Maria Aderuza Horst
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View article: Impact of Polymorphisms in Genes Related to Vitamin D Metabolism on Serum Response to Supplementation in Adults and Elderly: A Systematic Review and Meta‐Analysis Protocol
Impact of Polymorphisms in Genes Related to Vitamin D Metabolism on Serum Response to Supplementation in Adults and Elderly: A Systematic Review and Meta‐Analysis Protocol Open
Background and Aims Vitamin D deficiency is a major public health issue, with varying individual responses to supplementation. Genetic factors, especially single‐nucleotide polymorphisms (SNPs) in Vitamin D metabolism genes, likely play a …
View article: Single nucleotide polymorphism SULT2A1 rs4149448 and genetic risk score as biomarkers of frailty and progression of chronic kidney disease
Single nucleotide polymorphism SULT2A1 rs4149448 and genetic risk score as biomarkers of frailty and progression of chronic kidney disease Open
Specific genetic variants, including a higher GRS and the SNP SULT2A1 rs4149448 genotype, were associated with CKD progression and frailty, suggesting their potential role in risk stratification.
View article: Telomeres and Telomerase: Targets for Chemoprevention of Hepatocellular Carcinoma With Bioactive Food Compounds
Telomeres and Telomerase: Targets for Chemoprevention of Hepatocellular Carcinoma With Bioactive Food Compounds Open
The maintenance of telomere length by telomerase plays an essential role in senescence, aging, and cancer. Mutations in the TERT promoter, a telomerase subunit, are frequent in human cancers. In hepatocellular carcinoma (HCC), telomere sho…
View article: Interaction Between Dietary Fiber Intake and MTNR1B rs10830963 Polymorphism on Glycemic Profiles in Young Brazilian Adults
Interaction Between Dietary Fiber Intake and MTNR1B rs10830963 Polymorphism on Glycemic Profiles in Young Brazilian Adults Open
Background/Objective: The single-nucleotide polymorphism (SNP) rs10830963 in the melatonin receptor 1B (MTNR1B) gene influences insulin secretion and glucose metabolism and has been associated with an increased risk of type-2 diabetes. Thi…
View article: Association between Serum Fatty Acids Profile and MetScore in Women with Severe Obesity
Association between Serum Fatty Acids Profile and MetScore in Women with Severe Obesity Open
Background: Metabolic syndrome (MetS) is a set of conditions associated with an increased cardiovascular risk. Several serum fatty acids (FAs) seem to play an essential role in the development of cardiometabolic diseases and mortality. Thu…
View article: Serum Fatty Acids and Inflammatory Patterns in Severe Obesity: A Preliminary Investigation in Women
Serum Fatty Acids and Inflammatory Patterns in Severe Obesity: A Preliminary Investigation in Women Open
Background: Inflammation plays a central role in many chronic diseases that characterize modern society. Leptin/adiponectin and adiponectin/leptin ratios have been recognized as notable markers of dysfunctional adipose tissue and, conseque…
View article: Interaction between genetic risk score and dietary fat intake on lipid-related traits in Brazilian young adults
Interaction between genetic risk score and dietary fat intake on lipid-related traits in Brazilian young adults Open
The occurrence of dyslipidaemia, which is an established risk factor for cardiovascular diseases, has been attributed to multiple factors including genetic and environmental factors. We used a genetic risk score (GRS) to assess the interac…
View article: HOMA-IR as a Predictor of PAI-1 Levels in Women with Severe Obesity
HOMA-IR as a Predictor of PAI-1 Levels in Women with Severe Obesity Open
Background: Obesity is a chronic inflammatory disorder that increases the risk of cardiovascular diseases (CVDs). Given the high CVD mortality rate among individuals with obesity, early screening should be considered. Plasminogen activator…
View article: The degree of food processing can influence serum fatty acid and lipid profiles in women with severe obesity
The degree of food processing can influence serum fatty acid and lipid profiles in women with severe obesity Open
Background The increase in the prevalence of obesity is associated with the increase in the consumption of ultra-processed foods and may be related to the increase in the disorders involving metabolism and the transport and storage of fatt…
