with primary immune deficiency Open
A 59-year-old man, who suffered from periodic fever with continuous elevation of the C-reactive protein (CRP) level was referred to our hospital. He had frequent respiratory infections and diarrhea since his childhood. The serum immunoglob…