Mari Nerhus
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View article: Sex differences in autonomic adverse effects related to antipsychotic treatment and associated hormone profiles
Sex differences in autonomic adverse effects related to antipsychotic treatment and associated hormone profiles Open
Autonomic adverse effects of antipsychotic drugs (APs) cause clinical challenges, but few studies have investigated sex differences and their underlying biological pathways. Sex-specific regulation of relevant hormones could be involved. W…
View article: Genome-wide Association Analysis of Schizophrenia and Vitamin D Levels Shows Shared Genetic Architecture and Identifies Novel Risk Loci
Genome-wide Association Analysis of Schizophrenia and Vitamin D Levels Shows Shared Genetic Architecture and Identifies Novel Risk Loci Open
Low vitamin D (vitD) levels have been consistently reported in schizophrenia (SCZ) suggesting a role in the etiopathology. However, little is known about the role of underlying shared genetic mechanisms. We applied a conditional/conjunctio…
View article: Developing “MinDag” – an app to capture symptom variation and illness mechanisms in bipolar disorder
Developing “MinDag” – an app to capture symptom variation and illness mechanisms in bipolar disorder Open
Introduction The illness course of bipolar disorder (BD) is highly heterogeneous with substantial variation between individuals with the same BD subtype and within individuals over time. This heterogeneity is not well-delineated and hamper…
View article: Plan D- Vitamin D supplementation in psychotic disorders: a placebo controlled randomized trial (Preprint)
Plan D- Vitamin D supplementation in psychotic disorders: a placebo controlled randomized trial (Preprint) Open
BACKGROUND Cognitive impairments and negative symptoms in schizophrenia are associated with poor outcome, and may have common underlying mechanisms, such as psychomotor retardation. Vitamin D is a neuroactive component associated to both …
View article: The Influence of Mental Health Literacy, Migration, and Education on the Duration of Untreated Psychosis
The Influence of Mental Health Literacy, Migration, and Education on the Duration of Untreated Psychosis Open
Background: Duration of untreated psychosis (DUP) is associated with outcome in psychotic disorders and influenced by contextual factors such as immigration. Here we aimed to investigate the effect of mental health literacy (MHL) on durati…
View article: Substance Misuse Trajectories and Risk of Relapse in the Early Course of Bipolar Disorder
Substance Misuse Trajectories and Risk of Relapse in the Early Course of Bipolar Disorder Open
Substance misuse is highly prevalent in bipolar disorder even in the early illness phases. However, the trajectories of misuse of different substances after treatment initiation is not well-studied. Also, knowledge on how substance misuse …
View article: Vitamin D levels, brain volume, and genetic architecture in patients with psychosis
Vitamin D levels, brain volume, and genetic architecture in patients with psychosis Open
This is the first study of the association between vitamin D levels and brain volume in patients with psychotic disorders that takes into account possible interaction with genetic polymorphisms. The present findings warrant replication in …
View article: M85. Age-Related Effect of Vitamin D on Hippocampus Volume in Schizophrenia and Bipolar Disorder
M85. Age-Related Effect of Vitamin D on Hippocampus Volume in Schizophrenia and Bipolar Disorder Open
Background: Schizophrenia and bipolar spectrum disorders (SZBD) are devastating mental disorders with unknown cause and suboptimal treatment. Vitamin D (25OHD) deficiency during development is considered a risk factor for developing schizo…
View article: Migration and Vitamin D in psychotic disorders – A cross sectional study of clinical and cognitive correlates
Migration and Vitamin D in psychotic disorders – A cross sectional study of clinical and cognitive correlates Open
Migration is a major environmental risk factor associated with schizophrenia and other psychotic disorders. Furthermore, people with migration background may have specific challenges due to their migration background or ethnic background i…
View article: Contribution of oxytocin receptor polymorphisms to amygdala activation in schizophrenia spectrum disorders
Contribution of oxytocin receptor polymorphisms to amygdala activation in schizophrenia spectrum disorders Open
Background Oxytocin has been proposed to mediate amygdala dysfunction associated with altered emotion processing in schizophrenia, but the contribution of oxytocin pathway genes is yet to be investigated. Aims To identify potential differe…
View article: <i>VRK2</i> gene expression in schizophrenia, bipolar disorder and healthy controls
<i>VRK2</i> gene expression in schizophrenia, bipolar disorder and healthy controls Open
Background Common variants in the Vaccinia-related kinase 2 ( VRK2 ) gene have been associated with schizophrenia, but the relevance of its encoded protein VRK2 in the disorder remains unclear. Aims To identify potential differences in VRK…