View article: Association between the Processed Dietary Pattern and Tumor Staging in Patients Newly Diagnosed with Head and Neck Squamous Cell Carcinoma
Association between the Processed Dietary Pattern and Tumor Staging in Patients Newly Diagnosed with Head and Neck Squamous Cell Carcinoma Open
Purpose: This study aimed to assess the association between dietary patterns and tumor staging and the degree of cell differentiation in patients with head and neck squamous cell carcinoma (HNSCC). Methods: This cross-sectional study inclu…
View article: Dietary inflammatory index and its relation to the pathophysiological aspects of obesity: a narrative review
Dietary inflammatory index and its relation to the pathophysiological aspects of obesity: a narrative review Open
Obesity, a complex disease that involves energy imbalance and chronic low-grade inflammation, is implicated in the pathogenesis of several chronic non-communicable diseases. As dietary components modulate the human body's inflammatory stat…
View article: Supplementary_Tables_Lima_et_al
Supplementary_Tables_Lima_et_al Open
Supplementary_Tables_Lima_et_al
View article: Triglyceride-to-High-Density-Lipoprotein-Cholesterol Ratio as a Predictor of Metabolic Syndrome According to Stage of Life at Obesity Onset in Women with Severe Obesity—A Pilot Study
Triglyceride-to-High-Density-Lipoprotein-Cholesterol Ratio as a Predictor of Metabolic Syndrome According to Stage of Life at Obesity Onset in Women with Severe Obesity—A Pilot Study Open
The triglyceride-to-high-density lipoprotein-cholesterol (TG/HDL-c) ratio is a simple but effective indicator of metabolic imbalance that characterizes metabolic syndrome (MetS) and can consequently indicate a higher cardiovascular risk. I…
View article: Organic Curcuma Caesia Roxb. Extract Induces p21 Expression and G0/G1 Cell Cycle Arrest in FaDu Oropharyngeal Cancer Cells
Organic Curcuma Caesia Roxb. Extract Induces p21 Expression and G0/G1 Cell Cycle Arrest in FaDu Oropharyngeal Cancer Cells Open
Novel Techniques in Nutrition and Food Science Organic Curcuma Caesia Roxb. Extract Induces p21 Expression and G0/G1 Cell Cycle Arrest in FaDu Oropharyngeal Cancer Cells Campos ADS1,2, Silva ACG3, Braga PAC4, Reyes FGR4, Fernandes PM5, Bot…
View article: BJN volume 128 issue 6 Cover and Back matter
BJN volume 128 issue 6 Cover and Back matter Open
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View article: Impact of Genetic Risk Score and Dietary Protein Intake on Vitamin D Status in Young Adults from Brazil
Impact of Genetic Risk Score and Dietary Protein Intake on Vitamin D Status in Young Adults from Brazil Open
Given the relationship between vitamin D deficiency (VDD) and adverse outcomes of metabolic diseases, we investigated the interplay of dietary and genetic components on vitamin D levels and metabolic traits in young adults from Brazil. Gen…
View article: Organic Beet Leaves and Stalk Juice Attenuates the Glutathione Peroxidase Increase Induced by High-Fat Meal in Dyslipidemic Patients: A Pilot Double-Blind, Randomized, Controlled Trial
Organic Beet Leaves and Stalk Juice Attenuates the Glutathione Peroxidase Increase Induced by High-Fat Meal in Dyslipidemic Patients: A Pilot Double-Blind, Randomized, Controlled Trial Open
The beet, including the leaves and stalk (BLS), is a vegetable with great antioxidant potential. The aim of this study was to evaluate the differences in the nutritional composition and the concentration of total phenolics between the orga…
View article: Optimization of total carotenoids extraction from pequi pulp (Caryocar brasiliense Camb.) using a mixture planning method/ Otimização da extração de carotenoides totais da polpa de pequi (Caryocar brasiliense Camb.) usando método de planejamento de misturas
Optimization of total carotenoids extraction from pequi pulp (Caryocar brasiliense Camb.) using a mixture planning method/ Otimização da extração de carotenoides totais da polpa de pequi (Caryocar brasiliense Camb.) usando método de planejamento de misturas Open
The pequi is a native fruit of the Brazilian Savanna and the consumption of its carotenoid-rich pulp has been associated with several health benefits. However, there are considerable differences in carotenoid content reported for this frui…
View article: Effect of dietary fat intake and genetic risk on glucose and insulin-related traits in Brazilian young adults
