Mari Shimada
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View article: Regulatory B cells drive immune evasion in the tumor microenvironment and are involved peritoneal metastasis in gastric cancer
Regulatory B cells drive immune evasion in the tumor microenvironment and are involved peritoneal metastasis in gastric cancer Open
Background: Peritoneal metastasis (PM) of gastric cancer (GC) has an immune escape environment. Regulatory B cells (Bregs), characterized by IL-10 production, play an important role in the tumor immunity; however, the function of Bregs in …
View article: Successful Treatment of Advanced Esophageal Cancer with a Constitutional Indocyanine Green Excretory Defect Using Multidisciplinary Radical Therapy: A Case Report
Successful Treatment of Advanced Esophageal Cancer with a Constitutional Indocyanine Green Excretory Defect Using Multidisciplinary Radical Therapy: A Case Report Open
症例は57歳の男性で,全身倦怠感と食欲不振の精査にて進行食道癌と診断された.治療前indocyanine green(以下,ICGと略記)検査で15分値が72.1%と異常高値,99m-Tc-galactosyl-human serum albumin(GSA)肝シンチグラフィでも肝予備能の低下を認めたが,血液検査ではChild-Pugh Grade Aに相当した.術前化学療法としてDCF療法を3コース後,術前肝生検を踏まえ耐術可能な体質性ICG排泄異常症と診断した.手術はロ…
View article: Chemoprevention of esophageal adenocarcinoma in a rat surgical model by a cysteinyl leukotriene receptor‑1 antagonist
Chemoprevention of esophageal adenocarcinoma in a rat surgical model by a cysteinyl leukotriene receptor‑1 antagonist Open
Reflux of gastroduodenal contents into the esophagus leads to the development of esophagitis and inflammation-associated pathologies, such as Barrett's esophagus (BE) and esophageal adenocarcinoma (EAC). The role of the lipoxygenase (LOX) …
View article: Thoracoscopic endoscopic cooperative surgery for gastric tube cancer after esophagectomy: a case report
Thoracoscopic endoscopic cooperative surgery for gastric tube cancer after esophagectomy: a case report Open
The incidence of gastric tube cancer (GTC) is increasing due to the improved prognosis of patients after esophagectomy for esophageal cancer. Total resection of the gastric tube is expected to be curative for patients with GTC. However, se…
View article: Novel Utility of Leucine-Rich Alpha-2-Glycoprotein as a Biomarker in Ulcerative Colitis: A Predictor of Endoscopic Remission Independent of Symptoms
Novel Utility of Leucine-Rich Alpha-2-Glycoprotein as a Biomarker in Ulcerative Colitis: A Predictor of Endoscopic Remission Independent of Symptoms Open
Introduction: Leucine-rich alpha-2-glycoprotein (LRG) is a potential biomarker for disease activity and reflects mucosal healing in patients with ulcerative colitis (UC). However, only a few studies have described a detailed sensitivity an…
View article: Robot-assisted transhiatal lower esophagectomy and proximal gastrectomy for Siewert type II advanced esophagogastric junction cancer with situs inversus totalis: a case report
Robot-assisted transhiatal lower esophagectomy and proximal gastrectomy for Siewert type II advanced esophagogastric junction cancer with situs inversus totalis: a case report Open
Background Situs inversus totalis (SIT) is a rare congenital abnormality in which the thoracic and abdominal organs are reversed or mirrored from their usual positions. We herein report the first case of robot-assisted transhiatal lower es…
View article: High <scp>CD8</scp>/<scp>CD33</scp> ratio in peritoneal metastatic lesions is associated with favorable prognosis in gastric cancer
High <span>CD8</span>/<span>CD33</span> ratio in peritoneal metastatic lesions is associated with favorable prognosis in gastric cancer Open
Background Tumor‐infiltrating lymphocytes (TILs) and other immune cells have been reported as a prognostic factor in several tumors, including gastric cancer, and they play an important role in antitumor effect at the primary site. There w…
View article: Gastrointestinal stromal tumor metastasis to the ovary: A case report
Gastrointestinal stromal tumor metastasis to the ovary: A case report Open
Gastrointestinal stromal tumors are common mesenchymal tumors of the gastrointestinal tract. The major site of metastasis for gastrointestinal stromal tumors is the liver or peritoneum, while metastasis to the ovary is exceptionally rare. …
View article: A phase I study of preoperative (neoadjuvant) chemotherapy with gemcitabine plus nab‑paclitaxel for resectable pancreatic cancer
A phase I study of preoperative (neoadjuvant) chemotherapy with gemcitabine plus nab‑paclitaxel for resectable pancreatic cancer Open
Neoadjuvant chemotherapy (NAC) has become a standard treatment for borderline resectable pancreatic ductal adenocarcinoma (PDAC). The present study examined the maximum tolerated dose of NAC with gemcitabine plus nab-paclitaxel (GnP) in pa…
View article: Comparison of prognostic impact of anatomic location of the pancreas on postoperative pancreatic fistula in laparoscopic and open gastrectomy
Comparison of prognostic impact of anatomic location of the pancreas on postoperative pancreatic fistula in laparoscopic and open gastrectomy Open
Background Postoperative pancreatic fistula (POPF) is a serious complication after gastric cancer surgery. The current study aimed to investigate the significance of the anatomic location of the pancreas as a predictor for POPF in both lap…
View article: A Case of Unknown Primary Cancer with Cystic Metastases to the Ascending Colon
A Case of Unknown Primary Cancer with Cystic Metastases to the Ascending Colon Open
症例は40歳の女性．血尿を主訴に当院泌尿器科を受診し，腹腔内に嚢胞性腫瘤を指摘され当科を紹介受診した．腹部CTにて上行結腸背側に約50mmの嚢胞性腫瘤を認めた．診断を兼ねて外科的切除の方針とし，回盲部切除術を施行した．病理組織学的所見にて上行結腸への転移性腺癌と診断され，術後のFDG-PET検査においても原発巣は指摘できなかった．原発巣として卵巣が疑われたため両側卵巣切除術を施行したが，卵巣標本においても悪性所見は指摘できず，原発不明癌と診断した．術後の治療は患者本人の希望…
View article: A Case of Intestinal Obstruction Caused by Riedel's Lobe of the Liver Treated by Laparoscopic Surgery
A Case of Intestinal Obstruction Caused by Riedel's Lobe of the Liver Treated by Laparoscopic Surgery Open
症例は73歳の女性．自動車同士の交通事故にて当院へ救急搬送された．右側腹部に強い痛みを訴え，腹部CTにて肝臓から小腸へ繋がる索状物と索状物による小腸閉塞と口側腸管の拡張を認めた．索状物による腸閉塞と診断し単孔式腹腔鏡下イレウス解除術を施行した．手術所見として，小腸へ繋がるように肝右葉下縁が舌状に伸展し，その部位での腸閉塞を認めた．舌状に伸展した肝をクリップし超音波凝固切開装置にて切離し腸閉塞を解除した．病理学的所見にて肝細胞ならびに胆管の組織を認め，肝副葉（Riedel葉）…
View article: Being aware of potentially fatal interstitial lung disease in patients with head and neck cancer treated with concurrent cetuximab and radiotherapy
Being aware of potentially fatal interstitial lung disease in patients with head and neck cancer treated with concurrent cetuximab and radiotherapy Open
Cetuximab-induced interstitial lung disease (ILD), especially for tumors in the head and neck area, has rarely been reported. The present case may serve as an important reference to alert clinicians who use this chemotherapeutic agent. We …