Effect of dietary fat intake and genetic risk on glucose and insulin-related traits in Brazilian young adults Open
Purpose The development of metabolic diseases such as type 2 diabetes (T2D) is closely linked to a complex interplay between genetic and dietary factors. The prevalence of abdominal obesity, hyperinsulinemia, dyslipidaemia, and high blood …
View article: Total phenolic compounds and antioxidant capacity of baru almond and by-products evaluated under optimizing extraction conditions
Total phenolic compounds and antioxidant capacity of baru almond and by-products evaluated under optimizing extraction conditions Open
The baru almond has a high nutrient and phytochemical density, such as monounsaturated fatty acids, dietary fiber, vitamin E, zinc, and phenolic compounds.This study aimed to optimize the extraction conditions of total phenolic compounds f…
View article: Antiangiogenic effects of the chemopreventive agent tributyrin, a butyric acid prodrug, during the promotion phase of hepatocarcinogenesis
Antiangiogenic effects of the chemopreventive agent tributyrin, a butyric acid prodrug, during the promotion phase of hepatocarcinogenesis Open
Agents that inhibit angiogenic factors may prevent the development of hepatocellular carcinoma (HCC). Thus, the objective of this study was to kinetically evaluate the antiangiogenic activity of tributyrin (TB), a butyric acid prodrug, in …
View article: Peel and pulp of baru (Dipteryx Alata Vog.) provide high fiber, phenolic content and antioxidant capacity
Peel and pulp of baru (Dipteryx Alata Vog.) provide high fiber, phenolic content and antioxidant capacity Open
Baru (Dipteryx alata Vog.) is a native fruit of the Brazilian Savannah that can be used in the food industry and may contribute to the economy of the Brazilian Midwest. The proximate composition, the phenolic content and the antioxidant ca…
View article: Peel and pulp of baru (Dipteryx Alata Vog.) provide high fiber, phenolic content and antioxidant capacity
Peel and pulp of baru (Dipteryx Alata Vog.) provide high fiber, phenolic content and antioxidant capacity Open
Baru (Dipteryx alata Vog.) is a native fruit of the Brazilian Savannah that can be used in the food industry and may contribute to the economy of the Brazilian Midwest. The proximate composition, the phenolic content and the antioxidant ca…
View article: [O3–08–05]: PREDICTED BLOOD‐BASED MICRO‐RNAS FOR ADAM10 ARE DOWNREGULATED IN ALZHEIMER's DISEASE SUBJECTS COMPARED TO HEALTHY CONTROLS: A CROSS‐SECTIONAL SURVEY
[O3–08–05]: PREDICTED BLOOD‐BASED MICRO‐RNAS FOR ADAM10 ARE DOWNREGULATED IN ALZHEIMER's DISEASE SUBJECTS COMPARED TO HEALTHY CONTROLS: A CROSS‐SECTIONAL SURVEY Open
A Disintegrin And Metalloprotease 10 (ADAM10) is an α-secretase that cleaves Amyloid Precursor Protein (APP) in the non-amyloidogenic pathway, thereby inhibiting amyloidogenic Aβ production in Alzheimer's disease (AD). Several studies addr…
View article: [P2–174]: MICRO‐RNA 221 INHIBITS ADAM10 PROTEIN EXPRESSION IN SH‐SY5Y CELLS
[P2–174]: MICRO‐RNA 221 INHIBITS ADAM10 PROTEIN EXPRESSION IN SH‐SY5Y CELLS Open
In Alzheimer's disease (AD) non-amyloidogenic pathway, A Disintegrin And Metalloprotease 10 (ADAM10) acts as α-secretase, avoiding amyloid β (Aβ) production. We propose to analyze the overexpression of miR-144–5p, miR-374 and miR-221 in SH…
View article: Polymorphisms in PPARG and APOE: relationships with lipid profile of adolescents with cardiovascular risk factors
Polymorphisms in PPARG and APOE: relationships with lipid profile of adolescents with cardiovascular risk factors Open
Background Cardiovascular diseases constitute the main death cause worldwide resulting from a combination of genetic and lifestyle factors, and the prevalence among younger individuals has increased. It is important to early identify chang…
View article: Suppressing activity of tributyrin on hepatocarcinogenesis is associated with inhibiting the p53-CRM1 interaction and changing the cellular compartmentalization of p53 protein
Suppressing activity of tributyrin on hepatocarcinogenesis is associated with inhibiting the p53-CRM1 interaction and changing the cellular compartmentalization of p53 protein Open
Hepatocellular carcinoma (HCC), an aggressive and the fastest growing life-threatening cancer worldwide, is often diagnosed at intermediate or advanced stages of the disease, which substantially limits therapeutic approaches for its succes…